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Aliases for RPL7A Gene

Aliases for RPL7A Gene

  • Ribosomal Protein L7a 2 3 5
  • Surfeit Locus Protein 3 2 3 4
  • PLA-X Polypeptide 2 3 4
  • Thyroid Hormone Receptor Uncoupling Protein 2 3
  • Large Ribosomal Subunit Protein EL8 3 4
  • 60S Ribosomal Protein L7a 2 3
  • Surfeit 3 2 3
  • SURF3 3 4
  • SURF-3 4
  • TRUP 3
  • L7A 3
  • ; 2

External Ids for RPL7A Gene

Previous GeneCards Identifiers for RPL7A Gene

  • GC09P127304
  • GC09P127771
  • GC09P129568
  • GC09P131491
  • GC09P133231
  • GC09P135194
  • GC09P135217
  • GC09P135222
  • GC09P135228
  • GC09P135235
  • GC09P135240
  • GC09P136215

Summaries for RPL7A Gene

Entrez Gene Summary for RPL7A Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL7A Gene

RPL7A (Ribosomal Protein L7a) is a Protein Coding gene. Diseases associated with RPL7A include Tuberous Sclerosis 1. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL7A Gene

Additional gene information for RPL7A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL7A Gene

Genomics for RPL7A Gene

GeneHancer (GH) Regulatory Elements for RPL7A Gene

Promoters and enhancers for RPL7A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I133346 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.5 +0.6 603 4.5 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 MED22 RPL7A GC09P133386 GC09P133408 GC09P133432 GC09P133433 GC09P133435 GC09P133437 PIR63017 SNORD24
GH09I132977 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 33 -370.1 -370139 2 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF143 DEK SP5 REST GFI1B SETX GTF3C5 RPL7A MED22 EEF1A1P5 TSC1 SURF4 AK8 GC09P132965
GH09I133416 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 23.3 +69.8 69763 3.5 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 REXO4 SURF1 SURF6 MED22 RPL7A ENSG00000273473 GTF3C5 DDX31 BRD3OS ADAMTS13
GH09I133112 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15 -219.2 -219242 33.8 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 RALGDS GTF3C5 SETX RPL7A GBGT1 BRD3 EEF1A1P5 DDX31 SLC2A6 GTF3C4
GH09I133146 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -199.7 -199733 3.2 HDGF PKNOX1 CLOCK MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B RALGDS GTF3C5 DDX31 MED22 SETX RPL7A EEF1A1P5 TSC1 GTF3C4 GC09M133093
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPL7A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL7A gene promoter:

Genomic Locations for RPL7A Gene

Genomic Locations for RPL7A Gene
3,213 bases
Plus strand

Genomic View for RPL7A Gene

Genes around RPL7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7A Gene

Proteins for RPL7A Gene

  • Protein details for RPL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L7a
    Protein Accession:
    Secondary Accessions:
    • P11518
    • Q5T8U4

    Protein attributes for RPL7A Gene

    266 amino acids
    Molecular mass:
    29996 Da
    Quaternary structure:
    • Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).

    Three dimensional structures from OCA and Proteopedia for RPL7A Gene

neXtProt entry for RPL7A Gene

Post-translational modifications for RPL7A Gene

  • Ubiquitination at Lys26, Lys37, Lys48, Lys75, Lys97, Lys197, isoforms=217, isoforms=245, and Lys264
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL7A Gene

Domains & Families for RPL7A Gene

Gene Families for RPL7A Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL7A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL8 family.
  • Belongs to the eukaryotic ribosomal protein eL8 family.
genes like me logo Genes that share domains with RPL7A: view

Function for RPL7A Gene

Molecular function for RPL7A Gene

GENATLAS Biochemistry:
ribosomal protein L7a (see SURF@)

Phenotypes From GWAS Catalog for RPL7A Gene

Gene Ontology (GO) - Molecular Function for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IBA --
GO:0003735 structural constituent of ribosome NAS,TAS 12962325
GO:0005515 protein binding IPI 15303970
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL7A: view
genes like me logo Genes that share phenotypes with RPL7A: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL7A Gene

Localization for RPL7A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL7A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005730 nucleolus HDA,IDA 16791210
GO:0005737 cytoplasm HDA,IDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL7A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL7A Gene

Pathways & Interactions for RPL7A Gene

genes like me logo Genes that share pathways with RPL7A: view

Pathways by source for RPL7A Gene

1 GeneGo (Thomson Reuters) pathway for RPL7A Gene
1 Cell Signaling Technology pathway for RPL7A Gene

Gene Ontology (GO) - Biological Process for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IBA 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL7A: view

No data available for SIGNOR curated interactions for RPL7A Gene

Drugs & Compounds for RPL7A Gene

No Compound Related Data Available

Transcripts for RPL7A Gene

Unigene Clusters for RPL7A Gene

Ribosomal protein L7a:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for RPL7A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL7A Gene

