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Aliases for RPL39L Gene

Aliases for RPL39L Gene

  • Ribosomal Protein L39 Like 2 3 5
  • Large Ribosomal Subunit Protein EL39-Like 3 4
  • Ribosomal Protein L39-Like 1 2 3
  • 60S Ribosomal Protein L39-2 3 4
  • RPL39L1 3 4
  • Ribosomal Protein L39-Like Protein 3
  • 60S Ribosomal Protein L39-Like 3
  • Ribosomal Protein L39-Like 2
  • L39-2 3

External Ids for RPL39L Gene

Previous HGNC Symbols for RPL39L Gene

  • RPL39L1

Previous GeneCards Identifiers for RPL39L Gene

  • GC03M183636
  • GC03M188095
  • GC03M188240
  • GC03M188159
  • GC03M188321
  • GC03M186839
  • GC03M184243

Summaries for RPL39L Gene

Entrez Gene Summary for RPL39L Gene

  • This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL39L Gene

RPL39L (Ribosomal Protein L39 Like) is a Protein Coding gene. Diseases associated with RPL39L include Lacrimal Gland Adenocarcinoma. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL39.

Additional gene information for RPL39L Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL39L Gene

Genomics for RPL39L Gene

GeneHancer (GH) Regulatory Elements for RPL39L Gene

Promoters and enhancers for RPL39L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I187138 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.3 +41.5 41517 1.9 PKNOX1 SIN3A ZNF2 POLR2B CBX5 E2F8 ZNF143 SP3 REST SMARCA4 RPL39L ADIPOQ LOC100131635 TBCCD1 RPL39P19
GH03I187180 Enhancer 0.5 ENCODE dbSUPER 550.8 -0.6 -561 1.5 POLR2A RPL39L RTP1
GH03I187062 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 +116.3 116342 5.1 FOXA2 ARID4B YY1 ATF7 FOS RUNX3 JUNB REST NFIL3 HNF4A ENSG00000200418 SNORA4 TBCCD1 ADIPOQ RPL39L LOC100131635 SNORA81 ST6GAL1 PIR46786 GC03P186996
GH03I187129 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.4 +50.3 50328 2.4 IRF2 FOXA2 JUN MAX BATF KLF5 ZNF507 FOSL1 GATA3 ZNF26 SNORA81 ENSG00000200418 SNORA63 SNORA4 TBCCD1 RPL39L EIF4A2 ADIPOQ RFC4 RTP4
GH03I187113 Enhancer 0.6 ENCODE 11 +67.5 67520 0.2 CTCF SRF TRIM22 REST RAD21 ZNF592 ZNF830 KLF16 SMC3 ZNF143 RPL39L RPL39P19 PIR46786
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPL39L on UCSC Golden Path with GeneCards custom track

Genomic Locations for RPL39L Gene

Genomic Locations for RPL39L Gene
59,961 bases
Minus strand

Genomic View for RPL39L Gene

Genes around RPL39L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL39L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL39L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL39L Gene

Proteins for RPL39L Gene

  • Protein details for RPL39L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L39-like
    Protein Accession:
    Secondary Accessions:
    • Q8IUD0

    Protein attributes for RPL39L Gene

    51 amino acids
    Molecular mass:
    6293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPL39L Gene

Post-translational modifications for RPL39L Gene

No Post-translational modifications

Other Protein References for RPL39L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL39L Gene

Domains & Families for RPL39L Gene

Gene Families for RPL39L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL39L Gene

Suggested Antigen Peptide Sequences for RPL39L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL39 family.
  • Belongs to the eukaryotic ribosomal protein eL39 family.
genes like me logo Genes that share domains with RPL39L: view

Function for RPL39L Gene

Gene Ontology (GO) - Molecular Function for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPL39L: view
genes like me logo Genes that share phenotypes with RPL39L: view

miRNA for RPL39L Gene

miRTarBase miRNAs that target RPL39L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL39L Gene

Localization for RPL39L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL39L gene
Compartment Confidence
cytosol 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit NAS 12490704
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPL39L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPL39L Gene

Pathways & Interactions for RPL39L Gene

genes like me logo Genes that share pathways with RPL39L: view

Gene Ontology (GO) - Biological Process for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0007283 spermatogenesis IEP 12490704
genes like me logo Genes that share ontologies with RPL39L: view

No data available for SIGNOR curated interactions for RPL39L Gene

Drugs & Compounds for RPL39L Gene

No Compound Related Data Available

Transcripts for RPL39L Gene

mRNA/cDNA for RPL39L Gene

Unigene Clusters for RPL39L Gene

Ribosomal protein L39-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL39L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for RPL39L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL39L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL39L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPL39L Gene

This gene is overexpressed in Testis (x16.2).

NURSA nuclear receptor signaling pathways regulating expression of RPL39L Gene:


SOURCE GeneReport for Unigene cluster for RPL39L Gene:


mRNA Expression by UniProt/SwissProt for RPL39L Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with RPL39L: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL39L Gene

Orthologs for RPL39L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL39L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL39L 33 34
  • 99.35 (n)
(Bos Taurus)
Mammalia RPL39 34
  • 92 (a)
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
(Mus musculus)
Mammalia Rpl39l 34
  • 90 (a)
(Gallus gallus)
Aves RPL39 34
  • 92 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 90 (a)
(Danio rerio)
Actinopterygii rpl39 34
  • 90 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL39 34
  • 65 (a)
(Caenorhabditis elegans)
Secernentea rpl-39 34
  • 69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL39 34
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6039 34
  • 78 (a)
Species where no ortholog for RPL39L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL39L Gene

Gene Tree for RPL39L (if available)
Gene Tree for RPL39L (if available)

Paralogs for RPL39L Gene

Paralogs for RPL39L Gene

(2) SIMAP similar genes for RPL39L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL39L: view

Variants for RPL39L Gene

Sequence variations from dbSNP and Humsavar for RPL39L Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000238479 -- 187,130,973(-) C/A intron_variant
rs1000587625 -- 187,137,983(-) C/A intron_variant
rs1000662868 -- 187,125,485(-) C/T intron_variant
rs1001181372 -- 187,125,063(-) G/A intron_variant
rs1001213952 -- 187,132,101(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL39L Gene

Variant ID Type Subtype PubMed ID
nsv1004008 CNV gain 25217958
nsv1014596 CNV gain 25217958
nsv4157 CNV insertion 18451855
nsv965243 CNV duplication 23825009

Variation tolerance for RPL39L Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL39L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL39L Gene

Disorders for RPL39L Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL39L Gene - From: DISEASES

Disorder Aliases PubMed IDs
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPL39L

genes like me logo Genes that share disorders with RPL39L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL39L Gene

Publications for RPL39L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and derepressed in multiple cancer cells. (PMID: 12359333) Nadano D … Sato T (Biochimica et biophysica acta 2002) 3 4 58
  3. Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes. (PMID: 12490704) Uechi T … Kenmochi N (Nucleic acids research 2002) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors. (PMID: 24452241) Wong QW … Vardy LA (RNA biology 2014) 3 58

Products for RPL39L Gene

Sources for RPL39L Gene

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