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Aliases for RPL35 Gene

Aliases for RPL35 Gene

  • Ribosomal Protein L35 2 3 5
  • Large Ribosomal Subunit Protein UL29 3 4
  • 60S Ribosomal Protein L35 2 3
  • L35 3

External Ids for RPL35 Gene

Previous GeneCards Identifiers for RPL35 Gene

  • GC09M118734
  • GC09M119266
  • GC09M121073
  • GC09M122996
  • GC09M124699
  • GC09M126659
  • GC09M127620
  • GC09M097233

Summaries for RPL35 Gene

Entrez Gene Summary for RPL35 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL35 Gene

RPL35 (Ribosomal Protein L35) is a Protein Coding gene. Diseases associated with RPL35 include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot for RPL35 Gene

  • Component of the large ribosomal subunit.

Gene Wiki entry for RPL35 Gene

Additional gene information for RPL35 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL35 Gene

Genomics for RPL35 Gene

GeneHancer (GH) Regulatory Elements for RPL35 Gene

Promoters and enhancers for RPL35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J124858 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 723 6.5 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B ARPC5L RPL35 GAPVD1 GOLGA1 PRPS1P2 RABEPK WDR38
GH09J124768 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.6 +91.3 91328 3.5 CLOCK MLX FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000236643 NR6A1 PRPS1P2 GAPVD1 GOLGA1 WDR38 ARPC5L RPL35 MIR181A2HG
GH09J125238 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 -379.5 -379455 6.6 PKNOX1 CLOCK SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 GAPVD1 ENSG00000239705 GC09M125241 HSPA5 GOLGA1 PRPS1P2 LOC100419284 ENSG00000231149 RABEPK RPL35
GH09J124215 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +644.4 644380 4.4 HDGF PKNOX1 FOXA2 IRF4 ZNF48 ZNF207 ZNF143 ATF7 FOS RUNX3 NEK6 GOLGA1 RPL35 PRPS1P2 DENND1A GC09M124203
GH09J124795 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.1 +65.2 65234 3.4 ELF3 PKNOX1 FOXA2 SREBF2 ARID4B RAD21 ZNF48 ZSCAN9 RARA ZNF121 WDR38 ARPC5L RPL35 GAPVD1 RNU6-1020P MIR181A2HG PIR55692 OLFML2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL35 gene promoter:
  • PPAR-gamma1
  • GATA-2
  • PPAR-gamma2
  • Pax-2
  • Pax-2b
  • Pax-2a
  • C/EBPalpha
  • FOXO4
  • c-Ets-1
  • ZID

Genomic Locations for RPL35 Gene

Genomic Locations for RPL35 Gene
4,103 bases
Minus strand
4,103 bases
Minus strand

Genomic View for RPL35 Gene

Genes around RPL35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL35 Gene

Proteins for RPL35 Gene

  • Protein details for RPL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L35
    Protein Accession:
    Secondary Accessions:
    • A8K4V7
    • Q4VBY5
    • Q5JTN5
    • Q6IBC7
    • Q96QJ7
    • Q9BYF4

    Protein attributes for RPL35 Gene

    123 amino acids
    Molecular mass:
    14551 Da
    Quaternary structure:
    • Component of the large ribosomal subunit.
    • Sequence=CAI39638.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL35 Gene

neXtProt entry for RPL35 Gene

Post-translational modifications for RPL35 Gene

  • Ubiquitination at posLast=7979, posLast=6666, and Lys25
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL35 Gene

No data available for DME Specific Peptides for RPL35 Gene

Domains & Families for RPL35 Gene

Gene Families for RPL35 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL35 Gene

Suggested Antigen Peptide Sequences for RPL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL29 family.
  • Belongs to the universal ribosomal protein uL29 family.
genes like me logo Genes that share domains with RPL35: view

Function for RPL35 Gene

Molecular function for RPL35 Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.
GENATLAS Biochemistry:
60S ribosomal protein L35,12kDa

Phenotypes From GWAS Catalog for RPL35 Gene

Gene Ontology (GO) - Molecular Function for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003729 mRNA binding TAS 2891103
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
genes like me logo Genes that share ontologies with RPL35: view
genes like me logo Genes that share phenotypes with RPL35: view

Human Phenotype Ontology for RPL35 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL35 Gene

Localization for RPL35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL35 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005730 nucleolus TAS 2891103
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with RPL35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL35 Gene

Pathways & Interactions for RPL35 Gene

genes like me logo Genes that share pathways with RPL35: view

Pathways by source for RPL35 Gene

1 KEGG pathway for RPL35 Gene
1 GeneGo (Thomson Reuters) pathway for RPL35 Gene

Gene Ontology (GO) - Biological Process for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL35: view

