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Aliases for RPL18A Gene

Aliases for RPL18A Gene

  • Ribosomal Protein L18a 2 3 5
  • Large Ribosomal Subunit Protein EL20 3 4
  • Ribosomal Protein L18a-Like Protein 2 3
  • 60S Ribosomal Protein L18a 2 3
  • L18A 3

External Ids for RPL18A Gene

Previous GeneCards Identifiers for RPL18A Gene

  • GC12P103772
  • GC19P018362
  • GC19P017815
  • GC19P017831
  • GC19P017970
  • GC19P017536
  • GC19P017964
  • GC19P018175
  • GC19P018293
  • GC19P018327
  • GC19P018700
  • GC19P019010
  • GC19P019328
  • GC19P019664

Summaries for RPL18A Gene

Entrez Gene Summary for RPL18A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPL18A Gene

RPL18A (Ribosomal Protein L18a) is a Protein Coding gene. Diseases associated with RPL18A include Hepatitis C Virus. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL18A Gene

Additional gene information for RPL18A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL18A Gene

Genomics for RPL18A Gene

GeneHancer (GH) Regulatory Elements for RPL18A Gene

Promoters and enhancers for RPL18A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J017859 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 688.8 +2.9 2946 7.3 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 RPL18A GC19P020559 GC19P020443 GC19P020287 GC19P020146 SNORA68 PIR61491 PIR54406 GC19P020548 ENSG00000268030
GH19J018587 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30.6 +729.6 729564 3.6 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 REX1BD ENSG00000268030 UPF1 MAU2 ENSG00000268938 NR2C2AP IQCN ENSG00000269191 ELL MEF2B
GH19J018289 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +432.4 432360 6.1 YBX1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 MEF2D ENSG00000268030 NR2C2AP IQCN UPF1 SUGP2 ENSG00000268938 MVB12A COLGALT1 GTPBP3 ENSG00000269439
GH19J017072 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -782.6 -782622 8.6 CLOCK ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZFP41 HAUS8 MYO9B GC19M017078 ENSG00000269578 CHERP COLGALT1 SIN3B ENSG00000269044 MVB12A MED26
GH19J018414 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 +558.8 558819 9.2 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 MEF2D SSRP1 ZNF610 GLIS1 RCOR2 SSBP4 NR2C2AP ENSG00000268030 MAU2 UPF1 IQCN ENSG00000268938 ENSG00000269191 COLGALT1 MEF2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL18A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL18A gene promoter:
  • MyoD
  • AP-1
  • STAT5B
  • Sp1

Genomic Locations for RPL18A Gene

Genomic Locations for RPL18A Gene
4,278 bases
Plus strand
4,278 bases
Plus strand

Genomic View for RPL18A Gene

Genes around RPL18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL18A Gene

Proteins for RPL18A Gene

  • Protein details for RPL18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L18a
    Protein Accession:

    Protein attributes for RPL18A Gene

    176 amino acids
    Molecular mass:
    20762 Da
    Quaternary structure:
    • Binds IPO9 with high affinity.
    • Sequence=CAA56788.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL18A Gene

neXtProt entry for RPL18A Gene

Post-translational modifications for RPL18A Gene

  • Ubiquitination at posLast=170170, Lys151, Lys143, posLast=136136, Lys76, posLast=4141, posLast=2121, and posLast=1111
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL18A Gene

No data available for DME Specific Peptides for RPL18A Gene

Domains & Families for RPL18A Gene

Gene Families for RPL18A Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL18A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL20 family.
  • Belongs to the eukaryotic ribosomal protein eL20 family.
genes like me logo Genes that share domains with RPL18A: view

Function for RPL18A Gene

Molecular function for RPL18A Gene

GENATLAS Biochemistry:
60S ribosomal protein L18A

Phenotypes From GWAS Catalog for RPL18A Gene

Gene Ontology (GO) - Molecular Function for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IBA --
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL18A: view
genes like me logo Genes that share phenotypes with RPL18A: view

Animal Model Products

miRNA for RPL18A Gene

miRTarBase miRNAs that target RPL18A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL18A Gene

Localization for RPL18A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL18A gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane HDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA,IEA 25957688
GO:0042788 polysomal ribosome IDA 25957688
genes like me logo Genes that share ontologies with RPL18A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL18A Gene

