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Aliases for RPL31 Gene

Aliases for RPL31 Gene

  • Ribosomal Protein L31 2 3 5
  • Large Ribosomal Subunit Protein EL31 3 4
  • 60S Ribosomal Protein L31 3
  • L31 3

External Ids for RPL31 Gene

Previous GeneCards Identifiers for RPL31 Gene

  • GC02P099482
  • GC02P100071
  • GC02P101224
  • GC02P101240
  • GC02P101077
  • GC02P101618
  • GC02P095382

Summaries for RPL31 Gene

Entrez Gene Summary for RPL31 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL31 Gene

RPL31 (Ribosomal Protein L31) is a Protein Coding gene. Diseases associated with RPL31 include Chancroid and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL31 Gene

Additional gene information for RPL31 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL31 Gene

Genomics for RPL31 Gene

GeneHancer (GH) Regulatory Elements for RPL31 Gene

Promoters and enhancers for RPL31 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J101001 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.7 1680 3.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ENSG00000223947 RPL31 LOC101927142 NPAS2 CNOT11 GC02P101011
GH02J100880 Enhancer 1.4 Ensembl ENCODE dbSUPER 6 -118.9 -118930 4.1 FOXA2 MLX ARID4B DMAP1 IRF4 ZNF48 ETS1 YY1 TCF12 ATF7 ENSG00000232034 NPAS2 RPL31 GC02M100833 LOC101927142
GH02J101080 Enhancer 0.8 ENCODE dbSUPER 10.1 +79.7 79717 1.7 HLF CEBPB SIN3A ELF1 REST CEBPG SP1 ZNF121 ATF3 ZBTB33 LOC101927142 ENSG00000223947 RPL31 NPAS2 TBC1D8-AS1 TBC1D8 GC02P101087 GC02P101072
GH02J101047 Enhancer 0.6 ENCODE dbSUPER 10.9 +45.9 45914 1.2 RFX1 FOS ENSG00000223947 RPL31 NPAS2 ENSG00000232034 LOC101927142 SNORD89 BBIP1P1 LOC105373510 TBC1D8
GH02J100603 Enhancer 0.5 FANTOM5 ENCODE 11.2 -398.0 -398035 0.1 NRF1 LINC01849 RPL31 ENSG00000223947 PDCL3 GC02P100600
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL31 gene promoter:
  • AREB6
  • c-Rel
  • aMEF-2
  • MEF-2
  • MEF-2A
  • SRY
  • Hlf
  • POU3F2
  • CBF(2)
  • CBF-A

Genomic Locations for RPL31 Gene

Genomic Locations for RPL31 Gene
22,318 bases
Plus strand
22,318 bases
Plus strand

Genomic View for RPL31 Gene

Genes around RPL31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL31 Gene

Proteins for RPL31 Gene

  • Protein details for RPL31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L31
    Protein Accession:
    Secondary Accessions:
    • B7Z4K2
    • D3DVJ4
    • P12947
    • Q53SQ5
    • Q6IRZ0
    • Q6LBJ6

    Protein attributes for RPL31 Gene

    125 amino acids
    Molecular mass:
    14463 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL31 Gene

    Alternative splice isoforms for RPL31 Gene


neXtProt entry for RPL31 Gene

Post-translational modifications for RPL31 Gene

  • Ubiquitination at Lys115, Lys75, posLast=7070, Lys55, and Lys39
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL31 Gene

Domains & Families for RPL31 Gene

Gene Families for RPL31 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL31 family.
  • Belongs to the eukaryotic ribosomal protein eL31 family.
genes like me logo Genes that share domains with RPL31: view

Function for RPL31 Gene

Molecular function for RPL31 Gene

GENATLAS Biochemistry:
60S ribosomal protein L31,14kDa

Phenotypes From GWAS Catalog for RPL31 Gene

Gene Ontology (GO) - Molecular Function for RPL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,TAS 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL31: view
genes like me logo Genes that share phenotypes with RPL31: view

Animal Model Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL31

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL31 Gene

Localization for RPL31 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL31 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with RPL31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPL31 Gene

Pathways & Interactions for RPL31 Gene

genes like me logo Genes that share pathways with RPL31: view

Pathways by source for RPL31 Gene

1 KEGG pathway for RPL31 Gene
1 GeneGo (Thomson Reuters) pathway for RPL31 Gene

Gene Ontology (GO) - Biological Process for RPL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IDA,IBA 25957688
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL31: view

