Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30E family of ribosomal proteins. It is located in t... See more...

Aliases for RPL30 Gene

Aliases for RPL30 Gene

  • Ribosomal Protein L30 2 3 5
  • Large Ribosomal Subunit Protein EL30 3 4
  • 60S Ribosomal Protein L30 3 4
  • L30 3

External Ids for RPL30 Gene

Previous GeneCards Identifiers for RPL30 Gene

  • GC08M098062
  • GC08M099127
  • GC08M098713
  • GC08M099010
  • GC08M099123
  • GC08M094257
  • GC08M099037

Summaries for RPL30 Gene

Entrez Gene Summary for RPL30 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30E family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the U72 small nucleolar RNA gene, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL30 Gene

RPL30 (Ribosomal Protein L30) is a Protein Coding gene. Diseases associated with RPL30 include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL30 Gene

Additional gene information for RPL30 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL30 Gene

Genomics for RPL30 Gene

GeneHancer (GH) Regulatory Elements for RPL30 Gene

Promoters and enhancers for RPL30 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL30 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL30

Top Transcription factor binding sites by QIAGEN in the RPL30 gene promoter:
  • ATF6
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO3b
  • Lhx3a
  • LHX3b
  • p53
  • Sox5
  • USF-1
  • USF1

Genomic Locations for RPL30 Gene

Genomic Locations for RPL30 Gene
chr8:98,024,851-98,046,469
(GRCh38/hg38)
Size:
21,619 bases
Orientation:
Minus strand
chr8:99,037,079-99,058,697
(GRCh37/hg19)
Size:
21,619 bases
Orientation:
Minus strand

Genomic View for RPL30 Gene

Genes around RPL30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL30 Gene

Proteins for RPL30 Gene

  • Protein details for RPL30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62888-RL30_HUMAN
    Recommended name:
    60S ribosomal protein L30
    Protein Accession:
    P62888
    Secondary Accessions:
    • B2R591
    • P04645
    • Q502Z6

    Protein attributes for RPL30 Gene

    Size:
    115 amino acids
    Molecular mass:
    12784 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL30 Gene

neXtProt entry for RPL30 Gene

Post-translational modifications for RPL30 Gene

  • Ubiquitination at Lys9, Lys26, Lys32, Lys44, Lys57, Lys68, and Lys87
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL30 Gene

No data available for DME Specific Peptides for RPL30 Gene

Domains & Families for RPL30 Gene

Gene Families for RPL30 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL30 Gene

Blocks:
  • Ribosomal protein L7Ae/L30e/S12e/Gadd45
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL30 Gene

GenScript: Design optimal peptide antigens:
  • 60S ribosomal protein L30 (RL30_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62888

UniProtKB/Swiss-Prot:

RL30_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL30 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL30 family.
genes like me logo Genes that share domains with RPL30: view

Function for RPL30 Gene

Molecular function for RPL30 Gene

GENATLAS Biochemistry:
60S ribosomal protein L30,12kDa,likely same as D8S1364E

Phenotypes From GWAS Catalog for RPL30 Gene

Gene Ontology (GO) - Molecular Function for RPL30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,TAS 1577483
GO:0003735 structural constituent of ribosome IEA,TAS 1577483
GO:0005515 protein binding IPI 22720776
GO:0035368 selenocysteine insertion sequence binding IEA --
genes like me logo Genes that share ontologies with RPL30: view
genes like me logo Genes that share phenotypes with RPL30: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL30

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL30 Gene

Localization for RPL30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL30 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 22720776
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with RPL30: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL30 Gene

Pathways & Interactions for RPL30 Gene

genes like me logo Genes that share pathways with RPL30: view

Pathways by source for RPL30 Gene

1 KEGG pathway for RPL30 Gene
1 GeneGo (Thomson Reuters) pathway for RPL30 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPL30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006412 translation IEA,TAS 1577483
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL30: view

No data available for SIGNOR curated interactions for RPL30 Gene

Drugs & Compounds for RPL30 Gene

No Compound Related Data Available

Transcripts for RPL30 Gene

mRNA/cDNA for RPL30 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL30

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL30 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP8: -
SP9: - - -
SP10:

Relevant External Links for RPL30 Gene

GeneLoc Exon Structure for
RPL30

Expression for RPL30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL30 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.4) and Pancreas (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RPL30 Gene



Protein tissue co-expression partners for RPL30 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL30

SOURCE GeneReport for Unigene cluster for RPL30 Gene:

Hs.400295

Evidence on tissue expression from TISSUES for RPL30 Gene

  • Liver(4.8)
  • Eye(4.1)
  • Nervous system(4.1)
  • Muscle(4)
  • Intestine(3.7)
  • Skin(3.5)
  • Lung(3.4)
  • Pancreas(3.1)
  • Spleen(3.1)
  • Heart(3)
  • Lymph node(3)
  • Bone marrow(2.9)
  • Adrenal gland(2.8)
  • Blood(2.8)
  • Stomach(2.8)
  • Thyroid gland(2.8)
  • Bone(2.7)
  • Gall bladder(2.7)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with RPL30: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL30 Gene

Orthologs for RPL30 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL30 31 30
  • 99.42 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL30 31
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl30 17 31 30
  • 94.2 (n)
cow
(Bos Taurus)
Mammalia RPL30 31 30
  • 94.2 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPL30 31 30
  • 93.04 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362027 30
  • 93.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL30 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL30 31 30
  • 85.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 99 (a)
OneToMany
-- 31
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89963 30
  • 85.59 (n)
Str.750 30
zebrafish
(Danio rerio)
Actinopterygii rpl30 31 30
  • 81.16 (n)
OneToOne
wufa93d05 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003816 30
  • 72.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL30 31 32 30
  • 70.37 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpl-30 31 32 30
  • 63.36 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL30 33 31 30
  • 62 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR478W 30
  • 61.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10847g 30
  • 60 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G36240 30
  • 66.67 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7503 30
soybean
(Glycine max)
eudicotyledons Gma.15471 30
rice
(Oryza sativa)
Liliopsida Os01g0276000 30
  • 69.37 (n)
corn
(Zea mays)
Liliopsida Zm.12150 30
wheat
(Triticum aestivum)
Liliopsida Ta.3371 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 79 (a)
OneToOne
Cin.13337 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl3002 30
  • 62.09 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08963 30
  • 60.58 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13337 30
Species where no ortholog for RPL30 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL30 Gene

ENSEMBL:
Gene Tree for RPL30 (if available)
TreeFam:
Gene Tree for RPL30 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL30: view image

Paralogs for RPL30 Gene

No data available for Paralogs for RPL30 Gene

Variants for RPL30 Gene

Additional dbSNP identifiers (rs#s) for RPL30 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL30 Gene

Variant ID Type Subtype PubMed ID
esv2674440 CNV deletion 23128226

Variation tolerance for RPL30 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL30

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL30 Gene

Disorders for RPL30 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL30 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPL30 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL30

genes like me logo Genes that share disorders with RPL30: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL30 Gene

Publications for RPL30 Gene

  1. Crystallization and preliminary X-ray structure analysis of human ribosomal protein L30e. (PMID: 22139155) Kawaguchi A … Tanaka I (Acta crystallographica. Section F, Structural biology and crystallization communications 2011) 3 4 54
  2. Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. (PMID: 16968546) De Bortoli M … Kim JY (BMC cancer 2006) 3 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 54
  5. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PMID: 1577483) Feo S … Fried M (Genomics 1992) 2 3 54

Products for RPL30 Gene

Sources for RPL30 Gene