This gene encodes a protein that shares high sequence similarity with ribosomal protein L26. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2015] See more...

Aliases for RPL26L1 Gene

Aliases for RPL26L1 Gene

  • Ribosomal Protein L26 Like 1 2 3 5
  • Large Ribosomal Subunit Protein UL24-Like 1 3 4
  • Ribosomal Protein L26 Pseudogene 1 2 3
  • 60S Ribosomal Protein L26-Like 1 3 4
  • RPL26P1 3 4
  • Ribosomal Protein L26 Homolog 3
  • Ribosomal Protein L26-Like 1 2

External Ids for RPL26L1 Gene

Previous HGNC Symbols for RPL26L1 Gene

  • RPL26P1

Previous GeneCards Identifiers for RPL26L1 Gene

  • GC05P172643
  • GC05P173088
  • GC05P172316
  • GC05P172367
  • GC05P172319
  • GC05P167481
  • GC05P172385

Summaries for RPL26L1 Gene

Entrez Gene Summary for RPL26L1 Gene

  • This gene encodes a protein that shares high sequence similarity with ribosomal protein L26. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2015]

GeneCards Summary for RPL26L1 Gene

RPL26L1 (Ribosomal Protein L26 Like 1) is a Protein Coding gene. Diseases associated with RPL26L1 include Giant Cell Glioblastoma. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL26.

Additional gene information for RPL26L1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL26L1 Gene

Genomics for RPL26L1 Gene

GeneHancer (GH) Regulatory Elements for RPL26L1 Gene

Promoters and enhancers for RPL26L1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL26L1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL26L1

Top Transcription factor binding sites by QIAGEN in the RPL26L1 gene promoter:
  • AML1a
  • ATF
  • CREB
  • deltaCREB
  • Nkx2-5
  • Pax-3
  • SRF
  • SRF (504 AA)
  • STAT3

Genomic Locations for RPL26L1 Gene

Genomic Locations for RPL26L1 Gene
chr5:172,954,294-172,969,771
(GRCh38/hg38)
Size:
15,478 bases
Orientation:
Plus strand
chr5:172,385,732-172,396,774
(GRCh37/hg19)
Size:
11,043 bases
Orientation:
Plus strand

Genomic View for RPL26L1 Gene

Genes around RPL26L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL26L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL26L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL26L1 Gene

Proteins for RPL26L1 Gene

  • Protein details for RPL26L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNX3-RL26L_HUMAN
    Recommended name:
    60S ribosomal protein L26-like 1
    Protein Accession:
    Q9UNX3
    Secondary Accessions:
    • B3KY82
    • D3DQM0

    Protein attributes for RPL26L1 Gene

    Size:
    145 amino acids
    Molecular mass:
    17256 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPL26L1 Gene

Post-translational modifications for RPL26L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPL26L1 Gene

Domains & Families for RPL26L1 Gene

Gene Families for RPL26L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL26L1 Gene

Blocks:
  • KOW (Kyprides, Ouzounis, Woese) motif
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL26L1 Gene

GenScript: Design optimal peptide antigens:
  • 60S ribosomal protein L26-like 1 (RL26L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UNX3

UniProtKB/Swiss-Prot:

RL26L_HUMAN :
  • Belongs to the universal ribosomal protein uL24 family.
Family:
  • Belongs to the universal ribosomal protein uL24 family.
genes like me logo Genes that share domains with RPL26L1: view

Function for RPL26L1 Gene

Phenotypes From GWAS Catalog for RPL26L1 Gene

Gene Ontology (GO) - Molecular Function for RPL26L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA 21873635
GO:0003735 structural constituent of ribosome IEA,IBA 21873635
genes like me logo Genes that share ontologies with RPL26L1: view
genes like me logo Genes that share phenotypes with RPL26L1: view

Animal Model Products

CRISPR Products

miRNA for RPL26L1 Gene

miRTarBase miRNAs that target RPL26L1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL26L1 Gene

Localization for RPL26L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL26L1 gene
Compartment Confidence
cytosol 4
nucleus 3
golgi apparatus 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL26L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA --
GO:0022625 cytosolic large ribosomal subunit IBA 21873635
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with RPL26L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL26L1 Gene

Pathways & Interactions for RPL26L1 Gene

genes like me logo Genes that share pathways with RPL26L1: view

Pathways by source for RPL26L1 Gene

Gene Ontology (GO) - Biological Process for RPL26L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA 21873635
GO:0006412 translation IEA --
GO:0042273 ribosomal large subunit biogenesis IBA 21873635
genes like me logo Genes that share ontologies with RPL26L1: view

No data available for SIGNOR curated interactions for RPL26L1 Gene

Drugs & Compounds for RPL26L1 Gene

(3) Drugs for RPL26L1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL26L1: view

Transcripts for RPL26L1 Gene

mRNA/cDNA for RPL26L1 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL26L1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for RPL26L1 Gene

GeneLoc Exon Structure for
RPL26L1

Expression for RPL26L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL26L1 Gene

Protein differential expression in normal tissues from HIPED for RPL26L1 Gene

This gene is overexpressed in Bone (12.6), Lung (8.9), Cervix (8.7), and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL26L1 Gene



Protein tissue co-expression partners for RPL26L1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL26L1

SOURCE GeneReport for Unigene cluster for RPL26L1 Gene:

Hs.546390

Evidence on tissue expression from TISSUES for RPL26L1 Gene

  • Lung(4.3)
  • Nervous system(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with RPL26L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL26L1 Gene

Orthologs for RPL26L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL26L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL26L1 30
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia RPL26 31
  • 99 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia RPL26L1 31
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL26L1 31
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910721 30
  • 81.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL26L1 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL26L1 30
  • 82.99 (n)
zebrafish
(Danio rerio)
Actinopterygii rpl26 31
  • 94 (a)
OneToMany
Dr.26956 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8648 30
fruit fly
(Drosophila melanogaster)
Insecta CG6846 32
  • 71 (a)
RpL26 31
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-26 31 32
  • 61 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL26A 31
  • 52 (a)
ManyToMany
RPL26B 31
  • 52 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.9317 30
barley
(Hordeum vulgare)
Liliopsida Hv.12406 30
corn
(Zea mays)
Liliopsida Zm.6748 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11213 31 31
  • 74 (a)
ManyToMany
Species where no ortholog for RPL26L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL26L1 Gene

ENSEMBL:
Gene Tree for RPL26L1 (if available)
TreeFam:
Gene Tree for RPL26L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL26L1: view image

Paralogs for RPL26L1 Gene

Paralogs for RPL26L1 Gene

(2) SIMAP similar genes for RPL26L1 Gene using alignment to 3 proteins:

  • RL26L_HUMAN
  • E5RHH1_HUMAN
  • E5RIT6_HUMAN
genes like me logo Genes that share paralogs with RPL26L1: view

Variants for RPL26L1 Gene

Additional dbSNP identifiers (rs#s) for RPL26L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL26L1 Gene

Variant ID Type Subtype PubMed ID
nsv830555 CNV loss 17160897

Variation tolerance for RPL26L1 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL26L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL26L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL26L1 Gene

Disorders for RPL26L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL26L1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
giant cell glioblastoma
  • monstrocellular sarcoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPL26L1

genes like me logo Genes that share disorders with RPL26L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL26L1 Gene

Publications for RPL26L1 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  4. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 54

Products for RPL26L1 Gene

Sources for RPL26L1 Gene