Free for academic non-profit institutions. Other users need a Commercial license
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
RPL32 (Ribosomal Protein L32) is a Protein Coding gene. Diseases associated with RPL32 include Retinitis Pigmentosa 49 and Frontal Convexity Meningioma. Among its related pathways are rRNA processing in the nucleus and cytosol and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is POLR2L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003735 | structural constituent of ribosome | NAS | 12962325 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0005840 | ribosome | IEA | -- |
GO:0016020 | membrane | HDA | 19946888 |
GO:0022625 | cytosolic large ribosomal subunit | IDA | 25957688 |
GO:0042788 | polysomal ribosome | IDA | 25957688 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
CFTR translational fidelity (class I mutations)
.79
.77
.53
|
|
2 | Influenza Viral RNA Transcription and Replication | ||
3 | rRNA processing in the nucleus and cytosol |
.89
|
|
4 | HIV Life Cycle |
.45
|
|
5 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
GO:0002181 | cytoplasmic translation | IDA | 25957688 |
GO:0006412 | translation | NAS | 12962325 |
GO:0006413 | translational initiation | TAS | -- |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RPL32 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
RPL32 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RPL32 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RPL32 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gm6251 30 |
|
||
Gm21893 31 |
|
OneToMany | |||
Rpl32l 17 |
|
|
|||
Rat (Rattus norvegicus) |
Mammalia | LOC680959 30 |
|
||
Chicken (Gallus gallus) |
Aves | RPL32 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RPL32 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rpl32 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.26095 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rpl32 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | RpL32 30 31 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002122 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | rpl-32 30 31 32 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL281C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E06843g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPL32 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G18100 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.8117 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os08g0524600 30 |
|
||
Os.12339 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpl3202 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv763e201 | CNV | deletion | 23290073 |
dgv850e199 | CNV | deletion | 23128226 |
esv2751977 | CNV | gain | 17911159 |
esv3893663 | CNV | gain | 25118596 |
nsv1112379 | CNV | deletion | 24896259 |
nsv1147269 | CNV | deletion | 26484159 |
nsv460435 | CNV | loss | 19166990 |
nsv589715 | CNV | loss | 21841781 |
nsv589716 | CNV | loss | 21841781 |
nsv7351 | OTHER | inversion | 18451855 |
nsv821995 | CNV | gain | 20364138 |
nsv963297 | CNV | duplication | 23825009 |
nsv979805 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
retinitis pigmentosa 49 |
|
|
frontal convexity meningioma |
|
|
encephalopathy due to defective mitochondrial and peroxisomal fission 1 |
|
|
retinitis pigmentosa |
|
|