This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is ind... See more...

Aliases for RPL39L Gene

Aliases for RPL39L Gene

  • Ribosomal Protein L39 Like 2 3 5
  • Large Ribosomal Subunit Protein EL39-Like 3 4
  • 60S Ribosomal Protein L39-Like 3 4
  • Ribosomal Protein L39-Like 1 2 3
  • 60S Ribosomal Protein L39-2 3 4
  • RPL39L1 3 4
  • Ribosomal Protein L39-Like Protein 3
  • Ribosomal Protein L39-Like 2
  • L39-2 3

External Ids for RPL39L Gene

Previous HGNC Symbols for RPL39L Gene

  • RPL39L1

Previous GeneCards Identifiers for RPL39L Gene

  • GC03M183636
  • GC03M188095
  • GC03M188240
  • GC03M188159
  • GC03M188321
  • GC03M186839
  • GC03M184243

Summaries for RPL39L Gene

Entrez Gene Summary for RPL39L Gene

  • This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL39L Gene

RPL39L (Ribosomal Protein L39 Like) is a Protein Coding gene. Diseases associated with RPL39L include Lacrimal Gland Adenoid Cystic Carcinoma and Lacrimal Gland Carcinoma. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL39.

Additional gene information for RPL39L Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL39L Gene

Genomics for RPL39L Gene

GeneHancer (GH) Regulatory Elements for RPL39L Gene

Promoters and enhancers for RPL39L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J187138 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.3 +41.5 41527 2 ZBTB40 ZNF217 CTCF NRF1 MYC GTF2E2 PHF8 ZFX ZIC2 POLR2A HSALNG0031407 RPL39L ADIPOQ RPL39P19
GH03J187180 Promoter/Enhancer 0.9 Ensembl ENCODE dbSUPER 500.7 +0.8 806 4.2 ETS1 POU5F1 NANOG POLR2A RPL39L piR-48950-134 RTP1 CRYGS MG598801-017
GH03J187060 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11 +117.0 117007 7.8 ZNF217 CTCF TCF12 USF1 ZIC2 CLOCK TCF7 RFX1 MEF2C CUX1 ADIPOQ RPL39L ST6GAL1 piR-52787 lnc-RPL39L-3
GH03J187129 Enhancer 1 FANTOM5 ENCODE 11.4 +50.3 50328 2.4 FOXA2 ZNF384 USF2 USF1 FOS SRF FOSL1 IRF2 JUND ELF1 SNORA81 SNORA63B SNORA63 SNORA4 TBCCD1 RPL39L EIF4A2 ADIPOQ RFC4 RTP4
GH03J187113 Enhancer 0.8 Ensembl ENCODE 11 +67.6 67624 0.6 CTCF USF1 REST RAD21 TRIM22 SMC3 ZNF384 SRF KLF16 ATF3 RPL39L ADIPOQ ADIPOQ-AS1 RPL39P19 piR-52787
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL39L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL39L

Genomic Locations for RPL39L Gene

Genomic Locations for RPL39L Gene
chr3:187,120,948-187,180,908
(GRCh38/hg38)
Size:
59,961 bases
Orientation:
Minus strand
chr3:186,838,736-186,898,696
(GRCh37/hg19)
Size:
59,961 bases
Orientation:
Minus strand

Genomic View for RPL39L Gene

Genes around RPL39L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL39L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL39L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL39L Gene

Proteins for RPL39L Gene

  • Protein details for RPL39L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EH5-RL39L_HUMAN
    Recommended name:
    60S ribosomal protein L39-like
    Protein Accession:
    Q96EH5
    Secondary Accessions:
    • Q8IUD0

    Protein attributes for RPL39L Gene

    Size:
    51 amino acids
    Molecular mass:
    6293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPL39L Gene

Post-translational modifications for RPL39L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL39L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL39L Gene

Domains & Families for RPL39L Gene

Gene Families for RPL39L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL39L Gene

Blocks:
  • Ribosomal protein L39e
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL39L Gene

GenScript: Design optimal peptide antigens:
  • 60S ribosomal protein L39-2 (RL39L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96EH5

UniProtKB/Swiss-Prot:

RL39L_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL39 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL39 family.
genes like me logo Genes that share domains with RPL39L: view

Function for RPL39L Gene

Phenotypes From GWAS Catalog for RPL39L Gene

Gene Ontology (GO) - Molecular Function for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPL39L: view
genes like me logo Genes that share phenotypes with RPL39L: view

miRNA for RPL39L Gene

miRTarBase miRNAs that target RPL39L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL39L Gene

Localization for RPL39L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL39L gene
Compartment Confidence
cytosol 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit NAS 12490704
genes like me logo Genes that share ontologies with RPL39L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPL39L Gene

Pathways & Interactions for RPL39L Gene

genes like me logo Genes that share pathways with RPL39L: view

Gene Ontology (GO) - Biological Process for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0007283 spermatogenesis IEP 12490704
genes like me logo Genes that share ontologies with RPL39L: view

No data available for SIGNOR curated interactions for RPL39L Gene

Drugs & Compounds for RPL39L Gene

No Compound Related Data Available

Transcripts for RPL39L Gene

mRNA/cDNA for RPL39L Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL39L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for RPL39L Gene

GeneLoc Exon Structure for
RPL39L

Expression for RPL39L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL39L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPL39L Gene

This gene is overexpressed in Testis (x16.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL39L

SOURCE GeneReport for Unigene cluster for RPL39L Gene:

Hs.647900

mRNA Expression by UniProt/SwissProt for RPL39L Gene:

Q96EH5-RL39L_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with RPL39L: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL39L Gene

Orthologs for RPL39L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL39L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL39L 31 30
  • 99.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPL39 31
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl39l 31
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL39 31
  • 92 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 90 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rpl39 31
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RpL39 31
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-39 31
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL39 31
  • 55 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6039 31
  • 78 (a)
OneToMany
Species where no ortholog for RPL39L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL39L Gene

ENSEMBL:
Gene Tree for RPL39L (if available)
TreeFam:
Gene Tree for RPL39L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL39L: view image

Paralogs for RPL39L Gene

Paralogs for RPL39L Gene

(2) SIMAP similar genes for RPL39L Gene using alignment to 1 proteins:

  • RL39L_HUMAN
genes like me logo Genes that share paralogs with RPL39L: view

Variants for RPL39L Gene

Additional dbSNP identifiers (rs#s) for RPL39L Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL39L Gene

Variant ID Type Subtype PubMed ID
nsv1004008 CNV gain 25217958
nsv1014596 CNV gain 25217958
nsv4157 CNV insertion 18451855
nsv965243 CNV duplication 23825009

Variation tolerance for RPL39L Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL39L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL39L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL39L Gene

Disorders for RPL39L Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPL39L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lacrimal gland adenoid cystic carcinoma
  • adenoid cystic carcinoma of lacrimal gland
lacrimal gland carcinoma
  • carcinoma of the lacrimal gland
seborrheic infantile dermatitis
  • complement component 5 deficiency
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
lacrimal system cancer
  • lacrimal system neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPL39L

genes like me logo Genes that share disorders with RPL39L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL39L Gene

Publications for RPL39L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes. (PMID: 12490704) Uechi T … Kenmochi N (Nucleic acids research 2002) 3 4 54
  3. A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and derepressed in multiple cancer cells. (PMID: 12359333) Nadano D … Sato T (Biochimica et biophysica acta 2002) 3 4 54
  4. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for RPL39L Gene

Sources for RPL39L Gene