Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in t... See more...

Aliases for RPL36 Gene

Aliases for RPL36 Gene

  • Ribosomal Protein L36 2 3 5
  • Large Ribosomal Subunit Protein EL36 3 4
  • 60S Ribosomal Protein L36 3 4
  • L36 3

External Ids for RPL36 Gene

Previous GeneCards Identifiers for RPL36 Gene

  • GC19P005782
  • GC19P005621
  • GC19P005641
  • GC19P005451

Summaries for RPL36 Gene

Entrez Gene Summary for RPL36 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL36 Gene

RPL36 (Ribosomal Protein L36) is a Protein Coding gene. Diseases associated with RPL36 include Retinitis Pigmentosa 36 and Cyclosporiasis. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot Summary for RPL36 Gene

Gene Wiki entry for RPL36 Gene

Additional gene information for RPL36 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL36 Gene

Genomics for RPL36 Gene

GeneHancer (GH) Regulatory Elements for RPL36 Gene

Promoters and enhancers for RPL36 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL36 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL36

Top Transcription factor binding sites by QIAGEN in the RPL36 gene promoter:
  • AML1a
  • HOXA3
  • p300
  • Sox5
  • STAT5B

Genomic Locations for RPL36 Gene

Genomic Locations for RPL36 Gene
chr19:5,674,947-5,691,875
(GRCh38/hg38)
Size:
16,929 bases
Orientation:
Plus strand
chr19:5,674,958-5,691,887
(GRCh37/hg19)
Size:
16,930 bases
Orientation:
Plus strand

Genomic View for RPL36 Gene

Genes around RPL36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL36 Gene

Proteins for RPL36 Gene

  • Protein details for RPL36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3U8-RL36_HUMAN
    Recommended name:
    60S ribosomal protein L36
    Protein Accession:
    Q9Y3U8
    Secondary Accessions:
    • B2R4Y1
    • D6W634
    • Q6FIG1
    • Q9UQF6

    Protein attributes for RPL36 Gene

    Size:
    105 amino acids
    Molecular mass:
    12254 Da
    Quaternary structure:
    • Component of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPL36 Gene

neXtProt entry for RPL36 Gene

Post-translational modifications for RPL36 Gene

  • Ubiquitination at Lys62
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL36 Gene

No data available for DME Specific Peptides for RPL36 Gene

Domains & Families for RPL36 Gene

Gene Families for RPL36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL36 Gene

Blocks:
  • Ribosomal protein L36E
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL36 Gene

GenScript: Design optimal peptide antigens:
  • Ribosomal protein L36 (Q9BYF3_HUMAN)
  • 60S ribosomal protein L36 (RL36_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3U8

UniProtKB/Swiss-Prot:

RL36_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL36 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL36 family.
genes like me logo Genes that share domains with RPL36: view

Function for RPL36 Gene

Molecular function for RPL36 Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.

Phenotypes From GWAS Catalog for RPL36 Gene

Gene Ontology (GO) - Molecular Function for RPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome NAS,IBA 12962325
genes like me logo Genes that share ontologies with RPL36: view
genes like me logo Genes that share phenotypes with RPL36: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL36

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL36 Gene

Localization for RPL36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL36 Gene

Cytoplasm, cytosol. Cytoplasm. Note=Detected on cytosolic polysomes (PubMed:25957688). {ECO:0000250 UniProtKB:Q2YGT9, ECO:0000269 PubMed:25957688}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL36 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Endoplasmic reticulum (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,HDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL36: view

Pathways & Interactions for RPL36 Gene

genes like me logo Genes that share pathways with RPL36: view

Pathways by source for RPL36 Gene

1 KEGG pathway for RPL36 Gene
1 GeneGo (Thomson Reuters) pathway for RPL36 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA,IDA 25957688
GO:0006412 translation NAS,IEA 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL36: view

No data available for SIGNOR curated interactions for RPL36 Gene

Drugs & Compounds for RPL36 Gene

No Compound Related Data Available

Transcripts for RPL36 Gene

mRNA/cDNA for RPL36 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL36

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for RPL36 Gene

GeneLoc Exon Structure for
RPL36

Expression for RPL36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL36 Gene

Protein differential expression in normal tissues from HIPED for RPL36 Gene

This gene is overexpressed in Nasal epithelium (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL36 Gene



Protein tissue co-expression partners for RPL36 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL36

SOURCE GeneReport for Unigene cluster for RPL36 Gene:

Hs.408018

Evidence on tissue expression from TISSUES for RPL36 Gene

  • Skin(4.5)
  • Kidney(4.4)
  • Blood(4.3)
  • Nervous system(4)
  • Liver(3.4)
  • Adrenal gland(2.6)
  • Bone marrow(2.5)
  • Lymph node(2.5)
  • Muscle(2.5)
  • Pancreas(2.5)
  • Spleen(2.5)
  • Intestine(2.4)
  • Stomach(2.4)
  • Gall bladder(2.2)
  • Lung(2.2)
  • Heart(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with RPL36: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL36 Gene

Orthologs for RPL36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL36 31 30
  • 99.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl36-ps3 31
  • 98 (a)
OneToOne
Gm4604 30
  • 86.98 (n)
Rpl36-ps12 17
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 98 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPL36 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 92 (a)
OneToMany
RPL36 31 30
  • 90.16 (n)
OneToMany
-- 31
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL36 31 30
  • 91.84 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl36 30
  • 86.67 (n)
chicken
(Gallus gallus)
Aves RPL36 31
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8714 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.29254 30
zebrafish
(Danio rerio)
Actinopterygii rpl36 31
  • 92 (a)
OneToOne
Dr.1335 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8943 30
fruit fly
(Drosophila melanogaster)
Insecta RpL36 31 32
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpl-36 31
  • 57 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL36B 33 31
  • 46 (a)
RPL36A 31
  • 45 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.1156 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4420 31
  • 73 (a)
OneToOne
Species where no ortholog for RPL36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL36 Gene

ENSEMBL:
Gene Tree for RPL36 (if available)
TreeFam:
Gene Tree for RPL36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL36: view image

Paralogs for RPL36 Gene

No data available for Paralogs for RPL36 Gene

Variants for RPL36 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL36 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11556110 - p.Lys67Glu

Additional dbSNP identifiers (rs#s) for RPL36 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL36 Gene

Variant ID Type Subtype PubMed ID
nsv1062851 CNV gain 25217958
nsv953952 CNV deletion 24416366

Variation tolerance for RPL36 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL36 Gene

Human Gene Mutation Database (HGMD)
RPL36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL36

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL36 Gene

Disorders for RPL36 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPL36 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 36
  • rp36
cyclosporiasis
  • cyclospora infection
diamond-blackfan anemia
  • diamond-blackfan anemia 1
sarcocystosis
  • sarcosporidiosis
retinitis pigmentosa 59
  • rp59
- elite association - COSMIC cancer census association via MalaCards
Search RPL36 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL36

genes like me logo Genes that share disorders with RPL36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL36 Gene

Publications for RPL36 Gene

  1. Structural snapshots of actively translating human ribosomes. (PMID: 25957688) Behrmann E … Spahn CM (Cell 2015) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova TI … Karpova GG (Journal of protein chemistry 2003) 3 4 54
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 54
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54

Products for RPL36 Gene

Sources for RPL36 Gene