Pathways & Interactions for RPL18A Gene

genes like me logo Genes that share pathways with RPL18A: view

Pathways by source for RPL18A Gene

1 KEGG pathway for RPL18A Gene
1 GeneGo (Thomson Reuters) pathway for RPL18A Gene

Gene Ontology (GO) - Biological Process for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL18A: view

No data available for SIGNOR curated interactions for RPL18A Gene

Drugs & Compounds for RPL18A Gene

No Compound Related Data Available

Transcripts for RPL18A Gene

mRNA/cDNA for RPL18A Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(2297) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL18A Gene

Ribosomal protein L18a:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL18A Gene

No ASD Table

Relevant External Links for RPL18A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL18A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL18A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL18A Gene

This gene is overexpressed in Tlymphocyte (13.8) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL18A Gene

Protein tissue co-expression partners for RPL18A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL18A Gene:


SOURCE GeneReport for Unigene cluster for RPL18A Gene:


Evidence on tissue expression from TISSUES for RPL18A Gene

  • Nervous system(4.9)
  • Muscle(4.7)
  • Liver(4.6)
  • Lung(4.4)
  • Eye(4.3)
  • Skin(4.1)
  • Pancreas(3.8)
  • Intestine(3.6)
  • Kidney(3.5)
  • Stomach(3.1)
  • Blood(2.8)
  • Heart(2.5)
  • Spleen(2.3)
  • Lymph node(2.2)
  • Thyroid gland(2.2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with RPL18A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL18A Gene

Orthologs for RPL18A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL18A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL18A 34 33
  • 100 (n)
(Monodelphis domestica)
Mammalia RPL18A 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL18A 34
  • 97 (a)
(Bos Taurus)
Mammalia RPL18A 34 33
  • 91.67 (n)
(Canis familiaris)
Mammalia RPL18A 34 33
  • 90.91 (n)
(Mus musculus)
Mammalia Rpl18a 16 34 33
  • 88.83 (n)
(Rattus norvegicus)
Mammalia Rpl18a 33
  • 88.83 (n)
(Gallus gallus)
Aves RPL18A 34 33
  • 81.23 (n)
(Anolis carolinensis)
Reptilia RPL18A 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl18a 33
  • 80.68 (n)
Str.18648 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8369 33
(Danio rerio)
Actinopterygii rpl18a 34 33
  • 79.73 (n)
zgc56546 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8991 33
fruit fly
(Drosophila melanogaster)
Insecta RpL18A 34 35 33
  • 71.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012284 33
  • 66.67 (n)
(Caenorhabditis elegans)
Secernentea rpl-20 34 35
  • 60 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR330C 33
  • 57.79 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08657g 33
  • 56.55 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL20A 34 33
  • 55.75 (n)
RPL20B 36 34
  • 55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29965 33
  • 54.9 (n)
(Oryza sativa)
Liliopsida Os01g0752300 33
  • 58.68 (n)
Os.24956 33
(Triticum aestivum)
Liliopsida Ta.9955 33
bread mold
(Neurospora crassa)
Ascomycetes NCU08389 33
  • 63.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10110 34
  • 62 (a)
Cin.15368 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2002 33
  • 55.56 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15368 33
Species where no ortholog for RPL18A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL18A Gene

Gene Tree for RPL18A (if available)
Gene Tree for RPL18A (if available)
Evolutionary constrained regions (ECRs) for RPL18A: view image

Paralogs for RPL18A Gene

No data available for Paralogs for RPL18A Gene

Variants for RPL18A Gene

Sequence variations from dbSNP and Humsavar for RPL18A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000078583 -- 17,858,334(+) C/G upstream_transcript_variant
rs1000262 -- 17,859,818(+) C/G upstream_transcript_variant
rs1000338719 -- 17,861,301(+) G/C coding_sequence_variant, missense_variant
rs1000665306 -- 17,860,344(+) G/A intron_variant
rs1000718570 -- 17,860,554(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL18A Gene

Variant ID Type Subtype PubMed ID
nsv833772 CNV gain+loss 17160897
nsv978783 CNV duplication 23825009

Variation tolerance for RPL18A Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL18A Gene

Disorders for RPL18A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL18A Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RPL18A

genes like me logo Genes that share disorders with RPL18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL18A Gene

Publications for RPL18A Gene

  1. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. (PMID: 16195786) Dhar D … Das S (Archives of virology 2006) 3 22 58
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jäkel S … Görlich D (The EMBO journal 2002) 3 4 58

Products for RPL18A Gene

Sources for RPL18A Gene