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Aliases for RPL36A Gene

Aliases for RPL36A Gene

  • Ribosomal Protein L36a 2 3 5
  • Cell Growth-Inhibiting Gene 15 Protein 3 4
  • Cell Migration-Inducing Gene 6 Protein 3 4
  • Large Ribosomal Subunit Protein EL42 3 4
  • 60S Ribosomal Protein L44 3 4
  • RPL44 3 4
  • DJ164F3.3 (Ribosomal Protein L44) 3
  • 60S Ribosomal Protein L36a 3
  • L44-Like Ribosomal Protein 3
  • Ribosomal Protein L44 2
  • L36A 3
  • L44L 3
  • MIG6 3

External Ids for RPL36A Gene

Previous HGNC Symbols for RPL36A Gene

  • RPL44

Previous GeneCards Identifiers for RPL36A Gene

  • GC0XP095937
  • GC0XP097617
  • GC0XP098681
  • GC0XP099417
  • GC0XP100453
  • GC0XP100532
  • GC0XP100645
  • GC0XP090452

Summaries for RPL36A Gene

Entrez Gene Summary for RPL36A Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs between this locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for RPL36A Gene

RPL36A (Ribosomal Protein L36a) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL36AL.

Gene Wiki entry for RPL36A Gene

Additional gene information for RPL36A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL36A Gene

Genomics for RPL36A Gene

GeneHancer (GH) Regulatory Elements for RPL36A Gene

Promoters and enhancers for RPL36A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ101390 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 673.6 +1.1 1125 3.4 HNRNPUL1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 RPL36A RPL36A-HNRNPH2 BTK ARMCX4 ARL13A ARMCX2 ZMAT1 GLA CENPI PPIAP90
GH0XJ101395 Promoter 0.6 EPDnew 650.7 +4.5 4530 0.1 POLR2A RPL36A RPL36A-HNRNPH2 GLA
GH0XJ101406 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.8 +17.9 17903 5 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 GLA HNRNPH2 PPIAP90 RPL36A ARMCX4 ARMCX1 ENSG00000261101 RPL36A-HNRNPH2
GH0XJ101346 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23 -42.5 -42500 3 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF213 E2F8 ZNF143 TIMM8A PIR52449 RPL36A ARMCX4 BTK GLA BEX5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL36A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL36A gene promoter:
  • CREB
  • C/EBPbeta
  • ZID
  • AML1a
  • HOXA5
  • Pbx1a
  • E47
  • Hand1

Genomic Locations for RPL36A Gene

Genomic Locations for RPL36A Gene
chrX:101,390,824-101,396,154
(GRCh38/hg38)
Size:
5,331 bases
Orientation:
Plus strand
chrX:100,645,812-100,651,142
(GRCh37/hg19)
Size:
5,331 bases
Orientation:
Plus strand

Genomic View for RPL36A Gene

Genes around RPL36A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL36A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL36A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL36A Gene

Proteins for RPL36A Gene

  • Protein details for RPL36A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P83881-RL36A_HUMAN
    Recommended name:
    60S ribosomal protein L36a
    Protein Accession:
    P83881
    Secondary Accessions:
    • P09896
    • P10661
    • Q08ES5
    • Q5J9I6

    Protein attributes for RPL36A Gene

    Size:
    106 amino acids
    Molecular mass:
    12441 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL36A Gene

neXtProt entry for RPL36A Gene

Post-translational modifications for RPL36A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL36A Gene

No data available for DME Specific Peptides for RPL36A Gene

Domains & Families for RPL36A Gene

Gene Families for RPL36A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL36A Gene

Suggested Antigen Peptide Sequences for RPL36A Gene

Graphical View of Domain Structure for InterPro Entry

P83881

UniProtKB/Swiss-Prot:

RL36A_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL42 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL42 family.
genes like me logo Genes that share domains with RPL36A: view

Function for RPL36A Gene

Molecular function for RPL36A Gene

GENATLAS Biochemistry:
60S ribosomal protein L36A,12kDa

Gene Ontology (GO) - Molecular Function for RPL36A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL36A: view
genes like me logo Genes that share phenotypes with RPL36A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL36A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL36A Gene

Localization for RPL36A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL36A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL36A gene
Compartment Confidence
cytosol 5
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL36A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol TAS,IDA --
GO:0005840 ribosome NAS,IEA 3542712
genes like me logo Genes that share ontologies with RPL36A: view

