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Aliases for RPL37 Gene

Aliases for RPL37 Gene

  • Ribosomal Protein L37 2 3 5
  • Large Ribosomal Subunit Protein EL37 3 4
  • 60S Ribosomal Protein L37a 2 3
  • G1.16 3 4
  • 60S Ribosomal Protein L37 3
  • L37 3

External Ids for RPL37 Gene

Previous GeneCards Identifiers for RPL37 Gene

  • GC05M041139
  • GC05M041924
  • GC05M040878
  • GC05M040876
  • GC05M040866
  • GC05M040783

Summaries for RPL37 Gene

Entrez Gene Summary for RPL37 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL37 Gene

RPL37 (Ribosomal Protein L37) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include RNA binding and rRNA binding.

UniProtKB/Swiss-Prot for RPL37 Gene

  • Binds to the 23S rRNA.

Gene Wiki entry for RPL37 Gene

Additional gene information for RPL37 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL37 Gene

Genomics for RPL37 Gene

GeneHancer (GH) Regulatory Elements for RPL37 Gene

Promoters and enhancers for RPL37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J040832 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.9 856 4.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 RPL37 SNORD72 GC05M040833 PRKAA1 CARD6 PLCXD3 TTC33
GH05J040802 Enhancer 1 ENCODE 12.2 +33.2 33221 0.2 CLOCK ATF1 FOXA2 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 NCOA1 RPL37 SNORD72 CARD6 PRKAA1 GC05P040818
GH05J040783 Enhancer 0.9 ENCODE 11.5 +50.6 50598 2.5 ELF3 FOXA2 ARID4B RAD21 RARA YY1 ZNF614 EGR1 CREM THAP11 CARD6 TTC33 SNORD72 RPL37 GC05M040791 ENSG00000212567 PRKAA1
GH05J040404 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +427.1 427149 8 CTCF ELF3 MEIS2 JUN MAX ZBTB40 ZNF644 YY1 RELA HIC1 PTGER4 RPL37 CARD6 PRKAA1 GC05M039678 LOC105374736
GH05J040381 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +451.3 451345 5.6 CLOCK JUN MAX EBF1 RELA CTBP1 GATA3 RCOR1 FOSL2 FOS PTGER4 RPL37 CARD6 PRKAA1 GC05M039678 LOC105374736
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL37 gene promoter:
  • YY1
  • E47
  • ZID
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • HSF2
  • Ik-1

Genomic Locations for RPL37 Gene

Genomic Locations for RPL37 Gene
10,074 bases
Minus strand
10,074 bases
Minus strand

Genomic View for RPL37 Gene

Genes around RPL37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL37 Gene

Proteins for RPL37 Gene

  • Protein details for RPL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L37
    Protein Accession:
    Secondary Accessions:
    • B2R4H2
    • P02403
    • Q6IBB4
    • Q99883

    Protein attributes for RPL37 Gene

    97 amino acids
    Molecular mass:
    11078 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL37 Gene

neXtProt entry for RPL37 Gene

Post-translational modifications for RPL37 Gene

  • Ubiquitination at posLast=3131
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL37 Gene

Domains & Families for RPL37 Gene

Gene Families for RPL37 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL37 Gene

Suggested Antigen Peptide Sequences for RPL37 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL37 family.
  • Belongs to the eukaryotic ribosomal protein eL37 family.
genes like me logo Genes that share domains with RPL37: view

Function for RPL37 Gene

Molecular function for RPL37 Gene

UniProtKB/Swiss-Prot Function:
Binds to the 23S rRNA.
GENATLAS Biochemistry:
60S ribosomal protein L37,11kDa,overexpressed in colon cancer

Phenotypes From GWAS Catalog for RPL37 Gene

Gene Ontology (GO) - Molecular Function for RPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IEA 7545944
GO:0003735 structural constituent of ribosome IEA,TAS 7545944
GO:0019843 rRNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPL37: view
genes like me logo Genes that share phenotypes with RPL37: view

Animal Model Products

miRNA for RPL37 Gene

miRTarBase miRNAs that target RPL37

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL37 Gene

Localization for RPL37 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL37 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit TAS 7545944
genes like me logo Genes that share ontologies with RPL37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPL37 Gene

Pathways & Interactions for RPL37 Gene

genes like me logo Genes that share pathways with RPL37: view

Pathways by source for RPL37 Gene

1 KEGG pathway for RPL37 Gene
1 GeneGo (Thomson Reuters) pathway for RPL37 Gene

Gene Ontology (GO) - Biological Process for RPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,TAS 7545944
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL37: view

