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Aliases for RPL23A Gene

Aliases for RPL23A Gene

  • Ribosomal Protein L23a 2 3 5
  • Large Ribosomal Subunit Protein UL23 3 4
  • Melanoma Differentiation-Associated Gene 20 3
  • 60S Ribosomal Protein L23a 3
  • MDA20 3
  • L23a 3

External Ids for RPL23A Gene

Previous GeneCards Identifiers for RPL23A Gene

  • GC17P026892
  • GC17P028946
  • GC17P027192
  • GC17P024072
  • GC17P027046

Summaries for RPL23A Gene

Entrez Gene Summary for RPL23A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL23A Gene

RPL23A (Ribosomal Protein L23a) is a Protein Coding gene. Diseases associated with RPL23A include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL23A Gene

  • This protein binds to a specific region on the 26S rRNA.

Gene Wiki entry for RPL23A Gene

Additional gene information for RPL23A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL23A Gene

Genomics for RPL23A Gene

GeneHancer (GH) Regulatory Elements for RPL23A Gene

Promoters and enhancers for RPL23A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I028715 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 570.1 +3.5 3531 14.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ENSG00000264577 RPL23A RAB34 NEK8 GC17P028741 GC17P028746 GC17P028748 GC17P028753 PIR32969 SNORD42A
GH17I028944 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.1 +229.9 229946 8.9 CLOCK ZFP64 FEZF1 DMAP1 YY1 E2F8 ZNF143 ZNF263 SP3 NFYC PHF12 PIPOX SUPT6H NUFIP2 ENSG00000264577 ENSG00000265908 ENSG00000265205 SDF2 TMEM199 RPL23A
GH17I029290 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.4 +573.9 573873 4.8 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC NUFIP2 ENSG00000264577 SUPT6H TMEM199 LOC101927018 PHF12 RPL23A ENSG00000264044 RAB34 MYO18A
GH17I028901 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21 +183.2 183225 2.2 CLOCK YBX1 DMAP1 IRF4 ZNF213 ZNF143 ZNF263 SP3 NFYC SSRP1 DHRS13 SUPT6H LOC101927018 NUFIP2 PHF12 ENSG00000264577 ENSG00000265908 SDF2 ENSG00000265205 PIGS
GH17I028709 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21 -7.9 -7927 3.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF213 PROCA1 ENSG00000264577 NUFIP2 SUPT6H PHF12 SDF2 TMEM199 RPL23A ENSG00000265908 ENSG00000265205
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPL23A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL23A gene promoter:

Genomic Locations for RPL23A Gene

Genomic Locations for RPL23A Gene
chr17:28,719,393-28,724,359
(GRCh38/hg38)
Size:
4,967 bases
Orientation:
Plus strand
chr17:27,046,411-27,051,377
(GRCh37/hg19)

Genomic View for RPL23A Gene

Genes around RPL23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL23A Gene

Proteins for RPL23A Gene

  • Protein details for RPL23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62750-RL23A_HUMAN
    Recommended name:
    60S ribosomal protein L23a
    Protein Accession:
    P62750
    Secondary Accessions:
    • B2R5B2
    • P29316
    • P39024
    • Q92774

    Protein attributes for RPL23A Gene

    Size:
    156 amino acids
    Molecular mass:
    17695 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL23A Gene

neXtProt entry for RPL23A Gene

Post-translational modifications for RPL23A Gene

Other Protein References for RPL23A Gene

No data available for DME Specific Peptides for RPL23A Gene

Domains & Families for RPL23A Gene

Gene Families for RPL23A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL23A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62750

UniProtKB/Swiss-Prot:

RL23A_HUMAN :
  • Belongs to the universal ribosomal protein uL23 family.
Family:
  • Belongs to the universal ribosomal protein uL23 family.
genes like me logo Genes that share domains with RPL23A: view

Function for RPL23A Gene

Molecular function for RPL23A Gene

GENATLAS Biochemistry:
60S ribosomal protein L23A
UniProtKB/Swiss-Prot Function:
This protein binds to a specific region on the 26S rRNA.

