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Aliases for RPN2 Gene

Aliases for RPN2 Gene

  • Ribophorin II 2 3 4 5
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 63 KDa Subunit 3 4
  • Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 2 3
  • Ribophorin-2 3 4
  • RIBIIR 3 4
  • RPN-II 3 4
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 2 3
  • RPNII 3
  • SWP1 3

External Ids for RPN2 Gene

Previous GeneCards Identifiers for RPN2 Gene

  • GC20P035535
  • GC20P036445
  • GC20P036492
  • GC20P035240
  • GC20P035806
  • GC20P032542

Summaries for RPN2 Gene

Entrez Gene Summary for RPN2 Gene

  • This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for RPN2 Gene

RPN2 (Ribophorin II) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and N-Glycan biosynthesis. Gene Ontology (GO) annotations related to this gene include ribosome binding and dolichyl-diphosphooligosaccharide-protein glycotransferase activity.

UniProtKB/Swiss-Prot for RPN2 Gene

  • Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

Gene Wiki entry for RPN2 Gene

Additional gene information for RPN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPN2 Gene

Genomics for RPN2 Gene

GeneHancer (GH) Regulatory Elements for RPN2 Gene

Promoters and enhancers for RPN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J037177 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 674 +0.9 866 3.3 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 RPN2 MROH8 TTI1 RBL1 DSN1 AAR2 CTNNBL1 DLGAP4-AS1
GH20J038139 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.8 +977.6 977580 33.6 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 MCM3 SP3 NFYC TGM2 SNHG17 RALGAPB ACTR5 RN7SKP173 SNORA71A TTI1 SNORA71C RPN2 DHX35
GH20J038031 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.7 +855.3 855272 3.5 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TTI1 RPRD1B SNHG17 ACTR5 SNORA71A RALGAPB RPN2 SNORA71C RPS3P2 RN7SKP173
GH20J037288 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.3 +111.5 111537 2.8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 MANBAL TTI1 RPN2 RBL1 DSN1 CTNNBL1 TLDC2 GC20P037271 PIR39095 GC20M037240
GH20J037411 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 34.6 +233.8 233767 2 HDAC1 ARNT ZSCAN4 KLF17 YBX1 ZNF48 ZNF207 ZNF548 RUNX3 MCM3 RBL1 RPN2 DSN1 TLDC2 NNAT CTNNBL1 VSTM2L TGIF2 DLGAP4-AS1 SOGA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPN2 gene promoter:
  • CREB
  • c-Jun
  • c-Fos
  • AP-1
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Hand1
  • E47

Genomic Locations for RPN2 Gene

Genomic Locations for RPN2 Gene
63,214 bases
Plus strand
63,214 bases
Plus strand

Genomic View for RPN2 Gene

Genes around RPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPN2 Gene

Proteins for RPN2 Gene

  • Protein details for RPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
    Protein Accession:
    Secondary Accessions:
    • Q5JYR6
    • Q6IBA5
    • Q96E21
    • Q9BUQ3
    • Q9UBE1

    Protein attributes for RPN2 Gene

    631 amino acids
    Molecular mass:
    69284 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.

    Alternative splice isoforms for RPN2 Gene


neXtProt entry for RPN2 Gene

Post-translational modifications for RPN2 Gene

  • Glycosylation at isoforms=2106
  • Ubiquitination at isoforms=2627 and isoforms=2154
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPN2 Gene

Domains & Families for RPN2 Gene

Gene Families for RPN2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for RPN2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SWP1 family.
  • Belongs to the SWP1 family.
genes like me logo Genes that share domains with RPN2: view

Function for RPN2 Gene

Molecular function for RPN2 Gene

UniProtKB/Swiss-Prot Function:
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
GENATLAS Biochemistry:
ribophorin II,69.5kDa,component with RPN1 and DDOST of N-oligosacccharyl transferase

Phenotypes From GWAS Catalog for RPN2 Gene

Gene Ontology (GO) - Molecular Function for RPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity NAS,IBA 15835887
GO:0005515 protein binding IPI 24965446
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with RPN2: view
genes like me logo Genes that share phenotypes with RPN2: view

Animal Models for RPN2 Gene

MGI Knock Outs for RPN2:
  • Rpn2 Rpn2<tm1a(EUCOMM)Wtsi>

Animal Model Products

Clone Products

  • Addgene plasmids for RPN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPN2 Gene

Localization for RPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPN2 Gene

Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPN2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
plasma membrane 1
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0008250 oligosaccharyltransferase complex TAS,IEA 15835887
genes like me logo Genes that share ontologies with RPN2: view

Pathways & Interactions for RPN2 Gene

genes like me logo Genes that share pathways with RPN2: view

UniProtKB/Swiss-Prot P04844-RPN2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for RPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10660554
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation IEA,IBA --
GO:0007568 aging IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS,NAS --
genes like me logo Genes that share ontologies with RPN2: view

