Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in ... See more...

Aliases for RPL3 Gene

Aliases for RPL3 Gene

  • Ribosomal Protein L3 2 3 5
  • Large Ribosomal Subunit Protein UL3 3 4
  • HIV-1 TAR RNA-Binding Protein B 3 4
  • 60S Ribosomal Protein L3 3 4
  • TARBP-B 3 4
  • ASC-1 3
  • L3 3

External Ids for RPL3 Gene

Previous GeneCards Identifiers for RPL3 Gene

  • GC22M036323
  • GC22M037951
  • GC22M038033
  • GC22M038046
  • GC22M039710
  • GC22M039717
  • GC22M039719
  • GC22M039721
  • GC22M039723
  • GC22M039728
  • GC22M039821
  • GC22M040108
  • GC22M039333
  • GC22M039835
  • GC22M042773
  • GC22M042887
  • GC22M042944
  • GC22M039847
  • GC22M039942
  • GC22M040631
  • GC22M041078
  • GC22M041476
  • GC22M041884
  • GC22M042313
  • GC22M042664

Summaries for RPL3 Gene

Entrez Gene Summary for RPL3 Gene

  • Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL3 Gene

RPL3 (Ribosomal Protein L3) is a Protein Coding gene. Diseases associated with RPL3 include Diamond-Blackfan Anemia and Shwachman-Diamond Syndrome 1. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL3L.

UniProtKB/Swiss-Prot Summary for RPL3 Gene

  • The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

Gene Wiki entry for RPL3 Gene

Additional gene information for RPL3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL3 Gene

Genomics for RPL3 Gene

GeneHancer (GH) Regulatory Elements for RPL3 Gene

Promoters and enhancers for RPL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL3

Top Transcription factor binding sites by QIAGEN in the RPL3 gene promoter:
  • AML1a
  • ATF6
  • Bach2
  • CUTL1
  • ER-alpha
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2

Genomic Locations for RPL3 Gene

Genomic Locations for RPL3 Gene
chr22:39,312,882-39,320,389
(GRCh38/hg38)
Size:
7,508 bases
Orientation:
Minus strand
chr22:39,708,887-39,716,394
(GRCh37/hg19)
Size:
7,508 bases
Orientation:
Minus strand

Genomic View for RPL3 Gene

Genes around RPL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL3 Gene

Proteins for RPL3 Gene

  • Protein details for RPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39023-RL3_HUMAN
    Recommended name:
    60S ribosomal protein L3
    Protein Accession:
    P39023
    Secondary Accessions:
    • B2RDV9
    • Q15548
    • Q5I0G0

    Protein attributes for RPL3 Gene

    Size:
    403 amino acids
    Molecular mass:
    46109 Da
    Quaternary structure:
    • Component of the large ribosomal subunit (Probable). Interacts with METTL18 (PubMed:23349634). Interacts with DHX33 (PubMed:26100019).

    Three dimensional structures from OCA and Proteopedia for RPL3 Gene

neXtProt entry for RPL3 Gene

Post-translational modifications for RPL3 Gene

  • Ubiquitination at Lys39, Lys286, Lys294, Lys300, and Lys366
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL3 Gene

No data available for DME Specific Peptides for RPL3 Gene

Domains & Families for RPL3 Gene

Gene Families for RPL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL3 Gene

Blocks:
  • Ribosomal protein L3
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59135, highly similar to 60S ribosomal protein L3 (B4DN06_HUMAN)
  • Ribosomal protein L3, isoform CRA_b (Q49AJ9_HUMAN)
  • Ribosomal protein L3 (Q96QL0_HUMAN)
  • RPL3 protein (Q9BT63_HUMAN)
  • Ribosomal protein L3 (Q9NY85_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P39023

UniProtKB/Swiss-Prot:

RL3_HUMAN :
  • Belongs to the universal ribosomal protein uL3 family.
Family:
  • Belongs to the universal ribosomal protein uL3 family.
genes like me logo Genes that share domains with RPL3: view

Function for RPL3 Gene

Molecular function for RPL3 Gene

UniProtKB/Swiss-Prot Function:
The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
GENATLAS Biochemistry:
60S ribosomal protein L3

Phenotypes From GWAS Catalog for RPL3 Gene

Gene Ontology (GO) - Molecular Function for RPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,TAS 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 23349634
GO:0008097 5S rRNA binding IEA --
genes like me logo Genes that share ontologies with RPL3: view
genes like me logo Genes that share phenotypes with RPL3: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL3 Gene

Localization for RPL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL3 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus HDA,IEA 21630459
GO:0005730 nucleolus IDA 16963496
GO:0005737 cytoplasm IEA,HDA 16791210
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with RPL3: view

Pathways & Interactions for RPL3 Gene

genes like me logo Genes that share pathways with RPL3: view

Pathways by source for RPL3 Gene

1 KEGG pathway for RPL3 Gene
1 GeneGo (Thomson Reuters) pathway for RPL3 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA 21873635
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL3: view