No data available for SIGNOR curated interactions for RPL31 Gene

Drugs & Compounds for RPL31 Gene

No Compound Related Data Available

Transcripts for RPL31 Gene

mRNA/cDNA for RPL31 Gene

Unigene Clusters for RPL31 Gene

Ribosomal protein L31:
Representative Sequences:

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL31

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL31 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4
SP1: - - -
SP3: -

Relevant External Links for RPL31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL31 Gene

This gene is overexpressed in Hair follicle (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL31 Gene

Protein tissue co-expression partners for RPL31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL31 Gene:


SOURCE GeneReport for Unigene cluster for RPL31 Gene:


Evidence on tissue expression from TISSUES for RPL31 Gene

  • Liver(4.9)
  • Nervous system(4.9)
  • Muscle(4.6)
  • Lung(4.3)
  • Heart(4.1)
  • Eye(3.9)
  • Intestine(3.9)
  • Bone(3.7)
  • Pancreas(3.6)
  • Skin(3.5)
  • Kidney(3.2)
  • Stomach(3.2)
  • Blood(3.1)
  • Bone marrow(2.8)
  • Lymph node(2.8)
  • Adrenal gland(2.7)
  • Spleen(2.7)
  • Thyroid gland(2.7)
  • Gall bladder(2.6)
genes like me logo Genes that share expression patterns with RPL31: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL31 Gene

Orthologs for RPL31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL31 33
  • 100 (n)
-- 34
  • 77 (a)
(Monodelphis domestica)
Mammalia RPL31 34
  • 94 (a)
(Canis familiaris)
Mammalia RPL31 34 33
  • 93.87 (n)
(Rattus norvegicus)
Mammalia Rpl31 33
  • 92.27 (n)
(Bos Taurus)
Mammalia RPL31 34 33
  • 91.2 (n)
(Mus musculus)
Mammalia Rpl31 16 34 33
  • 90.93 (n)
(Gallus gallus)
Aves RPL31 34 33
  • 85.07 (n)
(Anolis carolinensis)
Reptilia RPL31 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl31 33
  • 81.07 (n)
(Danio rerio)
Actinopterygii rpl31 34 33
  • 79.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL31 34 35
  • 70 (a)
(Caenorhabditis elegans)
Secernentea rpl-31 34 35 33
  • 66.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL31B 36 34 33
  • 58.56 (n)
RPL31A 34
  • 57 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER076C 33
  • 58.48 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02937g 33
  • 57.96 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G26230 33
  • 57.41 (n)
(Oryza sativa)
Liliopsida Os06g0319700 33
  • 59.88 (n)
(Triticum aestivum)
Liliopsida Ta.13683 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10412 34
  • 74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08344 33
  • 62.76 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl31 33
  • 60.19 (n)
Species where no ortholog for RPL31 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL31 Gene

Gene Tree for RPL31 (if available)
Gene Tree for RPL31 (if available)
Evolutionary constrained regions (ECRs) for RPL31: view image

Paralogs for RPL31 Gene

(1) SIMAP similar genes for RPL31 Gene using alignment to 6 proteins:

  • RL31_HUMAN
  • B7Z4C8_HUMAN
  • B7Z4E3_HUMAN
  • C9JU56_HUMAN
  • H7C2W9_HUMAN
genes like me logo Genes that share paralogs with RPL31: view

No data available for Paralogs for RPL31 Gene

Variants for RPL31 Gene

Sequence variations from dbSNP and Humsavar for RPL31 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000073466 -- 101,002,603(+) C/T intron_variant
rs1000242396 -- 101,005,949(+) T/C intron_variant
rs1000395132 -- 101,011,366(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000405701 -- 101,017,268(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000408316 -- 101,005,644(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL31 Gene

Variant ID Type Subtype PubMed ID
esv34123 CNV loss 18971310
nsv834316 CNV gain 17160897
nsv961844 CNV duplication 23825009

Variation tolerance for RPL31 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL31 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL31 Gene

Disorders for RPL31 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPL31 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • ulcus molle, skin
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPL31 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL31

genes like me logo Genes that share disorders with RPL31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL31 Gene

Publications for RPL31 Gene

  1. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 2 3 4 58
  2. cDNA sequence of human ribosomal protein L31. (PMID: 2780320) Nobori T … Carson DA (Nucleic acids research 1989) 2 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58

Products for RPL31 Gene

Sources for RPL31 Gene

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