No data available for SIGNOR curated interactions for RPN2 Gene

Drugs & Compounds for RPN2 Gene

(1) Drugs for RPN2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved, Investigational Nutra 0

(1) Additional Compounds for RPN2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichyl diphosphate
genes like me logo Genes that share compounds with RPN2: view

Transcripts for RPN2 Gene

Unigene Clusters for RPN2 Gene

Ribophorin II:
Representative Sequences:

Clone Products

  • Addgene plasmids for RPN2

Alternative Splicing Database (ASD) splice patterns (SP) for RPN2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - - -
SP8: - -

ExUns: 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21
SP8: -

Relevant External Links for RPN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPN2 Gene

Protein differential expression in normal tissues from HIPED for RPN2 Gene

This gene is overexpressed in Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPN2 Gene

Protein tissue co-expression partners for RPN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPN2 Gene:


SOURCE GeneReport for Unigene cluster for RPN2 Gene:


mRNA Expression by UniProt/SwissProt for RPN2 Gene:

Tissue specificity: Expressed in all tissues tested.

Evidence on tissue expression from TISSUES for RPN2 Gene

  • Pancreas(4.8)
  • Liver(4.6)
  • Blood(4.4)
  • Muscle(4.4)
  • Nervous system(4.3)
  • Intestine(4.1)
  • Lung(3.8)
  • Skin(3.7)
  • Eye(3.1)
  • Kidney(2.2)
  • Thyroid gland(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RPN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPN2 Gene

Orthologs for RPN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPN2 34 33
  • 99.26 (n)
(Canis familiaris)
Mammalia RPN2 34 33
  • 91.8 (n)
(Bos Taurus)
Mammalia RPN2 34 33
  • 91.34 (n)
(Rattus norvegicus)
Mammalia Rpn2 33
  • 89.43 (n)
(Mus musculus)
Mammalia Rpn2 16 34 33
  • 88.38 (n)
(Monodelphis domestica)
Mammalia RPN2 34
  • 83 (a)
(Gallus gallus)
Aves RPN2 34 33
  • 75.83 (n)
(Anolis carolinensis)
Reptilia RPN2 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpn2 33
  • 69.27 (n)
Str.9570 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53764 33
(Danio rerio)
Actinopterygii rpn2 34 33
  • 66.83 (n)
Dr.4217 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1730 33
fruit fly
(Drosophila melanogaster)
Insecta OstDelta 33
  • 45.96 (n)
CG6370 34 35
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007638 33
  • 44.55 (n)
(Caenorhabditis elegans)
Secernentea ostd-1 34 33
  • 48.85 (n)
M01A10.3 35
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HAP6 33
  • 43.43 (n)
(Oryza sativa)
Liliopsida Os01g0911200 33
  • 43.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10212 34
  • 33 (a)
Species where no ortholog for RPN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPN2 Gene

Gene Tree for RPN2 (if available)
Gene Tree for RPN2 (if available)
Evolutionary constrained regions (ECRs) for RPN2: view image

Paralogs for RPN2 Gene

No data available for Paralogs for RPN2 Gene

Variants for RPN2 Gene

Sequence variations from dbSNP and Humsavar for RPN2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs376939930 likely-benign, Congenital disorder of glycosylation 37,232,290(+) C/G/T intron_variant
rs750026130 uncertain-significance, Congenital disorder of glycosylation 37,199,059(+) T/G coding_sequence_variant, intron_variant, missense_variant
rs148488636 uncertain-significance, not specified 37,184,362(+) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs727504128 uncertain-significance, not specified 37,203,945(+) C/T coding_sequence_variant, synonymous_variant
rs770535836 uncertain-significance, not specified 37,223,903(+) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for RPN2 Gene

Variant ID Type Subtype PubMed ID
dgv2248n106 CNV deletion 24896259
esv1174249 CNV deletion 17803354
esv2082246 CNV deletion 18987734
esv2516589 CNV deletion 19546169
esv2663037 CNV deletion 23128226
esv2722385 CNV deletion 23290073
esv3557043 CNV deletion 23714750
esv3567958 CNV loss 25503493
esv3645750 CNV gain 21293372
esv4013 CNV loss 18987735
esv8416 CNV loss 19470904
nsv1071694 CNV deletion 25765185
nsv1109378 CNV deletion 24896259
nsv1151621 CNV deletion 26484159
nsv519722 CNV loss 19592680
nsv956193 CNV deletion 24416366

Variation tolerance for RPN2 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPN2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPN2 Gene

Disorders for RPN2 Gene

Additional Disease Information for RPN2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RPN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPN2 Gene

Publications for RPN2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin SG … Alzheimer's Disease Neuroimaging Initiative (PloS one 2009) 3 44 58
  3. RPN2 gene confers docetaxel resistance in breast cancer. (PMID: 18724378) Honma K … Ochiya T (Nature medicine 2008) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RPN2 Gene

Sources for RPN2 Gene

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