Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in t... See more...

Aliases for RPL19 Gene

Aliases for RPL19 Gene

  • Ribosomal Protein L19 2 3 5
  • 60S Ribosomal Protein L19 2 3 4
  • Large Ribosomal Subunit Protein EL19 3 4
  • L19 2 3
  • Ribosomal Protein L19, Cytosolic, N-Terminus Truncated 2
  • DKFZp779D216 2
  • FLJ27452 2
  • MGC71997 2
  • RPL19 5

External Ids for RPL19 Gene

Previous GeneCards Identifiers for RPL19 Gene

  • GC17P036860
  • GC17P039354
  • GC17P037266
  • GC17P037731
  • GC17P034610
  • GC17P037356

Summaries for RPL19 Gene

Entrez Gene Summary for RPL19 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL19 Gene

RPL19 (Ribosomal Protein L19) is a Protein Coding gene. Diseases associated with RPL19 include Psoriasis 13 and Rectum Adenoma. Among its related pathways are Viral mRNA Translation and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL19 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL19 Gene

Genomics for RPL19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPL19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL19

Top Transcription factor binding sites by QIAGEN in the RPL19 gene promoter:
  • c-Myb
  • c-Myc
  • GATA-3
  • Max
  • MRF-2
  • p300
  • POU2F1
  • POU2F1a
  • SRF (504 AA)

Genomic Locations for RPL19 Gene

Latest Assembly
chr17:39,200,283-39,204,840
(GRCh38/hg38)
Size:
4,558 bases
Orientation:
Plus strand

Previous Assembly
chr17:37,356,536-37,360,985
(GRCh37/hg19 by Entrez Gene)
Size:
4,450 bases
Orientation:
Plus strand

chr17:37,356,536-37,360,980
(GRCh37/hg19 by Ensembl)
Size:
4,445 bases
Orientation:
Plus strand

Genomic View for RPL19 Gene

Genes around RPL19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL19 Gene

Proteins for RPL19 Gene

  • Protein details for RPL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84098-RL19_HUMAN
    Recommended name:
    60S ribosomal protein L19
    Protein Accession:
    P84098
    Secondary Accessions:
    • B2R4K2
    • P14118
    • P22908
    • Q502Y6
    • Q7Z6E4

    Protein attributes for RPL19 Gene

    Size:
    196 amino acids
    Molecular mass:
    23466 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD97677.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL19 Gene

neXtProt entry for RPL19 Gene

Post-translational modifications for RPL19 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys21, Lys43, Lys46, Lys92, Lys128, Lys152, Lys153, Lys180, Lys181, and Lys186
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for RPL19
  • Boster Bio Antibodies for RPL19

No data available for DME Specific Peptides for RPL19 Gene

Domains & Families for RPL19 Gene

Gene Families for RPL19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL19 Gene

GenScript: Design optimal peptide antigens:
  • 60S ribosomal protein L19 (RL19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P84098

UniProtKB/Swiss-Prot:

RL19_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL19 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL19 family.
genes like me logo Genes that share domains with RPL19: view

Function for RPL19 Gene

Molecular function for RPL19 Gene

GENATLAS Biochemistry:
60S ribosomal protein L19,23kDa

Phenotypes From GWAS Catalog for RPL19 Gene

Gene Ontology (GO) - Molecular Function for RPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,TAS 1577483
GO:0003735 structural constituent of ribosome IDA,TAS 1577483
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with RPL19: view
genes like me logo Genes that share phenotypes with RPL19: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL19

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL19 Gene

Localization for RPL19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL19 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA,TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with RPL19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL19 Gene

Pathways & Interactions for RPL19 Gene

genes like me logo Genes that share pathways with RPL19: view

Pathways by source for RPL19 Gene

2 KEGG pathways for RPL19 Gene
1 GeneGo (Thomson Reuters) pathway for RPL19 Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006412 translation IEA,TAS 1577483
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL19: view

No data available for SIGNOR curated interactions for RPL19 Gene

Drugs & Compounds for RPL19 Gene

(4) Drugs for RPL19 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anisomycin Experimental Pharma Target JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
L-3-Phenyllactic acid Experimental Pharma Target 0
puromycin Experimental Pharma Target 0

(1) Additional Compounds for RPL19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL19: view

Transcripts for RPL19 Gene

mRNA/cDNA for RPL19 Gene

2 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL19

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for RPL19 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2: -
SP3:

