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Aliases for RPL23 Gene

Aliases for RPL23 Gene

  • Ribosomal Protein L23 2 3 5
  • Large Ribosomal Subunit Protein UL14 3 4
  • 60S Ribosomal Protein L17 3 4
  • 60S Ribosomal Protein L23 3
  • Ribosomal Protein L17 3
  • RpL17 3
  • L23 3

External Ids for RPL23 Gene

Previous GeneCards Identifiers for RPL23 Gene

  • GC17M036491
  • GC17M039004
  • GC17M036914
  • GC17M037381
  • GC17M034259
  • GC17M037005

Summaries for RPL23 Gene

Entrez Gene Summary for RPL23 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL23 Gene

RPL23 (Ribosomal Protein L23) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL23 Gene

Additional gene information for RPL23 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL23 Gene

Genomics for RPL23 Gene

GeneHancer (GH) Regulatory Elements for RPL23 Gene

Promoters and enhancers for RPL23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J038850 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 661.7 +0.3 345 5.2 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A SNORA21 RPL23 RPS20P35 GC17M038850 GC17M038862 PIR54049 SNORA21B PIR38457 GC17P038858 GC17M038877
GH17J038823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 25.8 +28.9 28905 3 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CWC25 MIR4727 MED1 CDK12 SNORA21 LOC105371762 STARD3 RPL23 RPL19 PIP4K2B
GH17J038724 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.9 +124.4 124381 10.8 HDGF CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CISD3 ENSG00000279119 LASP1 CDK12 MED1 PCGF2 LOC105371762 RPL23 RPL19 FBXL20
GH17J038867 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.8 -17.9 -17860 9.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 SP3 LASP1 MED1 CDK12 LOC105371762 SNORA21 RPL23 CWC25 PSMB3 LINC02079 SNORA21B
GH17J039151 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.9 -299.5 -299493 3.9 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MCM3 PLXDC1 TRC-GCA2-3 TRC-GCA2-4 CDK12 MED1 LOC105371762 SNORA21 MED24 SNORD124 RPL23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL23 gene promoter:
  • deltaCREB
  • CREB
  • RFX1
  • AhR
  • Arnt
  • AREB6
  • Evi-1
  • CBF(2)

Genomic Locations for RPL23 Gene

Genomic Locations for RPL23 Gene
chr17:38,847,865-38,853,843
(GRCh38/hg38)
Size:
5,979 bases
Orientation:
Minus strand
chr17:37,004,118-37,010,096
(GRCh37/hg19)
Size:
5,979 bases
Orientation:
Minus strand

Genomic View for RPL23 Gene

Genes around RPL23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL23 Gene

Proteins for RPL23 Gene

  • Protein details for RPL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62829-RL23_HUMAN
    Recommended name:
    60S ribosomal protein L23
    Protein Accession:
    P62829
    Secondary Accessions:
    • P23131
    • P24048
    • Q29246
    • Q3SWV7
    • Q6P5S1

    Protein attributes for RPL23 Gene

    Size:
    140 amino acids
    Molecular mass:
    14865 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL23 Gene

neXtProt entry for RPL23 Gene

Post-translational modifications for RPL23 Gene

  • Ubiquitination at posLast=123123, Lys75, Lys66, posLast=4343, and posLast=3535
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL23 Gene

No data available for DME Specific Peptides for RPL23 Gene

Domains & Families for RPL23 Gene

Gene Families for RPL23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL23 Gene

Suggested Antigen Peptide Sequences for RPL23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62829

UniProtKB/Swiss-Prot:

RL23_HUMAN :
  • Belongs to the universal ribosomal protein uL14 family.
Family:
  • Belongs to the universal ribosomal protein uL14 family.
genes like me logo Genes that share domains with RPL23: view

Function for RPL23 Gene

Phenotypes From GWAS Catalog for RPL23 Gene

Gene Ontology (GO) - Molecular Function for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001223 transcription coactivator binding IPI 19160485
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 15314173
GO:0031625 ubiquitin protein ligase binding IPI 15314173
genes like me logo Genes that share ontologies with RPL23: view
genes like me logo Genes that share phenotypes with RPL23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL23

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL23 Gene

Localization for RPL23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL23 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 15314173
GO:0005730 nucleolus IDA 15314173
GO:0005737 cytoplasm IDA 15314173
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS,IEA 1874450
genes like me logo Genes that share ontologies with RPL23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL23 Gene

Pathways & Interactions for RPL23 Gene

genes like me logo Genes that share pathways with RPL23: view

Pathways by source for RPL23 Gene

1 KEGG pathway for RPL23 Gene
1 GeneGo (Thomson Reuters) pathway for RPL23 Gene

Gene Ontology (GO) - Biological Process for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 19160485
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL23: view

