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Aliases for RPL7 Gene

Aliases for RPL7 Gene

  • Ribosomal Protein L7 2 3 5
  • Large Ribosomal Subunit Protein UL30 3 4
  • 60S Ribosomal Protein L7 3
  • HumL7-1 3
  • L7 3

External Ids for RPL7 Gene

Previous GeneCards Identifiers for RPL7 Gene

  • GC08M073255
  • GC08M074143
  • GC08M073920
  • GC08M074252
  • GC08M074365
  • GC08M074202
  • GC08M069693

Summaries for RPL7 Gene

Entrez Gene Summary for RPL7 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL7 Gene

RPL7 (Ribosomal Protein L7) is a Protein Coding gene. Diseases associated with RPL7 include Collagen Disease and Retinitis Pigmentosa 22. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is RPL7L1.

UniProtKB/Swiss-Prot for RPL7 Gene

  • Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.

Gene Wiki entry for RPL7 Gene

Additional gene information for RPL7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL7 Gene

Genomics for RPL7 Gene

GeneHancer (GH) Regulatory Elements for RPL7 Gene

Promoters and enhancers for RPL7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J073291 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 665.5 +1.0 1026 5.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B RPL7 RDH10 RDH10-AS1
GH08J073292 Promoter 0.5 EPDnew 650.7 +4.7 4728 0.1 RPL7 RDH10 C8orf89
GH08J073975 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.4 -680.8 -680814 2.4 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 POLR2B TMEM70 RPL7 ENSG00000253341 ENSG00000272254 UBE2W GC08M073979
GH08J073970 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 -676.1 -676132 3.6 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 TMEM70 GC08M073941 ELOC ENSG00000253341 RPL7 GC08P073966
GH08J073007 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.2 +286.7 286725 2.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 FOS TERF1 ENSG00000253636 ENSG00000272254 RPL7 RNU6-285P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL7 gene promoter:
  • S8
  • FOXO4
  • En-1
  • Pax-5
  • HNF-3beta
  • Nkx6-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Pax-4a

Genomic Locations for RPL7 Gene

Genomic Locations for RPL7 Gene
5,523 bases
Minus strand
5,519 bases
Minus strand

Genomic View for RPL7 Gene

Genes around RPL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7 Gene

Proteins for RPL7 Gene

  • Protein details for RPL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L7
    Protein Accession:
    Secondary Accessions:
    • A8K504
    • Q15289
    • Q3KQU0
    • Q5I0X1
    • Q6IBM9

    Protein attributes for RPL7 Gene

    248 amino acids
    Molecular mass:
    29226 Da
    Quaternary structure:
    • Component of the large ribosomal subunit (Probable). Homodimer. Interacts with DHX33 (PubMed:26100019).
    • Sequence=CAA41026.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL7 Gene

neXtProt entry for RPL7 Gene

Post-translational modifications for RPL7 Gene

  • Ubiquitination at Lys223, Lys212, posLast=202202, posLast=199199, Lys181, Lys148, posLast=127127, posLast=124124, Lys107, Lys88, Lys77, and Lys40
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL7 Gene

No data available for DME Specific Peptides for RPL7 Gene

Domains & Families for RPL7 Gene

Gene Families for RPL7 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL30 family.
  • Belongs to the universal ribosomal protein uL30 family.
genes like me logo Genes that share domains with RPL7: view

Function for RPL7 Gene

Molecular function for RPL7 Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
GENATLAS Biochemistry:
60S ribosomal protein L7

Gene Ontology (GO) - Molecular Function for RPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 8441630
GO:0003723 RNA binding HDA,TAS 22658674
GO:0003729 mRNA binding IDA 8441630
GO:0003735 structural constituent of ribosome TAS,NAS 12962325
GO:0005515 protein binding IPI 18274552
genes like me logo Genes that share ontologies with RPL7: view
genes like me logo Genes that share phenotypes with RPL7: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL7 Gene

Localization for RPL7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL7 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005730 nucleolus HDA 16791210
GO:0005737 cytoplasm HDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL7 Gene

Pathways & Interactions for RPL7 Gene

genes like me logo Genes that share pathways with RPL7: view

Pathways by source for RPL7 Gene

1 KEGG pathway for RPL7 Gene
1 GeneGo (Thomson Reuters) pathway for RPL7 Gene

Gene Ontology (GO) - Biological Process for RPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation TAS,NAS 12962325
genes like me logo Genes that share ontologies with RPL7: view

No data available for SIGNOR curated interactions for RPL7 Gene

Drugs & Compounds for RPL7 Gene

(1) Additional Compounds for RPL7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL7: view

Transcripts for RPL7 Gene

mRNA/cDNA for RPL7 Gene

Unigene Clusters for RPL7 Gene

Ribosomal protein L7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - - - - - -
SP3: -
SP5: - - -

Relevant External Links for RPL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL7 Gene

Protein differential expression in normal tissues from HIPED for RPL7 Gene

This gene is overexpressed in Nasal epithelium (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RPL7 Gene

Protein tissue co-expression partners for RPL7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL7 Gene:


SOURCE GeneReport for Unigene cluster for RPL7 Gene:


Evidence on tissue expression from TISSUES for RPL7 Gene

  • Liver(4.9)
  • Lung(4.9)
  • Skin(4.9)
  • Eye(4.8)
  • Muscle(4.8)
  • Pancreas(4.7)
  • Nervous system(4.6)
  • Bone marrow(4.4)
  • Blood(4.2)
  • Intestine(4)
  • Kidney(4)
  • Bone(3.9)
  • Heart(3.4)
  • Stomach(3.4)
  • Spleen(2.6)
  • Lymph node(2.2)
  • Adrenal gland(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with RPL7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL7 Gene

Orthologs for RPL7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL7 33
  • 99.73 (n)
(Bos Taurus)
Mammalia -- 34
  • 94 (a)
RPL7 34 33
  • 92.74 (n)
-- 34
  • 88 (a)
(Canis familiaris)
Mammalia RPL7 34 33
  • 91.53 (n)
(Ornithorhynchus anatinus)
Mammalia RPL7 34
  • 91 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
-- 34
  • 85 (a)
-- 34
  • 75 (a)
(Rattus norvegicus)
Mammalia Rpl7 33
  • 89.39 (n)
(Mus musculus)
Mammalia Rpl7 16 34 33
  • 87.8 (n)
(Gallus gallus)
Aves RPL7 34 33
  • 76.19 (n)
(Anolis carolinensis)
Reptilia RPL7 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl7 33
  • 75.61 (n)
(Danio rerio)
Actinopterygii rpl7 34 33
  • 73.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008916 33
  • 57.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL7 34 35 33
  • 56.49 (n)
CG5317 35
  • 35 (a)
(Caenorhabditis elegans)
Secernentea rpl-7 34 35 33
  • 57.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03410g 33
  • 56.57 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL082W 33
  • 55.18 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL7A 34 33
  • 54.61 (n)
RPL7B 34
  • 51 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G13580 33
  • 60.73 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1884 33
(Glycine max)
eudicotyledons Gma.973 33
(Oryza sativa)
Liliopsida Os08g0234000 33
  • 61.84 (n)
Os.4880 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2360 34
  • 60 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07829 33
  • 58.44 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl702 33
  • 57.38 (n)
Species where no ortholog for RPL7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL7 Gene

Gene Tree for RPL7 (if available)
Gene Tree for RPL7 (if available)
Evolutionary constrained regions (ECRs) for RPL7: view image

Paralogs for RPL7 Gene

Paralogs for RPL7 Gene

(2) SIMAP similar genes for RPL7 Gene using alignment to 4 proteins:

  • C9JZ88_HUMAN
genes like me logo Genes that share paralogs with RPL7: view

Variants for RPL7 Gene

Sequence variations from dbSNP and Humsavar for RPL7 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000559104 -- 73,294,552(-) G/C upstream_transcript_variant
rs1000876795 -- 73,294,659(-) C/G upstream_transcript_variant
rs1000935960 -- 73,290,255(-) G/A downstream_transcript_variant
rs1001045157 -- 73,294,540(-) C/G upstream_transcript_variant
rs1001351954 -- 73,294,322(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL7 Gene

Variant ID Type Subtype PubMed ID
esv2737154 CNV deletion 23290073
nsv971665 CNV duplication 23825009

Variation tolerance for RPL7 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL7 Gene

Disorders for RPL7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPL7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
collagen disease
  • collagen disorder
retinitis pigmentosa 22
  • rp22
retinitis pigmentosa 23
  • rp23
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards
Search RPL7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL7 Gene

Publications for RPL7 Gene

  1. Structural and functional properties of ribosomal protein L7 from humans and rodents. (PMID: 8441630) Hemmerich P … Krawinkel U (Nucleic acids research 1993) 2 3 4 22 58
  2. Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells. (PMID: 7862521) Neumann F … Krawinkel U (Nucleic acids research 1995) 3 4 22 58
  3. Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene. (PMID: 8360149) Seshadri T … Campisi J (The Journal of biological chemistry 1993) 2 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Human ribosomal protein L7 displays an ER binding property and is involved in ribosome-ER association. (PMID: 17258209) Wu WC … Lin A (FEBS letters 2007) 3 22 58

Products for RPL7 Gene

Sources for RPL7 Gene

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