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Aliases for RPL34 Gene

Aliases for RPL34 Gene

  • Ribosomal Protein L34 2 3 5
  • Large Ribosomal Subunit Protein EL34 3 4
  • Leukemia-Associated Protein 3
  • 60S Ribosomal Protein L34 3
  • L34 3

External Ids for RPL34 Gene

Previous GeneCards Identifiers for RPL34 Gene

  • GC04P109969
  • GC04P109862
  • GC04P110000
  • GC04P109899
  • GC04P109761
  • GC04P109541
  • GC04P105273

Summaries for RPL34 Gene

Entrez Gene Summary for RPL34 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]

GeneCards Summary for RPL34 Gene

RPL34 (Ribosomal Protein L34) is a Protein Coding gene. Diseases associated with RPL34 include Baastrup's Syndrome and Supine Hypotensive Syndrome. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL34 Gene

  • Component of the large ribosomal subunit.

Gene Wiki entry for RPL34 Gene

Additional gene information for RPL34 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL34 Gene

Genomics for RPL34 Gene

GeneHancer (GH) Regulatory Elements for RPL34 Gene

Promoters and enhancers for RPL34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J108618 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 685.6 +0.5 452 4.2 HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 RPL34 RPL34-AS1 PIR53159 SETP20 SEC24B CDC42P4 OSTC GC04P108610
GH04J108610 Enhancer 1.1 VISTA UCNEbase dbSUPER 17.2 -9.0 -9035 1.6 CTCF GC04P108610 RPL34 RPL34-AS1
GH04J108591 Enhancer 0.9 Ensembl ENCODE 10.4 -28.1 -28106 1.1 SOX13 FOXA2 JUN ZNF644 RARA RERE ZNF366 HOMEZ GATAD2A HMG20B PIR53246 RPL34-AS1 RPL34 GC04P108610
GH04J108071 Enhancer 0.9 ENCODE dbSUPER 9.8 -548.0 -548005 2.5 KLF1 PKNOX1 ZNF384 FEZF1 ZIC2 KLF5 ZNF366 SCRT2 ATF7 KLF7 RPL34 RPL34-AS1 CYP2U1 HADH GC04M107959 GC04P108129 LEF1
GH04J108030 Enhancer 0.9 ENCODE dbSUPER 9.8 -589.9 -589856 1.9 CTCF CEBPG RAD21 RELA POLR2A ARID2 ZNF157 ZSCAN5C ZNF143 RFX1 HADH LOC101929595 RPL34-AS1 RPL34 GC04M107959 GC04P107997
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL34 gene promoter:
  • PPAR-gamma2
  • AREB6
  • PPAR-gamma1
  • Sox5
  • TBP

Genomic Locations for RPL34 Gene

Genomic Locations for RPL34 Gene
chr4:108,620,566-108,630,484
(GRCh38/hg38)
Size:
9,919 bases
Orientation:
Plus strand
chr4:109,541,722-109,551,640
(GRCh37/hg19)
Size:
9,919 bases
Orientation:
Plus strand

Genomic View for RPL34 Gene

Genes around RPL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL34 Gene

Proteins for RPL34 Gene

  • Protein details for RPL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49207-RL34_HUMAN
    Recommended name:
    60S ribosomal protein L34
    Protein Accession:
    P49207
    Secondary Accessions:
    • Q6FG66
    • Q9BUZ2

    Protein attributes for RPL34 Gene

    Size:
    117 amino acids
    Molecular mass:
    13293 Da
    Quaternary structure:
    • Component of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPL34 Gene

neXtProt entry for RPL34 Gene

Post-translational modifications for RPL34 Gene

  • Ubiquitination at Lys101, Lys85, posLast=6262, Lys43, and posLast=1919
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL34 Gene

Domains & Families for RPL34 Gene

Gene Families for RPL34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL34 Gene

Suggested Antigen Peptide Sequences for RPL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49207

UniProtKB/Swiss-Prot:

RL34_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL34 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL34 family.
genes like me logo Genes that share domains with RPL34: view

Function for RPL34 Gene

Molecular function for RPL34 Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.
GENATLAS Biochemistry:
60S ribosomal protein L34

Phenotypes From GWAS Catalog for RPL34 Gene

Gene Ontology (GO) - Molecular Function for RPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7490091
GO:0003735 structural constituent of ribosome TAS,NAS 12962325
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL34: view
genes like me logo Genes that share phenotypes with RPL34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL34

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL34 Gene

Localization for RPL34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL34 Gene

