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Aliases for RPL22L1 Gene

Aliases for RPL22L1 Gene

  • Ribosomal Protein L22 Like 1 2 3 5
  • Large Ribosomal Subunit Protein EL22-Like 1 4
  • Ribosomal Protein L22-Like 1 2

External Ids for RPL22L1 Gene

Previous GeneCards Identifiers for RPL22L1 Gene

  • GC03M172067
  • GC03M170582
  • GC03M167952

Summaries for RPL22L1 Gene

GeneCards Summary for RPL22L1 Gene

RPL22L1 (Ribosomal Protein L22 Like 1) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL22.

Additional gene information for RPL22L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL22L1 Gene

Genomics for RPL22L1 Gene

GeneHancer (GH) Regulatory Elements for RPL22L1 Gene

Promoters and enhancers for RPL22L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I170866 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 580.4 +1.2 1211 4.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 RPL22L1 PHC3 SEC62-AS1 RNY5P3
GH03I170907 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 18.3 -38.3 -38333 2.9 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B CBX5 ZNF302 EIF5A2 PHC3 SEC62-AS1 RPL22L1 PRKCI GC03M170953
GH03I171804 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -938.2 -938204 9.3 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 SP3 MEF2D SSRP1 ZNF610 PLD1 FNDC3B TMEM212 RPL22L1 ECT2 TNIK ENSG00000234594
GH03I170221 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 10.6 +647.2 647182 3.4 HDGF PKNOX1 CLOCK ARNT NEUROD1 SIN3A ZNF2 ZBTB7B YY1 SLC30A9 PRKCI ENSG00000270096 MYNN SEC62-AS1 PHC3 RPL22P1 GPR160 RPL22L1 SLC7A14 LRRC34
GH03I169964 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 +903.5 903536 3.9 PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC100128164 SEC62 MYNN SEC62-AS1 LRRC31 GPR160 PHC3 RPL22L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPL22L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL22L1 gene promoter:

Genomic Locations for RPL22L1 Gene

Genomic Locations for RPL22L1 Gene
5,609 bases
Minus strand

Genomic View for RPL22L1 Gene

Genes around RPL22L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL22L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL22L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL22L1 Gene

Proteins for RPL22L1 Gene

  • Protein details for RPL22L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L22-like 1
    Protein Accession:
    Secondary Accessions:
    • Q32Q77

    Protein attributes for RPL22L1 Gene

    122 amino acids
    Molecular mass:
    14607 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH62731.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RPL22L1 Gene

Post-translational modifications for RPL22L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL22L1 Gene

No data available for DME Specific Peptides for RPL22L1 Gene

Domains & Families for RPL22L1 Gene

Gene Families for RPL22L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL22L1 Gene

Suggested Antigen Peptide Sequences for RPL22L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL22 family.
  • Belongs to the eukaryotic ribosomal protein eL22 family.
genes like me logo Genes that share domains with RPL22L1: view

Function for RPL22L1 Gene

Phenotypes From GWAS Catalog for RPL22L1 Gene

Gene Ontology (GO) - Molecular Function for RPL22L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IEA,IBA --
genes like me logo Genes that share ontologies with RPL22L1: view

Phenotypes for RPL22L1 Gene

genes like me logo Genes that share phenotypes with RPL22L1: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL22L1 Gene

Localization for RPL22L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL22L1 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL22L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit IBA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPL22L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL22L1 Gene

Pathways & Interactions for RPL22L1 Gene

genes like me logo Genes that share pathways with RPL22L1: view

Pathways by source for RPL22L1 Gene

SIGNOR curated interactions for RPL22L1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RPL22L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA --
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with RPL22L1: view

Drugs & Compounds for RPL22L1 Gene

No Compound Related Data Available

Transcripts for RPL22L1 Gene

Unigene Clusters for RPL22L1 Gene

Ribosomal protein L22-like 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL22L1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for RPL22L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL22L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL22L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL22L1 Gene

This gene is overexpressed in Lung (37.3), Bone (16.7), and Pancreas (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL22L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPL22L1 Gene:


SOURCE GeneReport for Unigene cluster for RPL22L1 Gene:


Evidence on tissue expression from TISSUES for RPL22L1 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with RPL22L1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL22L1 Gene

Orthologs for RPL22L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL22L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL22L1 33 34
  • 99.73 (n)
(Bos Taurus)
Mammalia RPL22L1 34
  • 96 (a)
-- 34
  • 89 (a)
-- 34
  • 87 (a)
(Mus musculus)
Mammalia Rpl22l1 34
  • 96 (a)
(Canis familiaris)
Mammalia RPL22L1 33 34
  • 93.94 (n)
(Rattus norvegicus)
Mammalia Rpl22l2 33
  • 92.62 (n)
(Ornithorhynchus anatinus)
Mammalia RPL22L1 34
  • 79 (a)
(Gallus gallus)
Aves RPL22L1 34
  • 78 (a)
(Anolis carolinensis)
Reptilia RPL22L1 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl22l1 33
  • 76.67 (n)
Str.15461 33
(Danio rerio)
Actinopterygii rpl22l1 34
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13594 33
fruit fly
(Drosophila melanogaster)
Insecta RpL22 34
  • 21 (a)
RpL22-like 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea rpl-22 34
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL22A 34
  • 45 (a)
RPL22B 34 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4506 34
  • 61 (a)
CSA.5709 34
  • 61 (a)
Species where no ortholog for RPL22L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL22L1 Gene

Gene Tree for RPL22L1 (if available)
Gene Tree for RPL22L1 (if available)

Paralogs for RPL22L1 Gene

Paralogs for RPL22L1 Gene

(2) SIMAP similar genes for RPL22L1 Gene using alignment to 4 proteins: Pseudogenes for RPL22L1 Gene

genes like me logo Genes that share paralogs with RPL22L1: view

Variants for RPL22L1 Gene

Sequence variations from dbSNP and Humsavar for RPL22L1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000162312 -- 170,868,912(-) G/A intron_variant
rs1000306499 -- 170,865,766(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1001383133 -- 170,869,777(-) C/T intron_variant
rs1001981338 -- 170,867,025(-) T/C intron_variant
rs1002305825 -- 170,868,366(-) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL22L1 Gene

Variant ID Type Subtype PubMed ID
nsv1012255 CNV gain 25217958
nsv7356 OTHER inversion 18451855

Variation tolerance for RPL22L1 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL22L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL22L1 Gene

Disorders for RPL22L1 Gene

Additional Disease Information for RPL22L1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RPL22L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL22L1 Gene

Publications for RPL22L1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I … Pitt AR (Free radical biology & medicine 2016) 3 58
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58

Products for RPL22L1 Gene

Sources for RPL22L1 Gene

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