No data available for SIGNOR curated interactions for RPL3 Gene

Drugs & Compounds for RPL3 Gene

(5) Drugs for RPL3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Omacetaxine mepesuccinate Approved, Investigational Pharma Target, antagonist 0
Xanthinol Approved, Withdrawn Pharma Target, binder 0
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL3: view

Transcripts for RPL3 Gene

mRNA/cDNA for RPL3 Gene

2 REFSEQ mRNAs :
33 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^
SP1: - - - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - - - -
SP9: - - -
SP10: - - -
SP11: -
SP12:

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RPL3 Gene

GeneLoc Exon Structure for
RPL3

Expression for RPL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL3 Gene

Protein differential expression in normal tissues from HIPED for RPL3 Gene

This gene is overexpressed in Nasal epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL3 Gene



Protein tissue co-expression partners for RPL3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL3

SOURCE GeneReport for Unigene cluster for RPL3 Gene:

Hs.119598

Evidence on tissue expression from TISSUES for RPL3 Gene

  • Intestine(5)
  • Liver(5)
  • Lung(5)
  • Muscle(5)
  • Skin(5)
  • Nervous system(5)
  • Eye(4.9)
  • Pancreas(4.9)
  • Blood(4.7)
  • Kidney(4.7)
  • Stomach(4.6)
  • Bone(4.4)
  • Thyroid gland(4.2)
  • Heart(3.6)
  • Lymph node(2.9)
  • Adrenal gland(2.8)
  • Bone marrow(2.8)
  • Gall bladder(2.7)
  • Spleen(2.7)
genes like me logo Genes that share expression patterns with RPL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL3 Gene

Orthologs for RPL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL3 30
  • 99.65 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL3 31
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL3 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL3 31 30
  • 91.56 (n)
OneToMany
cow
(Bos Taurus)
Mammalia RPL3 31 30
  • 90.49 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl3 30
  • 89.74 (n)
mouse
(Mus musculus)
Mammalia Rpl3 17 31 30
  • 89.16 (n)
chicken
(Gallus gallus)
Aves RPL3 31 30
  • 84.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL3 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl3 30
  • 81.22 (n)
Str.6702 30
African clawed frog
(Xenopus laevis)
Amphibia rpl3-prov 30
zebrafish
(Danio rerio)
Actinopterygii rpl3 31 30
  • 80.31 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8466 30
fruit fly
(Drosophila melanogaster)
Insecta RpL3 31 32 30
  • 72.04 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003556 30
  • 67.87 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-3 31 30
  • 69.17 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR206W 30
  • 66.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16511g 30
  • 63.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL3 33 31 30
  • 62.86 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPL3B 30
  • 65.36 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7639 30
barley
(Hordeum vulgare)
Liliopsida Hv.977 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 74 (a)
OneToMany
Cin.3689 30
bread mold
(Neurospora crassa)
Ascomycetes NCU06843 30
  • 68.55 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl302 30
  • 64.59 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3689 30
Species where no ortholog for RPL3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL3 Gene

ENSEMBL:
Gene Tree for RPL3 (if available)
TreeFam:
Gene Tree for RPL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL3: view image

Paralogs for RPL3 Gene

Paralogs for RPL3 Gene

(2) SIMAP similar genes for RPL3 Gene using alignment to 10 proteins:

  • RL3_HUMAN
  • B4DN06_HUMAN
  • B5MCW2_HUMAN
  • F8WCR1_HUMAN
  • G5E9G0_HUMAN
  • H7C3M2_HUMAN
  • H7C422_HUMAN
  • Q49AJ9_HUMAN
  • Q96QL0_HUMAN
  • Q9BT63_HUMAN
genes like me logo Genes that share paralogs with RPL3: view

Variants for RPL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL3 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
781529 Benign: not provided 39,317,633(-) C/CA INTRON_VARIANT
VAR_069220 - p.His11Arg

Additional dbSNP identifiers (rs#s) for RPL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL3 Gene

Variant ID Type Subtype PubMed ID
nsv589033 CNV loss 21841781
nsv834198 CNV loss 17160897
nsv964632 CNV duplication 23825009
nsv966110 CNV duplication 23825009
nsv979677 CNV duplication 23825009

Variation tolerance for RPL3 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL3 Gene

Disorders for RPL3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPL3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • diamond-blackfan anemia 1
shwachman-diamond syndrome 1
  • sds1
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search RPL3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL3

genes like me logo Genes that share disorders with RPL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL3 Gene

Publications for RPL3 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 54
  2. Molecular cloning and characterization of a TAR-binding nuclear factor from T cells. (PMID: 7576925) Reddy TR … Wong-Staal F (AIDS research and human retroviruses 1995) 3 4 23 54
  3. The DHX33 RNA Helicase Promotes mRNA Translation Initiation. (PMID: 26100019) Zhang Y … Weber J (Molecular and cellular biology 2015) 3 4 54
  4. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 54
  5. Genes associated with telomerase activity levels in esophageal carcinoma cell lines. (PMID: 16364039) Bergqvist M … Paulsson-Karlsson Y (Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2006) 3 23 54

Products for RPL3 Gene