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Aliases for RPL36AL Gene

Aliases for RPL36AL Gene

  • Ribosomal Protein L36a Like 2 3 5
  • Large Ribosomal Subunit Protein EL42-Like 3 4
  • 60S Ribosomal Protein L36a-Like 3
  • Ribosomal Protein L36a-Like 2
  • Ribosomal Protein L36a 2
  • Ribosomal Protein HL44 3
  • RPL36A 3

External Ids for RPL36AL Gene

Previous HGNC Symbols for RPL36AL Gene

  • RPL36A

Previous GeneCards Identifiers for RPL36AL Gene

  • GC14M047405
  • GC14M043881
  • GC14M048073
  • GC14M048075
  • GC14M049155
  • GC14M050086
  • GC14M030202

Summaries for RPL36AL Gene

Entrez Gene Summary for RPL36AL Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. This gene and the human gene officially named ribosomal protein L36a (RPL36A) encode nearly identical proteins; however, they are distinct genes. Although the name of this gene has been referred to as ribosomal protein L36a (RPL36A), its official name is ribosomal protein L36a-like (RPL36AL). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL36AL Gene

RPL36AL (Ribosomal Protein L36a Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL36A.

Additional gene information for RPL36AL Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL36AL Gene

Genomics for RPL36AL Gene

GeneHancer (GH) Regulatory Elements for RPL36AL Gene

Promoters and enhancers for RPL36AL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I049618 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 599.2 -1.5 -1500 6.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 RPL36AL MGAT2 ENSG00000258377 LRR1 DNAAF2 RNU6ATAC30P VCPKMT RHOQP1 KLHDC2 NEMF
GH14I049594 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 55.4 +23.2 23165 7.8 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 LRR1 RPS29 RPL36AL VCPKMT RHOQP1 MGAT2 POLE2 ENSG00000278009 ENSG00000252919
GH14I049632 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 45.6 -13.8 -13822 5 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 DNAAF2 PIR31071 RPL36AL RNU6ATAC30P STK16P1 RHOQP1
GH14I049583 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 38.8 +34.9 34878 4 HDGF CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 GC14M049586 GC14M049587 GC14P049610 PIR42644 RN7SL1 ENSG00000283029 RPS29 RPL36AL LRR1 KLHDC1
GH14I049766 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.6 -148.6 -148626 5.7 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 KLHDC2 RPL36AL RNU6ATAC30P POLE2 KLHDC1 LRR1 GC14M049783
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPL36AL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL36AL gene promoter:

Genomic Locations for RPL36AL Gene

Genomic Locations for RPL36AL Gene
2,167 bases
Minus strand

Genomic View for RPL36AL Gene

Genes around RPL36AL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL36AL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL36AL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL36AL Gene

Proteins for RPL36AL Gene

  • Protein details for RPL36AL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L36a-like
    Protein Accession:
    Secondary Accessions:
    • Q3B7A5

    Protein attributes for RPL36AL Gene

    106 amino acids
    Molecular mass:
    12469 Da
    Quaternary structure:
    No Data Available
    • This gene has no introns in its coding regions, and therefore, was most likely produced by retrotransposition of the original X-linked gene during evolution.

neXtProt entry for RPL36AL Gene

Post-translational modifications for RPL36AL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL36AL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL36AL Gene

Domains & Families for RPL36AL Gene

Gene Families for RPL36AL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL36AL Gene

Suggested Antigen Peptide Sequences for RPL36AL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL42 family.
  • Belongs to the eukaryotic ribosomal protein eL42 family.
genes like me logo Genes that share domains with RPL36AL: view

Function for RPL36AL Gene

Phenotypes From GWAS Catalog for RPL36AL Gene

Gene Ontology (GO) - Molecular Function for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPL36AL: view
genes like me logo Genes that share phenotypes with RPL36AL: view

Animal Model Products

miRNA for RPL36AL Gene

miRTarBase miRNAs that target RPL36AL

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL36AL Gene

Localization for RPL36AL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL36AL Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL36AL gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 25468996
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RPL36AL: view

Pathways & Interactions for RPL36AL Gene

genes like me logo Genes that share pathways with RPL36AL: view

Pathways by source for RPL36AL Gene

Gene Ontology (GO) - Biological Process for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with RPL36AL: view

