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Aliases for RPL38 Gene

Aliases for RPL38 Gene

  • Ribosomal Protein L38 2 3 5
  • Large Ribosomal Subunit Protein EL38 3 4
  • 60S Ribosomal Protein L38 3
  • L38 3

External Ids for RPL38 Gene

Previous GeneCards Identifiers for RPL38 Gene

  • GC17P072221
  • GC17P075257
  • GC17P072663
  • GC17P072796
  • GC17P069711
  • GC17P067610
  • GC17P072202

Summaries for RPL38 Gene

Entrez Gene Summary for RPL38 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL38 Gene

RPL38 (Ribosomal Protein L38) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL38 Gene

Additional gene information for RPL38 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL38 Gene

Genomics for RPL38 Gene

GeneHancer (GH) Regulatory Elements for RPL38 Gene

Promoters and enhancers for RPL38 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074203 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.6 1569 4.3 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RPL38 GC17P074206 NT5C NAT9 RN7SL573P ENSG00000266765 ENSG00000265927 LINC02092 ENSG00000265935 SLC16A5
GH17J074295 Enhancer 1.4 FANTOM5 Ensembl ENCODE 12 +92.8 92807 1.5 HDGF PKNOX1 SMAD1 ATF1 ARNT TCF12 ZNF766 GATA2 ZNF143 ATF7 TTYH2 DNAI2 HID1-AS1 NAT9 MGC16275 RPL38 GGA3 RAB37 ENSG00000266106
GH17J074239 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 12 +37.1 37057 3.3 PKNOX1 BHLHE40 ZSCAN4 MAX CEBPB CEBPG PRDM10 PRDM4 MYC CD300E DNAI2 TTYH2 CD300C CD300LB MGC16275 RPL38 CD300LF CD300A CD300LD
GH17J074234 Enhancer 1 Ensembl ENCODE dbSUPER 12 +31.8 31795 2.4 HDAC1 ZNF687 CBFA2T3 ZMYM3 EBF1 MEF2B ZEB2 ATF4 MTA3 SCRT2 TTYH2 DNAI2 MGC16275 RPL38 CD300A CD300E ENSG00000264272
GH17J074248 Enhancer 0.8 ENCODE dbSUPER 11.6 +46.6 46573 2.4 HDGF MXI1 ZSCAN4 ZNF662 MNT ZNF512B NONO ZNF184 PHF20 POLR2A NUP85 NAT9 TTYH2 NT5C DNAI2 RN7SL573P MGC16275 RPL38 CDC42EP4 ENSG00000264272
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL38 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL38 gene promoter:
  • GATA-2
  • Max1
  • c-Myc
  • POU2F1a
  • POU2F1
  • FOXJ2 (long isoform)
  • Pbx1a
  • FOXJ2
  • Elk-1
  • Evi-1

Genomic Locations for RPL38 Gene

Genomic Locations for RPL38 Gene
7,074 bases
Plus strand
7,074 bases
Plus strand

Genomic View for RPL38 Gene

Genes around RPL38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL38 Gene

Proteins for RPL38 Gene

  • Protein details for RPL38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L38
    Protein Accession:
    Secondary Accessions:
    • B2R5A8
    • P23411

    Protein attributes for RPL38 Gene

    70 amino acids
    Molecular mass:
    8218 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL38 Gene

neXtProt entry for RPL38 Gene

Post-translational modifications for RPL38 Gene

  • Ubiquitination at posLast=5757, isoforms=55, and posLast=99
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL38 Gene

No data available for DME Specific Peptides for RPL38 Gene

Domains & Families for RPL38 Gene

Gene Families for RPL38 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL38 Gene

Suggested Antigen Peptide Sequences for RPL38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL38 family.
  • Belongs to the eukaryotic ribosomal protein eL38 family.
genes like me logo Genes that share domains with RPL38: view

Function for RPL38 Gene

Molecular function for RPL38 Gene

GENATLAS Biochemistry:
60S ribosomal protein L38

Phenotypes From GWAS Catalog for RPL38 Gene

Gene Ontology (GO) - Molecular Function for RPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9375793
GO:0003735 structural constituent of ribosome TAS,NAS 12962325
genes like me logo Genes that share ontologies with RPL38: view
genes like me logo Genes that share phenotypes with RPL38: view

