Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL28 Gene

Aliases for RPL28 Gene

  • Ribosomal Protein L28 2 3 5
  • Large Ribosomal Subunit Protein EL28 3 4
  • 60S Ribosomal Protein L28 2 3
  • L28 3

External Ids for RPL28 Gene

Previous GeneCards Identifiers for RPL28 Gene

  • GC19P056761
  • GC19P056320
  • GC19P060571
  • GC19P060589
  • GC19P055897
  • GC19P052219

Summaries for RPL28 Gene

Entrez Gene Summary for RPL28 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for RPL28 Gene

RPL28 (Ribosomal Protein L28) is a Protein Coding gene. Diseases associated with RPL28 include Albinism-Deafness Syndrome. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL28 Gene

  • Component of the large ribosomal subunit.

Gene Wiki entry for RPL28 Gene

Additional gene information for RPL28 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL28 Gene

Genomics for RPL28 Gene

GeneHancer (GH) Regulatory Elements for RPL28 Gene

Promoters and enhancers for RPL28 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055382 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 582.9 +1.8 1763 8.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 RPL28 MIR6805 TMEM238 PIR44435 ZNF628 LENG8-AS1 ZNF581 U2AF2 COX6B2 BRSK1
GH19I055246 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 21 -131.2 -131242 14.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP6R1 LENG8 U2AF2 ZNF581 LENG8-AS1 ENSG00000235681 ENSG00000267523 BRSK1 HSPBP1 FIZ1
GH19I055405 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 22.5 +22.3 22325 3.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 UBE2S U2AF2 ZNF628 LENG8 ENSG00000267523 ZNF581 LENG8-AS1 RPL28 ENSG00000235681 ENSG00000267096
GH19I055215 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 18.6 -168.4 -168396 2.9 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ENSG00000267649 LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ENSG00000267523 SSC5D ZNF580 ENSG00000267096 ZNF581
GH19I055337 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 -45.3 -45273 4 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC KMT5C ENSG00000276831 LENG8-AS1 U2AF2 LENG8 ZNF628 ENSG00000235681 ENSG00000267523 ENSG00000267096 FAM71E2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPL28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL28 gene promoter:

Genomic Locations for RPL28 Gene

Genomic Locations for RPL28 Gene
18,150 bases
Plus strand

Genomic View for RPL28 Gene

Genes around RPL28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL28 Gene

Proteins for RPL28 Gene

  • Protein details for RPL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L28
    Protein Accession:
    Secondary Accessions:
    • B2R4A6
    • B4DEP9
    • C9JB50
    • E9PB24
    • G5E9L2
    • Q6IAY0
    • Q96FX1
    • Q9BWQ0

    Protein attributes for RPL28 Gene

    137 amino acids
    Molecular mass:
    15748 Da
    Quaternary structure:
    • Component of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPL28 Gene

    Alternative splice isoforms for RPL28 Gene


neXtProt entry for RPL28 Gene

Post-translational modifications for RPL28 Gene

  • Ubiquitination at Lys19, Lys22, Lys33, isoforms=2, 3, 4, 547, isoforms=2, 3, 4, 558, isoforms=2, 3, 4, 565, isoforms=2, 372, and isoforms=2, 3101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL28 Gene

Domains & Families for RPL28 Gene

Gene Families for RPL28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL28 Gene

Suggested Antigen Peptide Sequences for RPL28 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL28 family.
  • Belongs to the eukaryotic ribosomal protein eL28 family.
genes like me logo Genes that share domains with RPL28: view

Function for RPL28 Gene

Molecular function for RPL28 Gene

GENATLAS Biochemistry:
60S ribosomal protein L28,15kDa
UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.

