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Aliases for RPL15 Gene

Aliases for RPL15 Gene

  • Ribosomal Protein L15 2 3 5
  • Large Ribosomal Subunit Protein EL15 3 4
  • EC45 3 4
  • 60S Ribosomal Protein L15 3
  • RPLY10 3
  • RPYL10 3
  • DBA12 3
  • RPL10 3
  • L15 3

External Ids for RPL15 Gene

Previous GeneCards Identifiers for RPL15 Gene

  • GC03M023392
  • GC03P023641
  • GC03P023807
  • GC03P023933

Summaries for RPL15 Gene

Entrez Gene Summary for RPL15 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]

GeneCards Summary for RPL15 Gene

RPL15 (Ribosomal Protein L15) is a Protein Coding gene. Diseases associated with RPL15 include Diamond-Blackfan Anemia 12 and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL15 Gene

Additional gene information for RPL15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL15 Gene

Genomics for RPL15 Gene

GeneHancer (GH) Regulatory Elements for RPL15 Gene

Promoters and enhancers for RPL15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J023915 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.7 669 4.1 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 NKIRAS1 RPL15 RPL24P7 NR1D2
GH03J023914 Enhancer 0.4 Ensembl 650.7 -1.6 -1644 0.2 OSR2 ZNF664 RPL15 PIR33503 NKIRAS1
GH03J023805 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23.2 -107.7 -107738 6.9 PKNOX1 FOXA2 SMAD1 ARNT SIN3A DMAP1 YBX1 ZNF2 YY1 POLR2B UBE2E1-AS1 UBE2E1 RPL15 NKIRAS1 NR1D2 GC03P023841
GH03J024489 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 18 +577.1 577050 7.7 SMAD1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B THRB-AS1 THRB RPL15 ENSG00000272554 THRB-IT1
GH03J024237 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.7 +321.9 321863 1.8 PKNOX1 FEZF1 ZNF2 ZNF213 ZNF143 FOS KLF13 SP3 YY2 REST NR1D2 RPL15 LOC101927854 GC03M024338 THRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL15 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • AML1a
  • C/EBPalpha
  • Pax-4a
  • POU2F1
  • POU2F1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • YY1

Genomic Locations for RPL15 Gene

Genomic Locations for RPL15 Gene
7,830 bases
Plus strand
7,148 bases
Plus strand

Genomic View for RPL15 Gene

Genes around RPL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL15 Gene

Proteins for RPL15 Gene

  • Protein details for RPL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L15
    Protein Accession:
    Secondary Accessions:
    • P39030
    • P41051
    • Q5U0C0
    • Q642I1
    • Q6IPX6
    • Q8WYP2
    • Q96C44
    • Q9H2E5

    Protein attributes for RPL15 Gene

    204 amino acids
    Molecular mass:
    24146 Da
    Quaternary structure:
    • Interacts with IFIT1 (via TPR repeats 1-4).
    • Sequence=AAA36583.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL15 Gene

    Alternative splice isoforms for RPL15 Gene


neXtProt entry for RPL15 Gene

Post-translational modifications for RPL15 Gene

  • Ubiquitination at posLast=179179, posLast=157157, Lys153, posLast=140140, Lys93, posLast=8383, posLast=5656, and posLast=55
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL15 Gene

Domains & Families for RPL15 Gene

Gene Families for RPL15 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL15 family.
  • Belongs to the eukaryotic ribosomal protein eL15 family.
genes like me logo Genes that share domains with RPL15: view

Function for RPL15 Gene

Molecular function for RPL15 Gene

GENATLAS Biochemistry:
60S ribosomal protein L15

Phenotypes From GWAS Catalog for RPL15 Gene

Gene Ontology (GO) - Molecular Function for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IBA --
GO:0003735 structural constituent of ribosome NAS,TAS 12962325
GO:0005515 protein binding IPI 21612406
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL15: view
genes like me logo Genes that share phenotypes with RPL15: view

Human Phenotype Ontology for RPL15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL15 Gene

Localization for RPL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL15 Gene

Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL15 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 25468996
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 9582194
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RPL15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RPL15 Gene

Pathways & Interactions for RPL15 Gene

genes like me logo Genes that share pathways with RPL15: view

Pathways by source for RPL15 Gene

1 KEGG pathway for RPL15 Gene
1 GeneGo (Thomson Reuters) pathway for RPL15 Gene

Gene Ontology (GO) - Biological Process for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,TAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL15: view

No data available for SIGNOR curated interactions for RPL15 Gene

Drugs & Compounds for RPL15 Gene

(3) Drugs for RPL15 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL15: view

Transcripts for RPL15 Gene

Unigene Clusters for RPL15 Gene

Ribosomal protein L15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL15

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL15 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for RPL15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL15 Gene

