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Aliases for RPL12 Gene

Aliases for RPL12 Gene

  • Ribosomal Protein L12 2 3 5
  • Large Ribosomal Subunit Protein UL11 3 4
  • 60S Ribosomal Protein L12 3
  • L12 3

External Ids for RPL12 Gene

Previous GeneCards Identifiers for RPL12 Gene

  • GC09M121324
  • GC09M121856
  • GC09M123663
  • GC09M125586
  • GC09M127289
  • GC09M129250
  • GC09M130209
  • GC09M099825

Summaries for RPL12 Gene

Entrez Gene Summary for RPL12 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL12 Gene

RPL12 (Ribosomal Protein L12) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL12 Gene

  • Binds directly to 26S ribosomal RNA.

Gene Wiki entry for RPL12 Gene

Additional gene information for RPL12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL12 Gene

Genomics for RPL12 Gene

GeneHancer (GH) Regulatory Elements for RPL12 Gene

Promoters and enhancers for RPL12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J127446 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 697 +1.9 1902 7.5 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC RPL12 SNORA65 GC09M127449 LRSAM1 ZNF79 NAIF1 LOC102723566 FPGS URM1 ENSG00000272696
GH09J127420 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 33.4 +28.2 28248 4.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 ZNF207 GC09M127421 ZNF79 RPL12 SLC2A8 ENSG00000272696 CDK9 NAIF1 SNORA65 PTRH1 PIR59639
GH09J127734 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24 -284.0 -283995 2.8 HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A YY1 ZNF207 ZNF143 TOR2A GC09P127735 FPGS CIZ1 LOC102723566 ZNF79 RPL12 GOLGA2 URM1 CDK9
GH09J127502 Enhancer 1.2 ENCODE dbSUPER 41 -55.2 -55158 7.7 PKNOX1 ARID4B SIN3A ZNF2 TCF12 ZNF121 ZNF766 GLIS2 GATA2 ARID2 RPL12 SLC2A8 ZNF79 FPGS GLE1 LRSAM1 LOC105376281 ENSG00000200788 FAM129B
GH09J128274 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.9 -824.5 -824483 3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF143 KLF13 SP3 SP5 SWI5 GOLGA2 RPL12 FPGS ZNF79 SNORA65 SLC27A4 LOC102723566 URM1 GLE1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL12 gene promoter:
  • FAC1
  • TGIF
  • Lmo2
  • E2F-1
  • E2F
  • LCR-F1
  • AP-4
  • AREB6
  • NF-E2 p45
  • NF-E2

Genomic Locations for RPL12 Gene

Genomic Locations for RPL12 Gene
3,759 bases
Minus strand
3,759 bases
Minus strand

Genomic View for RPL12 Gene

Genes around RPL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL12 Gene

Proteins for RPL12 Gene

  • Protein details for RPL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L12
    Protein Accession:
    Secondary Accessions:
    • Q5VVV2
    • Q6PB27

    Protein attributes for RPL12 Gene

    165 amino acids
    Molecular mass:
    17819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL12 Gene

    Alternative splice isoforms for RPL12 Gene


neXtProt entry for RPL12 Gene

Post-translational modifications for RPL12 Gene

  • Ubiquitination at posLast=130130, Lys99, Lys83, posLast=6161, and posLast=4848
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL12 Gene

Domains & Families for RPL12 Gene

Gene Families for RPL12 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL11 family.
  • Belongs to the universal ribosomal protein uL11 family.
genes like me logo Genes that share domains with RPL12: view

Function for RPL12 Gene

Molecular function for RPL12 Gene

UniProtKB/Swiss-Prot Function:
Binds directly to 26S ribosomal RNA.
GENATLAS Biochemistry:
60S ribosomal protein L12

