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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repre... See more...
Aliases for RPL13A Gene
Aliases for RPL13A Gene
External Ids for RPL13A Gene
- HGNC: 10304
- Entrez Gene: 23521
- Ensembl: ENSG00000142541
- UniProtKB: P40429
Previous HGNC Symbols for RPL13A Gene
- TSTA1
Previous GeneCards Identifiers for RPL13A Gene
- GC19P050649
- GC19P050359
- GC19P054666
- GC19P054682
- GC19P049991
Summaries for RPL13A Gene
-
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for RPL13A Gene
RPL13A (Ribosomal Protein L13a) is a Protein Coding gene. Diseases associated with RPL13A include Spermatogenic Failure 2 and Spermatogenic Failure 1. Among its related pathways are rRNA processing in the nucleus and cytosol and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is MRPL13.
UniProtKB/Swiss-Prot Summary for RPL13A Gene
-
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Additional gene information for RPL13A Gene
- HGNC(10304)
- Entrez Gene(23521)
- Ensembl(ENSG00000142541)
- UniProtKB(P40429)
- Open Targets Platform(ENSG00000142541)
- Search for RPL13A at DataMed
- Search for RPL13A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL13A Gene
Genomics for RPL13A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RPL13A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RPL13A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL13A
- Top Transcription factor binding sites by QIAGEN in the RPL13A gene promoter:
-
- AhR
- AP-4
- Arnt
- c-Ets-1
- E47
- FOXL1
- STAT3
- STAT5A
- Tal-1beta
- TBP
Genomic Locations for RPL13A Gene
Genomic Locations for RPL13A Gene
- chr19:49,487,554-49,492,308
- (GRCh38/hg38)
- Size:
- 4,755 bases
- Orientation:
- Plus strand
- chr19:49,990,811-49,995,565
- (GRCh37/hg19)
- Size:
- 4,755 bases
- Orientation:
- Plus strand
Genomic View for RPL13A Gene
Genes around RPL13A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
RPL13A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPL13A Gene
Proteins for RPL13A Gene
-
Protein details for RPL13A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40429-RL13A_HUMAN
- Recommended name:
- 60S ribosomal protein L13a
- Protein Accession:
- P40429
- A8K505
Protein attributes for RPL13A Gene
- Size:
- 203 amino acids
- Molecular mass:
- 23577 Da
- Quaternary structure:
-
- Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1.
Protein Expression for RPL13A Gene
Post-translational modifications for RPL13A Gene
- Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.
- Citrullinated by PADI4.
-
Ubiquitination at Lys25, Lys51, Lys53, Lys134, Lys148, and Lys191
- NX_P40429 (NX_P40429-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RPL13A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RPL13A Antibody
- GeneTex Anti-RPL13A antibody [N1C3]
- Novus Biologicals Antibodies for RPL13A
-
Abcam antibodies for RPL13A
- Invitrogen Antibodies for RPL13A (AFLGC-RPL13A)
-
Biorbyt antibodies for RPL13A
-
Santa Cruz Biotechnology (SCBT) Antibodies for RPL13A
Protein Products
-
OriGene Purified Proteins for RPL13A
- Search Origene for MassSpec and Protein Over-expression Lysates for RPL13A
- Origene Custom Protein Services for RPL13A
- Novus Biologicals proteins for RPL13A
-
Signalway Proteins for RPL13A
-
Abcam proteins for RPL13A
Assay Products
- antibodies-online: Show 7 available RPL13A Elisa Kits ranked by validation data
- Compare Top RPL13A Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for RPL13A
No data available for DME Specific Peptides for RPL13A Gene
Domains & Families for RPL13A Gene
Gene Families for RPL13A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for RPL13A Gene
- InterPro:
- Blocks:
-
- Ribosomal protein L13
- ProtoNet:
Suggested Antigen Peptide Sequences for RPL13A Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51256, highly similar to 60S ribosomal protein L13a (B4DNC8_HUMAN)
- RPL13A protein (Q0VGL3_HUMAN)
- Ribosomal protein L13a, isoform CRA_b (Q8J015_HUMAN)
- RPL13A protein (Q9BSQ6_HUMAN)
- 23 kDa highly basic protein (RL13A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P40429- Family:
-
- Belongs to the universal ribosomal protein uL13 family.
