RPP38 Gene (Protein Coding)

Ribonuclease P/MRP Subunit P38

GC10P015097
GIFtS:
35
See more...

Aliases for RPP38 Gene

Aliases for RPP38 Gene

  • Ribonuclease P/MRP Subunit P38 2 3 5
  • Ribonuclease P Protein Subunit P38 3 4
  • Ribonuclease P/MRP 38kDa Subunit 2 3
  • RNaseP Protein P38 3 4
  • EC 3.1.26.5 4
  • RPP38 5

External Ids for RPP38 Gene

Previous GeneCards Identifiers for RPP38 Gene

  • GC10P015121
  • GC10P015289
  • GC10P015143
  • GC10P015179
  • GC10P015050
  • GC10P015140

Summaries for RPP38 Gene

GeneCards Summary for RPP38 Gene

RPP38 (Ribonuclease P/MRP Subunit P38) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and tRNA processing. Gene Ontology (GO) annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot Summary for RPP38 Gene

  • Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9037013, PubMed:9630247, PubMed:10444065, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).

Gene Wiki entry for RPP38 Gene

Additional gene information for RPP38 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPP38 Gene

Genomics for RPP38 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for RPP38 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPP38 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPP38

Top Transcription factor binding sites by QIAGEN in the RPP38 gene promoter:
  • ATF-2
  • CRE-BP1
  • CUTL1
  • Egr-2
  • Evi-1
  • LyF-1
  • NF-kappaB
  • NRF-2
  • p53
  • Pax-6

Genomic Locations for RPP38 Gene

Genomic Locations for RPP38 Gene
chr10:15,097,180-15,139,818
(GRCh38/hg38)
Size:
42,639 bases
Orientation:
Plus strand
chr10:15,139,179-15,181,817
(GRCh37/hg19)
Size:
42,639 bases
Orientation:
Plus strand

Genomic View for RPP38 Gene

Genes around RPP38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP38 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RPP38 Gene

Proteins for RPP38 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RPP38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78345-RPP38_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p38
    Protein Accession:
    P78345
    Secondary Accessions:
    • B3KPY0
    • D3DRT8
    • Q53F71
    • Q8NHS8

    Protein attributes for RPP38 Gene

    Size:
    283 amino acids
    Molecular mass:
    31834 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:9037013, PubMed:10444065, PubMed:9630247, PubMed:16723659, PubMed:30454648). RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:9037013, PubMed:9630247, PubMed:10444065, PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:16723659, PubMed:28115465).
    Miscellaneous:
    • Autoantibodies against RPP38 are found in sera from scleroderma patients.

    Three dimensional structures from OCA and Proteopedia for RPP38 Gene

neXtProt entry for RPP38 Gene

Protein Expression for RPP38 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RPP38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPP38 Gene

Domains & Families for RPP38 Gene

Gene Families for RPP38 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPP38 Gene

InterPro:
Blocks:
  • Ribosomal protein L7Ae/L30e/S12e/Gadd45
ProtoNet:

Suggested Antigen Peptide Sequences for RPP38 Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease P protein subunit p38 (RPP38_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78345

UniProtKB/Swiss-Prot:

RPP38_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL8 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL8 family.
genes like me logo Genes that share domains with RPP38: view

Function for RPP38 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for RPP38 Gene

UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9037013, PubMed:9630247, PubMed:10444065, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.; EC=3.1.26.5; Evidence={ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247};.

