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Aliases for RPL37A Gene

Aliases for RPL37A Gene

  • Ribosomal Protein L37a 2 3 5
  • Large Ribosomal Subunit Protein EL43 3 4
  • 60S Ribosomal Protein L37a 3
  • L37A 3

External Ids for RPL37A Gene

Previous GeneCards Identifiers for RPL37A Gene

  • GC02P215460
  • GC02P216084
  • GC02P217327
  • GC02P217566
  • GC02P217189
  • GC02P217071
  • GC02P209217

Summaries for RPL37A Gene

Entrez Gene Summary for RPL37A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL37A Gene

RPL37A (Ribosomal Protein L37a) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL37A Gene

Additional gene information for RPL37A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL37A Gene

Genomics for RPL37A Gene

GeneHancer (GH) Regulatory Elements for RPL37A Gene

Promoters and enhancers for RPL37A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J216497 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.2 1203 3.8 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ENSG00000232485 RPL37A LOC100507554 GC02P216499 SMARCAL1 XRCC5 GC02M216502
GH02J217402 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.8 +905.0 905035 1.4 NFIB ZNF324 ZFHX2 ZNF366 PATZ1 VEZF1 FOSL2 FOS NFE2 EGR2 AAMP RPL37A SMARCAL1 IGFBP5 GC02M217383 GC02P217334 DIRC3
GH02J216475 Enhancer 0.5 Ensembl 11.9 -22.8 -22788 0.8 EED IKZF1 ETV6 IKZF2 IRF4 RUNX3 SPI1 RPL37A ENSG00000232485 GC02M216466 ENSG00000241520 SMARCAL1
GH02J216491 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.4 -5.4 -5420 1.9 FOXA2 MAX PAX8 EBF1 ZIC2 ZNF335 ZFHX2 POLR2A ZBTB48 EED SMARCAL1 RPL37A LOC100507554 ENSG00000241520 ENSG00000232485
GH02J216533 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +37.4 37441 4.1 FEZF1 ZNF48 ZNF207 FOS ATF7 RXRA KAT8 NFIL3 SSRP1 ZNF184 LOC101928180 IGFBP2 XRCC5 SMARCAL1 RPL37A LOC105373871
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL37A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL37A gene promoter:
  • MRF-2
  • Nkx2-5
  • STAT1beta
  • STAT1alpha
  • STAT1
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • AML1a

Genomic Locations for RPL37A Gene

Genomic Locations for RPL37A Gene
80,992 bases
Plus strand
80,992 bases
Plus strand

Genomic View for RPL37A Gene

Genes around RPL37A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL37A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL37A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL37A Gene

Proteins for RPL37A Gene

  • Protein details for RPL37A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L37a
    Protein Accession:
    Secondary Accessions:
    • P12751
    • Q6FGF5

    Protein attributes for RPL37A Gene

    92 amino acids
    Molecular mass:
    10275 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL37A Gene

neXtProt entry for RPL37A Gene

Post-translational modifications for RPL37A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPL37A Gene

Domains & Families for RPL37A Gene

Gene Families for RPL37A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL37A Gene

Suggested Antigen Peptide Sequences for RPL37A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL43 family.
  • Belongs to the eukaryotic ribosomal protein eL43 family.
genes like me logo Genes that share domains with RPL37A: view

Function for RPL37A Gene

Phenotypes From GWAS Catalog for RPL37A Gene

Gene Ontology (GO) - Molecular Function for RPL37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPL37A: view
genes like me logo Genes that share phenotypes with RPL37A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL37A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL37A Gene

Localization for RPL37A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL37A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus HDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with RPL37A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL37A Gene

Pathways & Interactions for RPL37A Gene

genes like me logo Genes that share pathways with RPL37A: view

Pathways by source for RPL37A Gene

1 KEGG pathway for RPL37A Gene
1 GeneGo (Thomson Reuters) pathway for RPL37A Gene

Gene Ontology (GO) - Biological Process for RPL37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL37A: view

No data available for SIGNOR curated interactions for RPL37A Gene

Drugs & Compounds for RPL37A Gene

No Compound Related Data Available

Transcripts for RPL37A Gene

mRNA/cDNA for RPL37A Gene

(1) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(2129) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL37A Gene

