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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in t... See more...
Aliases for RPL12 Gene
Aliases for RPL12 Gene
External Ids for RPL12 Gene
- HGNC: 10302
- NCBI Entrez Gene: 6136
- Ensembl: ENSG00000197958
- OMIM®: 180475
- UniProtKB/Swiss-Prot: P30050
Previous GeneCards Identifiers for RPL12 Gene
- GC09M121324
- GC09M121856
- GC09M123663
- GC09M125586
- GC09M127289
- GC09M129250
- GC09M130209
- GC09M099825
Summaries for RPL12 Gene
-
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
GeneCards Summary for RPL12 Gene
RPL12 (Ribosomal Protein L12) is a Protein Coding gene. Diseases associated with RPL12 include Neuronopathy, Distal Hereditary Motor, Type Viii and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is MRPL11.
UniProtKB/Swiss-Prot Summary for RPL12 Gene
-
Binds directly to 26S ribosomal RNA.
Additional gene information for RPL12 Gene
- HGNC (10302)
- NCBI Entrez Gene (6136)
- Ensembl (ENSG00000197958)
- OMIM® (180475)
- UniProtKB/Swiss-Prot (P30050)
- Open Targets Platform(ENSG00000197958)
- Search for RPL12 at DataMed
- Search for RPL12 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPL12 Gene
Genomics for RPL12 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RPL12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RPL12 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPL12
- Top Transcription factor binding sites by QIAGEN in the RPL12 gene promoter:
-
- AP-4
- AREB6
- E2F
- E2F-1
- FAC1
- LCR-F1
- Lmo2
- NF-E2
- NF-E2 p45
- TGIF
Genomic Locations for RPL12 Gene
Latest Assembly
- chr9:127,447,674-127,451,406
- (GRCh38/hg38)
- Size:
- 3,733 bases
- Orientation:
- Minus strand
Previous Assembly
- chr9:130,209,953-130,213,685
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,733 bases
- Orientation:
- Minus strand
- chr9:130,209,953-130,213,684
- (GRCh37/hg19 by Ensembl)
- Size:
- 3,732 bases
- Orientation:
- Minus strand
Genomic View for RPL12 Gene
Genes around RPL12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q33.3 by HGNC
- 9q33.3 by Entrez Gene
- 9q33.3 by Ensembl
RPL12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPL12 Gene
Proteins for RPL12 Gene
-
Protein details for RPL12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30050-RL12_HUMAN
- Recommended name:
- 60S ribosomal protein L12
- Protein Accession:
- P30050
- Q5VVV2
- Q6PB27
Protein attributes for RPL12 Gene
- Size:
- 165 amino acids
- Molecular mass:
- 17819 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for RPL12 Gene
Protein Expression for RPL12 Gene
Post-translational modifications for RPL12 Gene
Other Protein References for RPL12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences RPL12 / Ribosomal Protein L12 Antibody
- G Biosciences Immunotag™ RPL12 Antibody
-
Custom Antibody ServicesOriGene Antibodies for RPL12
- Novus Biologicals Antibodies for RPL12
-
Abcam antibodies for RPL12
- Invitrogen Antibodies for RPL12 (AFLGC-RPL12)
-
Custom Antibody ServicesProSci Antibodies for RPL12
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for RPL12
- Origene Custom Protein Services for RPL12
- ProSpec Recombinant Proteins for RPL12
-
Abcam proteins for RPL12
Assay products for research
No data available for DME Specific Peptides for RPL12 Gene
Domains & Families for RPL12 Gene
Gene Families for RPL12 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for RPL12 Gene
- InterPro:
- Blocks:
-
- Ribosomal protein L11
- ProtoNet:
Suggested Antigen Peptide Sequences for RPL12 Gene
- GenScript: Design optimal peptide antigens:
-
- 60S ribosomal protein L12 (RL12_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P30050- Family:
-
- Belongs to the universal ribosomal protein uL11 family.
Function for RPL12 Gene
Molecular function for RPL12 Gene
- UniProtKB/Swiss-Prot Function:
- Binds directly to 26S ribosomal RNA.
