Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can int... See more...

Aliases for RPL7A Gene

Aliases for RPL7A Gene

  • Ribosomal Protein L7a 2 3 5
  • 60S Ribosomal Protein L7a 2 3 4
  • Surfeit Locus Protein 3 2 3 4
  • PLA-X Polypeptide 2 3 4
  • SURF3 2 3 4
  • Thyroid Hormone Receptor Uncoupling Protein 2 3
  • Large Ribosomal Subunit Protein EL8 3 4
  • Surfeit 3 2 3
  • TRUP 2 3
  • L7A 2 3
  • SURF-3 4
  • RPL7A 5
  • ; 2

External Ids for RPL7A Gene

Previous GeneCards Identifiers for RPL7A Gene

  • GC09P127304
  • GC09P127771
  • GC09P129568
  • GC09P131491
  • GC09P133231
  • GC09P135194
  • GC09P135217
  • GC09P135222
  • GC09P135228
  • GC09P135235
  • GC09P135240
  • GC09P136215

Summaries for RPL7A Gene

Entrez Gene Summary for RPL7A Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL7A Gene

RPL7A (Ribosomal Protein L7a) is a Protein Coding gene. Diseases associated with RPL7A include Tuberous Sclerosis 1 and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RSL1D1.

Gene Wiki entry for RPL7A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL7A Gene

Genomics for RPL7A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPL7A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL7A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL7A

Top Transcription factor binding sites by QIAGEN in the RPL7A gene promoter:
  • Chx10
  • ER-alpha
  • FOXL1
  • HOXA3
  • HTF
  • Pax-2
  • Pax-2a
  • Pax-2b
  • PPAR-gamma2
  • Sox9

Genomic Locations for RPL7A Gene

Latest Assembly
chr9:133,348,218-133,351,426
(GRCh38/hg38)
Size:
3,209 bases
Orientation:
Plus strand

Previous Assembly
chr9:136,215,073-136,218,281
(GRCh37/hg19 by Entrez Gene)
Size:
3,209 bases
Orientation:
Plus strand

chr9:136,215,069-136,218,281
(GRCh37/hg19 by Ensembl)
Size:
3,213 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr9(PATCHES):174,312-177,520 (+)

Genomic View for RPL7A Gene

Genes around RPL7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7A Gene

Proteins for RPL7A Gene

  • Protein details for RPL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62424-RL7A_HUMAN
    Recommended name:
    60S ribosomal protein L7a
    Protein Accession:
    P62424
    Secondary Accessions:
    • P11518
    • Q5T8U4

    Protein attributes for RPL7A Gene

    Size:
    266 amino acids
    Molecular mass:
    29996 Da
    Quaternary structure:
    • Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).

    Three dimensional structures from OCA and Proteopedia for RPL7A Gene

neXtProt entry for RPL7A Gene

Post-translational modifications for RPL7A Gene

  • Ubiquitination at Lys26, Lys34, Lys37, Lys48, Lys75, Lys97, Lys197, Lys212, Lys217, Lys245, and Lys264
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL7A Gene

No data available for DME Specific Peptides for RPL7A Gene

Domains & Families for RPL7A Gene

Gene Families for RPL7A Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL7A Gene

Suggested Antigen Peptide Sequences for RPL7A Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92002, Homo sapiens ribosomal protein L7a (RPL7A), mRNA (Q5T8U4_HUMAN)
  • Surfeit locus protein 3 (RL7A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62424

UniProtKB/Swiss-Prot:

RL7A_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL8 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL8 family.
genes like me logo Genes that share domains with RPL7A: view

Function for RPL7A Gene

Molecular function for RPL7A Gene

GENATLAS Biochemistry:
ribosomal protein L7a (see SURF@)

Phenotypes From GWAS Catalog for RPL7A Gene

Gene Ontology (GO) - Molecular Function for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IBA 21873635
GO:0003735 structural constituent of ribosome TAS,NAS 12962325
GO:0005515 protein binding IPI 15303970
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with RPL7A: view
genes like me logo Genes that share phenotypes with RPL7A: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL7A

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL7A Gene

Localization for RPL7A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL7A gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005730 nucleolus IDA 25294810
GO:0005737 cytoplasm HDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL7A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL7A Gene

Pathways & Interactions for RPL7A Gene

genes like me logo Genes that share pathways with RPL7A: view

Pathways by source for RPL7A Gene

1 GeneGo (Thomson Reuters) pathway for RPL7A Gene
  • CFTR translational fidelity (class I mutations)
1 Cell Signaling Technology pathway for RPL7A Gene

Gene Ontology (GO) - Biological Process for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000470 maturation of LSU-rRNA IBA 21873635
GO:0006412 translation TAS,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL7A: view

No data available for SIGNOR curated interactions for RPL7A Gene

Drugs & Compounds for RPL7A Gene

No Compound Related Data Available

Transcripts for RPL7A Gene

mRNA/cDNA for RPL7A Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL7A

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -
SP9:
SP10:

