Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in th... See more...

Aliases for RPL4 Gene

Aliases for RPL4 Gene

  • Ribosomal Protein L4 2 3 5
  • 60S Ribosomal Protein L4 2 3 4
  • Large Ribosomal Subunit Protein UL4 3 4
  • 60S Ribosomal Protein L1 3 4
  • RPL1 4
  • L4 3

External Ids for RPL4 Gene

Previous GeneCards Identifiers for RPL4 Gene

  • GC15M062584
  • GC15M059890
  • GC15M064370
  • GC15M064507
  • GC15M064578
  • GC15M066790
  • GC15M043627

Summaries for RPL4 Gene

Entrez Gene Summary for RPL4 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL4 Gene

RPL4 (Ribosomal Protein L4) is a Protein Coding gene. Diseases associated with RPL4 include Babesiosis and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL4 Gene

Additional gene information for RPL4 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL4 Gene

Genomics for RPL4 Gene

GeneHancer (GH) Regulatory Elements for RPL4 Gene

Promoters and enhancers for RPL4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL4

Top Transcription factor binding sites by QIAGEN in the RPL4 gene promoter:
  • FOXF2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • TBP
  • TFIID

Genomic Locations for RPL4 Gene

Genomic Locations for RPL4 Gene
chr15:66,498,015-66,524,532
(GRCh38/hg38)
Size:
26,518 bases
Orientation:
Minus strand
chr15:66,790,355-66,816,870
(GRCh37/hg19)
Size:
26,516 bases
Orientation:
Minus strand

Genomic View for RPL4 Gene

Genes around RPL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL4 Gene

Proteins for RPL4 Gene

  • Protein details for RPL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36578-RL4_HUMAN
    Recommended name:
    60S ribosomal protein L4
    Protein Accession:
    P36578
    Secondary Accessions:
    • A8K502
    • P39029
    • Q4VBR0
    • Q969Z9

    Protein attributes for RPL4 Gene

    Size:
    427 amino acids
    Molecular mass:
    47697 Da
    Quaternary structure:
    • May bind IPO9 with low affinity. Interacts with RBM3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RPL4 Gene

neXtProt entry for RPL4 Gene

Post-translational modifications for RPL4 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys14, Lys20, Lys29, Lys46, Lys106, Lys140, Lys157, Lys162, Lys165, Lys175, Lys219, Lys234, Lys239, Lys259, Lys274, Lys283, Lys294, Lys327, Lys333, Lys353, and Lys364
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL4 Gene

No data available for DME Specific Peptides for RPL4 Gene

Domains & Families for RPL4 Gene

Gene Families for RPL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL4 Gene

Blocks:
  • Ribosomal protein L4/L1e
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50994, moderately similar to 60S ribosomal protein L4 (B4DMJ2_HUMAN)
  • cDNA FLJ51018, highly similar to 60S ribosomal protein L4 (B4DP82_HUMAN)
  • 60S ribosomal protein L1 (RL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P36578

UniProtKB/Swiss-Prot:

RL4_HUMAN :
  • Belongs to the universal ribosomal protein uL4 family.
Family:
  • Belongs to the universal ribosomal protein uL4 family.
genes like me logo Genes that share domains with RPL4: view

Function for RPL4 Gene

Molecular function for RPL4 Gene

GENATLAS Biochemistry:
60S ribosomal protein L4

Phenotypes From GWAS Catalog for RPL4 Gene

Gene Ontology (GO) - Molecular Function for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,TAS 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 22720776
genes like me logo Genes that share ontologies with RPL4: view
genes like me logo Genes that share phenotypes with RPL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL4 Gene

Localization for RPL4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL4 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
cytoskeleton 2
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005730 nucleolus HDA 16791210
GO:0005737 cytoplasm HDA 16791210
GO:0005791 rough endoplasmic reticulum IDA 24454821
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL4 Gene

