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Aliases for RPLP2 Gene

Aliases for RPLP2 Gene

  • Ribosomal Protein Lateral Stalk Subunit P2 2 3 5
  • Large Ribosomal Subunit Protein P2 3 4
  • Acidic Ribosomal Phosphoprotein P2 2 3
  • Renal Carcinoma Antigen NY-REN-44 3 4
  • 60S Acidic Ribosomal Protein P2 2 3
  • Ribosomal Protein, Large, P2 2 3
  • D11S2243E 3 4
  • RPP2 3 4
  • LP2 3
  • P2 3

External Ids for RPLP2 Gene

Previous HGNC Symbols for RPLP2 Gene

  • D11S2243E

Previous GeneCards Identifiers for RPLP2 Gene

  • GC11U990117
  • GC11M000732
  • GC11M000385
  • GC11P000801
  • GC11P000799
  • GC11P000625
  • GC11P000814
  • GC11P000816

Summaries for RPLP2 Gene

Entrez Gene Summary for RPLP2 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP2 Gene

RPLP2 (Ribosomal Protein Lateral Stalk Subunit P2) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP2 Gene

  • Plays an important role in the elongation step of protein synthesis.

Gene Wiki entry for RPLP2 Gene

Additional gene information for RPLP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP2 Gene

Genomics for RPLP2 Gene

GeneHancer (GH) Regulatory Elements for RPLP2 Gene

Promoters and enhancers for RPLP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000807 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 699.1 +1.3 1340 6.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC RPLP2 PIDD1 SNORA52 GC11P000839 GC11P000813 GC11P000812 TMEM80 ENSG00000255108 PHRF1 BET1L
GH11J000818 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 30.3 +10.9 10916 4.6 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 ZNF207 FOS SP3 PNPLA2 RPLP2 ENSG00000255108 LOC171391 TMEM80 RIC8A PIDD1 BET1L SNORA52 ENSG00000255158
GH11J000839 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 26.6 +34.1 34134 7.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 TSPAN4 POLR2L GC11M000841 CD151 TMEM80 PIDD1 SNORA52 RPLP2 ENSG00000255237 RIC8A
GH11J000803 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 30.1 -4.7 -4661 3.2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF143 PIDD1 ENSG00000255108 RPLP2 PHRF1 TMEM80 SNORA52 ENSG00000255237 BET1L PSMD13 LOC171391
GH11J000745 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.1 -61.6 -61638 5.1 HDGF FOXA2 ARID4B SIN3A POLR2B ZNF143 NFYC ZHX2 MXD4 REST TALDO1 ENSG00000255108 RPLP2 IRF7 LOC171391 DEAF1 TMEM80 IFITM2 GC11P000742 LOC105376509
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPLP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPLP2 gene promoter:
  • p53
  • Pax-5
  • p300
  • YY1
  • Max1
  • NF-kappaB
  • NF-kappaB1
  • RelA

Genomic Locations for RPLP2 Gene

Genomic Locations for RPLP2 Gene
3,234 bases
Plus strand
3,234 bases
Plus strand

Genomic View for RPLP2 Gene

Genes around RPLP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPLP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPLP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP2 Gene

Proteins for RPLP2 Gene

  • Protein details for RPLP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S acidic ribosomal protein P2
    Protein Accession:
    Secondary Accessions:
    • Q6FG96

    Protein attributes for RPLP2 Gene

    115 amino acids
    Molecular mass:
    11665 Da
    Quaternary structure:
    • Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPLP2 Gene

neXtProt entry for RPLP2 Gene

Post-translational modifications for RPLP2 Gene

  • Ubiquitination at posLast=6161, posLast=4141, isoforms=25, and posLast=2121
  • Modification sites at PhosphoSitePlus

Other Protein References for RPLP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPLP2 Gene

Domains & Families for RPLP2 Gene

Gene Families for RPLP2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Ribosomal proteins

Protein Domains for RPLP2 Gene

Suggested Antigen Peptide Sequences for RPLP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein P1/P2 family.
  • Belongs to the eukaryotic ribosomal protein P1/P2 family.
genes like me logo Genes that share domains with RPLP2: view

Function for RPLP2 Gene

Molecular function for RPLP2 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the elongation step of protein synthesis.
GENATLAS Biochemistry:
60S acidic ribosomal protein P2

Phenotypes From GWAS Catalog for RPLP2 Gene

Gene Ontology (GO) - Molecular Function for RPLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 22135285
genes like me logo Genes that share ontologies with RPLP2: view
genes like me logo Genes that share phenotypes with RPLP2: view

Animal Model Products

CRISPR Products

miRNA for RPLP2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPLP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP2 Gene