Function for RPL13A Gene
Molecular function for RPL13A Gene
- UniProtKB/Swiss-Prot Function:
- Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
- GENATLAS Biochemistry:
- 60S ribosomal protein L13-2
Phenotypes From GWAS Catalog for RPL13A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003729 | mRNA binding | IBA | 21873635 |
| GO:0003735 | structural constituent of ribosome | IEA,NAS | 12962325 |
Phenotypes for RPL13A Gene
- MGI mutant phenotypes for RPL13A:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for RPL13A:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased cell number
- Inconclusive
- Increased S DNA content
- Decreased homologous recombination repair frequency
- Decreased G3BP1 protein expression and assembly in stress granules and decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- S arrest
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RPL13A - Select products 50% OFF >
- * RPL13A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RPL13A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPL13A
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPL13A
miRNA for RPL13A Gene
- miRTarBase miRNAs that target RPL13A
-
- hsa-miR-877-3p (MIRT037072)
- hsa-miR-769-3p (MIRT039128)
- hsa-miR-576-5p (MIRT040518)
- hsa-miR-320a (MIRT044446)
- hsa-miR-197-3p (MIRT048145)
- hsa-miR-92a-3p (MIRT049196)
- hsa-miR-26a-5p (MIRT050090)
- hsa-miR-3912-3p (MIRT293948)
- hsa-miR-3915 (MIRT293949)
- hsa-miR-3928-3p (MIRT293950)
- hsa-miR-6721-5p (MIRT454598)
- hsa-miR-4742-5p (MIRT454599)
- hsa-miR-7843-5p (MIRT454600)
- hsa-miR-6879-5p (MIRT454601)
- hsa-miR-6735-5p (MIRT454602)
- hsa-miR-4632-5p (MIRT454603)
- hsa-miR-4436b-3p (MIRT454604)
- hsa-miR-125a-3p (MIRT736632)
- hsa-miR-181a-5p (MIRT738026)
- hsa-miR-181b-5p (MIRT738035)
- hsa-miR-181c-5p (MIRT738042)
- hsa-miR-181d-5p (MIRT738050)
- hsa-miR-196a-3p (MIRT738649)
- hsa-miR-214-5p (MIRT739013)
- hsa-miR-3150b-3p (MIRT740329)
- hsa-miR-3202 (MIRT741171)
- hsa-miR-3678-5p (MIRT742175)
- hsa-miR-4262 (MIRT743485)
- hsa-miR-4476 (MIRT745049)
- hsa-miR-4649-5p (MIRT746501)
- hsa-miR-4685-5p (MIRT746971)
- hsa-miR-4689 (MIRT747040)
- hsa-miR-4710 (MIRT747422)
- hsa-miR-4784 (MIRT748846)
- hsa-miR-4802-5p (MIRT749019)
- hsa-miR-552-3p (MIRT750885)
- hsa-miR-6514-3p (MIRT753267)
- hsa-miR-6717-5p (MIRT753733)
- hsa-miR-6729-5p (MIRT753964)
- hsa-miR-6811-3p (MIRT756678)
- hsa-miR-6837-5p (MIRT757253)
- hsa-miR-6858-5p (MIRT757798)
- hsa-miR-6876-5p (MIRT758159)
- hsa-miR-6894-5p (MIRT758790)
- hsa-miR-7113-5p (MIRT759121)
- hsa-miR-7154-3p (MIRT759241)
- hsa-miR-765 (MIRT759587)
- hsa-miR-766-5p (MIRT759659)
- hsa-miR-103a-2-5p (MIRT761084)
- hsa-miR-138-2-3p (MIRT762601)
- hsa-miR-141-5p (MIRT762644)
- hsa-miR-323b-5p (MIRT765562)
- hsa-miR-410-5p (MIRT767923)
- hsa-miR-4777-5p (MIRT772235)
- hsa-miR-494-5p (MIRT772769)
- hsa-miR-518d-5p (MIRT773594)
- hsa-miR-518e-5p (MIRT773597)
- hsa-miR-518f-5p (MIRT773600)
- hsa-miR-519a-5p (MIRT773688)
- hsa-miR-519b-5p (MIRT773702)
- hsa-miR-519c-5p (MIRT773716)
- hsa-miR-520c-5p (MIRT773797)
- hsa-miR-522-5p (MIRT773895)
- hsa-miR-523-5p (MIRT773898)
- hsa-miR-526a (MIRT773911)
- hsa-miR-544a (MIRT773990)
- hsa-miR-6071 (MIRT775431)
- hsa-miR-6508-5p (MIRT776629)
- hsa-miR-6738-3p (MIRT778098)
- hsa-miR-6828-3p (MIRT779949)
- hsa-miR-7977 (MIRT782286)
- hsa-miR-8067 (MIRT782362)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPL13A
- Browse OriGene Inhibitory RNA Products For RPL13A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL13A
Clone Products
- Applied Biological Materials (abm): Clones for RPL13A - Select products 50% OFF >
- * RPL13A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RPL13A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPL13A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL13A Gene
Localization for RPL13A Gene
Subcellular locations from UniProtKB/Swiss-Prot for RPL13A Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005730 | nucleolus | HDA | 16791210 |
| GO:0005737 | cytoplasm | IEA,HDA | 16791210 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005840 | ribosome | IEA,IBA | 21873635 |
Pathways & Interactions for RPL13A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
