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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
RPL37 (Ribosomal Protein L37) is a Protein Coding gene. Diseases associated with RPL37 include Noonan Syndrome 5 and Retinitis Pigmentosa 27. Among its related pathways are rRNA processing in the nucleus and cytosol and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include RNA binding and rRNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA,TAS | 7545944 |
GO:0003735 | structural constituent of ribosome | IEA,TAS | 7545944 |
GO:0019843 | rRNA binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0005840 | ribosome | IEA | -- |
GO:0022625 | cytosolic large ribosomal subunit | TAS | 7545944 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
CFTR translational fidelity (class I mutations)
.79
.77
.53
|
|
2 | Influenza Viral RNA Transcription and Replication | ||
3 | rRNA processing in the nucleus and cytosol |
.89
|
|
4 | HIV Life Cycle |
.45
|
|
5 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
GO:0006412 | translation | IEA,TAS | 7545944 |
GO:0006413 | translational initiation | TAS | -- |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | -- |
GO:0019083 | viral transcription | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Anisomycin | Experimental | Pharma | Target | JNK agonist, potent and specific, JNK, SAPK and p38 activator | 0 | |
L-3-Phenyllactic acid | Experimental | Pharma | Target | 0 | ||
puromycin | Experimental | Pharma | Target | 0 | ||
PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE | Experimental | Pharma | Target | 0 | ||
Virginiamycin S1 | Experimental | Pharma | Target | 0 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||
SP2: | - | - | |||||||||||||||||
SP3: | - | ||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RPL37 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
RPL37 30 |
|
||||
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RPL37 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | RPL37 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100360841 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rpl37 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RPL37 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RPL37 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rpl37 30 |
|
||
Str.11137 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | rpl37 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9091 32 |
|
|
|
RpL37a 30 31 |
|
OneToMany | |||
CG9873 32 |
|
|
|||
RpL37b 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000952 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | rpl-37 31 |
|
OneToMany | |
W01D2.1 30 31 |
|
OneToMany | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR688C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C01870g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPL37A 30 31 33 |
|
OneToMany | |
RPL37B 31 |
|
OneToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G52300 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0111700 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.12413 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.5687 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpl3702 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01966 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
noonan syndrome 5 |
|
|
retinitis pigmentosa 27 |
|
|
osteogenesis imperfecta, type iv |
|
|
diamond-blackfan anemia |
|
|