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Aliases for RPL4 Gene

Aliases for RPL4 Gene

  • Ribosomal Protein L4 2 3 5
  • Large Ribosomal Subunit Protein UL4 3 4
  • 60S Ribosomal Protein L4 2 3
  • 60S Ribosomal Protein L1 3 4
  • RPL1 4
  • L4 3

External Ids for RPL4 Gene

Previous GeneCards Identifiers for RPL4 Gene

  • GC15M062584
  • GC15M059890
  • GC15M064370
  • GC15M064507
  • GC15M064578
  • GC15M066790
  • GC15M043627

Summaries for RPL4 Gene

Entrez Gene Summary for RPL4 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL4 Gene

RPL4 (Ribosomal Protein L4) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL4 Gene

Additional gene information for RPL4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL4 Gene

Genomics for RPL4 Gene

GeneHancer (GH) Regulatory Elements for RPL4 Gene

Promoters and enhancers for RPL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J066502 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 660.4 +20.3 20286 4.3 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A SNORD16 ZWILCH RPL4 SNORD18A PIR57266 GC15M066541 GC15M066539 INTS14 ENSG00000260773 RPL35AP32
GH15J065609 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 18.9 +913.1 913120 3.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 INTS14 SLC24A1 ENSG00000260773 PARP16 SNORD16 RPL35AP32 PDCD7 ENSG00000264937 ENSG00000259635 TIPIN
GH15J066495 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.3 +27.3 27324 3.9 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SNAPC5 MIR4512 TIPIN ENSG00000260773 SLC24A1 RPL4 ZWILCH HACD3 SMAD3 DENND4A
GH15J067060 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.1 -541.6 -541621 11 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF263 SP3 SMAD3 PIR44207 LOC102723493 ENSG00000260773 SKOR1 ENSG00000259202 ENSG00000259410 MAP2K5 IQCH-AS1 PIAS1
GH15J067253 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -729.8 -729787 2.6 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 IQCH AAGAB RPL35AP32 SNORD16 TIPIN PIAS1 MAP2K5 ZWILCH RPL4 ENSG00000260773
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL4 gene promoter:
  • TBP
  • Meis-1a
  • Meis-1b
  • Meis-1
  • FOXF2

Genomic Locations for RPL4 Gene

Genomic Locations for RPL4 Gene
26,518 bases
Minus strand
26,516 bases
Minus strand

Genomic View for RPL4 Gene

Genes around RPL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL4 Gene

Proteins for RPL4 Gene

  • Protein details for RPL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L4
    Protein Accession:
    Secondary Accessions:
    • A8K502
    • P39029
    • Q4VBR0
    • Q969Z9

    Protein attributes for RPL4 Gene

    427 amino acids
    Molecular mass:
    47697 Da
    Quaternary structure:
    • May bind IPO9 with low affinity. Interacts with RBM3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RPL4 Gene

neXtProt entry for RPL4 Gene

Post-translational modifications for RPL4 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys353, posLast=333333, posLast=327327, posLast=283283, Lys274, Lys259, Lys239, posLast=234234, posLast=219219, Lys175, posLast=165165, posLast=157157, posLast=140140, Lys106, posLast=4646, Lys29, and posLast=2020
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL4 Gene

No data available for DME Specific Peptides for RPL4 Gene

Domains & Families for RPL4 Gene

Gene Families for RPL4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL4 family.
  • Belongs to the universal ribosomal protein uL4 family.
genes like me logo Genes that share domains with RPL4: view

Function for RPL4 Gene

Molecular function for RPL4 Gene

GENATLAS Biochemistry:
60S ribosomal protein L4

Phenotypes From GWAS Catalog for RPL4 Gene

Gene Ontology (GO) - Molecular Function for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA,TAS --
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 22720776
genes like me logo Genes that share ontologies with RPL4: view
genes like me logo Genes that share phenotypes with RPL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL4 Gene

Localization for RPL4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL4 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005730 nucleolus HDA 16791210
GO:0005737 cytoplasm HDA 16791210
GO:0005791 rough endoplasmic reticulum IDA 24454821
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL4 Gene

Pathways & Interactions for RPL4 Gene

genes like me logo Genes that share pathways with RPL4: view

Pathways by source for RPL4 Gene

1 KEGG pathway for RPL4 Gene
1 GeneGo (Thomson Reuters) pathway for RPL4 Gene

Gene Ontology (GO) - Biological Process for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL4: view