CFTR translational fidelity (class I mutations)
.79
.77
.53
|
|
| 2 | Influenza Viral RNA Transcription and Replication | ||
| 3 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Translational Control | ||
Pathways by source for RPL13A Gene
1 BioSystems pathway for RPL13A Gene
28 Reactome pathways for RPL13A Gene
1 KEGG pathway for RPL13A Gene
1 GeneGo (Thomson Reuters) pathway for RPL13A Gene
- CFTR translational fidelity (class I mutations)
1 Cell Signaling Technology pathway for RPL13A Gene
Interacting Proteins for RPL13A Gene
Selected Interacting proteins:
P40429-RL13A_HUMAN
ENSP00000375730
for RPL13A Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for RPL13A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
| GO:0006412 | translation | IEA,NAS | 12962325 |
| GO:0006413 | translational initiation | TAS | -- |
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | -- |
Transcripts for RPL13A Gene
mRNA/cDNA for RPL13A Gene
- 2 REFSEQ mRNAs :
- 22 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000391857 1127 nts (view in UCSC)
- ENST00000467825 660 nts (view in UCSC)
- ENST00000468655 407 nts (view in UCSC)
- ENST00000472481 728 nts (view in UCSC)
- ENST00000474171 521 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RPL13A - Select products 50% OFF >
- * RPL13A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RPL13A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPL13A
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPL13A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPL13A
- Browse OriGene Inhibitory RNA Products For RPL13A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL13A
Clone Products
- Applied Biological Materials (abm): Clones for RPL13A - Select products 50% OFF >
- * RPL13A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RPL13A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPL13A
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | ||||||||||||||||||||||||||||||||||||
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| SP13: | - | - | |||||||||||||||||||||||||||||||||||||
| SP14: |
Relevant External Links for RPL13A Gene
- GeneLoc Exon Structure for
- RPL13A
Expression for RPL13A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tonsil (Hematopoietic System)
This gene is overexpressed in Nasal epithelium (13.7) and Peripheral blood mononuclear cells (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL13A Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL13A
SOURCE GeneReport for Unigene cluster for RPL13A Gene:
Hs.523185Evidence on tissue expression from TISSUES for RPL13A Gene
- Lung(5)
- Pancreas(5)
- Skin(5)
- Nervous system(5)
- Muscle(5)
- Intestine(4.9)
- Liver(4.9)
- Eye(4.9)
- Kidney(4.8)
- Bone(4.7)
- Stomach(4.7)
- Blood(4.7)
- Heart(4.4)
- Spleen(4.2)
- Lymph node(3.2)
- Bone marrow(3.1)
- Thyroid gland(3)
- Adrenal gland(2.8)
Primer Products
-
OriGene qPCR primer pairs for RPL13A
-
OriGene qPCR primer pairs and template standards for RPL13A
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL13A Gene
Orthologs for RPL13A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RPL13A 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RPL13A 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RPL13A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RPL13A 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Rpl13a-ps1 31 |
|
OneToMany | |
| Rpl13a 30 17 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Rpl13a 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RPL13A 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RPL13A 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rpl13a 30 |
|
||
| Str.6691 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | rpl13a-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rpl13a 30 31 |
|
OneToOne | |
| Gstp1 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | RpL13A 30 31 |
|
OneToOne | |
| CG1475 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | rpl-16 30 31 32 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F04675g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER367C 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPL16A 31 |