Pathways & Interactions for RPL4 Gene

genes like me logo Genes that share pathways with RPL4: view

Pathways by source for RPL4 Gene

1 KEGG pathway for RPL4 Gene
1 GeneGo (Thomson Reuters) pathway for RPL4 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0019083 viral transcription TAS --
genes like me logo Genes that share ontologies with RPL4: view

No data available for SIGNOR curated interactions for RPL4 Gene

Drugs & Compounds for RPL4 Gene

(3) Drugs for RPL4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 113
genes like me logo Genes that share compounds with RPL4: view

Transcripts for RPL4 Gene

mRNA/cDNA for RPL4 Gene

1 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL4

Alternative Splicing Database (ASD) splice patterns (SP) for RPL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7:
SP8: - - - -
SP9:
SP10: -

Relevant External Links for RPL4 Gene

GeneLoc Exon Structure for
RPL4

Expression for RPL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL4 Gene



Protein tissue co-expression partners for RPL4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL4

SOURCE GeneReport for Unigene cluster for RPL4 Gene:

Hs.186350

Evidence on tissue expression from TISSUES for RPL4 Gene

  • Blood(5)
  • Liver(5)
  • Muscle(5)
  • Nervous system(5)
  • Eye(4.9)
  • Intestine(4.9)
  • Lung(4.9)
  • Skin(4.9)
  • Pancreas(4.8)
  • Kidney(4.7)
  • Stomach(4.6)
  • Bone(4.5)
  • Heart(4)
  • Spleen(3.6)
  • Thyroid gland(3.2)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Adrenal gland(2.5)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with RPL4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL4 Gene

Orthologs for RPL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL4 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 97 (a)
OneToMany
-- 31
  • 93 (a)
OneToMany
-- 31
  • 75 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL4 31 31
  • 96 (a)
OneToMany
-- 31
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPL4 31 30
  • 91.55 (n)
OneToMany
-- 31
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL4 31 30
  • 88.89 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl4 30
  • 87.18 (n)
mouse
(Mus musculus)
Mammalia Rpl4 17 31 30
  • 85.52 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL4 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL4 31 30
  • 80.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL4 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl4 30
  • 76.58 (n)
Str.8811 30
African clawed frog
(Xenopus laevis)
Amphibia MGC64318 30
zebrafish
(Danio rerio)
Actinopterygii rpl4 31 30
  • 76.15 (n)
OneToOne
wufa97a02 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.806 30
fruit fly
(Drosophila melanogaster)
Insecta RpL1 32
  • 62 (a)
RpL4 31 30
  • 61.88 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002306 30
  • 59.62 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-4 31 32 30
  • 58.59 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR191C 30
  • 61.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL4A 33 31 30
  • 60.59 (n)
RPL4B 31
  • 57 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07139g 30
  • 60.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09630 30
  • 57.48 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1107 30
rice
(Oryza sativa)
Liliopsida Os07g0180900 30
  • 55.65 (n)
Os.8767 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4071 31
  • 67 (a)
OneToOne
Cin.5831 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl401 30
  • 60.37 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03757 30
  • 56.5 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5831 30
Species where no ortholog for RPL4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL4 Gene

ENSEMBL:
Gene Tree for RPL4 (if available)
TreeFam:
Gene Tree for RPL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL4: view image

Paralogs for RPL4 Gene

No data available for Paralogs for RPL4 Gene

Variants for RPL4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL4 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs1567034808 Uncertain Significance: Severe Myopia 66,501,906(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for RPL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL4 Gene

Variant ID Type Subtype PubMed ID
nsv974591 CNV duplication 23825009

Variation tolerance for RPL4 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL4 Gene

Disorders for RPL4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPL4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
babesiosis
  • babesiasis
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPL4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL4

genes like me logo Genes that share disorders with RPL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL4 Gene

Publications for RPL4 Gene

  1. Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. (PMID: 8268230) Bagni C … Amaldi F (Biochimica et biophysica acta 1993) 2 3 4 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jäkel S … Görlich D (The EMBO journal 2002) 3 4 54
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 54
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 54

Products for RPL4 Gene

Sources for RPL4 Gene