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Aliases for RPL27A Gene

Aliases for RPL27A Gene

  • Ribosomal Protein L27a 2 3 5
  • Large Ribosomal Subunit Protein UL15 3 4
  • 60S Ribosomal Protein L27a 3
  • L27A 3

External Ids for RPL27A Gene

Previous GeneCards Identifiers for RPL27A Gene

  • GC11P009474
  • GC11P009150
  • GC11P008743
  • GC11P008668
  • GC11P008660
  • GC11P008703
  • GC11P008371

Summaries for RPL27A Gene

Entrez Gene Summary for RPL27A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL27A Gene

RPL27A (Ribosomal Protein L27a) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL27A Gene

Additional gene information for RPL27A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL27A Gene

Genomics for RPL27A Gene

GeneHancer (GH) Regulatory Elements for RPL27A Gene

Promoters and enhancers for RPL27A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J008681 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 683.5 +3.4 3444 8.7 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SNORA3B RPL27A GC11P008725 GC11P008726 GC11P008728 GC11P008729 GC11P008731 GC11P008732 PIR32700 PIR61800
GH11J009458 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 32 +779.0 778988 5 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 ZNF143 LOC644656 SNORA3B RPL27A RPL21P97 TMEM9B-AS1 WEE1 TRIM66 IPO7 GC11P009430
GH11J007985 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.1 -695.2 -695222 2.7 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC EIF3F SNORA3B OLFML1 TMEM9B-AS1 RPL27A ST5 CASC23 TUB ZNF214 PIR63023
GH11J009611 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.1 +933.7 933662 8.5 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D SNORA3B SWAP70 RPL21P97 WEE1 RPL27A ENSG00000238387 TRIM66 ZNF143 DENND5A GC11M009621
GH11J009383 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +702.9 702896 3.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 IPO7 SNORA3B ZNF143 RPL27A RPL21P97 GC11P009428
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL27A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL27A gene promoter:
  • FOXO1a
  • FOXO1
  • FOXO4
  • RORalpha2
  • GCNF-2
  • GCNF-1
  • GCNF
  • AML1a
  • c-Ets-1
  • PPAR-gamma1

Genomic Locations for RPL27A Gene

Genomic Locations for RPL27A Gene
chr11:8,682,411-8,714,759
(GRCh38/hg38)
Size:
32,349 bases
Orientation:
Plus strand
chr11:8,703,958-8,736,306
(GRCh37/hg19)
Size:
32,349 bases
Orientation:
Plus strand

Genomic View for RPL27A Gene

Genes around RPL27A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL27A Gene

Proteins for RPL27A Gene

  • Protein details for RPL27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46776-RL27A_HUMAN
    Recommended name:
    60S ribosomal protein L27a
    Protein Accession:
    P46776
    Secondary Accessions:
    • B2R4B3

    Protein attributes for RPL27A Gene

    Size:
    148 amino acids
    Molecular mass:
    16561 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL27A Gene

neXtProt entry for RPL27A Gene

Post-translational modifications for RPL27A Gene

  • Hydroxylated on His-39 by MINA.
  • Ubiquitination at Lys92, posLast=7777, posLast=5555, and Lys47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL27A Gene

Domains & Families for RPL27A Gene

Gene Families for RPL27A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL27A Gene

Suggested Antigen Peptide Sequences for RPL27A Gene

Graphical View of Domain Structure for InterPro Entry

P46776

UniProtKB/Swiss-Prot:

RL27A_HUMAN :
  • Belongs to the universal ribosomal protein uL15 family.
Family:
  • Belongs to the universal ribosomal protein uL15 family.
genes like me logo Genes that share domains with RPL27A: view

Function for RPL27A Gene

Molecular function for RPL27A Gene

GENATLAS Biochemistry:
60S ribosomal protein L27A,16kDa

Phenotypes From GWAS Catalog for RPL27A Gene

Gene Ontology (GO) - Molecular Function for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IBA --
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with RPL27A: view
genes like me logo Genes that share phenotypes with RPL27A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL27A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL27A Gene

Localization for RPL27A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL27A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IDA,TAS --
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with RPL27A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL27A Gene

Pathways & Interactions for RPL27A Gene

genes like me logo Genes that share pathways with RPL27A: view

Pathways by source for RPL27A Gene

1 KEGG pathway for RPL27A Gene
1 GeneGo (Thomson Reuters) pathway for RPL27A Gene

Gene Ontology (GO) - Biological Process for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL27A: view