Localization for RPLP2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPLP2 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
nucleus 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with RPLP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPLP2 Gene

Pathways & Interactions for RPLP2 Gene

genes like me logo Genes that share pathways with RPLP2: view

Pathways by source for RPLP2 Gene

1 KEGG pathway for RPLP2 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP2 Gene

SIGNOR curated interactions for RPLP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RPLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPLP2: view

Drugs & Compounds for RPLP2 Gene

(1) Additional Compounds for RPLP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPLP2: view

Transcripts for RPLP2 Gene

mRNA/cDNA for RPLP2 Gene

Unigene Clusters for RPLP2 Gene

Ribosomal protein, large, P2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPLP2

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP2 Gene

No ASD Table

Relevant External Links for RPLP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPLP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPLP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPLP2 Gene

This gene is overexpressed in Amniocyte (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPLP2 Gene

Protein tissue co-expression partners for RPLP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPLP2 Gene:


SOURCE GeneReport for Unigene cluster for RPLP2 Gene:


Evidence on tissue expression from TISSUES for RPLP2 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Skin(4.8)
  • Kidney(4.6)
  • Lung(4.4)
  • Muscle(4.2)
  • Pancreas(4.2)
  • Heart(3.9)
  • Intestine(3.9)
  • Eye(3.8)
  • Spleen(3.5)
  • Stomach(2.9)
  • Blood(2.8)
  • Lymph node(2.8)
  • Bone marrow(2.4)
  • Adrenal gland(2.3)
  • Thyroid gland(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with RPLP2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPLP2 Gene

Orthologs for RPLP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPLP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPLP2 34 33
  • 98.84 (n)
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
-- 34
  • 91 (a)
(Mus musculus)
Mammalia Rplp2 16 34 33
  • 89.86 (n)
(Bos Taurus)
Mammalia RPLP2 34 33
  • 87.54 (n)
-- 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia RPLP2 34
  • 51 (a)
(Gallus gallus)
Aves RPLP2 34 33
  • 81.16 (n)
(Anolis carolinensis)
Reptilia RPLP2 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp2 33
  • 67.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24718 33
(Danio rerio)
Actinopterygii rplp2l 34 33
  • 73.74 (n)
Dr.26791 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003025 33
  • 62.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpLP2 34
  • 58 (a)
(Caenorhabditis elegans)
Secernentea C37A2.7 34
  • 58 (a)
rla-2 34
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP2B 36 34
  • 55 (a)
RPP2A 34
  • 55 (a)
(Hordeum vulgare)
Liliopsida Hv.5710 33
(Triticum aestivum)
Liliopsida Ta.2539 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11199 34
  • 65 (a)
Cin.4372 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4372 33
Species where no ortholog for RPLP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPLP2 Gene

Gene Tree for RPLP2 (if available)
Gene Tree for RPLP2 (if available)
Evolutionary constrained regions (ECRs) for RPLP2: view image

Paralogs for RPLP2 Gene Pseudogenes for RPLP2 Gene

genes like me logo Genes that share paralogs with RPLP2: view

No data available for Paralogs for RPLP2 Gene

Variants for RPLP2 Gene

Sequence variations from dbSNP and Humsavar for RPLP2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000118985 -- 811,147(+) A/G intron_variant
rs1000267176 -- 809,693(+) G/A upstream_transcript_variant
rs1000272107 -- 811,007(+) C/A intron_variant
rs1000340319 -- 809,521(+) T/G upstream_transcript_variant
rs1001051325 -- 810,435(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPLP2 Gene

Variant ID Type Subtype PubMed ID
dgv1013n100 CNV gain 25217958
dgv1526n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
esv2759794 CNV loss 17122850
nsv1040044 CNV gain+loss 25217958
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv552870 CNV loss 21841781
nsv552871 CNV loss 21841781
nsv832044 CNV loss 17160897
nsv8759 CNV gain 18304495
nsv951272 CNV deletion 24416366

Variation tolerance for RPLP2 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPLP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPLP2 Gene

Disorders for RPLP2 Gene

Additional Disease Information for RPLP2

No disorders were found for RPLP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPLP2 Gene

Publications for RPLP2 Gene

  1. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. (PMID: 3323886) Rich BE … Steitz JA (Molecular and cellular biology 1987) 2 3 4 58
  2. Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk. (PMID: 20385603) Lee KM … Wong KB (Nucleic acids research 2010) 3 4 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Identification and characterization of phosphorylated proteins in the human pituitary. (PMID: 14997482) Giorgianni F … Desiderio DM (Proteomics 2004) 3 4 58

Products for RPLP2 Gene

Sources for RPLP2 Gene

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