This gene is overexpressed in Ovary (6.5) and Saliva (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL15 Gene

Protein tissue co-expression partners for RPL15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL15 Gene:


SOURCE GeneReport for Unigene cluster for RPL15 Gene:


Evidence on tissue expression from TISSUES for RPL15 Gene

  • Nervous system(5)
  • Intestine(4.9)
  • Lung(4.9)
  • Skin(4.9)
  • Pancreas(4.8)
  • Bone(4.7)
  • Eye(4.5)
  • Blood(4.4)
  • Heart(4)
  • Kidney(3.9)
  • Liver(3.8)
  • Muscle(3.5)
  • Stomach(3)
  • Thyroid gland(2.5)
  • Bone marrow(2.4)
  • Lymph node(2.4)
  • Adrenal gland(2.3)
  • Spleen(2.3)
  • Gall bladder(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL15 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • inner ear
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • aorta
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • intestine
  • kidney
  • large intestine
  • pelvis
  • penis
  • ureter
  • urethra
  • urinary bladder
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with RPL15: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL15 Gene

Orthologs for RPL15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL15 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia RPL15 34
  • 100 (a)
(Monodelphis domestica)
Mammalia RPL15 34
  • 100 (a)
(Pan troglodytes)
Mammalia RPL15 34 33
  • 99.67 (n)
(Mus musculus)
Mammalia Rpl15 16 34 33
  • 93.14 (n)
(Canis familiaris)
Mammalia RPL15 34 33
  • 93.14 (n)
(Rattus norvegicus)
Mammalia Rpl15 33
  • 91.67 (n)
(Bos Taurus)
Mammalia RPL15 34 33
  • 89.54 (n)
(Gallus gallus)
Aves RPL15 34 33
  • 83.17 (n)
(Anolis carolinensis)
Reptilia RPL15 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl15 33
  • 81.86 (n)
Str.6192 33
African clawed frog
(Xenopus laevis)
Amphibia rpl15-prov 33
(Danio rerio)
Actinopterygii rpl15 34 33
  • 79.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RL15_ANOGA 33
  • 66.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL15 34 35 33
  • 64.71 (n)
(Caenorhabditis elegans)
Secernentea rpl-15 34 35
  • 76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL15A 34
  • 71 (a)
RPL15B 34 33
  • 60.92 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR214C 33
  • 62.56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17633g 33
  • 61.74 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16720 33
  • 65.35 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10328 33
(Oryza sativa)
Liliopsida Os05g0274700 33
  • 67 (n)
(Triticum aestivum)
Liliopsida Ta.26531 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7913 34
  • 83 (a)
Cin.10603 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl15 33
  • 65.67 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01776 33
  • 64.53 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10603 33
Species where no ortholog for RPL15 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL15 Gene

Gene Tree for RPL15 (if available)
Gene Tree for RPL15 (if available)
Evolutionary constrained regions (ECRs) for RPL15: view image

Paralogs for RPL15 Gene

(1) SIMAP similar genes for RPL15 Gene using alignment to 5 proteins:

  • RL15_HUMAN
  • E7EX53_HUMAN
genes like me logo Genes that share paralogs with RPL15: view

No data available for Paralogs for RPL15 Gene

Variants for RPL15 Gene

Sequence variations from dbSNP and Humsavar for RPL15 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs886041445 pathogenic, not provided 23,919,194(+) A/G splice_acceptor_variant
rs35629664 likely-benign, not specified 23,917,934(+) C/G/T coding_sequence_variant, synonymous_variant
rs1000387932 -- 23,916,005(+) T/C upstream_transcript_variant
rs1000436754 -- 23,916,207(+) T/C upstream_transcript_variant
rs1000942407 -- 23,922,343(+) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL15 Gene

Variant ID Type Subtype PubMed ID
nsv1005186 CNV gain 25217958
nsv834638 CNV loss 17160897
nsv966996 CNV duplication 23825009

Variation tolerance for RPL15 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL15 Gene

Disorders for RPL15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPL15 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 12
  • dba12
diamond-blackfan anemia
  • diamond-blackfan anemia 1
retinitis pigmentosa 10
  • rp10
macrocytic anemia
  • anemia macrocytic
pierre robin syndrome
  • prbns
- elite association - COSMIC cancer census association via MalaCards
Search RPL15 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 12 (DBA12) [MIM:615550]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:23812780}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for RPL15

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPL15: view

No data available for Genatlas for RPL15 Gene

Publications for RPL15 Gene

  1. Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. (PMID: 23812780) Landowski M … Gazda HT (Human genetics 2013) 3 4 58
  2. A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells. (PMID: 21612406) Hsu YA … Chen BH (DNA and cell biology 2011) 3 4 58
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RPL15 Gene

Sources for RPL15 Gene

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