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Aliases for RPL41 Gene

Subcategory (RNA class) for RPL41 Gene


Aliases for RPL41 Gene

  • Ribosomal Protein L41 2 3 5
  • Large Ribosomal Subunit Protein EL41 3 4
  • Homologue Of Yeast Ribosomal Protein YL41 3
  • 60S Ribosomal Protein L41 3
  • HG12 Protein 3
  • HG12 4
  • L41 3

External Ids for RPL41 Gene

ORGUL Members for RPL41 Gene

Previous GeneCards Identifiers for RPL41 Gene

  • GC05P055402
  • GC12M056871
  • GC12P056227
  • GC12P054796
  • GC12P056510
  • GC07P136542

Summaries for RPL41 Gene

Entrez Gene Summary for RPL41 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL41 Gene

RPL41 (Ribosomal Protein L41) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL41 Gene

  • Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

Gene Wiki entry for RPL41 Gene

Additional gene information for RPL41 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL41 Gene

Genomics for RPL41 Gene

GeneHancer (GH) Regulatory Elements for RPL41 Gene

Promoters and enhancers for RPL41 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J056114 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 661.8 +1.7 1738 6.8 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZC3H10 RPL41 ESYT1 ENSG00000258345 PIR42205 GC12M056121 BAZ2A NEMP1 DNAJC14 RN7SL809P
GH12J056298 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33.6 +184.2 184224 4.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 ENSG00000257303 IL23A CS BAZ2A ZC3H10 NEMP1 RN7SL809P CDK2 DNAJC14 RPL41
GH12J057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 31.9 +994.7 994668 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 CDK4 ANKRD52 DTX3
GH12J056040 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.5 -74.6 -74587 3.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS26 LOC105369780 BAZ2A RN7SL809P ZC3H10 STAT2 PAN2 CDK2 DNAJC14 ENSG00000258199
GH12J056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.2 +106.3 106296 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 RNF41 NABP2 NEMP1 BAZ2A PAN2 DNAJC14 ZBTB39 RN7SL809P ZC3H10 PHC1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL41 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL41 gene promoter:
  • ATF
  • NF-Y
  • c-Ets-1
  • ITF-2
  • Tal-1beta
  • Nkx2-5
  • Egr-4
  • RFX1
  • CBF(2)
  • CREB

Genomic Locations for RPL41 Gene

Genomic Locations for RPL41 Gene
1,358 bases
Plus strand
1,358 bases
Plus strand

Genomic View for RPL41 Gene

Genes around RPL41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL41 Gene

Proteins for RPL41 Gene

  • Protein details for RPL41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L41
    Protein Accession:
    Secondary Accessions:
    • A6NG21
    • P28751

    Protein attributes for RPL41 Gene

    25 amino acids
    Molecular mass:
    3456 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL41 Gene

neXtProt entry for RPL41 Gene

Post-translational modifications for RPL41 Gene

No Post-translational modifications

Other Protein References for RPL41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL41 Gene

Domains & Families for RPL41 Gene

Gene Families for RPL41 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL41 Gene


Suggested Antigen Peptide Sequences for RPL41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL41 family.
  • Belongs to the eukaryotic ribosomal protein eL41 family.
genes like me logo Genes that share domains with RPL41: view

Function for RPL41 Gene

Molecular function for RPL41 Gene

UniProtKB/Swiss-Prot Function:
Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.
GENATLAS Biochemistry:
60S ribosomal protein L41

Phenotypes From GWAS Catalog for RPL41 Gene

Gene Ontology (GO) - Molecular Function for RPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 1326959
GO:0003730 mRNA 3-UTR binding IDA 16213212
GO:0003735 structural constituent of ribosome TAS,NAS 12962325
GO:0048027 mRNA 5-UTR binding IDA 16213212
genes like me logo Genes that share ontologies with RPL41: view
genes like me logo Genes that share phenotypes with RPL41: view

Animal Model Products

miRNA for RPL41 Gene

miRTarBase miRNAs that target RPL41

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL41 Gene

Localization for RPL41 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL41 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit IDA,TAS 25957688
GO:0042788 polysomal ribosome IDA 25957688
genes like me logo Genes that share ontologies with RPL41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPL41 Gene

Pathways & Interactions for RPL41 Gene

genes like me logo Genes that share pathways with RPL41: view

Pathways by source for RPL41 Gene

1 KEGG pathway for RPL41 Gene
1 GeneGo (Thomson Reuters) pathway for RPL41 Gene

Gene Ontology (GO) - Biological Process for RPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006364 rRNA processing TAS --
GO:0006412 translation TAS,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL41: view

No data available for SIGNOR curated interactions for RPL41 Gene

Drugs & Compounds for RPL41 Gene

No Compound Related Data Available

Transcripts for RPL41 Gene

mRNA/cDNA for RPL41 Gene

Unigene Clusters for RPL41 Gene

Ribosomal protein L41:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL41 Gene

No ASD Table

Relevant External Links for RPL41 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of RPL41 Gene:


SOURCE GeneReport for Unigene cluster for RPL41 Gene:


Evidence on tissue expression from TISSUES for RPL41 Gene

  • Nervous system(4.9)
  • Muscle(4.8)
  • Blood(4.4)
  • Intestine(4.4)
  • Lung(4.4)
  • Bone(4.3)
  • Eye(4.3)
  • Liver(4.2)
  • Pancreas(4.2)
  • Skin(4.2)
  • Heart(4.1)
  • Stomach(4)
  • Kidney(3.8)
  • Spleen(2.9)
  • Thyroid gland(2.9)
  • Adrenal gland(2.8)
  • Bone marrow(2.8)
  • Lymph node(2.8)
  • Gall bladder(2.4)
genes like me logo Genes that share expression patterns with RPL41: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL41 Gene

Orthologs for RPL41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPL41 Gene

Organism Taxonomy Gene Similarity Type Details
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17123 33
Species where no ortholog for RPL41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RPL41 Gene

Gene Tree for RPL41 (if available)
Gene Tree for RPL41 (if available)
Evolutionary constrained regions (ECRs) for RPL41: view image

Paralogs for RPL41 Gene

No data available for Paralogs for RPL41 Gene

Variants for RPL41 Gene

Sequence variations from dbSNP and Humsavar for RPL41 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000210094 -- 56,115,412(+) C/A upstream_transcript_variant
rs1000303257 -- 56,115,764(+) C/T upstream_transcript_variant
rs1001181999 -- 56,118,101(+) T/C downstream_transcript_variant
rs1001226144 -- 56,115,317(+) C/T upstream_transcript_variant
rs1001692193 -- 56,117,959(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL41 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832427 CNV loss 17160897
nsv973076 CNV duplication 23825009

Additional Variant Information for RPL41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RPL41 Gene

Disorders for RPL41 Gene

Additional Disease Information for RPL41

No disorders were found for RPL41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL41 Gene

Publications for RPL41 Gene

  1. Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41. (PMID: 1326959) Klaudiny J … Scheit KH (Biochemical and biophysical research communications 1992) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 58
  5. Genomic structure of the human ribosomal protein L41 gene. (PMID: 9891856) Go H … Taniguchi S (Biochemistry and molecular biology international 1998) 3 22 58

Products for RPL41 Gene

Sources for RPL41 Gene

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