Relevant External Links for RPL7A Gene

GeneLoc Exon Structure for
RPL7A

Expression for RPL7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Tonsil (Hematopoietic System)

Protein differential expression in normal tissues from HIPED for RPL7A Gene

This gene is overexpressed in Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL7A Gene



Protein tissue co-expression partners for RPL7A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL7A

SOURCE GeneReport for Unigene cluster for RPL7A Gene:

Hs.499839

Evidence on tissue expression from TISSUES for RPL7A Gene

  • Nervous system(5)
  • Lung(5)
  • Skin(5)
  • Liver(5)
  • Eye(5)
  • Pancreas(4.9)
  • Blood(4.9)
  • Intestine(4.8)
  • Muscle(4.7)
  • Kidney(4.5)
  • Stomach(4.3)
  • Bone(4)
  • Heart(3)
  • Lymph node(2.6)
  • Thyroid gland(2.6)
  • Bone marrow(2.2)
  • Adrenal gland(2.1)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with RPL7A: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL7A Gene

Orthologs for RPL7A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL7A Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Gm8226 30
  • 100 (a)
OneToMany
Gm16477 30
  • 99 (a)
OneToMany
Gm5619 30
  • 99 (a)
OneToMany
Rpl7a-ps10 30
  • 98 (a)
OneToMany
Rpl7a-ps5 30
  • 97 (a)
OneToMany
Rpl7a-ps3 30
  • 96 (a)
OneToMany
Rpl7a-ps8 30
  • 95 (a)
OneToMany
Gm14214 30
  • 92 (a)
OneToMany
Rpl7a 29 16 30
  • 88.35 (n)
OneToMany
Gm4877 30
  • 87 (a)
OneToMany
Chimpanzee
(Pan troglodytes)
Mammalia RPL7A 29 30
  • 99.62 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RPL7A 30
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPL7A 30
  • 90 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RPL7A 29 30
  • 89.72 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rpl7a 29
  • 89.47 (n)
Cow
(Bos Taurus)
Mammalia RPL7A 29 30
  • 88.1 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RPL7A 29 30
  • 82.34 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPL7A 30
  • 98 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii rpl7a 29 30
  • 81.81 (n)
OneToOne
-- 29
Fruit Fly
(Drosophila melanogaster)
Insecta RpL7A 30 31
  • 67 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y24D9A.4a 31
  • 63 (a)
rpl-7A 30
  • 62 (a)
OneToMany
Y24D9A.4c 31
  • 58 (a)
Y73B3A.18 30
  • 36 (a)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACL070C 29
  • 60.3 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL8B 29 30 32
  • 58.79 (n)
OneToMany
RPL8A 30
  • 57 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00573g 29
  • 55.87 (n)
Rice
(Oryza sativa)
Liliopsida Os.37882 29
Bread mold
(Neurospora crassa)
Ascomycetes NCU04779 29
  • 62.26 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl8 29
  • 58.26 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5318 30
  • 58 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.14745 29
Species where no ortholog for RPL7A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RPL7A Gene

ENSEMBL:
Gene Tree for RPL7A (if available)
TreeFam:
Gene Tree for RPL7A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL7A: view image
Alliance of Genome Resources:
Additional Orthologs for RPL7A

Paralogs for RPL7A Gene

Paralogs for RPL7A Gene

(1) SIMAP similar genes for RPL7A Gene using alignment to 3 proteins:

  • RL7A_HUMAN
  • Q5T8U2_HUMAN
  • Q5T8U3_HUMAN

Pseudogenes.org Pseudogenes for RPL7A Gene

genes like me logo Genes that share paralogs with RPL7A: view

Variants for RPL7A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RPL7A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RPL7A Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1125319 OTHER inversion 24896259
nsv972461 CNV duplication 23825009

Variation tolerance for RPL7A Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL7A
Leiden Open Variation Database (LOVD)
RPL7A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL7A Gene

Disorders for RPL7A Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPL7A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
tuberous sclerosis 1
  • tsc1
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPL7A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RL7A_HUMAN
  • Note=Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.

Additional Disease Information for RPL7A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RPL7A: view

No data available for Genatlas for RPL7A Gene

Publications for RPL7A Gene

  1. Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene. (PMID: 8482538) De Falco S … Pietropaolo C (Gene 1993) 3 4 22
  2. The organization and expression of the human L7a ribosomal protein gene. (PMID: 1756182) Colombo P … Fried M (Biochimica et biophysica acta 1991) 3 4 22
  3. Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences. (PMID: 2966065) Kozma SC … Hynes NE (The EMBO journal 1988) 2 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  5. Down-regulation of ribosomal protein L7A in human osteosarcoma. (PMID: 19125294) Zheng SE … Tang LN (Journal of cancer research and clinical oncology 2009) 3 22

Products for RPL7A Gene

Sources for RPL7A Gene