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This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal protein L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple transcript variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include frameshifted C-terminal regions derived from the do... See more...
Aliases for RPL17-C18orf32 Gene
Aliases for RPL17-C18orf32 Gene
External Ids for RPL17-C18orf32 Gene
- HGNC: 44661
- Entrez Gene: 100526842
- Ensembl: ENSG00000215472
- UniProtKB: A0A0A0MRF8
- UniProtKB: A0A0A6YYL6
Previous GeneCards Identifiers for RPL17-C18orf32 Gene
- GC18M047009
Summaries for RPL17-C18orf32 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal protein L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple transcript variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include frameshifted C-terminal regions derived from the downstream gene exons. [provided by RefSeq, Dec 2010]
GeneCards Summary for RPL17-C18orf32 Gene
RPL17-C18orf32 (RPL17-C18orf32 Readthrough) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL17.
Additional gene information for RPL17-C18orf32 Gene
- HGNC(44661)
- Entrez Gene(100526842)
- Ensembl(ENSG00000215472)
- UniProtKB(A0A0A0MRF8)
- UniProtKB(A0A0A6YYL6)
- Search for RPL17-C18orf32 at DataMed
- Search for RPL17-C18orf32 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL17-C18orf32 Gene
Genomics for RPL17-C18orf32 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RPL17-C18orf32 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18J049520 | Enhancer | 1 | Ensembl ENCODE | 11.1 | -27.9 | -27922 | 3.2 | PRDM10 ZNF629 IKZF1 ZNF692 PRDM1 ZIC2 ZSCAN4 ZNF501 ZNF600 SOX6 | MBD1 LIPG RPL17-C18orf32 SNORD58A SNORD58C DYM C18orf32 ENSG00000265496 piR-43107-130 LINC02837 | |
| GH18J049465 | Enhancer | 0.8 | Ensembl ENCODE | 11.2 | +27.1 | 27078 | 1.6 | TEAD4 PRDM1 ZIC2 RAD21 ZNF501 ZNF600 ZNF341 ZBTB44 OSR2 ZBTB17 | SNORD58C RPL17-C18orf32 SNORD58A DYM NONHSAG023835.2 C18orf32 | |
| GH18J049515 | Enhancer | 0.3 | Ensembl | 11.1 | -23.5 | -23522 | 0.8 | MNT | piR-43107-130 C18orf32 RPL17-C18orf32 SNORD58A SNORD58C RF00017-2676 LINC02837 RPL17 LIPG | |
| GH18J049485 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.7 | +2.6 | 2643 | 8.5 | BRCA1 ARHGAP35 SP1 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 REST TFE3 | C18orf32 SNORD58A SNORD58B SNORD58C RPL17 piR-33856 piR-33879 piR-43849-004 piR-61298 CXXC1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RPL17-C18orf32 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL17-C18orf32
Genomic Locations for RPL17-C18orf32 Gene
Genomic Locations for RPL17-C18orf32 Gene
- chr18:49,481,178-49,492,479
- (GRCh38/hg38)
- Size:
- 11,302 bases
- Orientation:
- Minus strand
- chr18:47,007,548-47,018,935
- (GRCh37/hg19)
- Size:
- 11,388 bases
- Orientation:
- Minus strand
Genomic View for RPL17-C18orf32 Gene
Genes around RPL17-C18orf32 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.1 by HGNC
- 18q21.1 by Entrez Gene
- 18q21.1 by Ensembl
RPL17-C18orf32 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPL17-C18orf32 Gene
Proteins for RPL17-C18orf32 Gene
-
Protein details for RPL17-C18orf32 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A0A0MRF8-A0A0A0MRF8_HUMAN
- Recommended name:
- RPL17-C18orf32 readthrough
- Protein Accession:
- A0A0A0MRF8
Protein attributes for RPL17-C18orf32 Gene
- Size:
- 190 amino acids
- Molecular mass:
- 22070 Da
- Quaternary structure:
- No Data Available
-
Protein details for RPL17-C18orf32 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A0A6YYL6-A0A0A6YYL6_HUMAN
- Recommended name:
- Protein RPL17-C18orf32
- Protein Accession:
- A0A0A6YYL6
Protein attributes for RPL17-C18orf32 Gene
- Size:
- 228 amino acids
- Molecular mass:
- 26373 Da
- Quaternary structure:
- No Data Available
Protein Expression for RPL17-C18orf32 Gene
Post-translational modifications for RPL17-C18orf32 Gene
No Post-translational modifications
Other Protein References for RPL17-C18orf32 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RPL17-C18orf32
- Origene Custom Protein Services for RPL17-C18orf32
No data available for DME Specific Peptides for RPL17-C18orf32 Gene
Domains & Families for RPL17-C18orf32 Gene
Gene Families for RPL17-C18orf32 Gene
- Unknown:
-
- Belongs to the universal ribosomal protein uL22 family.
- Belongs to the universal ribosomal protein uL22 family.