|
OneToMany | |
| RPL16B 31 |
|
OneToMany | |||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7126 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.2053 30 |
|
||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.12482 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.807 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.4020 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3458 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU01221 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpl1601 30 |
|
- Species where no ortholog for RPL13A was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for RPL13A Gene
- ENSEMBL:
- Gene Tree for RPL13A (if available)
- TreeFam:
- Gene Tree for RPL13A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RPL13A: view image
Paralogs for RPL13A Gene
(1) SIMAP similar genes for RPL13A Gene using alignment to 5 proteins:
- RL13A_HUMAN
- M0QYS1_HUMAN
- M0QZU1_HUMAN
- Q0VGL3_HUMAN
- Q9BSQ6_HUMAN
Pseudogenes.org Pseudogenes for RPL13A Gene
- PGOHUM00000290831
- PGOHUM00000291186
- PGOHUM00000291280
- PGOHUM00000291319
- PGOHUM00000291559
- PGOHUM00000291692
- PGOHUM00000292345
- PGOHUM00000292673
- PGOHUM00000292744
- PGOHUM00000295701
- PGOHUM00000295796
- PGOHUM00000296735
- PGOHUM00000296744
- PGOHUM00000297364
- PGOHUM00000306010
- PGOHUM00000298843
- PGOHUM00000298944
- PGOHUM00000300259
- PGOHUM00000300659
- PGOHUM00000306063
- PGOHUM00000300950
- PGOHUM00000301525
- PGOHUM00000301729
- PGOHUM00000302827
- PGOHUM00000302886
- PGOHUM00000303264
- PGOHUM00000304466
- PGOHUM00000287756
- PGOHUM00000289037
- PGOHUM00000306883
- PGOHUM00000289207
- PGOHUM00000289303
- PGOHUM00000289395
- PGOHUM00000289484
- PGOHUM00000289858
- PGOHUM00000289990
Variants for RPL13A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL13A Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 715747 | Likely Benign: not provided | 49,490,776(+) | C/T | INTRON_VARIANT | |
| 723856 | Benign: not provided | 49,490,813(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 750491 | Likely Benign: not provided | 49,491,743(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 769031 | Benign: not provided | 49,490,225(+) | C/T | INTRON_VARIANT | |
| 770467 | Benign: not provided | 49,491,420(+) | C/G | INTRON_VARIANT |
Residual Variation Intolerance Score:
49.1% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RPL13A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RPL13A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL13A Gene
Disorders for RPL13A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spermatogenic failure 2 |
|
|
| spermatogenic failure 1 |
|
|
| haemophilus meningitis |
|
|
| retinitis pigmentosa 22 |
|
|
| diamond-blackfan anemia |
|
|
Search RPL13A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RPL13A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RPL13A Gene
Publications for RPL13A Gene
- DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. (PMID: 18995835) Mukhopadhyay R … Fox PL (Molecular cell 2008) 3 4 23
- Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation. (PMID: 17921318) Chaudhuri S … Mazumder B (RNA (New York, N.Y.) 2007) 3 4 23
- L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control. (PMID: 17218275) Kapasi P … Mazumder B (Molecular cell 2007) 3 4 23
- Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. (PMID: 14567916) Mazumder B … Fox PL (Cell 2003) 3 4 23
- Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome. (PMID: 10580157) Higa S … Kenmochi N (Gene 1999) 3 4 23
ExternalLinks
Products for RPL13A Gene
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- OriGene Purified Proteins for RPL13A
- Search Origene for MassSpec and Protein Over-expression Lysates for RPL13A
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- Browse OriGene Inhibitory RNA Products For RPL13A
- OriGene qPCR primer pairs for RPL13A
- OriGene qPCR primer pairs and template standards for RPL13A
- OriGene CRISPR knockouts for RPL13A
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- Sino Biological Human cDNA Clone for RPL13A
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for RPL13A
- Novus Biologicals proteins for RPL13A