No data available for SIGNOR curated interactions for RPL4 Gene

Drugs & Compounds for RPL4 Gene

(3) Drugs for RPL4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
genes like me logo Genes that share compounds with RPL4: view

Transcripts for RPL4 Gene

mRNA/cDNA for RPL4 Gene

Unigene Clusters for RPL4 Gene

Ribosomal protein L4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL4

Alternative Splicing Database (ASD) splice patterns (SP) for RPL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP8: - - - -
SP10: -

Relevant External Links for RPL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL4 Gene

Protein tissue co-expression partners for RPL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL4 Gene:


SOURCE GeneReport for Unigene cluster for RPL4 Gene:


Evidence on tissue expression from TISSUES for RPL4 Gene

  • Blood(5)
  • Liver(5)
  • Muscle(5)
  • Nervous system(5)
  • Eye(4.9)
  • Intestine(4.9)
  • Lung(4.9)
  • Skin(4.9)
  • Pancreas(4.8)
  • Kidney(4.7)
  • Stomach(4.6)
  • Bone(4.5)
  • Heart(4)
  • Spleen(3.6)
  • Thyroid gland(3.2)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Adrenal gland(2.5)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with RPL4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL4 Gene

Orthologs for RPL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 97 (a)
-- 34
  • 93 (a)
-- 34
  • 75 (a)
(Canis familiaris)
Mammalia RPL4 34 34
  • 96 (a)
-- 34
  • 95 (a)
(Bos Taurus)
Mammalia RPL4 34 33
  • 91.55 (n)
-- 34
  • 89 (a)
(Pan troglodytes)
Mammalia RPL4 34 33
  • 88.89 (n)
(Rattus norvegicus)
Mammalia Rpl4 33
  • 87.18 (n)
(Mus musculus)
Mammalia Rpl4 16 34 33
  • 85.52 (n)
(Monodelphis domestica)
Mammalia RPL4 34
  • 84 (a)
(Gallus gallus)
Aves RPL4 34 33
  • 80.73 (n)
(Anolis carolinensis)
Reptilia RPL4 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl4 33
  • 76.58 (n)
Str.8811 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64318 33
(Danio rerio)
Actinopterygii rpl4 34 33
  • 76.15 (n)
wufa97a02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.806 33
fruit fly
(Drosophila melanogaster)
Insecta RpL1 35
  • 62 (a)
RpL4 34 33
  • 61.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002306 33
  • 59.62 (n)
(Caenorhabditis elegans)
Secernentea rpl-4 34 35 33
  • 58.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR191C 33
  • 61.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL4A 36 34 33
  • 60.59 (n)
RPL4B 34
  • 57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07139g 33
  • 60.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09630 33
  • 57.48 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1107 33
(Oryza sativa)
Liliopsida Os07g0180900 33
  • 55.65 (n)
Os.8767 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4071 34
  • 67 (a)
Cin.5831 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl401 33
  • 60.37 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03757 33
  • 56.5 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5831 33
Species where no ortholog for RPL4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL4 Gene

Gene Tree for RPL4 (if available)
Gene Tree for RPL4 (if available)
Evolutionary constrained regions (ECRs) for RPL4: view image

Paralogs for RPL4 Gene

No data available for Paralogs for RPL4 Gene

Variants for RPL4 Gene

Sequence variations from dbSNP and Humsavar for RPL4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000194503 -- 66,500,899(-) T/C intron_variant
rs1000289102 -- 66,505,351(-) C/A/G upstream_transcript_variant
rs1000408247 -- 66,503,846(-) A/C intron_variant
rs1000482133 -- 66,505,594(-) G/A upstream_transcript_variant
rs1000707260 -- 66,501,605(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL4 Gene

Variant ID Type Subtype PubMed ID
nsv974591 CNV duplication 23825009

Variation tolerance for RPL4 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL4 Gene

Disorders for RPL4 Gene

Additional Disease Information for RPL4

No disorders were found for RPL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL4 Gene

Publications for RPL4 Gene

  1. Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. (PMID: 8268230) Bagni C … Amaldi F (Biochimica et biophysica acta 1993) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 58
  4. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jäkel S … Görlich D (The EMBO journal 2002) 3 4 58
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 58

Products for RPL4 Gene

Sources for RPL4 Gene