Ribosomal protein L37a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL37A

Alternative Splicing Database (ASD) splice patterns (SP) for RPL37A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for RPL37A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL37A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL37A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL37A Gene

This gene is overexpressed in Tlymphocyte (7.8) and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL37A Gene

Protein tissue co-expression partners for RPL37A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL37A Gene:


SOURCE GeneReport for Unigene cluster for RPL37A Gene:


Evidence on tissue expression from TISSUES for RPL37A Gene

  • Muscle(4.9)
  • Nervous system(4.9)
  • Skin(4.8)
  • Liver(4.2)
  • Pancreas(4)
  • Eye(3.8)
  • Intestine(3.8)
  • Lung(3.8)
  • Bone(3.7)
  • Blood(3.6)
  • Heart(3.2)
  • Kidney(3.1)
  • Stomach(3)
  • Adrenal gland(2.9)
  • Bone marrow(2.9)
  • Lymph node(2.9)
  • Spleen(2.8)
  • Thyroid gland(2.8)
  • Gall bladder(2.7)
genes like me logo Genes that share expression patterns with RPL37A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL37A Gene

Orthologs for RPL37A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL37A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL37A 34 33
  • 100 (n)
(Monodelphis domestica)
Mammalia RPL37A 34
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPL37A 34
  • 99 (a)
(Mus musculus)
Mammalia Rpl37a 16 34 33
  • 90.58 (n)
(Canis familiaris)
Mammalia -- 34
  • 90 (a)
RPL37A 33
  • 89.13 (n)
-- 34
  • 79 (a)
-- 34
  • 57 (a)
(Bos Taurus)
Mammalia RPL37A 34 33
  • 89.49 (n)
(Rattus norvegicus)
Mammalia Rpl37a 33
  • 84.78 (n)
(Gallus gallus)
Aves RPL37A 34 33
  • 83.7 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 98 (a)
-- 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl37a 33
  • 84.42 (n)
Str.1005 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64282 33
(Danio rerio)
Actinopterygii RPL37A 34
  • 97 (a)
zgc:171772 33
  • 81.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL37a 35
  • 76 (a)
RpL37A 34 33
  • 71.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009920 33
  • 69.66 (n)
(Caenorhabditis elegans)
Secernentea rpl-43 34 33
  • 67.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL43B 34
  • 66 (a)
RPL43A 34 33
  • 64.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL310C 33
  • 65.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05941g 33
  • 62.64 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G10950 33
  • 59.85 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2253 33
(Oryza sativa)
Liliopsida Os05g0557000 33
  • 62.5 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07562 33
  • 62.64 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl4302 33
  • 56.41 (n)
Species where no ortholog for RPL37A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL37A Gene

Gene Tree for RPL37A (if available)
Gene Tree for RPL37A (if available)
Evolutionary constrained regions (ECRs) for RPL37A: view image

Paralogs for RPL37A Gene

(1) SIMAP similar genes for RPL37A Gene using alignment to 7 proteins:

  • C9J4Z3_HUMAN
  • G5E9R3_HUMAN
  • M0R0A1_HUMAN
  • M0R2L6_HUMAN
  • Q6P4E4_HUMAN
genes like me logo Genes that share paralogs with RPL37A: view

No data available for Paralogs for RPL37A Gene

Variants for RPL37A Gene

Sequence variations from dbSNP and Humsavar for RPL37A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000212798 -- 216,497,076(+) C/T upstream_transcript_variant
rs1000379461 -- 216,498,813(+) C/T 5_prime_UTR_variant
rs1001396366 -- 216,499,595(+) C/T intron_variant
rs1001934509 -- 216,500,784(+) C/T intron_variant
rs1002939540 -- 216,501,942(+) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL37A Gene

Variant ID Type Subtype PubMed ID
nsv1006201 CNV gain 25217958

Variation tolerance for RPL37A Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL37A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL37A Gene

Disorders for RPL37A Gene

Additional Disease Information for RPL37A

No disorders were found for RPL37A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL37A Gene

Publications for RPL37A Gene

  1. Primary sequence of the human ribosomal protein L37a. (PMID: 1437567) Hoof T … Tümmler B (Nucleic acids research 1992) 2 3 4 22 58
  2. Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines. (PMID: 8224875) Saha DP … Howells RD (Gene 1993) 3 4 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RPL37A Gene

Sources for RPL37A Gene

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