Relevant External Links for RPL19 Gene

GeneLoc Exon Structure for
RPL19

Expression for RPL19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL19 Gene

This gene is overexpressed in Nasal epithelium (7.5) and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL19 Gene



Protein tissue co-expression partners for RPL19 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL19

SOURCE GeneReport for Unigene cluster for RPL19 Gene:

Hs.381061

Evidence on tissue expression from TISSUES for RPL19 Gene

  • Nervous system(5)
  • Liver(4.9)
  • Intestine(4.9)
  • Muscle(4.9)
  • Blood(4.8)
  • Lung(4.5)
  • Skin(4.3)
  • Pancreas(4)
  • Eye(4)
  • Kidney(3.8)
  • Stomach(3.6)
  • Heart(3.5)
  • Spleen(3.3)
  • Lymph node(3.3)
  • Bone(3.2)
  • Bone marrow(3.1)
  • Thyroid gland(3)
  • Adrenal gland(2.9)
  • Gall bladder(2.4)
genes like me logo Genes that share expression patterns with RPL19: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL19 Gene

Orthologs for RPL19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL19 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia RPL19 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia RPL19 30 31
  • 99.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RPL19 30 31
  • 93.37 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rpl19 30 17 31
  • 92.01 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RPL19 30 31
  • 92.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rpl19 30
  • 90.99 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RPL19 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RPL19 30 31
  • 84.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPL19 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rpl19 30
  • 81.29 (n)
Zebrafish
(Danio rerio)
Actinopterygii rpl19 30 31
  • 78.06 (n)
OneToOne
Dr.29055 30
Fruit Fly
(Drosophila melanogaster)
Insecta RpL19 30 31 32
  • 70.47 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004422 30
  • 68.73 (n)
Worm
(Caenorhabditis elegans)
Secernentea rpl-19 30 31 32
  • 62.2 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL19A 31 33
  • 57 (a)
OneToMany
RPL19B 30 31 33
  • 54.3 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER179C 30
  • 55.91 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12453g 30
  • 54.3 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G02230 30
  • 63.84 (n)
Soybean
(Glycine max)
eudicotyledons Gma.10683 30
Rice
(Oryza sativa)
Liliopsida Os03g0337800 30
  • 63.4 (n)
Barley
(Hordeum vulgare)
Liliopsida Hv.3248 30
Wheat
(Triticum aestivum)
Liliopsida Ta.2739 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5596 31
  • 71 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU05804 30
  • 62.67 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1902 30
  • 56.48 (n)
Species where no ortholog for RPL19 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL19 Gene

ENSEMBL:
Gene Tree for RPL19 (if available)
TreeFam:
Gene Tree for RPL19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL19: view image

Paralogs for RPL19 Gene

No data available for Paralogs for RPL19 Gene

Variants for RPL19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL19 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
960880 Uncertain Significance: not provided 39,203,103(+) G/A
NM_000981.4(RPL19):c.350G>A (p.Arg117His)
MISSENSE
964835 Uncertain Significance: not provided 39,200,346(+) T/G
NM_000981.4(RPL19):c.2T>G (p.Met1Arg)
INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RPL19 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RPL19 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv833440 CNV loss 17160897
nsv833441 CNV loss 17160897
nsv960100 CNV duplication 23825009

Variation tolerance for RPL19 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL19 Gene

Human Gene Mutation Database (HGMD)
RPL19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL19

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL19 Gene

Disorders for RPL19 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RPL19 Gene - From: COP

Disorder Aliases PubMed IDs
psoriasis 13
  • psoriasis 13, susceptibility to
rectum adenoma
nivelon-nivelon-mabille syndrome
  • nnms
achromatopsia 4
  • achm4
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPL19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPL19

genes like me logo Genes that share disorders with RPL19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL19 Gene

Publications for RPL19 Gene

  1. High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2. (PMID: 8095182) Henry JL … King CR (Cancer research 1993) 3 4 23
  2. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. (PMID: 1598220) Kumabe T … Yamamoto T (Nucleic acids research 1992) 3 4 23
  3. Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma. (PMID: 19799608) Kuroda K … Yasumoto K (Cancer science 2010) 3 23
  4. Ribosomal protein l19 is a prognostic marker for human prostate cancer. (PMID: 16609016) Bee A … Foster CS (Clinical cancer research : an official journal of the American Association for Cancer Research 2006) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for RPL19 Gene