No data available for SIGNOR curated interactions for RPL27A Gene

Drugs & Compounds for RPL27A Gene

No Compound Related Data Available

Transcripts for RPL27A Gene

mRNA/cDNA for RPL27A Gene

Unigene Clusters for RPL27A Gene

Ribosomal protein L27a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL27A

Alternative Splicing Database (ASD) splice patterns (SP) for RPL27A Gene

No ASD Table

Relevant External Links for RPL27A Gene

GeneLoc Exon Structure for
RPL27A
ECgene alternative splicing isoforms for
RPL27A

Expression for RPL27A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL27A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL27A Gene



Protein tissue co-expression partners for RPL27A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL27A Gene:

RPL27A

SOURCE GeneReport for Unigene cluster for RPL27A Gene:

Hs.523463

Evidence on tissue expression from TISSUES for RPL27A Gene

  • Intestine(4.9)
  • Kidney(4.8)
  • Lung(4.7)
  • Nervous system(4.6)
  • Heart(4.3)
  • Skin(4)
  • Eye(3.9)
  • Liver(3.9)
  • Pancreas(3.8)
  • Spleen(2.8)
  • Thyroid gland(2.8)
  • Blood(2.6)
  • Lymph node(2.6)
  • Muscle(2.6)
  • Bone(2.5)
  • Bone marrow(2.5)
  • Adrenal gland(2.4)
  • Stomach(2.3)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with RPL27A: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL27A Gene

Orthologs for RPL27A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL27A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL27A 34 33
  • 99.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm7536 34
  • 97 (a)
OneToMany
Rpl27a 16 34 33
  • 90.99 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
OneToMany
RPL27A 33
  • 92.12 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL27A 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL27A 34 33
  • 90.99 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl27a 33
  • 88.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPL27A 34 33
  • 80.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 91 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl27a 33
  • 77.03 (n)
Str.14185 33
zebrafish
(Danio rerio)
Actinopterygii rpl27a 33
  • 75.23 (n)
wufa93g12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8028 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011706 33
  • 67.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL27A 34 35 33
  • 66.67 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y37E3.8a 35
  • 69 (a)
Y37E3.8 34 33
  • 65.52 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL035C 33
  • 63.06 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06831g 33
  • 61.71 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL28 36 34 33
  • 60.59 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G70600 33
  • 68.28 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.184 33
rice
(Oryza sativa)
Liliopsida Os03g0408300 33
  • 63.91 (n)
corn
(Zea mays)
Liliopsida Zm.16909 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6935 34
  • 79 (a)
OneToOne
Cin.2593 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2801 33
  • 61.26 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03806 33
  • 61.19 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2593 33
Species where no ortholog for RPL27A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL27A Gene

ENSEMBL:
Gene Tree for RPL27A (if available)
TreeFam:
Gene Tree for RPL27A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL27A: view image

Paralogs for RPL27A Gene

(4) SIMAP similar genes for RPL27A Gene using alignment to 7 proteins:

  • RL27A_HUMAN
  • E9PJD9_HUMAN
  • E9PKT2_HUMAN
  • E9PLL6_HUMAN
  • E9PLX7_HUMAN
  • H0YF34_HUMAN
  • Q6NZ52_HUMAN
genes like me logo Genes that share paralogs with RPL27A: view

No data available for Paralogs for RPL27A Gene

Variants for RPL27A Gene

Sequence variations from dbSNP and Humsavar for RPL27A Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000036465 -- 8,681,402(+) G/A upstream_transcript_variant
rs1000488056 -- 8,681,369(+) G/A upstream_transcript_variant
rs1001394543 -- 8,684,284(+) G/A intron_variant
rs1001578248 -- 8,681,133(+) AA/AAA upstream_transcript_variant
rs1002378478 -- 8,685,051(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL27A Gene

Variant ID Type Subtype PubMed ID
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855
nsv975880 CNV duplication 23825009

Variation tolerance for RPL27A Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL27A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL27A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL27A Gene

Disorders for RPL27A Gene

Additional Disease Information for RPL27A

No disorders were found for RPL27A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL27A Gene

Publications for RPL27A Gene

  1. Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A. (PMID: 10449908) Kusuda J … Hashimoto K (Cytogenetics and cell genetics 1999) 3 4 22 58
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  3. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio JM … Iovanna JL (Biochimica et biophysica acta 1995) 2 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RPL27A Gene

Sources for RPL27A Gene

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