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RPL17-C18orf32 Gene
- InterPro:
- ProtoNet:
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RPL17-C18orf32 Gene
Function for RPL17-C18orf32 Gene
Phenotypes From GWAS Catalog for RPL17-C18orf32 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003735 | structural constituent of ribosome | IEA | -- |
Phenotypes for RPL17-C18orf32 Gene
- GenomeRNAi human phenotypes for RPL17-C18orf32:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for RPL17-C18orf32
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miRNA for RPL17-C18orf32 Gene
- miRTarBase miRNAs that target RPL17-C18orf32
-
- hsa-miR-4803 (MIRT290603)
- hsa-miR-8075 (MIRT571706)
- hsa-miR-29a-5p (MIRT571708)
- hsa-miR-512-3p (MIRT571709)
- hsa-miR-802 (MIRT571710)
- hsa-miR-520e (MIRT571711)
- hsa-miR-520d-3p (MIRT571712)
- hsa-miR-520c-3p (MIRT571713)
- hsa-miR-520b (MIRT571714)
- hsa-miR-520a-3p (MIRT571715)
- hsa-miR-373-3p (MIRT571716)
- hsa-miR-372-3p (MIRT571717)
- hsa-miR-302e (MIRT571718)
- hsa-miR-302d-3p (MIRT571719)
- hsa-miR-302c-3p (MIRT571720)
- hsa-miR-302b-3p (MIRT571721)
- hsa-miR-302a-3p (MIRT571722)
- hsa-miR-4796-3p (MIRT571723)
- hsa-miR-93-5p (MIRT571724)
- hsa-miR-526b-3p (MIRT571725)
- hsa-miR-519d-3p (MIRT571726)
- hsa-miR-20b-5p (MIRT571727)
- hsa-miR-20a-5p (MIRT571728)
- hsa-miR-17-5p (MIRT571729)
- hsa-miR-106b-5p (MIRT571730)
- hsa-miR-106a-5p (MIRT571731)
- hsa-miR-548ah-5p (MIRT571732)
- hsa-miR-3609 (MIRT571733)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for RPL17-C18orf32
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Cell Line Products
-
Horizon Cell Lines for RPL17-C18orf32
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL17-C18orf32 Gene
Localization for RPL17-C18orf32 Gene
- Cytosol (3)
- Endoplasmic reticulum (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005840 | ribosome | IEA | -- |
| GO:0015934 | large ribosomal subunit | IEA | -- |
| GO:0022625 | cytosolic large ribosomal subunit | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for RPL17-C18orf32 Gene
Pathways & Interactions for RPL17-C18orf32 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.53
|
|
Pathways by source for RPL17-C18orf32 Gene
1 KEGG pathway for RPL17-C18orf32 Gene
Interacting Proteins for RPL17-C18orf32 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| NSUN6 | ||
| ABCE1 | ||
| ANKFY1 | ||
| ANKHD1 | ||
| ANKHD1-EIF4EBP3 |
GPS-Prot Interaction Network for RPL17-C18orf32
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002181 | cytoplasmic translation | IBA | -- |
| GO:0006412 | translation | IEA | -- |
No data available for SIGNOR curated interactions for RPL17-C18orf32 Gene
Transcripts for RPL17-C18orf32 Gene
mRNA/cDNA for RPL17-C18orf32 Gene
- 2 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332968 948 nts (view in UCSC)
- ENST00000577910 1012 nts (view in UCSC)
- ENST00000584895 1440 nts (view in UCSC)
CRISPR Products
-
OriGene CRISPR knockouts for RPL17-C18orf32
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for RPL17-C18orf32
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Relevant External Links for RPL17-C18orf32 Gene
- GeneLoc Exon Structure for
- RPL17-C18orf32
Expression for RPL17-C18orf32 Gene
This gene is overexpressed in Tlymphocyte (10.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for RPL17-C18orf32 Gene
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL17-C18orf32 Gene
Orthologs for RPL17-C18orf32 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Rpl17 31 |
|
ManyToMany | |
| Gm10362 30 17 |
|
||||
| Gm6133 31 |
|
ManyToMany | |||
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | LOC499522 30 |
|
||
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rpl17 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rpl17 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | RL17_ANOGA 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | RpL17 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rpl-17 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPL17A 31 |
|
ManyToMany | |
| RPL17B 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4564 31 |
|
OneToMany |
- Species where no ortholog for RPL17-C18orf32 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Paralogs for RPL17-C18orf32 Gene
Pseudogenes.org Pseudogenes for RPL17-C18orf32 Gene
Variants for RPL17-C18orf32 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1065279 | CNV | gain | 25217958 |
| nsv1160523 | CNV | deletion | 26073780 |
| nsv2294 | CNV | deletion | 18451855 |
| nsv2295 | CNV | insertion | 18451855 |
| nsv978629 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.18;
39.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RPL17-C18orf32 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RPL17-C18orf32
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL17-C18orf32 Gene
Disorders for RPL17-C18orf32 Gene
Additional Disease Information for RPL17-C18orf32
No disorders were found for RPL17-C18orf32 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL17-C18orf32 Gene
Publications for RPL17-C18orf32 Gene
- Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF. (PMID: 30459231) Marino MM … Pedone PV (The Journal of biological chemistry 2019) 3
- Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease. (PMID: 28902428) Brady GF … Omary MB (Hepatology (Baltimore, Md.) 2018) 3
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
- DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 13
Products for RPL17-C18orf32 Gene
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Sources for RPL17-C18orf32 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (50) miRBase
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- (53) PubMed
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- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
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- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
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- (143) Applied Biosystems
- (144) GlyConnect
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- (148) RNACentral
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- (159) GeneImprint
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- (165) LNCipedia
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- (177) snoDB
- (178) MirGeneDB