- GENATLAS Biochemistry:
- 60S ribosomal protein L12
Phenotypes From GWAS Catalog for RPL12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA,HDA | 22681889 |
| GO:0003735 | structural constituent of ribosome | IBA,NAS | 12962325 |
| GO:0005515 | protein binding | IPI | 22314232 |
| GO:0070180 | large ribosomal subunit rRNA binding | IBA | 21873635 |
Phenotypes for RPL12 Gene
- MGI mutant phenotypes for RPL12:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RPL12:
-
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Decreased viability
- no effect
- Decreased vaccinia virus (VACV) infection
- Reduced mammosphere formation
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Nuclear 60S biogenesis defects
- Decreased cell number
- Decreased viability of wild-type and TP53 knockout cells
- Decreased Sindbis virus (SINV) infection
- Decreased HIV-1 infection
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RPL12 - Starting at $85 >
- * RPL12 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RPL12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPL12
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPL12
miRNA for RPL12 Gene
- miRTarBase miRNAs that target RPL12
-
- mmu-miR-24-3p (MIRT013735)
- hsa-miR-16-5p (MIRT031402)
- hsa-miR-193b-3p (MIRT041418)
- hsa-let-7g-5p (MIRT046558)
- hsa-miR-222-3p (MIRT046650)
- hsa-miR-218-5p (MIRT046988)
- hsa-let-7e-5p (MIRT051475)
- hsa-let-7b-5p (MIRT051997)
- hsa-miR-6864-3p (MIRT446148)
- hsa-miR-3672 (MIRT446149)
- hsa-miR-4769-5p (MIRT446150)
- hsa-miR-580-3p (MIRT446151)
- hsa-miR-4654 (MIRT446152)
- hsa-miR-6778-5p (MIRT446153)
- hsa-miR-1233-5p (MIRT446154)
- hsa-miR-4648 (MIRT446155)
- hsa-miR-5196-5p (MIRT446156)
- hsa-miR-4747-5p (MIRT446157)
- hsa-miR-873-3p (MIRT446158)
- hsa-miR-539-5p (MIRT446159)
- hsa-miR-134-3p (MIRT446160)
- hsa-miR-1273g-3p (MIRT682942)
- hsa-miR-7703 (MIRT682943)
- hsa-miR-6720-5p (MIRT682944)
- hsa-miR-6512-3p (MIRT682945)
- hsa-miR-31-5p (MIRT682946)
- hsa-miR-661 (MIRT682947)
- hsa-miR-6860 (MIRT682948)
- hsa-miR-612 (MIRT682949)
- hsa-miR-5189-5p (MIRT682950)
- hsa-miR-3187-5p (MIRT682951)
- hsa-miR-1285-3p (MIRT682952)
- hsa-miR-4793-3p (MIRT682953)
- hsa-miR-766-3p (MIRT682954)
- hsa-miR-939-3p (MIRT682955)
- hsa-miR-6849-3p (MIRT682956)
- hsa-miR-335-5p (MIRT682957)
- hsa-miR-508-5p (MIRT682958)
- hsa-miR-200a-3p (MIRT682959)
- hsa-miR-141-3p (MIRT682960)
- hsa-miR-3675-3p (MIRT766692)
- hsa-miR-4293 (MIRT768443)
- hsa-miR-4433a-3p (MIRT769036)
- hsa-miR-4684-5p (MIRT771024)
- hsa-miR-4786-5p (MIRT772324)
- hsa-miR-548c-3p (MIRT774339)
- hsa-miR-6771-3p (MIRT778654)
- hsa-miR-769-5p (MIRT781967)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPL12
- Browse OriGene Inhibitory RNA Products For RPL12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL12
Clone products for research
- Applied Biological Materials (abm): Clones for RPL12 - Starting at $45 >
- * RPL12 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RPL12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPL12
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL12 Gene
Localization for RPL12 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 3 |
| golgi apparatus | 3 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005840 | ribosome | IEA | -- |
| GO:0005925 | focal adhesion | HDA | 21423176 |
| GO:0014069 | postsynaptic density | IDA | 21170055 |
| GO:0015934 | large ribosomal subunit | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL12 Gene
Pathways & Interactions for RPL12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
CFTR translational fidelity (class I mutations)
.79
.77
.53
|
|
| 2 | Influenza Viral RNA Transcription and Replication | ||
| 3 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Gene Expression |
.48
|
|
Pathways by source for RPL12 Gene
1 BioSystems pathway for RPL12 Gene
28 Reactome pathways for RPL12 Gene
2 KEGG pathways for RPL12 Gene
1 GeneGo (Thomson Reuters) pathway for RPL12 Gene
- CFTR translational fidelity (class I mutations)
Interacting Proteins for RPL12 Gene
Selected Interacting proteins:
P30050-RL12_HUMAN
ENSP00000354739
for RPL12 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RPL12
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000027 | ribosomal large subunit assembly | IBA | -- |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
| GO:0006412 | translation | IBA,NAS | 12962325 |
| GO:0006413 | translational initiation | TAS | -- |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | -- |
Transcripts for RPL12 Gene
mRNA/cDNA for RPL12 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000361436 634 nts (view in UCSC)
- ENST00000483598 344 nts (view in UCSC)
- ENST00000497322 2275 nts (view in UCSC)
- ENST00000497825 864 nts (view in UCSC)
- ENST00000536368 499 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RPL12 - Starting at $85 >
- * RPL12 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RPL12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPL12
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPL12
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPL12
- Browse OriGene Inhibitory RNA Products For RPL12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL12
Clone products for research
- Applied Biological Materials (abm): Clones for RPL12 - Starting at $45 >
- * RPL12 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RPL12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPL12
Relevant External Links for RPL12 Gene
- GeneLoc Exon Structure for
- RPL12
Expression for RPL12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Tlymphocyte (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL12 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPL12
SOURCE GeneReport for Unigene cluster for RPL12 Gene:
Hs.408054Evidence on tissue expression from TISSUES for RPL12 Gene
- Liver(4.9)
- Nervous system(4.7)
- Lung(4.6)
- Pancreas(4.5)
- Skin(4.4)
- Blood(4.4)
- Eye(4.4)
- Intestine(4.2)
- Muscle(3.7)
- Bone(3.6)
- Kidney(3.6)
