Aliases for RPL7L1 Gene

Aliases for RPL7L1 Gene

  • Ribosomal Protein L7 Like 1 2 3 5
  • Large Ribosomal Subunit Protein UL30-Like 1 3 4
  • 60S Ribosomal Protein L7-Like 1 3 4
  • Ribosomal Protein L7-Like 1 2
  • DJ475N16.4 3

External Ids for RPL7L1 Gene

Previous GeneCards Identifiers for RPL7L1 Gene

  • GC06P042894
  • GC06P042956
  • GC06P042847
  • GC06P042565
  • GC06P043178
  • GC06P043278
  • GC06P043166
  • GC06P043164

Summaries for RPL7L1 Gene

GeneCards Summary for RPL7L1 Gene

RPL7L1 (Ribosomal Protein L7 Like 1) is a Protein Coding gene. An important paralog of this gene is RPL7.

Additional gene information for RPL7L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL7L1 Gene

Genomics for RPL7L1 Gene

GeneHancer (GH) Regulatory Elements for RPL7L1 Gene

Promoters and enhancers for RPL7L1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL7L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL7L1 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • GATA-1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)

Genomic Locations for RPL7L1 Gene

Genomic Locations for RPL7L1 Gene
chr6:42,879,618-42,889,925
(GRCh38/hg38)
Size:
10,308 bases
Orientation:
Plus strand
chr6:42,847,356-42,857,663
(GRCh37/hg19)
Size:
10,308 bases
Orientation:
Plus strand

Genomic View for RPL7L1 Gene

Genes around RPL7L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL7L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL7L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7L1 Gene

Proteins for RPL7L1 Gene

  • Protein details for RPL7L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DKI1-RL7L_HUMAN
    Recommended name:
    60S ribosomal protein L7-like 1
    Protein Accession:
    Q6DKI1
    Secondary Accessions:
    • A8K7D4
    • B7Z652
    • Q5TFZ5
    • Q6PEK3

    Protein attributes for RPL7L1 Gene

    Size:
    255 amino acids
    Molecular mass:
    29669 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH58020.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH73890.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF84638.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH13138.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RPL7L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL7L1 Gene

Post-translational modifications for RPL7L1 Gene

  • Ubiquitination at Lys122 and Lys129
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL7L1 Gene

No data available for DME Specific Peptides for RPL7L1 Gene

Domains & Families for RPL7L1 Gene

Gene Families for RPL7L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL7L1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50850, highly similar to Ribosomal protein L7-like 1 (B7Z652_HUMAN)
  • 60S ribosomal protein L7-like 1 (RL7L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6DKI1

UniProtKB/Swiss-Prot:

RL7L_HUMAN :
  • Belongs to the universal ribosomal protein uL30 family.
Family:
  • Belongs to the universal ribosomal protein uL30 family.
genes like me logo Genes that share domains with RPL7L1: view

Function for RPL7L1 Gene

Phenotypes From GWAS Catalog for RPL7L1 Gene

Gene Ontology (GO) - Molecular Function for RPL7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA 21873635
genes like me logo Genes that share ontologies with RPL7L1: view
genes like me logo Genes that share phenotypes with RPL7L1: view

Animal Models for RPL7L1 Gene

MGI Knock Outs for RPL7L1:
  • Rpl7l1 Rpl7l1<tm2b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for RPL7L1 Gene

miRTarBase miRNAs that target RPL7L1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPL7L1 Gene

Localization for RPL7L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL7L1 gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit IBA 21873635
genes like me logo Genes that share ontologies with RPL7L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL7L1 Gene

Pathways & Interactions for RPL7L1 Gene

PathCards logo

SuperPathways for RPL7L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPL7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0001825 blastocyst formation IEA --
genes like me logo Genes that share ontologies with RPL7L1: view

No data available for Pathways by source and SIGNOR curated interactions for RPL7L1 Gene

Drugs & Compounds for RPL7L1 Gene

No Compound Related Data Available

Transcripts for RPL7L1 Gene

mRNA/cDNA for RPL7L1 Gene

(2) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7L1 Gene

No ASD Table

Relevant External Links for RPL7L1 Gene

GeneLoc Exon Structure for
RPL7L1
ECgene alternative splicing isoforms for
RPL7L1

Expression for RPL7L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL7L1 Gene

Protein differential expression in normal tissues from HIPED for RPL7L1 Gene

This gene is overexpressed in Lung (47.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL7L1 Gene



Protein tissue co-expression partners for RPL7L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPL7L1 Gene:

RPL7L1

SOURCE GeneReport for Unigene cluster for RPL7L1 Gene:

Hs.520133

Evidence on tissue expression from TISSUES for RPL7L1 Gene

  • Nervous system(4.8)
  • Eye(4.2)
  • Liver(3)
genes like me logo Genes that share expression patterns with RPL7L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL7L1 Gene

Orthologs for RPL7L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL7L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL7L1 33 32
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 33
  • 89 (a)
OneToMany
RPL7L1 32
  • 88.62 (n)
-- 33
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPL7L1 33 32
  • 87.53 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl7l1 32
  • 86.39 (n)
mouse
(Mus musculus)
Mammalia Rpl7l1 17 33 32
  • 84.63 (n)
1700084J12Rik 33
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL7L1 33
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL7L1 33
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL7L1 33 32
  • 68.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL7L1 33
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25248 32
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76334 32
zebrafish
(Danio rerio)
Actinopterygii rpl7l1 33 32
  • 59.49 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL7 33
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-7 33
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL7B 33
  • 33 (a)
ManyToMany
RPL7A 33
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2360 33
  • 45 (a)
OneToMany
Species where no ortholog for RPL7L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL7L1 Gene

ENSEMBL:
Gene Tree for RPL7L1 (if available)
TreeFam:
Gene Tree for RPL7L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL7L1: view image

Paralogs for RPL7L1 Gene

Variants for RPL7L1 Gene

Sequence variations from dbSNP and Humsavar for RPL7L1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000375280 -- 42,886,954(+) A/G 3_prime_UTR_variant, intron_variant
rs1000572564 -- 42,882,413(+) G/A intron_variant
rs1000639245 -- 42,881,319(+) G/C intron_variant
rs1000677699 -- 42,888,457(+) T/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1001010086 -- 42,879,502(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL7L1 Gene

Variant ID Type Subtype PubMed ID
esv3576145 CNV gain 25503493
nsv1017398 CNV gain 25217958
nsv830651 CNV loss 17160897
nsv969394 CNV duplication 23825009

Variation tolerance for RPL7L1 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL7L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL7L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL7L1 Gene

Disorders for RPL7L1 Gene

Additional Disease Information for RPL7L1

No disorders were found for RPL7L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL7L1 Gene

Publications for RPL7L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56
  4. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 56
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56

Products for RPL7L1 Gene

Sources for RPL7L1 Gene