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Aliases for RPL29 Gene

Aliases for RPL29 Gene

  • Ribosomal Protein L29 2 3 5
  • Cell Surface Heparin-Binding Protein HIP 2 3 4
  • Heparin/Heparan Sulfate-Interacting Protein 2 3
  • Heparin/Heparan Sulfate-Binding Protein 2 3
  • Large Ribosomal Subunit Protein EL29 3 4
  • 60S Ribosomal Protein L29 2 3
  • HP/HS-Interacting Protein 2 3
  • Ribosomal Protein L29 Pseudogene 10 2
  • Ribosomal Protein YL43 Homologue 3
  • RPL29_3_370 3
  • HUMRPL29 3
  • RPL29P10 3
  • HIP 3
  • L29 3

External Ids for RPL29 Gene

Previous HGNC Symbols for RPL29 Gene

  • RPL29P10

Previous GeneCards Identifiers for RPL29 Gene

  • GC03M051120
  • GC03M051280
  • GC03M051879
  • GC03M051986
  • GC03M052002
  • GC03M052028

Summaries for RPL29 Gene

Entrez Gene Summary for RPL29 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL29 Gene

RPL29 (Ribosomal Protein L29) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL29 Gene

  • Component of the large ribosomal subunit.

Gene Wiki entry for RPL29 Gene

Additional gene information for RPL29 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL29 Gene

Genomics for RPL29 Gene

GeneHancer (GH) Regulatory Elements for RPL29 Gene

Promoters and enhancers for RPL29 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J051994 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.6 641 2.5 ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC RCOR2 NBN RPL29 PBRM1 RRP9 RAD54L2 ABHD14B NISCH GNL3 PARP3 NT5DC2
GH03J052044 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -55.7 -55680 14 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF416 DUSP7 DCAF1 GPR62 RAD54L2 PHF7 NT5DC2 RPL29 PCBP4 WDR82 SFMBT1
GH03J051955 Enhancer 0.9 Ensembl ENCODE dbSUPER 33.1 +39.8 39806 2 ZNF664 CTCF POLR2A MAX CTBP2 EZH2 GPR62 RPL29 NT5DC2 PARP3 GC03P051963
GH03J052194 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.4 -200.9 -200876 5.4 HDGF ZFP64 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 YY1 POLR2B ALAS1 PBRM1 RFT1 ABHD14B RPL29 STIMATE RRP9 GLYCTK NT5DC2 ALDOAP1
GH03J052452 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.3 -458.8 -458842 5.5 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B NISCH TNNC1 PBRM1 RFT1 ABHD14B RPL29 STIMATE PPM1M RRP9 NT5DC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL29 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL29 gene promoter:
  • HNF-4alpha2
  • HNF-4alpha1
  • p53
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • Pax-2a
  • Pax-2
  • AML1a

Genomic Locations for RPL29 Gene

Genomic Locations for RPL29 Gene
2,343 bases
Minus strand
2,343 bases
Minus strand

Genomic View for RPL29 Gene

Genes around RPL29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL29 Gene

Proteins for RPL29 Gene

  • Protein details for RPL29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L29
    Protein Accession:
    Secondary Accessions:
    • A8K0H3
    • B2R4M8
    • Q6IPY3

    Protein attributes for RPL29 Gene

    159 amino acids
    Molecular mass:
    17752 Da
    Quaternary structure:
    • Component of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPL29 Gene

neXtProt entry for RPL29 Gene

Post-translational modifications for RPL29 Gene

  • Ubiquitination at posLast=7373, posLast=6363, Lys56, and posLast=3838
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL29 Gene

Domains & Families for RPL29 Gene

Gene Families for RPL29 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL29 Gene


Suggested Antigen Peptide Sequences for RPL29 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL29 family.
  • Belongs to the eukaryotic ribosomal protein eL29 family.
genes like me logo Genes that share domains with RPL29: view

Function for RPL29 Gene

Molecular function for RPL29 Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.
GENATLAS Biochemistry:
60S ribosomal protein L29,identical to a cell surface heparin/heparan (HP/HS) binding protein

Phenotypes From GWAS Catalog for RPL29 Gene

Gene Ontology (GO) - Molecular Function for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,TAS 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0008201 heparin binding IEA,TAS --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL29: view
genes like me logo Genes that share phenotypes with RPL29: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL29 Gene

Localization for RPL29 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL29 gene
Compartment Confidence
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane HDA 19946888
GO:0022625 cytosolic large ribosomal subunit IBA,TAS --
genes like me logo Genes that share ontologies with RPL29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL29 Gene

Pathways & Interactions for RPL29 Gene

genes like me logo Genes that share pathways with RPL29: view

Pathways by source for RPL29 Gene

1 KEGG pathway for RPL29 Gene
1 GeneGo (Thomson Reuters) pathway for RPL29 Gene

Gene Ontology (GO) - Biological Process for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL29: view