No data available for SIGNOR curated interactions for RPL35 Gene

Drugs & Compounds for RPL35 Gene

(1) Drugs for RPL35 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
genes like me logo Genes that share compounds with RPL35: view

Transcripts for RPL35 Gene

mRNA/cDNA for RPL35 Gene

Unigene Clusters for RPL35 Gene

Ribosomal protein L35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4

Relevant External Links for RPL35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL35 Gene

This gene is overexpressed in Tlymphocyte (9.6) and Hair follicle (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL35 Gene

Protein tissue co-expression partners for RPL35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL35 Gene:


SOURCE GeneReport for Unigene cluster for RPL35 Gene:


Evidence on tissue expression from TISSUES for RPL35 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Lung(4.7)
  • Muscle(4.6)
  • Blood(3.4)
  • Intestine(3.3)
  • Skin(3)
  • Stomach(2.8)
  • Eye(2.7)
  • Lymph node(2.7)
  • Bone marrow(2.5)
  • Heart(2.5)
  • Pancreas(2.5)
  • Spleen(2.5)
  • Thyroid gland(2.5)
  • Gall bladder(2.4)
  • Adrenal gland(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with RPL35: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL35 Gene

Orthologs for RPL35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL35 34 33
  • 100 (n)
(Mus musculus)
Mammalia Gm2000 34
  • 98 (a)
Gm10269 34
  • 96 (a)
Rpl35 16 34 33
  • 89.16 (n)
(Monodelphis domestica)
Mammalia RPL35 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL35 34
  • 98 (a)
(Bos Taurus)
Mammalia -- 34
  • 98 (a)
RPL35 34 33
  • 91.6 (n)
(Canis familiaris)
Mammalia RPL35 34 33
  • 92.68 (n)
(Rattus norvegicus)
Mammalia Rpl35 33
  • 89.7 (n)
(Gallus gallus)
Aves RPL35 34 33
  • 82.66 (n)
(Anolis carolinensis)
Reptilia RPL35 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl35 33
  • 77.78 (n)
MGC76336 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29067 33
(Danio rerio)
Actinopterygii rpl35 34 33 33
  • 80.22 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8401 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001408 33
  • 67.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL35 34 33
  • 66.12 (n)
(Caenorhabditis elegans)
Secernentea rpl-35 34 35 33
  • 63.41 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR095W 33
  • 58.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL35B 36 34
  • 58 (a)
RPL35A 34 33
  • 54.44 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05247g 33
  • 55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02610 33
  • 63.96 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7399 33
(Glycine max)
eudicotyledons Gma.9631 33
(Oryza sativa)
Liliopsida Os04g0376000 33
  • 67.21 (n)
Os.37768 33
(Triticum aestivum)
Liliopsida Ta.28696 33
(Zea mays)
Liliopsida Zm.878 33
(Hordeum vulgare)
Liliopsida Hv.314 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4820 34
  • 79 (a)
Cin.3995 33
bread mold
(Neurospora crassa)
Ascomycetes NCU10498 33
  • 60.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl35 33
  • 56.11 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3995 33
Species where no ortholog for RPL35 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL35 Gene

Gene Tree for RPL35 (if available)
Gene Tree for RPL35 (if available)
Evolutionary constrained regions (ECRs) for RPL35: view image

Paralogs for RPL35 Gene

(1) SIMAP similar genes for RPL35 Gene using alignment to 2 proteins:

  • RL35_HUMAN
  • F2Z388_HUMAN
genes like me logo Genes that share paralogs with RPL35: view

No data available for Paralogs for RPL35 Gene

Variants for RPL35 Gene

Sequence variations from dbSNP and Humsavar for RPL35 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001371271 -- 124,862,510(-) T/A upstream_transcript_variant
rs1001506741 -- 124,862,844(-) T/A upstream_transcript_variant
rs1002335213 -- 124,863,073(-) C/T upstream_transcript_variant
rs1002377383 -- 124,861,692(-) T/G intron_variant
rs1003259699 -- 124,858,792(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL35 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV gain 17160897
nsv951760 CNV deletion 24416366

Variation tolerance for RPL35 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL35 Gene

Disorders for RPL35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL35 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPL35 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL35

genes like me logo Genes that share disorders with RPL35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL35 Gene

Publications for RPL35 Gene

  1. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. (PMID: 11401437) Uechi T … Kenmochi N (Genomics 2001) 2 3 4 58
  2. The role of expansion segment of human ribosomal protein L35 in nuclear entry, translation activity, and endoplasmic reticulum docking. (PMID: 18523488) Chen IJ … Lin A (Biochemistry and cell biology = Biochimie et biologie cellulaire 2008) 3 22 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova TI … Karpova GG (Journal of protein chemistry 2003) 3 4 58

Products for RPL35 Gene

Sources for RPL35 Gene

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