Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral repl... See more...

Aliases for RPL18A Gene

Aliases for RPL18A Gene

  • Ribosomal Protein L18a 2 3 5
  • 60S Ribosomal Protein L18a 2 3 4
  • Large Ribosomal Subunit Protein EL20 3 4
  • Ribosomal Protein L18a-Like Protein 2 3
  • L18A 2 3
  • RPL18A 5

External Ids for RPL18A Gene

Previous GeneCards Identifiers for RPL18A Gene

  • GC12P103772
  • GC19P018362
  • GC19P017815
  • GC19P017831
  • GC19P017970
  • GC19P017536
  • GC19P017964
  • GC19P018175
  • GC19P020481
  • GC19P020624
  • GC19P020729
  • GC19P022238
  • GC19P018293
  • GC19P018327
  • GC19P018700
  • GC19P019010
  • GC19P019328
  • GC19P019664
  • GC19P020022
  • GC19P020339
  • GC19P023313

Summaries for RPL18A Gene

Entrez Gene Summary for RPL18A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPL18A Gene

RPL18A (Ribosomal Protein L18a) is a Protein Coding gene. Diseases associated with RPL18A include Hepatitis C Virus. Among its related pathways are Viral mRNA Translation and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL18A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL18A Gene

Genomics for RPL18A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPL18A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J017859 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 288.8 +2.8 2836 7.5 CHD2 SP1 MXD4 CEBPA SIX5 NR2C1 MNT DEK SMAD5 ETS1 RPL18A HSALNG0124568 MN297184-002 SNORA68 NONHSAG025111.2 piR-33407-002 piR-38446-002 ENSG00000268030 UPF1 ENSG00000268938
GH19J018587 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 20 +729.5 729516 3.7 ZSCAN16 CHD2 TBP ZBTB10 MXD4 CEBPA MNT IKZF1 SMAD5 ETS1 REX1BD HSALNG0124646 piR-57461-107 ENSG00000268030 UPF1 MAU2 ENSG00000268938 NR2C2AP IQCN ENSG00000269191
GH19J018289 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.4 +432.3 432326 6.1 ZSCAN16 TBP ZBTB10 MXD4 SP1 BCL11A NR2C1 MNT IKZF1 SMAD5 HSALNG0124607 HSALNG0124608 IQCN ENSG00000268030 NR2C2AP UPF1 COLGALT1 ENSG00000268938 PGLS-DT SUGP2
GH19J018414 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 +558.7 558725 9.3 ZSCAN16 CHD2 TBP ZBTB10 MXD4 MNT IKZF1 BRCA1 SMAD5 ETS1 SSBP4 HSALNG0124621 NONHSAG025131.2 MAU2 NR2C2AP ENSG00000268030 UPF1 IQCN ENSG00000268938 ENSG00000269191
GH19J017333 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -523.8 -523817 6.2 ZSCAN16 CHD2 TBP ZBTB10 SP1 FEZF1 SIX5 NR2C1 MNT DEK GTPBP3 ANO8 lnc-DDA1-1 CHERP ENSG00000269578 IQCN ENSG00000268743 C19orf44 SIN3B MED26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL18A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL18A

Top Transcription factor binding sites by QIAGEN in the RPL18A gene promoter:
  • AP-1
  • MyoD
  • Sp1
  • STAT5B

Genomic Locations for RPL18A Gene

Latest Assembly
chr19:17,859,910-17,864,153
(GRCh38/hg38)
Size:
4,244 bases
Orientation:
Plus strand

Previous Assembly
chr19:17,970,719-17,974,128
(GRCh37/hg19 by Entrez Gene)
Size:
3,410 bases
Orientation:
Plus strand

chr19:17,970,685-17,974,962
(GRCh37/hg19 by Ensembl)
Size:
4,278 bases
Orientation:
Plus strand

Genomic View for RPL18A Gene

Genes around RPL18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL18A Gene

Proteins for RPL18A Gene

  • Protein details for RPL18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02543-RL18A_HUMAN
    Recommended name:
    60S ribosomal protein L18a
    Protein Accession:
    Q02543

    Protein attributes for RPL18A Gene

    Size:
    176 amino acids
    Molecular mass:
    20762 Da
    Quaternary structure:
    • Binds IPO9 with high affinity.
    SequenceCaution:
    • Sequence=CAA56788.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL18A Gene

neXtProt entry for RPL18A Gene

Post-translational modifications for RPL18A Gene

  • Ubiquitination at Lys11, Lys21, Lys41, Lys70, Lys76, Lys136, Lys143, Lys151, and Lys170
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL18A Gene

No data available for DME Specific Peptides for RPL18A Gene

Domains & Families for RPL18A Gene

Gene Families for RPL18A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL18A Gene

Suggested Antigen Peptide Sequences for RPL18A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51501, highly similar to 60S ribosomal protein L18a (B4DM74_HUMAN)
  • 60S ribosomal protein L18a (RL18A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02543

UniProtKB/Swiss-Prot:

RL18A_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL20 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL20 family.
genes like me logo Genes that share domains with RPL18A: view

Function for RPL18A Gene

Molecular function for RPL18A Gene

GENATLAS Biochemistry:
60S ribosomal protein L18A

Phenotypes From GWAS Catalog for RPL18A Gene

Gene Ontology (GO) - Molecular Function for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,HDA 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL18A: view
genes like me logo Genes that share phenotypes with RPL18A: view

miRNA for RPL18A Gene

miRTarBase miRNAs that target RPL18A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL18A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL18A Gene

Localization for RPL18A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL18A gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane HDA 19946888
GO:0022625 cytosolic large ribosomal subunit TAS,IDA 25957688
GO:0042788 polysomal ribosome IDA 25957688
genes like me logo Genes that share ontologies with RPL18A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL18A Gene

Pathways & Interactions for RPL18A Gene

genes like me logo Genes that share pathways with RPL18A: view

Pathways by source for RPL18A Gene

2 KEGG pathways for RPL18A Gene
1 GeneGo (Thomson Reuters) pathway for RPL18A Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL18A: view

No data available for SIGNOR curated interactions for RPL18A Gene

Drugs & Compounds for RPL18A Gene

No Compound Related Data Available

Transcripts for RPL18A Gene

mRNA/cDNA for RPL18A Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL18A

Alternative Splicing Database (ASD) splice patterns (SP) for RPL18A Gene

No ASD Table

Relevant External Links for RPL18A Gene

GeneLoc Exon Structure for
RPL18A

Expression for RPL18A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL18A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL18A Gene

This gene is overexpressed in Tlymphocyte (13.8) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL18A Gene



Protein tissue co-expression partners for RPL18A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL18A

SOURCE GeneReport for Unigene cluster for RPL18A Gene:

Hs.337766

Evidence on tissue expression from TISSUES for RPL18A Gene

  • Nervous system(4.9)
  • Muscle(4.8)
  • Liver(4.7)
  • Blood(4.6)
  • Lung(4.4)
  • Eye(4.3)
  • Skin(4.3)
  • Pancreas(3.8)
  • Kidney(3.8)
  • Intestine(3.6)
  • Stomach(3.1)
  • Spleen(2.6)
  • Thyroid gland(2.6)
  • Lymph node(2.5)
  • Heart(2.5)
genes like me logo Genes that share expression patterns with RPL18A: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL18A Gene

Orthologs for RPL18A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL18A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RPL18A 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RPL18A 31
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RPL18A 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RPL18A 30 31
  • 91.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RPL18A 30 31
  • 90.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rpl18a 30 17 31
  • 88.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rpl18a 30
  • 88.83 (n)
Chicken
(Gallus gallus)
Aves RPL18A 30 31
  • 81.23 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RPL18A 31
  • 99 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rpl18a 30
  • 80.68 (n)
Str.18648 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8369 30
Zebrafish
(Danio rerio)
Actinopterygii rpl18a 30 31
  • 79.73 (n)
OneToOne
zgc56546 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8991 30
Fruit Fly
(Drosophila melanogaster)
Insecta RpL18A 30 31 32
  • 71.59 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012284 30
  • 66.67 (n)
Worm
(Caenorhabditis elegans)
Secernentea rpl-20 31 32
  • 60 (a)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR330C 30
  • 57.79 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08657g 30
  • 56.55 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL20A 30 31
  • 55.75 (n)
OneToMany
RPL20B 31 33
  • 55 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G29965 30
  • 54.9 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0752300 30
  • 58.68 (n)
Os.24956 30
Wheat
(Triticum aestivum)
Liliopsida Ta.9955 30
Bread mold
(Neurospora crassa)
Ascomycetes NCU08389 30
  • 63.94 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10110 31
  • 62 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2002 30
  • 55.56 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.15368 30
Species where no ortholog for RPL18A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL18A Gene

ENSEMBL:
Gene Tree for RPL18A (if available)
TreeFam:
Gene Tree for RPL18A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL18A: view image

Paralogs for RPL18A Gene

No data available for Paralogs for RPL18A Gene

Variants for RPL18A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RPL18A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RPL18A Gene

Variant ID Type Subtype PubMed ID
nsv833772 CNV gain+loss 17160897
nsv978783 CNV duplication 23825009

Variation tolerance for RPL18A Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL18A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL18A Gene

Disorders for RPL18A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL18A Gene - From: GCD

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPL18A

genes like me logo Genes that share disorders with RPL18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL18A Gene

Publications for RPL18A Gene

  1. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. (PMID: 16195786) Dhar D … Das S (Archives of virology 2006) 3 23
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jäkel S … Görlich D (The EMBO journal 2002) 3 4

Products for RPL18A Gene