No data available for SIGNOR curated interactions for RPL29 Gene

Drugs & Compounds for RPL29 Gene

(4) Drugs for RPL29 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 905

(3) Additional Compounds for RPL29 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL29: view

Transcripts for RPL29 Gene

mRNA/cDNA for RPL29 Gene

Unigene Clusters for RPL29 Gene

Ribosomal protein L29:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL29 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4
SP2: - -

Relevant External Links for RPL29 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL29 Gene

Protein differential expression in normal tissues from HIPED for RPL29 Gene

This gene is overexpressed in Stomach (9.9) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RPL29 Gene

Protein tissue co-expression partners for RPL29 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL29 Gene:


SOURCE GeneReport for Unigene cluster for RPL29 Gene:


Evidence on tissue expression from TISSUES for RPL29 Gene

  • Nervous system(4.8)
  • Pancreas(4.7)
  • Liver(4.6)
  • Lung(4.5)
  • Eye(3.8)
  • Intestine(3.7)
  • Muscle(3.6)
  • Bone(3.2)
  • Skin(3.1)
  • Stomach(3)
  • Heart(2.9)
  • Kidney(2.8)
  • Bone marrow(2.5)
  • Lymph node(2.5)
  • Spleen(2.4)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
  • Thyroid gland(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with RPL29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL29 Gene

Orthologs for RPL29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL29 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL29 34 33
  • 99.57 (n)
(Canis familiaris)
Mammalia RPL29 33
  • 92.78 (n)
-- 34
  • 78 (a)
-- 34
  • 64 (a)
-- 34
  • 46 (a)
-- 34
  • 45 (a)
(Bos Taurus)
Mammalia RPL29 34 33
  • 91.34 (n)
(Mus musculus)
Mammalia Gm4889 34
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
-- 34
  • 48 (a)
(Gallus gallus)
Aves RPL29 34 33
  • 87.3 (n)
(Anolis carolinensis)
Reptilia RPL29 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl29 33
  • 84.66 (n)
(Danio rerio)
Actinopterygii RPL29 34
  • 86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8224 33
fruit fly
(Drosophila melanogaster)
Insecta RpL29 34
  • 49 (a)
(Caenorhabditis elegans)
Secernentea rpl-29 34
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL29 34
  • 66 (a)
(Zea mays)
Liliopsida Zm.6182 33
(Oryza sativa)
Liliopsida Os.1082 33
(Triticum aestivum)
Liliopsida Ta.12895 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4934 34
  • 71 (a)
Species where no ortholog for RPL29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL29 Gene

Gene Tree for RPL29 (if available)
Gene Tree for RPL29 (if available)
Evolutionary constrained regions (ECRs) for RPL29: view image

Paralogs for RPL29 Gene

genes like me logo Genes that share paralogs with RPL29: view

No data available for Paralogs for RPL29 Gene

Variants for RPL29 Gene

Sequence variations from dbSNP and Humsavar for RPL29 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000729098 -- 51,997,099(-) A/C upstream_transcript_variant
rs1001394559 -- 51,997,094(-) G/C upstream_transcript_variant
rs1001988804 -- 51,993,192(-) C/T downstream_transcript_variant
rs1002217181 -- 51,997,622(-) T/A upstream_transcript_variant
rs1003495295 -- 51,995,176(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL29 Gene

Variant ID Type Subtype PubMed ID
nsv1003453 CNV gain 25217958
nsv508922 CNV insertion 20534489
nsv519445 CNV gain+loss 19592680
nsv520211 CNV gain 19592680
nsv954857 CNV deletion 24416366
nsv963318 CNV duplication 23825009

Variation tolerance for RPL29 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL29 Gene

Disorders for RPL29 Gene

Additional Disease Information for RPL29

No disorders were found for RPL29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL29 Gene

Publications for RPL29 Gene

  1. A novel cDNA encoding a human homologue of ribosomal protein L29. (PMID: 8597591) Law PT … Waye MM (Biochimica et biophysica acta 1996) 2 3 4 22 58
  2. cDNA cloning and expression of HIP, a novel cell surface heparan sulfate/heparin-binding protein of human uterine epithelial cells and cell lines. (PMID: 8662616) Liu S … Carson DD (The Journal of biological chemistry 1996) 3 4 22 58
  3. Repression of HIP/RPL29 expression induces differentiation in colon cancer cells. (PMID: 16475173) Liu JJ … Hooi SC (Journal of cellular physiology 2006) 3 22 58
  4. Analysis of eluted peptides from type 1 diabetes-susceptible HLA class II molecules identified novel islet protein, heparin/heparan sulfate-interacting protein. (PMID: 15721314) Nakanishi K … Matsushita H (Biochemical and biophysical research communications 2005) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RPL29 Gene

Sources for RPL29 Gene

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