Cytoplasm, cytosol. Cytoplasm. Endoplasmic reticulum. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250 UniProtKB:Q29223, ECO:0000269 PubMed:25957688}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL34 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL34: view

Pathways & Interactions for RPL34 Gene

genes like me logo Genes that share pathways with RPL34: view

Pathways by source for RPL34 Gene

1 KEGG pathway for RPL34 Gene
1 GeneGo (Thomson Reuters) pathway for RPL34 Gene

Gene Ontology (GO) - Biological Process for RPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IBA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL34: view

No data available for SIGNOR curated interactions for RPL34 Gene

Drugs & Compounds for RPL34 Gene

No Compound Related Data Available

Transcripts for RPL34 Gene

Unigene Clusters for RPL34 Gene

Ribosomal protein L34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL34

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL34 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: -
SP6: - -

Relevant External Links for RPL34 Gene

GeneLoc Exon Structure for
RPL34
ECgene alternative splicing isoforms for
RPL34

Expression for RPL34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL34 Gene

This gene is overexpressed in Nasal epithelium (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL34 Gene



Protein tissue co-expression partners for RPL34 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL34 Gene:

RPL34

SOURCE GeneReport for Unigene cluster for RPL34 Gene:

Hs.438227

Evidence on tissue expression from TISSUES for RPL34 Gene

  • Eye(4.6)
  • Liver(4.6)
  • Bone(4.4)
  • Blood(4.3)
  • Nervous system(4.3)
  • Muscle(4)
  • Lung(3.3)
  • Skin(3.1)
  • Heart(2.9)
  • Pancreas(2.8)
  • Spleen(2.8)
  • Lymph node(2.7)
  • Adrenal gland(2.5)
  • Bone marrow(2.5)
  • Intestine(2.5)
  • Thyroid gland(2.5)
  • Gall bladder(2.4)
  • Kidney(2.3)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with RPL34: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL34 Gene

Orthologs for RPL34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL34 34 33
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL34 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl34 34
  • 97 (a)
OneToMany
Gm6404 33
  • 90.6 (n)
Gm2178 34
  • 82 (a)
OneToMany
Rpl34-ps2 16
dog
(Canis familiaris)
Mammalia LOC100685685 33
  • 91.45 (n)
RPL34 34
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl34l1 33
  • 90.8 (n)
cow
(Bos Taurus)
Mammalia RPL34 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL34 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL34 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.573 33
African clawed frog
(Xenopus laevis)
Amphibia XL34 33
zebrafish
(Danio rerio)
Actinopterygii rpl34 34
  • 93 (a)
OneToOne
Dr.29071 33
fruit fly
(Drosophila melanogaster)
Insecta RpL34a 34
  • 41 (a)
OneToMany
RpL34b 34
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-34 34
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL34B 34
  • 50 (a)
OneToMany
RPL34A 34
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1788 34
  • 65 (a)
OneToOne
Species where no ortholog for RPL34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL34 Gene

ENSEMBL:
Gene Tree for RPL34 (if available)
TreeFam:
Gene Tree for RPL34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL34: view image

Paralogs for RPL34 Gene

genes like me logo Genes that share paralogs with RPL34: view

No data available for Paralogs for RPL34 Gene

Variants for RPL34 Gene

Sequence variations from dbSNP and Humsavar for RPL34 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000321 -- 108,629,038(+) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000267587 -- 108,623,126(+) G/A intron_variant
rs1000396080 -- 108,627,931(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000514685 -- 108,622,155(+) G/A coding_sequence_variant, missense_variant
rs1000638637 -- 108,627,698(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL34 Gene

Variant ID Type Subtype PubMed ID
esv3601724 CNV gain 21293372
nsv964079 CNV duplication 23825009
nsv980238 CNV duplication 23825009

Variation tolerance for RPL34 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL34 Gene

Disorders for RPL34 Gene

MalaCards: The human disease database

(10) MalaCards diseases for RPL34 Gene - From: DISEASES

Disorder Aliases PubMed IDs
baastrup's syndrome
  • baastrup syndrome
supine hypotensive syndrome
  • antepartum maternal hypotension syndrome
bone structure disease
pain agnosia
  • analgesia
agnosia
  • dyspraxia
- elite association - COSMIC cancer census association via MalaCards
Search RPL34 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL34

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPL34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL34 Gene

Publications for RPL34 Gene

  1. Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. (PMID: 7490091) Rommens JM … Morgan K (Genomics 1995) 2 3 4 22 58
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RPL34 Gene

Sources for RPL34 Gene

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