No data available for SIGNOR curated interactions for RPL36AL Gene

Drugs & Compounds for RPL36AL Gene

No Compound Related Data Available

Transcripts for RPL36AL Gene

mRNA/cDNA for RPL36AL Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(361) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL36AL Gene

Ribosomal protein L36a-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL36AL Gene

No ASD Table

Relevant External Links for RPL36AL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL36AL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL36AL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL36AL Gene

This gene is overexpressed in Lymph node (11.8), Monocytes (10.5), Pancreas (6.9), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL36AL Gene

Protein tissue co-expression partners for RPL36AL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL36AL Gene:


SOURCE GeneReport for Unigene cluster for RPL36AL Gene:


mRNA Expression by UniProt/SwissProt for RPL36AL Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for RPL36AL Gene

  • Kidney(4.5)
  • Muscle(4.5)
  • Blood(2.7)
  • Nervous system(2.7)
  • Liver(2.6)
  • Heart(2.4)
  • Spleen(2.4)
  • Lung(2.3)
  • Adrenal gland(2.2)
  • Lymph node(2.2)
  • Bone marrow(2.1)
  • Intestine(2.1)
  • Stomach(2.1)
  • Thyroid gland(2.1)
  • Gall bladder(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with RPL36AL: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL36AL Gene

Orthologs for RPL36AL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL36AL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL36AL 33 34
  • 100 (n)
(Bos Taurus)
Mammalia RPL36A 34
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
(Mus musculus)
Mammalia Rpl36a 34
  • 99 (a)
Rpl36al 33 16
  • 92.14 (n)
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
LOC480311 33
  • 94.03 (n)
-- 34
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
(Rattus norvegicus)
Mammalia Rpl36al 33
  • 91.82 (n)
(Gallus gallus)
Aves -- 34
  • 89 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1359 33
(Danio rerio)
Actinopterygii rpl36a 34
  • 97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8630 33
fruit fly
(Drosophila melanogaster)
Insecta RpL36A 34
  • 78 (a)
CG7424 35
  • 76 (a)
(Caenorhabditis elegans)
Secernentea rpl-41 34
  • 80 (a)
C09H10.2 35
  • 79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL42A 34 36
  • 74 (a)
RPL42B 34
  • 74 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1846 33
(Hordeum vulgare)
Liliopsida Hv.4260 33
(Oryza sativa)
Liliopsida Os.22631 33
(Zea mays)
Liliopsida Zm.2895 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6059 34
  • 77 (a)
Species where no ortholog for RPL36AL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL36AL Gene

Gene Tree for RPL36AL (if available)
Gene Tree for RPL36AL (if available)

Paralogs for RPL36AL Gene

Paralogs for RPL36AL Gene

(2) SIMAP similar genes for RPL36AL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL36AL: view

Variants for RPL36AL Gene

Sequence variations from dbSNP and Humsavar for RPL36AL Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001102787 uncertain-significance, Congenital disorder of glycosylation 49,620,814(-) C/G/T upstream_transcript_variant
rs104894446 pathogenic, Carbohydrate-deficient glycoprotein syndrome type II 49,622,137(-) C/T upstream_transcript_variant
rs104894447 pathogenic, Carbohydrate-deficient glycoprotein syndrome type II 49,622,053(-) A/G upstream_transcript_variant
rs104894448 pathogenic, Carbohydrate-deficient glycoprotein syndrome type II 49,622,220(-) A/G upstream_transcript_variant
rs104894449 pathogenic, Carbohydrate-deficient glycoprotein syndrome type II 49,622,285(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL36AL Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV gain+loss 19812545
nsv976338 CNV duplication 23825009

Variation tolerance for RPL36AL Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL36AL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL36AL Gene

Disorders for RPL36AL Gene

Additional Disease Information for RPL36AL

No disorders were found for RPL36AL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL36AL Gene

Publications for RPL36AL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes. (PMID: 12490704) Uechi T … Kenmochi N (Nucleic acids research 2002) 3 4 58
  3. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PMID: 1577483) Feo S … Fried M (Genomics 1992) 2 3 58
  4. Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein. (PMID: 3542712) Davies MS … Craig RK (Gene 1986) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RPL36AL Gene

Sources for RPL36AL Gene

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