Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in th... See more...

Aliases for RPL8 Gene

Aliases for RPL8 Gene

  • Ribosomal Protein L8 2 3 5
  • Large Ribosomal Subunit Protein UL2 3 4
  • 60S Ribosomal Protein L8 3 4
  • L8 3

External Ids for RPL8 Gene

Previous GeneCards Identifiers for RPL8 Gene

  • GC08M143622
  • GC08M146052
  • GC08M145619
  • GC08M146019
  • GC08M145985
  • GC08M141130
  • GC08M146015

Summaries for RPL8 Gene

Entrez Gene Summary for RPL8 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL8 Gene

RPL8 (Ribosomal Protein L8) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is MRPL2.

UniProtKB/Swiss-Prot Summary for RPL8 Gene

Gene Wiki entry for RPL8 Gene

Additional gene information for RPL8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL8 Gene

Genomics for RPL8 Gene

GeneHancer (GH) Regulatory Elements for RPL8 Gene

Promoters and enhancers for RPL8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL8 gene promoter:
  • Pax-3
  • TBP

Genomic Locations for RPL8 Gene

Genomic Locations for RPL8 Gene
chr8:144,789,765-144,792,587
(GRCh38/hg38)
Size:
2,823 bases
Orientation:
Minus strand
chr8:146,015,150-146,017,972
(GRCh37/hg19)
Size:
2,823 bases
Orientation:
Minus strand

Genomic View for RPL8 Gene

Genes around RPL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL8 Gene

Proteins for RPL8 Gene

  • Protein details for RPL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62917-RL8_HUMAN
    Recommended name:
    60S ribosomal protein L8
    Protein Accession:
    P62917
    Secondary Accessions:
    • A8K094
    • D3DWN2
    • P25120
    • Q567Q7
    • Q969V7
    • Q9BWQ9

    Protein attributes for RPL8 Gene

    Size:
    257 amino acids
    Molecular mass:
    28025 Da
    Quaternary structure:
    • Component of the large ribosomal subunit (Probable). Interacts with CRY1 (By similarity).
    Miscellaneous:
    • This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the endogenous protein.

    Three dimensional structures from OCA and Proteopedia for RPL8 Gene

neXtProt entry for RPL8 Gene

Post-translational modifications for RPL8 Gene

  • Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.
  • Ubiquitination at Lys10, Lys46, Lys60, and Lys181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL8 Gene

Domains & Families for RPL8 Gene

Gene Families for RPL8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL8 Gene

GenScript: Design optimal peptide antigens:
  • 60S ribosomal protein L8 (RL8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62917

UniProtKB/Swiss-Prot:

RL8_HUMAN :
  • Belongs to the universal ribosomal protein uL2 family.
Family:
  • Belongs to the universal ribosomal protein uL2 family.
genes like me logo Genes that share domains with RPL8: view

Function for RPL8 Gene

Molecular function for RPL8 Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.
GENATLAS Biochemistry:
60S ribosomal protein L8

Phenotypes From GWAS Catalog for RPL8 Gene

Gene Ontology (GO) - Molecular Function for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,HDA 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPL8: view
genes like me logo Genes that share phenotypes with RPL8: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL8 Gene

Localization for RPL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL8 gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0014069 postsynaptic density IDA 21170055
genes like me logo Genes that share ontologies with RPL8: view

Pathways & Interactions for RPL8 Gene

genes like me logo Genes that share pathways with RPL8: view

Pathways by source for RPL8 Gene

1 KEGG pathway for RPL8 Gene
1 GeneGo (Thomson Reuters) pathway for RPL8 Gene

Gene Ontology (GO) - Biological Process for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA,IDA 25957688
GO:0006412 translation NAS,IEA 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL8: view

No data available for SIGNOR curated interactions for RPL8 Gene

Drugs & Compounds for RPL8 Gene

(3) Drugs for RPL8 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL8: view

Transcripts for RPL8 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - - - -
SP12: - -

Relevant External Links for RPL8 Gene

GeneLoc Exon Structure for
RPL8
ECgene alternative splicing isoforms for
RPL8

Expression for RPL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL8 Gene



Protein tissue co-expression partners for RPL8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL8 Gene:

RPL8

SOURCE GeneReport for Unigene cluster for RPL8 Gene:

Hs.178551

Evidence on tissue expression from TISSUES for RPL8 Gene

  • Skin(5)
  • Nervous system(5)
  • Kidney(4.9)
  • Liver(4.9)
  • Lung(4.8)
  • Pancreas(4.8)
  • Eye(4.6)
  • Intestine(4.6)
  • Muscle(4.3)
  • Stomach(3.9)
  • Bone(3.8)
  • Blood(3.3)
  • Thyroid gland(3)
  • Heart(2.9)
  • Bone marrow(2.8)
  • Lymph node(2.8)
  • Spleen(2.7)
  • Adrenal gland(2.6)
  • Gall bladder(2.6)
genes like me logo Genes that share expression patterns with RPL8: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL8 Gene

Orthologs for RPL8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL8 33 32
  • 99.22 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL8 33
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 99 (a)
OneToMany
-- 33
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 33
  • 96 (a)
OneToMany
RPL8 33 32
  • 89.88 (n)
OneToMany
dog
(Canis familiaris)
Mammalia RPL8 33 32
  • 90.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl8 17 33 32
  • 87.68 (n)
chicken
(Gallus gallus)
Aves RPL8 33 32
  • 81.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 99 (a)
OneToMany
-- 33
  • 97 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl8 32
  • 79.64 (n)
MGC75725 32
African clawed frog
(Xenopus laevis)
Amphibia rpl8-prov 32
zebrafish
(Danio rerio)
Actinopterygii rpl8 33 32
  • 80.16 (n)
OneToOne
zgc73105 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8639 32
fruit fly
(Drosophila melanogaster)
Insecta RpL8 33 34 32
  • 74.13 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RL8_ANOGA 32
  • 71.35 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-2 33 34 32
  • 67.19 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL2A 33
  • 72 (a)
OneToMany
RPL2B 35 33 32
  • 63.52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL127C 32
  • 65.22 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16027g 32
  • 63.52 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51190 32
  • 64.52 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.710 32
soybean
(Glycine max)
eudicotyledons Gma.10752 32
wheat
(Triticum aestivum)
Liliopsida Ta.28331 32
corn
(Zea mays)
Liliopsida Zm.13965 32
rice
(Oryza sativa)
Liliopsida Os.11297 32
barley
(Hordeum vulgare)
Liliopsida Hv.12793 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4346 33
  • 78 (a)
OneToOne
Cin.15561 32
bread mold
(Neurospora crassa)
Ascomycetes NCU00413 32
  • 65.49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl801 32
  • 64.69 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15561 32
Species where no ortholog for RPL8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL8 Gene

ENSEMBL:
Gene Tree for RPL8 (if available)
TreeFam:
Gene Tree for RPL8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL8: view image

Paralogs for RPL8 Gene

Paralogs for RPL8 Gene

genes like me logo Genes that share paralogs with RPL8: view

Variants for RPL8 Gene

Sequence variations from dbSNP and Humsavar for RPL8 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000119275 -- 144,790,231(-) C/A intron_variant
rs1002056004 -- 144,792,813(-) G/T upstream_transcript_variant
rs1002820317 -- 144,790,714(-) A/G intron_variant
rs1002823533 -- 144,793,907(-) C/T upstream_transcript_variant
rs1002893912 -- 144,790,858(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL8 Gene

Variant ID Type Subtype PubMed ID
nsv522459 CNV loss 19592680
nsv612969 CNV loss 21841781

Variation tolerance for RPL8 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL8 Gene

Disorders for RPL8 Gene

Additional Disease Information for RPL8

No disorders were found for RPL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL8 Gene

Publications for RPL8 Gene

  1. Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. (PMID: 7506540) Hanes J … Scheit KH (Biochemical and biophysical research communications 1993) 2 3 4 23 56
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 56
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova TI … Karpova GG (Journal of protein chemistry 2003) 3 4 56

Products for RPL8 Gene

Sources for RPL8 Gene