- Stomach(3.2)
- Heart(3.1)
- Spleen(2.5)
Primer products for research
-
OriGene qPCR primer pairs for RPL12
-
OriGene qPCR primer pairs and template standards for RPL12
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL12 Gene
Orthologs for RPL12 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RPL12 31 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RPL12 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | RPL12 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | RPL12 30 31 31 |
|
OneToMany | |
| Rat (Rattus norvegicus) |
Mammalia | LOC102555453 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rpl12 30 17 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | RPL12 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RPL12 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rpl12 30 |
|
||
| Str.17078 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | rpl12-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rpl12 30 31 |
|
OneToOne | |
| Dr.24686 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8947 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010065 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | RpL12 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | rpl-12 30 31 32 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPL12B 31 |
|
OneToMany | |
| RPL12A 30 31 |
|
OneToMany | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAR134W 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A01903g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G37190 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1323 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.11290 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os04g0598200 30 |
|
||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.656 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8009 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU01317 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpl1202 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3108 30 |
|
- Species where no ortholog for RPL12 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RPL12 Gene
- ENSEMBL:
- Gene Tree for RPL12 (if available)
- TreeFam:
- Gene Tree for RPL12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RPL12: view image
Paralogs for RPL12 Gene
(1) SIMAP similar genes for RPL12 Gene using alignment to 1 proteins:
- RL12_HUMAN
Pseudogenes.org Pseudogenes for RPL12 Gene
- PGOHUM00000290437
- PGOHUM00000290861
- PGOHUM00000291144
- PGOHUM00000291611
- PGOHUM00000291823
- PGOHUM00000292183
- PGOHUM00000292319
- PGOHUM00000292611
- PGOHUM00000292711
- PGOHUM00000293003
- PGOHUM00000293883
- PGOHUM00000294172
- PGOHUM00000294556
- PGOHUM00000294769
- PGOHUM00000294813
- PGOHUM00000294883
- PGOHUM00000295393
- PGOHUM00000296225
- PGOHUM00000296255
- PGOHUM00000296277
- PGOHUM00000296975
- PGOHUM00000297122
- PGOHUM00000297145
- PGOHUM00000297244
- PGOHUM00000298089
- PGOHUM00000298303
- PGOHUM00000298425
- PGOHUM00000298494
- PGOHUM00000299423
- PGOHUM00000300186
- PGOHUM00000300771
- PGOHUM00000300825
- PGOHUM00000301781
- PGOHUM00000301797
- PGOHUM00000302019
- PGOHUM00000302549
- PGOHUM00000303346
- PGOHUM00000303510
- PGOHUM00000304072
- PGOHUM00000304901
- PGOHUM00000304955
- PGOHUM00000305272
- PGOHUM00000289935
- PGOHUM00000289969
- PGOHUM00000289999
- PGOHUM00000290189
Variants for RPL12 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.31;
6.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RPL12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RPL12
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPL12 Gene
Disorders for RPL12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuronopathy, distal hereditary motor, type viii |
|
|
| diamond-blackfan anemia |
|
|
Search RPL12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RPL12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RPL12 Gene
Publications for RPL12 Gene
- The primary structure of human ribosomal protein L12. (PMID: 8441690) Chu W … Burns DK (Nucleic acids research 1993) 2 3 4 23
- Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A … Vieira AR (American journal of medical genetics. Part A 2010) 3 41
- Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 41
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
ExternalLinks
Products for RPL12 Gene
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- Custom Assay Services
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for RPL12
- Browse OriGene Inhibitory RNA Products For RPL12
- OriGene qPCR primer pairs for RPL12
- OriGene qPCR primer pairs and template standards for RPL12
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- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RPL12
- Novus Biologicals proteins and lysates for RPL12
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RPL12
- Abcam proteins for RPL12
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for RPL12 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RPL12 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RPL12 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RPL12 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RPL12
- antibodies-online: Show 18 available RPL12 Antibodies ranked by validation data
- Compare Top RPL12 Antibodies
- antibodies-online: Search results for available RPL12 related products ranked by validation data
- antibodies-online: Show 18 available RPL12 Proteins ranked by validation data
- Compare Top RPL12 Proteins
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for RPL12 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RPL12
- Custom Antibody ServicesProSci Antibodies for RPL12
- Search for RPL12 Proteins at ProSci
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RPL12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RPL12
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RPL12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL12
Sources for RPL12 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB