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Aliases for RPL6 Gene

Aliases for RPL6 Gene

  • Ribosomal Protein L6 2 3 5
  • Tax-Responsive Enhancer Element-Binding Protein 107 3 4
  • Large Ribosomal Subunit Protein EL6 3 4
  • Neoplasm-Related Protein C140 3 4
  • TXREB1 3 4
  • DNA-Binding Protein TAXREB107 3
  • 60S Ribosomal Protein L6 3
  • TAXREB107 3
  • TaxREB107 4
  • SHUJUN-2 3
  • L6 3

External Ids for RPL6 Gene

Previous HGNC Symbols for RPL6 Gene

  • TXREB1

Previous GeneCards Identifiers for RPL6 Gene

  • GC12M111698
  • GC12M112621
  • GC12M111254
  • GC12M111305
  • GC12M112842
  • GC07P136752

Summaries for RPL6 Gene

Entrez Gene Summary for RPL6 Gene

  • This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for RPL6 Gene

RPL6 (Ribosomal Protein L6) is a Protein Coding gene. Diseases associated with RPL6 include Metachondromatosis and T-Cell Leukemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL6 Gene

  • Component of the large ribosomal subunit.

  • (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378).

Gene Wiki entry for RPL6 Gene

Additional gene information for RPL6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL6 Gene

Genomics for RPL6 Gene

GeneHancer (GH) Regulatory Elements for RPL6 Gene

Promoters and enhancers for RPL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J112407 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 672 +10.1 10105 3 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B RPL6 MAPKAPK5 ADAM1A SLC8B1 NAA25 DDX54 RPS2P41 TMEM116 PTPN11 GC12M112409
GH12J112417 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.3 -311 2.4 HDGF CLOCK ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ATXN2 PTPN11 RPL6 ADAM1A PCNPP1 TMEM116 GC12M112409
GH12J112011 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.3 +405.3 405274 4.3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TMEM116 ERP29 HSPA8P14 MAPKAPK5 RPL6 HECTD4 BRAP ADAM1A NAA25 PCNPP1
GH12J113183 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.7 -766.8 -766816 3.7 PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B RITA1 DDX54 RBM19 HECTD4 RPL6 SLC8B1 CFAP73 DYNLL1P4 GC12M113186 ENSG00000257286
GH12J111684 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 +733.0 733008 2.8 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 BRAP ACAD10 HSPA8P14 ALDH2 MAPKAPK5 TRAFD1 RPL6 RPS2P41 PHETA1 PCNPP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL6 gene promoter:
  • STAT3
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alphaA
  • AP-2alpha isoform 4

Genomic Locations for RPL6 Gene

Genomic Locations for RPL6 Gene
chr12:112,405,190-112,418,838
(GRCh38/hg38)
Size:
13,649 bases
Orientation:
Minus strand
chr12:112,842,994-112,856,642
(GRCh37/hg19)
Size:
13,649 bases
Orientation:
Minus strand

Genomic View for RPL6 Gene

Genes around RPL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL6 Gene

Proteins for RPL6 Gene

  • Protein details for RPL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02878-RL6_HUMAN
    Recommended name:
    60S ribosomal protein L6
    Protein Accession:
    Q02878
    Secondary Accessions:
    • Q2M3Q3
    • Q8WW97

    Protein attributes for RPL6 Gene

    Size:
    288 amino acids
    Molecular mass:
    32728 Da
    Quaternary structure:
    • Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). May bind IPO9 with low affinity (By similarity).

    Three dimensional structures from OCA and Proteopedia for RPL6 Gene

neXtProt entry for RPL6 Gene

Post-translational modifications for RPL6 Gene

  • Ubiquitination at Lys285, posLast=262262, posLast=237237, posLast=210210, posLast=207207, Lys130, Lys100, Lys94, and Lys87
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL6 Gene

Domains & Families for RPL6 Gene

Gene Families for RPL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL6 Gene

Suggested Antigen Peptide Sequences for RPL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q02878

UniProtKB/Swiss-Prot:

RL6_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL6 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL6 family.
genes like me logo Genes that share domains with RPL6: view

Function for RPL6 Gene

Molecular function for RPL6 Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378).
GENATLAS Biochemistry:
60S ribosomal protein L6-like,also homologous to TAXREB107 and C140 product from thyroid carcinoma,intracellular partner for FGF2,mediating the DNA binding for HLV1 transactivator tax

Phenotypes From GWAS Catalog for RPL6 Gene

Gene Ontology (GO) - Molecular Function for RPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8457378
GO:0003723 RNA binding IBA,TAS --
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL6: view
genes like me logo Genes that share phenotypes with RPL6: view

Animal Model Products

CRISPR Products

miRNA for RPL6 Gene

miRTarBase miRNAs that target RPL6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL6 Gene

Localization for RPL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL6 Gene

Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250 UniProtKB:Q2YGT9, ECO:0000269 PubMed:25957688}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 25468996
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005791 rough endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with RPL6: view

Pathways & Interactions for RPL6 Gene

genes like me logo Genes that share pathways with RPL6: view

Pathways by source for RPL6 Gene

1 KEGG pathway for RPL6 Gene
1 GeneGo (Thomson Reuters) pathway for RPL6 Gene

Gene Ontology (GO) - Biological Process for RPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA,IDA 25957688
GO:0006355 regulation of transcription, DNA-templated TAS 8457378
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RPL6: view

No data available for SIGNOR curated interactions for RPL6 Gene

Drugs & Compounds for RPL6 Gene

No Compound Related Data Available

Transcripts for RPL6 Gene

Unigene Clusters for RPL6 Gene

Ribosomal protein L6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: -
SP10:

Relevant External Links for RPL6 Gene

GeneLoc Exon Structure for
RPL6
ECgene alternative splicing isoforms for
RPL6

Expression for RPL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL6 Gene

Protein differential expression in normal tissues from HIPED for RPL6 Gene

This gene is overexpressed in Tlymphocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RPL6 Gene



Protein tissue co-expression partners for RPL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL6 Gene:

RPL6

SOURCE GeneReport for Unigene cluster for RPL6 Gene:

Hs.546283

Evidence on tissue expression from TISSUES for RPL6 Gene

  • Lung(5)
  • Nervous system(5)
  • Liver(4.9)
  • Pancreas(4.8)
  • Eye(4.5)
  • Skin(4.5)
  • Intestine(4.3)
  • Kidney(4.3)
  • Muscle(4.2)
  • Bone(4.1)
  • Blood(3.8)
  • Heart(3.8)
  • Stomach(3.8)
  • Spleen(2.5)
  • Adrenal gland(2.3)
  • Lymph node(2.3)
  • Bone marrow(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with RPL6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL6 Gene

Orthologs for RPL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL6 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 96 (a)
OneToMany
RPL6 33
  • 90.05 (n)
-- 34
  • 88 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
OneToMany
RPL6 34 33
  • 86.76 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl6 34 33
  • 84.03 (n)
OneToMany
Gm5428 34
  • 83 (a)
OneToMany
Rpl6l 16
rat
(Rattus norvegicus)
Mammalia Rpl6 33
  • 83.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL6 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL6 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL6 34 33
  • 75.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 73 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl6 33
  • 71.43 (n)
Str.6008 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25949 33
zebrafish
(Danio rerio)
Actinopterygii rpl6 34 33
  • 71.82 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8548 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001911 33
  • 52.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL6 34 33
  • 49.72 (n)
OneToOne
CG11522 35
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-6 34 35 33
  • 54.42 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL6B 34
  • 46 (a)
OneToMany
RPL6A 36 34
  • 45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G74060 33
  • 55.41 (n)
rice
(Oryza sativa)
Liliopsida Os02g0591700 33
  • 52.59 (n)
Species where no ortholog for RPL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL6 Gene

ENSEMBL:
Gene Tree for RPL6 (if available)
TreeFam:
Gene Tree for RPL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL6: view image

Paralogs for RPL6 Gene

No data available for Paralogs for RPL6 Gene

Variants for RPL6 Gene

Sequence variations from dbSNP and Humsavar for RPL6 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1028419374 uncertain-significance, Noonan syndrome with multiple lentigines, Noonan syndrome, Metachondromatosis 112,418,973(-) G/A/C/T upstream_transcript_variant
rs267606990 pathogenic, Noonan syndrome 1, not provided, Noonan syndrome 112,419,116(-) C/T upstream_transcript_variant
rs377496292 uncertain-significance, Metachondromatosis, Noonan syndrome with multiple lentigines, Noonan syndrome 112,418,825(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs545369072 uncertain-significance, Noonan syndrome, Metachondromatosis, Noonan syndrome with multiple lentigines 112,418,933(-) G/C/T upstream_transcript_variant
rs58805176 likely-benign, Noonan syndrome, Metachondromatosis, Noonan syndrome with multiple lentigines 112,418,839(-) G/A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL6 Gene

Variant ID Type Subtype PubMed ID
esv3580466 CNV loss 25503493
nsv976652 CNV duplication 23825009
nsv983365 CNV duplication 23825009

Variation tolerance for RPL6 Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL6 Gene

Disorders for RPL6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPL6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
metachondromatosis
  • metcds
t-cell leukemia
  • leukemia t-cell
noonan syndrome with multiple lentigines
  • lentiginosis profusa
noonan syndrome 1
  • ns1
- elite association - COSMIC cancer census association via MalaCards
Search RPL6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL6

genes like me logo Genes that share disorders with RPL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL6 Gene

Publications for RPL6 Gene

  1. Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. (PMID: 8457378) Morita T … Shimotohno K (AIDS research and human retroviruses 1993) 2 3 4 22 58
  2. Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. (PMID: 8479925) Zaman GJ (Nucleic acids research 1993) 2 3 4 22 58
  3. Structural snapshots of actively translating human ribosomes. (PMID: 25957688) Behrmann E … Spahn CM (Cell 2015) 3 4 58
  4. Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells. (PMID: 20171175) Gou Y … Fan D (Biochemical and biophysical research communications 2010) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RPL6 Gene

Sources for RPL6 Gene

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