Protein differential expression in normal tissues from HIPED for RPL7A Gene

This gene is overexpressed in Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL7A Gene

Protein tissue co-expression partners for RPL7A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL7A Gene:


SOURCE GeneReport for Unigene cluster for RPL7A Gene:


Evidence on tissue expression from TISSUES for RPL7A Gene

  • Eye(5)
  • Lung(5)
  • Skin(5)
  • Nervous system(5)
  • Liver(4.9)
  • Pancreas(4.9)
  • Intestine(4.7)
  • Muscle(4.7)
  • Kidney(4.4)
  • Stomach(4.3)
  • Blood(4.1)
  • Bone(3.8)
  • Heart(2.7)
  • Lymph node(2.3)
  • Bone marrow(2.2)
  • Thyroid gland(2.2)
  • Adrenal gland(2.1)
  • Gall bladder(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RPL7A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL7A Gene

Orthologs for RPL7A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL7A Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Gm8226 34
  • 100 (a)
Gm16477 34
  • 99 (a)
Gm5619 34
  • 99 (a)
Rpl7a-ps10 34
  • 98 (a)
Rpl7a-ps5 34
  • 97 (a)
Rpl7a-ps3 34
  • 96 (a)
Rpl7a-ps8 34
  • 95 (a)
Gm14214 34
  • 92 (a)
Rpl7a 16 34 33
  • 88.35 (n)
Gm4877 34
  • 87 (a)
(Pan troglodytes)
Mammalia RPL7A 34 33
  • 99.62 (n)
(Monodelphis domestica)
Mammalia RPL7A 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RPL7A 34
  • 90 (a)
(Canis familiaris)
Mammalia RPL7A 33 34
  • 89.72 (n)
(Rattus norvegicus)
Mammalia Rpl7a 33
  • 89.47 (n)
(Bos Taurus)
Mammalia RPL7A 33 34
  • 88.1 (n)
(Gallus gallus)
Aves RPL7A 34 33
  • 82.34 (n)
(Anolis carolinensis)
Reptilia RPL7A 34
  • 98 (a)
(Danio rerio)
Actinopterygii rpl7a 33 34
  • 81.81 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta RpL7A 35 34
  • 68 (a)
(Caenorhabditis elegans)
Secernentea Y24D9A.4a 35
  • 63 (a)
rpl-7A 34
  • 62 (a)
Y24D9A.4c 35
  • 58 (a)
Y73B3A.18 34
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL070C 33
  • 60.3 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL8B 33 34 36
  • 58.79 (n)
RPL8A 34
  • 57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00573g 33
  • 55.87 (n)
(Oryza sativa)
Liliopsida Os.37882 33
bread mold
(Neurospora crassa)
Ascomycetes NCU04779 33
  • 62.26 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl8 33
  • 58.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5318 34
  • 58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14745 33
Species where no ortholog for RPL7A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL7A Gene

Gene Tree for RPL7A (if available)
Gene Tree for RPL7A (if available)

Paralogs for RPL7A Gene

(1) SIMAP similar genes for RPL7A Gene using alignment to 3 proteins: Pseudogenes for RPL7A Gene

genes like me logo Genes that share paralogs with RPL7A: view

No data available for Paralogs for RPL7A Gene

Variants for RPL7A Gene

Sequence variations from dbSNP and Humsavar for RPL7A Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000171207 -- 133,346,889(+) G/T upstream_transcript_variant
rs1000288609 -- 133,350,957(+) A/G intron_variant
rs1000438055 -- 133,347,855(+) A/C/T upstream_transcript_variant
rs1000861174 -- 133,347,994(+) C/T upstream_transcript_variant
rs1001079473 -- 133,347,738(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL7A Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1125319 OTHER inversion 24896259
nsv972461 CNV duplication 23825009

Variation tolerance for RPL7A Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL7A Gene

Disorders for RPL7A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL7A Gene - From: GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis 1
  • ts
- elite association - COSMIC cancer census association via MalaCards
Search RPL7A in MalaCards View complete list of genes associated with diseases


  • Note=Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.

Additional Disease Information for RPL7A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPL7A: view

No data available for Genatlas for RPL7A Gene

Publications for RPL7A Gene

  1. Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene. (PMID: 8482538) De Falco S … Pietropaolo C (Gene 1993) 3 4 22 58
  2. The organization and expression of the human L7a ribosomal protein gene. (PMID: 1756182) Colombo P … Fried M (Biochimica et biophysica acta 1991) 3 4 22 58
  3. Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences. (PMID: 2966065) Kozma SC … Hynes NE (The EMBO journal 1988) 2 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Down-regulation of ribosomal protein L7A in human osteosarcoma. (PMID: 19125294) Zheng SE … Tang LN (Journal of cancer research and clinical oncology 2009) 3 22 58

Products for RPL7A Gene

Sources for RPL7A Gene