No data available for SIGNOR curated interactions for RPL37 Gene

Drugs & Compounds for RPL37 Gene

(5) Drugs for RPL37 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
Virginiamycin S1 Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL37: view

Transcripts for RPL37 Gene

mRNA/cDNA for RPL37 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2010) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL37 Gene

Ribosomal protein L37:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
SP2: - -
SP3: -
SP4: -

Relevant External Links for RPL37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL37 Gene

Protein differential expression in normal tissues from HIPED for RPL37 Gene

This gene is overexpressed in Lung (32.8), Peripheral blood mononuclear cells (13.1), Cervix (8.9), and Bone (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL37 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPL37 Gene:


SOURCE GeneReport for Unigene cluster for RPL37 Gene:


Evidence on tissue expression from TISSUES for RPL37 Gene

  • Blood(4.8)
  • Intestine(4.8)
  • Lung(4.8)
  • Muscle(4.8)
  • Nervous system(4.7)
  • Liver(4.3)
  • Heart(3.8)
  • Stomach(3.8)
  • Skin(3.4)
  • Pancreas(3)
  • Bone(2.9)
  • Kidney(2.9)
  • Eye(2.7)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Spleen(2.5)
  • Adrenal gland(2.4)
  • Gall bladder(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with RPL37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL37 Gene

Orthologs for RPL37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL37 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
-- 34
  • 100 (a)
RPL37 33
  • 95.88 (n)
-- 34
  • 92 (a)
(Pan troglodytes)
Mammalia RPL37 34 33
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia RPL37 34
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
-- 34
  • 98 (a)
(Bos Taurus)
Mammalia RPL37 34 33
  • 95.53 (n)
(Rattus norvegicus)
Mammalia LOC100360841 33
  • 95.19 (n)
(Mus musculus)
Mammalia Rpl37 16 34 33
  • 92.78 (n)
(Gallus gallus)
Aves RPL37 34 33
  • 83.33 (n)
(Anolis carolinensis)
Reptilia RPL37 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl37 33
  • 86.36 (n)
Str.11137 33
(Danio rerio)
Actinopterygii rpl37 34 33
  • 81.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9091 35
  • 75 (a)
RpL37a 34 33
  • 68.94 (n)
CG9873 35
  • 66 (a)
RpL37b 34
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000952 33
  • 63.26 (n)
(Caenorhabditis elegans)
Secernentea rpl-37 34
  • 60 (a)
W01D2.1 34 33
  • 59.39 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR688C 33
  • 65.43 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C01870g 33
  • 63.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL37A 36 34 33
  • 63.18 (n)
RPL37B 34
  • 61 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G52300 33
  • 61.69 (n)
(Oryza sativa)
Liliopsida Os02g0111700 33
  • 64.02 (n)
(Hordeum vulgare)
Liliopsida Hv.12413 33
(Triticum aestivum)
Liliopsida Ta.5687 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl3702 33
  • 63.37 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01966 33
  • 60.57 (n)
Species where no ortholog for RPL37 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL37 Gene

Gene Tree for RPL37 (if available)
Gene Tree for RPL37 (if available)
Evolutionary constrained regions (ECRs) for RPL37: view image

Paralogs for RPL37 Gene

No data available for Paralogs for RPL37 Gene

Variants for RPL37 Gene

Sequence variations from dbSNP and Humsavar for RPL37 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000353977 -- 40,835,370(-) C/T upstream_transcript_variant
rs1001162175 -- 40,832,939(-) C/A intron_variant
rs1002149875 -- 40,834,948(-) G/A intron_variant
rs1002815952 -- 40,836,663(-) G/A upstream_transcript_variant
rs1003113881 -- 40,832,281(-) T/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL37 Gene

Variant ID Type Subtype PubMed ID
nsv518711 CNV loss 19592680
nsv597877 CNV gain 21841781
nsv968907 CNV duplication 23825009

Variation tolerance for RPL37 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL37 Gene

Disorders for RPL37 Gene

Additional Disease Information for RPL37

No disorders were found for RPL37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL37 Gene

Publications for RPL37 Gene

  1. Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain. (PMID: 7545944) Barnard GF … Chen LB (Biochimica et biophysica acta 1994) 2 3 4 22 58
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  3. Cell cycle, differentiation and tissue-independent expression of ribosomal protein L37. (PMID: 7588717) Su S … Bird RC (European journal of biochemistry 1995) 3 4 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism. (PMID: 15485924) Schwartz EI … Maraia RJ (Molecular and cellular biology 2004) 3 22 58

Products for RPL37 Gene

Sources for RPL37 Gene

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