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Aliases for RPLP1 Gene

Aliases for RPLP1 Gene

  • Ribosomal Protein Lateral Stalk Subunit P1 2 3 5
  • Large Ribosomal Subunit Protein P1 3 4
  • Ribosomal Protein, Large, P1 2 3
  • Acidic Ribosomal Phosphoprotein P1 3
  • 60S Acidic Ribosomal Protein P1 3
  • RPP1 3
  • RRP1 4
  • LP1 3
  • P1 3

External Ids for RPLP1 Gene

Previous GeneCards Identifiers for RPLP1 Gene

  • GC15P065586
  • GC15P062843
  • GC15P067324
  • GC15P067460
  • GC15P067532
  • GC15P069745
  • GC15P046578
  • GC15P069454
  • GC15P069455

Summaries for RPLP1 Gene

Entrez Gene Summary for RPLP1 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP1 Gene

RPLP1 (Ribosomal Protein Lateral Stalk Subunit P1) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP1 Gene

  • Plays an important role in the elongation step of protein synthesis.

Gene Wiki entry for RPLP1 Gene

Additional gene information for RPLP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP1 Gene

Genomics for RPLP1 Gene

GeneHancer (GH) Regulatory Elements for RPLP1 Gene

Promoters and enhancers for RPLP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J069451 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.4 398 4.1 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 SP3 NFYC ZFP41 MEF2D RPLP1 ENSG00000259265 CORO2B TLE3 NOX5 GC15M069460 ENSG00000207119
GH15J069457 Enhancer 0.8 ENCODE 0.7 +4.7 4724 0.6 PKNOX1 MZF1 FEZF1 ZEB1 TCF12 CTBP1 POLR2A ZBTB48 PATZ1 ZSCAN5C ENSG00000207119 GC15M069460 RPLP1
GH15J069456 Enhancer 0.6 ENCODE 0.7 +4.3 4283 0.2 SMAD5 USF2 SP1 SSRP1 POLR2B POLR2A SCRT2 RBM22 SNRNP70 SUPT5H GC15M069460 ENSG00000207119 RPLP1
GH15J069455 Enhancer 0.5 ENCODE 0.7 +2.8 2813 0.2 POLR2A MZF1 KLF14 SUPT5H YY1 ENSG00000207119 RPLP1 GC15M069460
GH15J069442 Enhancer 0.6 ENCODE dbSUPER 0.4 -9.7 -9668 0.7 PKNOX1 ZNF362 SPI1 GC15M069428 RPLP1 KIF23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPLP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPLP1 gene promoter:
  • E2F-2
  • PPAR-gamma2
  • E2F
  • E2F-1
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-1
  • PPAR-gamma1
  • GATA-2

Genomic Locations for RPLP1 Gene

Genomic Locations for RPLP1 Gene
chr15:69,452,784-69,456,194
(GRCh38/hg38)
Size:
3,411 bases
Orientation:
Plus strand
chr15:69,745,123-69,748,255
(GRCh37/hg19)
Size:
3,133 bases
Orientation:
Plus strand

Genomic View for RPLP1 Gene

Genes around RPLP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPLP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP1 Gene

Proteins for RPLP1 Gene

  • Protein details for RPLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05386-RLA1_HUMAN
    Recommended name:
    60S acidic ribosomal protein P1
    Protein Accession:
    P05386
    Secondary Accessions:
    • A6NIB2

    Protein attributes for RPLP1 Gene

    Size:
    114 amino acids
    Molecular mass:
    11514 Da
    Quaternary structure:
    • Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPLP1 Gene

    Alternative splice isoforms for RPLP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPLP1 Gene

Post-translational modifications for RPLP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPLP1 Gene

No data available for DME Specific Peptides for RPLP1 Gene

Domains & Families for RPLP1 Gene

Gene Families for RPLP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPLP1 Gene

Suggested Antigen Peptide Sequences for RPLP1 Gene

Graphical View of Domain Structure for InterPro Entry

P05386

UniProtKB/Swiss-Prot:

RLA1_HUMAN :
  • Belongs to the eukaryotic ribosomal protein P1/P2 family.
Family:
  • Belongs to the eukaryotic ribosomal protein P1/P2 family.
genes like me logo Genes that share domains with RPLP1: view

Function for RPLP1 Gene

Molecular function for RPLP1 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the elongation step of protein synthesis.

