Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in t... See more...

Aliases for RPL32 Gene

Aliases for RPL32 Gene

  • Ribosomal Protein L32 2 3 5
  • Large Ribosomal Subunit Protein EL32 3 4
  • 60S Ribosomal Protein L32 3 4
  • L32 2 3
  • PP9932 3
  • RPL32 5

External Ids for RPL32 Gene

Previous GeneCards Identifiers for RPL32 Gene

  • GC03M012806
  • GC03M012869
  • GC03M012852
  • GC03M012853
  • GC03M012810
  • GC03M012876
  • GC03M012877

Summaries for RPL32 Gene

Entrez Gene Summary for RPL32 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL32 Gene

RPL32 (Ribosomal Protein L32) is a Protein Coding gene. Diseases associated with RPL32 include Retinitis Pigmentosa 49 and Frontal Convexity Meningioma. Among its related pathways are rRNA processing in the nucleus and cytosol and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is POLR2L.

Gene Wiki entry for RPL32 Gene

Additional gene information for RPL32 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL32 Gene

Genomics for RPL32 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPL32 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL32 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL32

Top Transcription factor binding sites by QIAGEN in the RPL32 gene promoter:
  • GR
  • GR-alpha
  • TBP

Genomic Locations for RPL32 Gene

Genomic Locations for RPL32 Gene
chr3:12,834,485-12,841,582
(GRCh38/hg38)
Size:
7,098 bases
Orientation:
Minus strand
chr3:12,875,984-12,883,087
(GRCh37/hg19)
Size:
7,104 bases
Orientation:
Minus strand

Genomic View for RPL32 Gene

Genes around RPL32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL32 Gene

Proteins for RPL32 Gene

  • Protein details for RPL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62910-RL32_HUMAN
    Recommended name:
    60S ribosomal protein L32
    Protein Accession:
    P62910
    Secondary Accessions:
    • B2R4Q3
    • P02433

    Protein attributes for RPL32 Gene

    Size:
    135 amino acids
    Molecular mass:
    15860 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL32 Gene

neXtProt entry for RPL32 Gene

Post-translational modifications for RPL32 Gene

  • Ubiquitination at Lys50
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL32 Gene

Domains & Families for RPL32 Gene

Gene Families for RPL32 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL32 Gene

Suggested Antigen Peptide Sequences for RPL32 Gene

GenScript: Design optimal peptide antigens:
  • 60S ribosomal protein L32 (RL32_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62910

UniProtKB/Swiss-Prot:

RL32_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL32 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL32 family.
genes like me logo Genes that share domains with RPL32: view

Function for RPL32 Gene

Molecular function for RPL32 Gene

GENATLAS Biochemistry:
60S ribosomal protein L32,15kDa

Phenotypes From GWAS Catalog for RPL32 Gene

Gene Ontology (GO) - Molecular Function for RPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome NAS 12962325
genes like me logo Genes that share ontologies with RPL32: view
genes like me logo Genes that share phenotypes with RPL32: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL32

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL32 Gene

Localization for RPL32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL32 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
mitochondrion 3
plasma membrane 2
extracellular 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane HDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 25957688
GO:0042788 polysomal ribosome IDA 25957688
genes like me logo Genes that share ontologies with RPL32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL32 Gene

Pathways & Interactions for RPL32 Gene

genes like me logo Genes that share pathways with RPL32: view

Pathways by source for RPL32 Gene

1 KEGG pathway for RPL32 Gene
1 GeneGo (Thomson Reuters) pathway for RPL32 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL32: view

No data available for SIGNOR curated interactions for RPL32 Gene

Drugs & Compounds for RPL32 Gene

(1) Additional Compounds for RPL32 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL32: view

Transcripts for RPL32 Gene

mRNA/cDNA for RPL32 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL32

Alternative Splicing Database (ASD) splice patterns (SP) for RPL32 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RPL32 Gene

GeneLoc Exon Structure for
RPL32

Expression for RPL32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL32 Gene

This gene is overexpressed in Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL32 Gene



Protein tissue co-expression partners for RPL32 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL32

SOURCE GeneReport for Unigene cluster for RPL32 Gene:

Hs.265174

Evidence on tissue expression from TISSUES for RPL32 Gene

  • Blood(4.8)
  • Nervous system(4.8)
  • Muscle(4.6)
  • Intestine(4.5)
  • Lung(4.2)
  • Skin(4.2)
  • Pancreas(4.1)
  • Eye(4)
  • Liver(4)
  • Heart(4)
  • Bone(3.9)
  • Stomach(3.9)
  • Kidney(3.6)
  • Spleen(3.4)
  • Lymph node(3.3)
  • Bone marrow(3.1)
  • Thyroid gland(3)
  • Adrenal gland(2.9)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with RPL32: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL32 Gene

Orthologs for RPL32 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL32 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPL32 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 97 (a)
OneToMany
RPL32 30
  • 94.07 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RPL32 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RPL32 30 31
  • 92.1 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm6251 30
  • 88.47 (n)
Gm21893 31
  • 45 (a)
OneToMany
Rpl32l 17
Rat
(Rattus norvegicus)
Mammalia LOC680959 30
  • 87.16 (n)
Chicken
(Gallus gallus)
Aves RPL32 30 31
  • 83.7 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPL32 31
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rpl32 30
  • 79.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26095 30
Zebrafish
(Danio rerio)
Actinopterygii rpl32 30 31
  • 80 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta RpL32 30 31 32
  • 69.92 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002122 30
  • 69.42 (n)
Worm
(Caenorhabditis elegans)
Secernentea rpl-32 30 31 32
  • 59.9 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGL281C 30
  • 62.56 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06843g 30
  • 60.7 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL32 30 31 33
  • 59.69 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G18100 30
  • 64.62 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8117 30
Rice
(Oryza sativa)
Liliopsida Os08g0524600 30
  • 67.44 (n)
Os.12339 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 70 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl3202 30
  • 59.56 (n)
Species where no ortholog for RPL32 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RPL32 Gene

ENSEMBL:
Gene Tree for RPL32 (if available)
TreeFam:
Gene Tree for RPL32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL32: view image

Paralogs for RPL32 Gene

Paralogs for RPL32 Gene

genes like me logo Genes that share paralogs with RPL32: view

Variants for RPL32 Gene

Additional dbSNP identifiers (rs#s) for RPL32 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL32 Gene

Variant ID Type Subtype PubMed ID
dgv763e201 CNV deletion 23290073
dgv850e199 CNV deletion 23128226
esv2751977 CNV gain 17911159
esv3893663 CNV gain 25118596
nsv1112379 CNV deletion 24896259
nsv1147269 CNV deletion 26484159
nsv460435 CNV loss 19166990
nsv589715 CNV loss 21841781
nsv589716 CNV loss 21841781
nsv7351 OTHER inversion 18451855
nsv821995 CNV gain 20364138
nsv963297 CNV duplication 23825009
nsv979805 CNV duplication 23825009

Variation tolerance for RPL32 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL32

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL32 Gene

Disorders for RPL32 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPL32 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search RPL32 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with RPL32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL32 Gene

Publications for RPL32 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4
  4. Assignment of the L32 ribosomal protein gene (RPL32) to human chromosome 3q13.3-->q21 by in situ hybridization. (PMID: 9284913) Vorobieva NV … Graphodatsky AS (Cytogenetics and cell genetics 1997) 2 3
  5. A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family. (PMID: 3866218) Young JA … Trowsdale J (Nucleic acids research 1985) 3 4

Products for RPL32 Gene

Sources for RPL32 Gene