This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal protein L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple transcript variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include frameshifted C-terminal regions derived from the do... See more...

Aliases for RPL17-C18orf32 Gene

Aliases for RPL17-C18orf32 Gene

  • RPL17-C18orf32 Readthrough 2 3 5 13
  • Large Ribosomal Subunit Protein UL22 3
  • 60S Ribosomal Protein L17 3
  • 60S Ribosomal Protein L23 3
  • RPL17-C18orf32 Protein 3
  • Protein RPL17-C18orf32 13
  • RPL17-C18orf32 5
  • RPL17 3
  • PD-1 3

External Ids for RPL17-C18orf32 Gene

Previous GeneCards Identifiers for RPL17-C18orf32 Gene

  • GC18M047009

Summaries for RPL17-C18orf32 Gene

Entrez Gene Summary for RPL17-C18orf32 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal protein L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple transcript variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include frameshifted C-terminal regions derived from the downstream gene exons. [provided by RefSeq, Dec 2010]

GeneCards Summary for RPL17-C18orf32 Gene

RPL17-C18orf32 (RPL17-C18orf32 Readthrough) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL17.

Additional gene information for RPL17-C18orf32 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL17-C18orf32 Gene

Genomics for RPL17-C18orf32 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RPL17-C18orf32 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J049520 Enhancer 1 Ensembl ENCODE 11.1 -27.9 -27922 3.2 PRDM10 ZNF629 IKZF1 ZNF692 PRDM1 ZIC2 ZSCAN4 ZNF501 ZNF600 SOX6 MBD1 LIPG RPL17-C18orf32 SNORD58A SNORD58C DYM C18orf32 ENSG00000265496 piR-43107-130 LINC02837
GH18J049465 Enhancer 0.8 Ensembl ENCODE 11.2 +27.1 27078 1.6 TEAD4 PRDM1 ZIC2 RAD21 ZNF501 ZNF600 ZNF341 ZBTB44 OSR2 ZBTB17 SNORD58C RPL17-C18orf32 SNORD58A DYM NONHSAG023835.2 C18orf32
GH18J049515 Enhancer 0.3 Ensembl 11.1 -23.5 -23522 0.8 MNT piR-43107-130 C18orf32 RPL17-C18orf32 SNORD58A SNORD58C RF00017-2676 LINC02837 RPL17 LIPG
GH18J049485 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 0.7 +2.6 2643 8.5 BRCA1 ARHGAP35 SP1 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 REST TFE3 C18orf32 SNORD58A SNORD58B SNORD58C RPL17 piR-33856 piR-33879 piR-43849-004 piR-61298 CXXC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL17-C18orf32 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL17-C18orf32

Genomic Locations for RPL17-C18orf32 Gene

Genomic Locations for RPL17-C18orf32 Gene
chr18:49,481,178-49,492,479
(GRCh38/hg38)
Size:
11,302 bases
Orientation:
Minus strand
chr18:47,007,548-47,018,935
(GRCh37/hg19)
Size:
11,388 bases
Orientation:
Minus strand

Genomic View for RPL17-C18orf32 Gene

Genes around RPL17-C18orf32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL17-C18orf32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL17-C18orf32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL17-C18orf32 Gene

Proteins for RPL17-C18orf32 Gene

  • Protein details for RPL17-C18orf32 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A0MRF8-A0A0A0MRF8_HUMAN
    Recommended name:
    RPL17-C18orf32 readthrough
    Protein Accession:
    A0A0A0MRF8

    Protein attributes for RPL17-C18orf32 Gene

    Size:
    190 amino acids
    Molecular mass:
    22070 Da
    Quaternary structure:
    No Data Available
  • Protein details for RPL17-C18orf32 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYL6-A0A0A6YYL6_HUMAN
    Recommended name:
    Protein RPL17-C18orf32
    Protein Accession:
    A0A0A6YYL6

    Protein attributes for RPL17-C18orf32 Gene

    Size:
    228 amino acids
    Molecular mass:
    26373 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPL17-C18orf32 Gene

Protein Expression for RPL17-C18orf32 Gene

Post-translational modifications for RPL17-C18orf32 Gene

No Post-translational modifications

Other Protein References for RPL17-C18orf32 Gene

No data available for DME Specific Peptides for RPL17-C18orf32 Gene

Domains & Families for RPL17-C18orf32 Gene

Gene Families for RPL17-C18orf32 Gene

Unknown:
  • Belongs to the universal ribosomal protein uL22 family.
  • Belongs to the universal ribosomal protein uL22 family.
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RPL17-C18orf32 Gene

genes like me logo Genes that share domains with RPL17-C18orf32: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RPL17-C18orf32 Gene