Phenotypes From GWAS Catalog for RPL28 Gene

Gene Ontology (GO) - Molecular Function for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,HDA 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 20434207
genes like me logo Genes that share ontologies with RPL28: view
genes like me logo Genes that share phenotypes with RPL28: view

miRNA for RPL28 Gene

miRTarBase miRNAs that target RPL28

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL28 Gene

Localization for RPL28 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL28 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
peroxisome 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA,HDA 19946888
GO:0022625 cytosolic large ribosomal subunit HDA,TAS 12962325
genes like me logo Genes that share ontologies with RPL28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL28 Gene

Pathways & Interactions for RPL28 Gene

genes like me logo Genes that share pathways with RPL28: view

Pathways by source for RPL28 Gene

Gene Ontology (GO) - Biological Process for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL28: view

No data available for SIGNOR curated interactions for RPL28 Gene

Drugs & Compounds for RPL28 Gene

No Compound Related Data Available

Transcripts for RPL28 Gene

Unigene Clusters for RPL28 Gene

Ribosomal protein L28:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL28 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP5: - - -

Relevant External Links for RPL28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL28 Gene

This gene is overexpressed in Nasal epithelium (14.8) and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL28 Gene

Protein tissue co-expression partners for RPL28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL28 Gene:


SOURCE GeneReport for Unigene cluster for RPL28 Gene:


Evidence on tissue expression from TISSUES for RPL28 Gene

  • Nervous system(5)
  • Intestine(4.9)
  • Kidney(4.5)
  • Pancreas(4.4)
  • Skin(4.4)
  • Lung(4.3)
  • Eye(3.9)
  • Blood(3.8)
  • Liver(3.6)
  • Muscle(3.3)
  • Stomach(3)
  • Heart(2.7)
  • Lymph node(2.7)
  • Spleen(2.7)
  • Bone marrow(2.6)
  • Adrenal gland(2.4)
  • Gall bladder(2.4)
  • Thyroid gland(2.4)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with RPL28: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL28 Gene

Orthologs for RPL28 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL28 34
  • 99 (a)
(Bos Taurus)
Mammalia RPL28 33 34
  • 90.27 (n)
(Canis familiaris)
Mammalia RPL28 33 34
  • 90.02 (n)
(Mus musculus)
Mammalia Rpl28 33 16 34
  • 89.29 (n)
Rpl28-ps4 34
  • 66 (a)
(Rattus norvegicus)
Mammalia Rpl28 33
  • 89.05 (n)
(Monodelphis domestica)
Mammalia RPL28 34
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
-- 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl28 33
  • 70.07 (n)
Str.5096 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17523 33
(Danio rerio)
Actinopterygii rpl28 33 34
  • 76.96 (n)
zgc66289 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8348 33
fruit fly
(Drosophila melanogaster)
Insecta RpL28 33 34
  • 56.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005427 33
  • 56.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4607 34
  • 53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06210 33
  • 51.79 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl44 33
  • 43.44 (n)
Species where no ortholog for RPL28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPL28 Gene

Gene Tree for RPL28 (if available)
Gene Tree for RPL28 (if available)

Paralogs for RPL28 Gene

genes like me logo Genes that share paralogs with RPL28: view

No data available for Paralogs for RPL28 Gene

Variants for RPL28 Gene

Sequence variations from dbSNP and Humsavar for RPL28 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000121465 -- 55,386,972(+) C/A/T 3_prime_UTR_variant, intron_variant
rs1000302654 -- 55,386,249(+) T/G intron_variant
rs1000355646 -- 55,386,454(+) A/T intron_variant
rs1000594492 -- 55,385,528(+) A/C upstream_transcript_variant
rs1000939876 -- 55,389,601(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL28 Gene

Variant ID Type Subtype PubMed ID
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for RPL28 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.70; 91.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL28 Gene

Disorders for RPL28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL28 Gene - From: GeneCards

Disorder Aliases PubMed IDs
albinism-deafness syndrome
  • adfn
- elite association - COSMIC cancer census association via MalaCards
Search RPL28 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL28

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPL28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL28 Gene

Publications for RPL28 Gene

  1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio JM … Iovanna JL (Biochimica et biophysica acta 1995) 2 3 4 58
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova TI … Karpova GG (Journal of protein chemistry 2003) 3 4 58

Products for RPL28 Gene

Sources for RPL28 Gene