Aliases for RPRD1A Gene
External Ids for RPRD1A Gene
Previous GeneCards Identifiers for RPRD1A Gene
This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]
GeneCards Summary for RPRD1A Gene
RPRD1A (Regulation Of Nuclear Pre-MRNA Domain Containing 1A) is a Protein Coding gene. Diseases associated with RPRD1A include Retroperitoneal Leiomyosarcoma and Retroperitoneal Sarcoma. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Gene Expression. An important paralog of this gene is RPRD1B.
UniProtKB/Swiss-Prot Summary for RPRD1A Gene
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.