Enzyme Numbers (IUBMB) for RPP38 Gene

Phenotypes From GWAS Catalog for RPP38 Gene

Gene Ontology (GO) - Molecular Function for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004526 contributes_to ribonuclease P activity IEA,IDA 30454648
GO:0005515 protein binding IPI 15096576
GO:0016787 hydrolase activity IEA --
GO:0033204 ribonuclease P RNA binding IDA 30454648
genes like me logo Genes that share ontologies with RPP38: view
genes like me logo Genes that share phenotypes with RPP38: view

Animal Model Products

CRISPR Products

miRNA for RPP38 Gene

miRTarBase miRNAs that target RPP38

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPP38

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP38 Gene

Localization for RPP38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP38 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPP38 gene
Compartment Confidence
nucleus 5
mitochondrion 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 10444065
GO:0030681 multimeric ribonuclease P complex IDA 30454648
genes like me logo Genes that share ontologies with RPP38: view

Pathways & Interactions for RPP38 Gene

genes like me logo Genes that share pathways with RPP38: view

Gene Ontology (GO) - Biological Process for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5'-leader removal TAS --
GO:0006364 rRNA processing IEA --
GO:0008033 tRNA processing IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RPP38: view

No data available for SIGNOR curated interactions for RPP38 Gene

Drugs & Compounds for RPP38 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for RPP38 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RPP38 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPP38

Alternative Splicing Database (ASD) splice patterns (SP) for RPP38 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5:
SP6: - -

Relevant External Links for RPP38 Gene

GeneLoc Exon Structure for
RPP38

Expression for RPP38 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPP38 Gene

mRNA expression in normal human tissues for RPP38 Gene
mRNA expression by GTEx for RPP38 GenemRNA expression by BioGPS for RPP38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for RPP38 Gene

This gene is overexpressed in Breast (21.4), Lung (16.9), Fetal gut (10.8), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPP38 Gene



Protein tissue co-expression partners for RPP38 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPP38

SOURCE GeneReport for Unigene cluster for RPP38 Gene:

Hs.94986

Evidence on tissue expression from TISSUES for RPP38 Gene

  • Muscle(4.3)
  • Kidney(2.2)
  • Nervous system(2.2)
  • Heart(2.1)
  • Liver(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RPP38: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPP38 Gene

Orthologs for RPP38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP38 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia RPP38 30 31
  • 99.53 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia RPP38 30 31
  • 80.55 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Rpp38 30 17 31
  • 79.62 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Rpp38 30
  • 78.65 (n)
Cow
(Bos Taurus)
 Mammalia RPP38 30 31
  • 76.83 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia RPP38 31
  • 68 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves RPP38 30 31
  • 59.06 (n)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia rpp38 30
  • 55.6 (n)
Zebrafish
(Danio rerio)
 Actinopterygii rpp38 30 31
  • 50.46 (n)
 OneToOne
Species where no ortholog for RPP38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RPP38 Gene

ENSEMBL:
Gene Tree for RPP38 (if available)
TreeFam:
Gene Tree for RPP38 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPP38: view image

Paralogs for RPP38 Gene

No data available for Paralogs for RPP38 Gene

Variants for RPP38 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPP38 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
768349 Benign: not provided 15,104,080(+) T/C SYNONYMOUS_VARIANT
rs10242 - p.Ile212Thr
rs1052157 - p.Glu88Asp
rs1132078 - p.Ala114Val
rs12249258 - p.Ser202Arg

Additional dbSNP identifiers (rs#s) for RPP38 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPP38 Gene

Variant ID Type Subtype PubMed ID
nsv1113256 CNV deletion 24896259
nsv831794 CNV loss 17160897

Variation tolerance for RPP38 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.22; 90.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPP38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPP38

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP38 Gene

Disorders for RPP38 Gene

Additional Disease Information for RPP38

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for RPP38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP38 Gene

Publications for RPP38 Gene

  1. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N … Altman S (RNA (New York, N.Y.) 1998) 2 3 4 23
  2. Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (PMID: 9037013) Eder PS … Altman S (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 23
  3. Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P. (PMID: 10444065) Jarrous N … Altman S (The Journal of cell biology 1999) 3 4 23
  4. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. (PMID: 30454648) Wu J … Lei M (Cell 2018) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41

ExternalLinks

View latest publications for RPP38 gene in Mastermind

Products for RPP38 Gene

  • Addgene plasmids for RPP38

Sources for RPP38 Gene