No data available for SIGNOR curated interactions for RPL23 Gene

Drugs & Compounds for RPL23 Gene

(4) Drugs for RPL23 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL23: view

Transcripts for RPL23 Gene

mRNA/cDNA for RPL23 Gene

Unigene Clusters for RPL23 Gene

Ribosomal protein L23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL23

Alternative Splicing Database (ASD) splice patterns (SP) for RPL23 Gene

No ASD Table

Relevant External Links for RPL23 Gene

GeneLoc Exon Structure for
RPL23
ECgene alternative splicing isoforms for
RPL23

Expression for RPL23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL23 Gene

This gene is overexpressed in Bone (7.5) and Bone marrow mesenchymal stem cell (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL23 Gene



Protein tissue co-expression partners for RPL23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL23 Gene:

RPL23

SOURCE GeneReport for Unigene cluster for RPL23 Gene:

Hs.406300

Evidence on tissue expression from TISSUES for RPL23 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Kidney(4.5)
  • Lung(4.5)
  • Eye(3.8)
  • Skin(3.7)
  • Intestine(3.6)
  • Heart(3.3)
  • Muscle(3.3)
  • Pancreas(2.9)
  • Blood(2.6)
  • Lymph node(2.6)
  • Bone marrow(2.5)
  • Spleen(2.5)
  • Adrenal gland(2.4)
  • Thyroid gland(2.4)
  • Gall bladder(2.3)
  • Stomach(2.3)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with RPL23: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL23 Gene

Orthologs for RPL23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL23 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia RPL23 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL23 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL23 34 33
  • 99.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPL23 34 33
  • 93.57 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl23 33
  • 92.86 (n)
dog
(Canis familiaris)
Mammalia RPL23 34 33
  • 92.38 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl23 16 34 33
  • 91.19 (n)
chicken
(Gallus gallus)
Aves RPL23 34 33
  • 82.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL23 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl23 33
  • 81.19 (n)
Str.17122 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8093 33
zebrafish
(Danio rerio)
Actinopterygii rpl23 34 33
  • 84.05 (n)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta RpL17A 35
  • 85 (a)
RpL23 34 33
  • 73.57 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010252 33
  • 73.57 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-23 34 35 33
  • 72.62 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL23A 34
  • 79 (a)
OneToMany
RPL23B 36 34 33
  • 68.43 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL288W 33
  • 68.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06997g 33
  • 67.93 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G33370 33
  • 74.58 (n)
soybean
(Glycine max)
eudicotyledons Gma.5613 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6927 33
rice
(Oryza sativa)
Liliopsida Os02g0814700 33
  • 72.66 (n)
corn
(Zea mays)
Liliopsida Zm.12634 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7198 34
  • 86 (a)
OneToOne
Cin.5835 33
bread mold
(Neurospora crassa)
Ascomycetes NCU02905 33
  • 69.32 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2301 33
  • 68.14 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5835 33
Species where no ortholog for RPL23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL23 Gene

ENSEMBL:
Gene Tree for RPL23 (if available)
TreeFam:
Gene Tree for RPL23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL23: view image

Paralogs for RPL23 Gene

(1) SIMAP similar genes for RPL23 Gene using alignment to 6 proteins:

  • RL23_HUMAN
  • B9ZVP7_HUMAN
  • C9JD32_HUMAN
  • J3KT29_HUMAN
  • J3KTJ3_HUMAN
  • J3QQT9_HUMAN
genes like me logo Genes that share paralogs with RPL23: view

No data available for Paralogs for RPL23 Gene

Variants for RPL23 Gene

Sequence variations from dbSNP and Humsavar for RPL23 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000125424 -- 38,854,507(-) G/C upstream_transcript_variant
rs1000500603 -- 38,854,655(-) G/T upstream_transcript_variant
rs1001082164 -- 38,855,351(-) C/T upstream_transcript_variant
rs1001492971 -- 38,855,641(-) G/C upstream_transcript_variant
rs1001954447 -- 38,851,486(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL23 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv833439 CNV loss 17160897

Variation tolerance for RPL23 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL23

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL23 Gene

Disorders for RPL23 Gene

Additional Disease Information for RPL23

No disorders were found for RPL23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL23 Gene

Publications for RPL23 Gene

  1. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PMID: 1861993) Hérault Y … Brun G (Nucleic acids research 1991) 2 3 4 58
  2. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. (PMID: 19160485) Wanzel M … Eilers M (Nature cell biology 2008) 3 22 58
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. (PMID: 15314173) Dai MS … Lu H (Molecular and cellular biology 2004) 3 22 58

Products for RPL23 Gene

Sources for RPL23 Gene

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