Pathways & Interactions for RPL36A Gene

genes like me logo Genes that share pathways with RPL36A: view

Pathways by source for RPL36A Gene

1 KEGG pathway for RPL36A Gene
1 GeneGo (Thomson Reuters) pathway for RPL36A Gene

Gene Ontology (GO) - Biological Process for RPL36A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IC,IDA 25957688
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL36A: view

No data available for SIGNOR curated interactions for RPL36A Gene

Drugs & Compounds for RPL36A Gene

No Compound Related Data Available

Transcripts for RPL36A Gene

mRNA/cDNA for RPL36A Gene

Unigene Clusters for RPL36A Gene

Ribosomal protein L36a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL36A

Alternative Splicing Database (ASD) splice patterns (SP) for RPL36A Gene

No ASD Table

Relevant External Links for RPL36A Gene

GeneLoc Exon Structure for
RPL36A
ECgene alternative splicing isoforms for
RPL36A

Expression for RPL36A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL36A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL36A Gene

This gene is overexpressed in Lung (41.8) and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL36A Gene



Protein tissue co-expression partners for RPL36A Gene

NURSA nuclear receptor signaling pathways regulating expression of RPL36A Gene:

RPL36A

SOURCE GeneReport for Unigene cluster for RPL36A Gene:

Hs.432485

Evidence on tissue expression from TISSUES for RPL36A Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Eye(4.6)
  • Kidney(4.3)
  • Liver(4.1)
  • Intestine(3.7)
  • Pancreas(3.6)
  • Muscle(3.5)
  • Skin(3.4)
  • Blood(2.8)
  • Spleen(2.8)
  • Heart(2.6)
  • Stomach(2.5)
  • Lymph node(2.3)
  • Bone(2.2)
  • Bone marrow(2.2)
  • Thyroid gland(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with RPL36A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL36A Gene

Orthologs for RPL36A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL36A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RPL36A 34
  • 100 (a)
OneToOne
LOC480987 33
  • 89.91 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL36A 33
  • 99.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPL36A 33
  • 94.03 (n)
-- 34
  • 84 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100912182 33
  • 89.94 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 90 (a)
OneToMany
RPL36A 33
  • 79.57 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 97 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl36a 33
  • 83.65 (n)
zebrafish
(Danio rerio)
Actinopterygii rpl36a 34 33 33
  • 84.28 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7424 35
  • 75 (a)
RpL36A 34 33
  • 68.91 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003538 33
  • 66.35 (n)
worm
(Caenorhabditis elegans)
Secernentea C09H10.2 35
  • 78 (a)
rpl-41 34 33
  • 68.91 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL42A 34
  • 75 (a)
ManyToMany
RPL42B 34 33
  • 67.63 (n)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR034W 33
  • 69.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07832g 33
  • 68.59 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G14320 33
  • 66.99 (n)
rice
(Oryza sativa)
Liliopsida Os07g0523500 33
  • 69.61 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.9601 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6059 34
  • 78 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl42 33
  • 70.51 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00706 33
  • 67.95 (n)
Species where no ortholog for RPL36A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL36A Gene

ENSEMBL:
Gene Tree for RPL36A (if available)
TreeFam:
Gene Tree for RPL36A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL36A: view image

Paralogs for RPL36A Gene

Paralogs for RPL36A Gene

(2) SIMAP similar genes for RPL36A Gene using alignment to 5 proteins:

  • RL36A_HUMAN
  • H0Y5B4_HUMAN
  • H7BY91_HUMAN
  • J3KQN4_HUMAN
  • R4GN19_HUMAN
genes like me logo Genes that share paralogs with RPL36A: view

Variants for RPL36A Gene

Sequence variations from dbSNP and Humsavar for RPL36A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs5951308 benign, not specified 101,390,479(+) T/C upstream_transcript_variant
rs1000073656 -- 101,389,238(+) T/C upstream_transcript_variant
rs1000424934 -- 101,389,643(+) C/T upstream_transcript_variant
rs1003026035 -- 101,396,587(+) G/T downstream_transcript_variant
rs1003413854 -- 101,393,358(+) T/C 3_prime_UTR_variant, intron_variant

Variation tolerance for RPL36A Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL36A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL36A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL36A Gene

Disorders for RPL36A Gene

Additional Disease Information for RPL36A

No disorders were found for RPL36A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL36A Gene

Publications for RPL36A Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma. (PMID: 14752831) Kim JH … Kim DG (Hepatology (Baltimore, Md.) 2004) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. (PMID: 9110171) Oeltjen JC … Belmont JW (Genome research 1997) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RPL36A Gene

Sources for RPL36A Gene

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