Phenotypes From GWAS Catalog for RPL23A Gene

Gene Ontology (GO) - Molecular Function for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IEA,NAS 9417910
GO:0005515 protein binding IPI 9687515
GO:0019843 rRNA binding IEA --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL23A: view
genes like me logo Genes that share phenotypes with RPL23A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL23A Gene

Localization for RPL23A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL23A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 9687515
GO:0005730 nucleolus HDA,IDA 16791210
GO:0005737 cytoplasm HDA,IDA 16791210
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL23A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPL23A Gene

Pathways & Interactions for RPL23A Gene

genes like me logo Genes that share pathways with RPL23A: view

Pathways by source for RPL23A Gene

1 KEGG pathway for RPL23A Gene
1 GeneGo (Thomson Reuters) pathway for RPL23A Gene

Gene Ontology (GO) - Biological Process for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 9417910
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL23A: view

No data available for SIGNOR curated interactions for RPL23A Gene

Drugs & Compounds for RPL23A Gene

(3) Drugs for RPL23A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL23A: view

Transcripts for RPL23A Gene

Unigene Clusters for RPL23A Gene

Ribosomal protein L23a:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL23A Gene

No ASD Table

Relevant External Links for RPL23A Gene

GeneLoc Exon Structure for
RPL23A
ECgene alternative splicing isoforms for
RPL23A

Expression for RPL23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL23A Gene

Protein differential expression in normal tissues from HIPED for RPL23A Gene

This gene is overexpressed in Tlymphocyte (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL23A Gene



Protein tissue co-expression partners for RPL23A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL23A Gene:

RPL23A

SOURCE GeneReport for Unigene cluster for RPL23A Gene:

Hs.419463

Evidence on tissue expression from TISSUES for RPL23A Gene

  • Liver(4.9)
  • Skin(4.9)
  • Eye(4.8)
  • Lung(4.8)
  • Pancreas(4.5)
  • Nervous system(4.5)
  • Adrenal gland(4.4)
  • Intestine(4.4)
  • Muscle(4.3)
  • Blood(4.1)
  • Kidney(4)
  • Heart(3.2)
  • Stomach(3.2)
  • Thyroid gland(3.2)
  • Bone(2.9)
  • Lymph node(2.2)
  • Bone marrow(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with RPL23A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL23A Gene

Orthologs for RPL23A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL23A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
-- 34
  • 100 (a)
OneToMany
-- 34
  • 99 (a)
OneToMany
-- 34
  • 99 (a)
OneToMany
LOC610129 33
  • 89.96 (n)
-- 34
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm10132 34
  • 100 (a)
OneToMany
Gm10335 34
  • 99 (a)
OneToMany
Rpl23a-ps3 34
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL23A 34 33
  • 100 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL23A 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 94 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPL23A 34 33
  • 91.03 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564606 33
  • 89.1 (n)
chicken
(Gallus gallus)
Aves RPL23A 34
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL23A 34
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25182 33
zebrafish
(Danio rerio)
Actinopterygii rpl23a 34
  • 94 (a)
OneToOne
wufa93f05 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.728 33
fruit fly
(Drosophila melanogaster)
Insecta RpL23a 35
  • 71 (a)
RpL23A 34
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006037 33
  • 66.95 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-25.1 35 34
  • 65 (a)
rpl-25.2 35 34
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL25 34 36
  • 64 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2702 33
corn
(Zea mays)
Liliopsida Zm.6079 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1725 34
  • 77 (a)
OneToOne
Species where no ortholog for RPL23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL23A Gene

ENSEMBL:
Gene Tree for RPL23A (if available)
TreeFam:
Gene Tree for RPL23A (if available)

Paralogs for RPL23A Gene

(2) SIMAP similar genes for RPL23A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RPL23A Gene

genes like me logo Genes that share paralogs with RPL23A: view

No data available for Paralogs for RPL23A Gene

Variants for RPL23A Gene

Sequence variations from dbSNP and Humsavar for RPL23A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000340537 -- 28,723,984(+) C/G 3_prime_UTR_variant
rs1000673498 -- 28,722,930(+) G/C intron_variant
rs1001178674 -- 28,721,774(+) TCTTTCTT/TCTT intron_variant
rs1001666210 -- 28,724,805(+) A/G downstream_transcript_variant
rs1001859064 -- 28,721,564(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL23A Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958
nsv960457 CNV duplication 23825009

Variation tolerance for RPL23A Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL23A Gene

Disorders for RPL23A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL23A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPL23A

genes like me logo Genes that share disorders with RPL23A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL23A Gene

Publications for RPL23A Gene

  1. Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene. (PMID: 9417910) Fan W … Lennon G (Genomics 1997) 2 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PMID: 9687515) Jäkel S … Görlich D (The EMBO journal 1998) 3 22 58
  5. Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta. (PMID: 9053844) Jiang H … Fisher PB (Oncogene 1997) 3 22 58

Products for RPL23A Gene

Sources for RPL23A Gene

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