Animal Models for RPL38 Gene

MGI Knock Outs for RPL38:

Animal Model Products

miRNA for RPL38 Gene

miRTarBase miRNAs that target RPL38

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPL38 Gene

Localization for RPL38 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL38 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0022625 cytosolic large ribosomal subunit IDA,TAS 25957688
genes like me logo Genes that share ontologies with RPL38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL38 Gene

Pathways & Interactions for RPL38 Gene

genes like me logo Genes that share pathways with RPL38: view

Pathways by source for RPL38 Gene

Gene Ontology (GO) - Biological Process for RPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RPL38: view

No data available for SIGNOR curated interactions for RPL38 Gene

Drugs & Compounds for RPL38 Gene

No Compound Related Data Available

Transcripts for RPL38 Gene

mRNA/cDNA for RPL38 Gene

Unigene Clusters for RPL38 Gene

Ribosomal protein L38:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL38 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP8: -

Relevant External Links for RPL38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL38 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (14.1) and Bone (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL38 Gene

Protein tissue co-expression partners for RPL38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL38 Gene:


SOURCE GeneReport for Unigene cluster for RPL38 Gene:


Evidence on tissue expression from TISSUES for RPL38 Gene

  • Lung(4.8)
  • Skin(4.6)
  • Nervous system(4.5)
  • Blood(4.4)
  • Muscle(3.8)
  • Kidney(3.4)
  • Heart(3.3)
  • Intestine(3.3)
  • Pancreas(3.3)
  • Eye(3.1)
  • Bone marrow(2.7)
  • Liver(2.7)
  • Lymph node(2.7)
  • Spleen(2.7)
  • Adrenal gland(2.6)
  • Stomach(2.6)
  • Thyroid gland(2.4)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with RPL38: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL38 Gene

Orthologs for RPL38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL38 34 33
  • 100 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
-- 34
  • 87 (a)
(Bos Taurus)
Mammalia RPL38 34 33
  • 92.38 (n)
(Mus musculus)
Mammalia Rpl38 16 34 33
  • 89.52 (n)
(Canis familiaris)
Mammalia RPL38 34
  • 71 (a)
(Gallus gallus)
Aves RPL38 34 33
  • 84.76 (n)
(Anolis carolinensis)
Reptilia RPL38 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl38 33
  • 83.81 (n)
Str.3048 33
(Danio rerio)
Actinopterygii rpl38 34 33
  • 84.76 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8403 33
African malaria mosquito
(Anopheles gambiae)
Insecta RL38_ANOGA 33
  • 69.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL38 34 33
  • 65.24 (n)
(Caenorhabditis elegans)
Secernentea rpl-38 34 33
  • 74.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL38 36 34
  • 49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G43460 33
  • 71.98 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2465 33
(Oryza sativa)
Liliopsida Os05g0507200 33
  • 70.05 (n)
(Triticum aestivum)
Liliopsida Ta.912 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6016 34
  • 86 (a)
Cin.4751 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4751 33
Species where no ortholog for RPL38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL38 Gene

Gene Tree for RPL38 (if available)
Gene Tree for RPL38 (if available)
Evolutionary constrained regions (ECRs) for RPL38: view image

Paralogs for RPL38 Gene

genes like me logo Genes that share paralogs with RPL38: view

No data available for Paralogs for RPL38 Gene

Variants for RPL38 Gene

Sequence variations from dbSNP and Humsavar for RPL38 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000143463 -- 74,203,381(+) C/G upstream_transcript_variant
rs1000956638 -- 74,208,251(+) G/T intron_variant
rs1001124697 -- 74,203,899(+) C/T intron_variant
rs1001343425 -- 74,208,245(+) T/C intron_variant
rs1001446004 -- 74,206,579(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL38 Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv587e214 CNV gain 21293372
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
nsv509673 CNV insertion 20534489
nsv517569 CNV gain+loss 19592680
nsv833538 CNV gain 17160897

Variation tolerance for RPL38 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL38 Gene

Disorders for RPL38 Gene

Additional Disease Information for RPL38

No disorders were found for RPL38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL38 Gene

Publications for RPL38 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  2. Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene. (PMID: 9375793) Espinosa L … Navarro E (Biochimica et biophysica acta 1997) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for RPL38 Gene

Sources for RPL38 Gene

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