Phenotypes From GWAS Catalog for RPLP1 Gene

Gene Ontology (GO) - Molecular Function for RPLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS,IDA 12962325
GO:0005515 protein binding IPI 11277934
GO:0030295 protein kinase activator activity IBA --
genes like me logo Genes that share ontologies with RPLP1: view
genes like me logo Genes that share phenotypes with RPLP1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP1 Gene

Localization for RPLP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPLP1 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0022625 cytosolic large ribosomal subunit HDA,IDA 3323886
genes like me logo Genes that share ontologies with RPLP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPLP1 Gene

Pathways & Interactions for RPLP1 Gene

genes like me logo Genes that share pathways with RPLP1: view

Pathways by source for RPLP1 Gene

1 KEGG pathway for RPLP1 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP1 Gene

Gene Ontology (GO) - Biological Process for RPLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPLP1: view

No data available for SIGNOR curated interactions for RPLP1 Gene

Drugs & Compounds for RPLP1 Gene

No Compound Related Data Available

Transcripts for RPLP1 Gene

mRNA/cDNA for RPLP1 Gene

Unigene Clusters for RPLP1 Gene

Ribosomal protein, large, P1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: -

Relevant External Links for RPLP1 Gene

GeneLoc Exon Structure for
RPLP1
ECgene alternative splicing isoforms for
RPLP1

Expression for RPLP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPLP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPLP1 Gene



Protein tissue co-expression partners for RPLP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPLP1 Gene:

RPLP1

SOURCE GeneReport for Unigene cluster for RPLP1 Gene:

Hs.356502

Evidence on tissue expression from TISSUES for RPLP1 Gene

  • Eye(4.9)
  • Nervous system(4.9)
  • Pancreas(4.7)
  • Muscle(4.6)
  • Heart(4.4)
  • Liver(4.3)
  • Intestine(4.2)
  • Skin(4.2)
  • Lung(4.1)
  • Kidney(3.8)
  • Blood(3.4)
  • Spleen(2.8)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Thyroid gland(2.6)
  • Adrenal gland(2.5)
  • Bone(2.4)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with RPLP1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPLP1 Gene

Orthologs for RPLP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPLP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPLP1 34 33
  • 99.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rplp1 34
  • 97 (a)
OneToMany
Gm10073 34
  • 96 (a)
OneToMany
Gm17511 34
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPLP1 34 33
  • 93.27 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rplp1 33
  • 88.89 (n)
dog
(Canis familiaris)
Mammalia RPLP1 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPLP1 34 33
  • 80.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPLP1 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp1 33
  • 73.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20833 33
zebrafish
(Danio rerio)
Actinopterygii rplp1 34 33
  • 70.5 (n)
OneToOne
wufa93f02 33
fruit fly
(Drosophila melanogaster)
Insecta RpLP1 34
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rla-1 34
  • 65 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP1A 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 65 (a)
OneToOne
Species where no ortholog for RPLP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPLP1 Gene

ENSEMBL:
Gene Tree for RPLP1 (if available)
TreeFam:
Gene Tree for RPLP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPLP1: view image

Paralogs for RPLP1 Gene

No data available for Paralogs for RPLP1 Gene

Variants for RPLP1 Gene

Sequence variations from dbSNP and Humsavar for RPLP1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1001925283 -- 69,451,228(+) C/A upstream_transcript_variant
rs1002090835 -- 69,451,195(+) A/C upstream_transcript_variant
rs1002587722 -- 69,453,323(+) G/A intron_variant
rs1002810961 -- 69,453,347(+) G/T intron_variant
rs1002950809 -- 69,453,127(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPLP1 Gene

Variant ID Type Subtype PubMed ID
esv2760037 CNV loss 17122850
nsv1585 CNV insertion 18451855
nsv520964 CNV gain 19592680
nsv976947 CNV duplication 23825009

Variation tolerance for RPLP1 Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPLP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPLP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPLP1 Gene

Disorders for RPLP1 Gene

Additional Disease Information for RPLP1

No disorders were found for RPLP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPLP1 Gene

Publications for RPLP1 Gene

  1. Identification and characterization of phosphorylated proteins in the human pituitary. (PMID: 14997482) Giorgianni F … Desiderio DM (Proteomics 2004) 3 4 22 58
  2. Solution structure of the dimerization domain of the eukaryotic stalk P1/P2 complex reveals the structural organization of eukaryotic stalk complex. (PMID: 22135285) Lee KM … Wong KB (Nucleic acids research 2012) 3 4 58
  3. Phosphoproteomic analysis of the human pituitary. (PMID: 16807684) Beranova-Giorgianni S … Giorgianni F (Pituitary 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 58

Products for RPLP1 Gene

Sources for RPLP1 Gene

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