Function for RPL17-C18orf32 Gene

Phenotypes From GWAS Catalog for RPL17-C18orf32 Gene

Gene Ontology (GO) - Molecular Function for RPL17-C18orf32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with RPL17-C18orf32: view

Phenotypes for RPL17-C18orf32 Gene

genes like me logo Genes that share phenotypes with RPL17-C18orf32: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL17-C18orf32

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL17-C18orf32 Gene

Localization for RPL17-C18orf32 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL17-C18orf32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA --
GO:0022625 cytosolic large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with RPL17-C18orf32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for RPL17-C18orf32 Gene

Pathways & Interactions for RPL17-C18orf32 Gene

PathCards logo

SuperPathways for RPL17-C18orf32 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.53
genes like me logo Genes that share pathways with RPL17-C18orf32: view

Pathways by source for RPL17-C18orf32 Gene

1 KEGG pathway for RPL17-C18orf32 Gene

Interacting Proteins for RPL17-C18orf32 Gene

Gene Ontology (GO) - Biological Process for RPL17-C18orf32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA --
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with RPL17-C18orf32: view

No data available for SIGNOR curated interactions for RPL17-C18orf32 Gene

Drugs & Compounds for RPL17-C18orf32 Gene

No Compound Related Data Available

Transcripts for RPL17-C18orf32 Gene

mRNA/cDNA for RPL17-C18orf32 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL17-C18orf32

Alternative Splicing Database (ASD) splice patterns (SP) for RPL17-C18orf32 Gene

No ASD Table

Relevant External Links for RPL17-C18orf32 Gene

GeneLoc Exon Structure for
RPL17-C18orf32

Expression for RPL17-C18orf32 Gene

Protein differential expression in normal tissues from HIPED for RPL17-C18orf32 Gene

This gene is overexpressed in Tlymphocyte (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for RPL17-C18orf32 Gene



Protein tissue co-expression partners for RPL17-C18orf32 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL17-C18orf32 Gene

Orthologs for RPL17-C18orf32 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL17-C18orf32 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 92 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 92 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Rpl17 31
  • 92 (a)
ManyToMany
Gm10362 30 17
  • 89.22 (n)
Gm6133 31
  • 81 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 91 (a)
ManyToMany
-- 31
  • 72 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 89 (a)
OneToMany
-- 31
  • 86 (a)
OneToMany
-- 31
  • 84 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia LOC499522 30
  • 85.88 (n)
Chicken
(Gallus gallus)
Aves -- 31
  • 92 (a)
ManyToMany
-- 31
  • 92 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rpl17 30
  • 78.34 (n)
Zebrafish
(Danio rerio)
Actinopterygii rpl17 30 31
  • 77.59 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta RL17_ANOGA 30
  • 66.27 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta RpL17 30 31
  • 64.76 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rpl-17 30 31
  • 60.62 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL17A 31
  • 52 (a)
ManyToMany
RPL17B 31
  • 52 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4564 31
  • 73 (a)
OneToMany
Species where no ortholog for RPL17-C18orf32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RPL17-C18orf32 Gene

ENSEMBL:
Gene Tree for RPL17-C18orf32 (if available)
TreeFam:
Gene Tree for RPL17-C18orf32 (if available)

Paralogs for RPL17-C18orf32 Gene

Paralogs for RPL17-C18orf32 Gene

Pseudogenes.org Pseudogenes for RPL17-C18orf32 Gene

genes like me logo Genes that share paralogs with RPL17-C18orf32: view

Variants for RPL17-C18orf32 Gene

Additional dbSNP identifiers (rs#s) for RPL17-C18orf32 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL17-C18orf32 Gene

Variant ID Type Subtype PubMed ID
nsv1065279 CNV gain 25217958
nsv1160523 CNV deletion 26073780
nsv2294 CNV deletion 18451855
nsv2295 CNV insertion 18451855
nsv978629 CNV duplication 23825009

Variation tolerance for RPL17-C18orf32 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL17-C18orf32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL17-C18orf32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL17-C18orf32 Gene

Disorders for RPL17-C18orf32 Gene

Additional Disease Information for RPL17-C18orf32

No disorders were found for RPL17-C18orf32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL17-C18orf32 Gene

Publications for RPL17-C18orf32 Gene

  1. Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF. (PMID: 30459231) Marino MM … Pedone PV (The Journal of biological chemistry 2019) 3
  2. Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease. (PMID: 28902428) Brady GF … Omary MB (Hepatology (Baltimore, Md.) 2018) 3
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  4. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 13

Products for RPL17-C18orf32 Gene

Sources for RPL17-C18orf32 Gene