Phenotypes From GWAS Catalog for RPL12 Gene

Gene Ontology (GO) - Molecular Function for RPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22681889
GO:0003735 structural constituent of ribosome IBA,NAS 12962325
GO:0005515 protein binding IPI 22314232
GO:0019843 rRNA binding IBA --
genes like me logo Genes that share ontologies with RPL12: view
genes like me logo Genes that share phenotypes with RPL12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL12 Gene

Localization for RPL12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL12 gene
Compartment Confidence
extracellular 5
cytosol 5
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IBA,IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane HDA 19946888
GO:0022625 cytosolic large ribosomal subunit HDA,IBA --
genes like me logo Genes that share ontologies with RPL12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL12 Gene

Pathways & Interactions for RPL12 Gene

genes like me logo Genes that share pathways with RPL12: view

Pathways by source for RPL12 Gene

1 KEGG pathway for RPL12 Gene
1 GeneGo (Thomson Reuters) pathway for RPL12 Gene

SIGNOR curated interactions for RPL12 Gene

Other effect:

Gene Ontology (GO) - Biological Process for RPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IBA 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL12: view

Drugs & Compounds for RPL12 Gene

No Compound Related Data Available

Transcripts for RPL12 Gene

mRNA/cDNA for RPL12 Gene

Unigene Clusters for RPL12 Gene

Ribosomal protein L12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL12

Alternative Splicing Database (ASD) splice patterns (SP) for RPL12 Gene

No ASD Table

Relevant External Links for RPL12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL12 Gene

This gene is overexpressed in Tlymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL12 Gene

Protein tissue co-expression partners for RPL12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL12 Gene:


SOURCE GeneReport for Unigene cluster for RPL12 Gene:


Evidence on tissue expression from TISSUES for RPL12 Gene

  • Liver(4.9)
  • Nervous system(4.6)
  • Lung(4.5)
  • Pancreas(4.4)
  • Eye(4.3)
  • Skin(4.2)
  • Intestine(4)
  • Bone(3.6)
  • Muscle(3.5)
  • Kidney(3.3)
  • Stomach(3.2)
  • Heart(2.7)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with RPL12: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL12 Gene

Orthologs for RPL12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL12 34 34
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPL12 34
  • 96 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 95 (a)
-- 34
  • 82 (a)
(Canis familiaris)
Mammalia RPL12 34 33
  • 93.33 (n)
-- 34
  • 85 (a)
-- 34
  • 81 (a)
-- 34
  • 66 (a)
(Bos Taurus)
Mammalia RPL12 34 34 33
  • 91.52 (n)
(Rattus norvegicus)
Mammalia LOC102555453 33
  • 90.1 (n)
(Mus musculus)
Mammalia Rpl12 16 34 33
  • 89.49 (n)
(Gallus gallus)
Aves RPL12 34 33
  • 81.21 (n)
(Anolis carolinensis)
Reptilia RPL12 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl12 33
  • 80.61 (n)
Str.17078 33
African clawed frog
(Xenopus laevis)
Amphibia rpl12-prov 33
(Danio rerio)
Actinopterygii rpl12 34 33
  • 78.73 (n)
Dr.24686 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8947 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010065 33
  • 72.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL12 34 35 33
  • 70.12 (n)
(Caenorhabditis elegans)
Secernentea rpl-12 34 35 33
  • 69.11 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL12B 34
  • 70 (a)
RPL12A 34 33
  • 66.67 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR134W 33
  • 66.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01903g 33
  • 64.83 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37190 33
  • 62.58 (n)
(Glycine max)
eudicotyledons Gma.11290 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1323 33
(Oryza sativa)
Liliopsida Os04g0598200 33
  • 64.04 (n)
(Hordeum vulgare)
Liliopsida Hv.656 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8009 34
  • 75 (a)
Cin.3108 33
bread mold
(Neurospora crassa)
Ascomycetes NCU01317 33
  • 65.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1201 33
  • 64.83 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3108 33
Species where no ortholog for RPL12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL12 Gene

Gene Tree for RPL12 (if available)
Gene Tree for RPL12 (if available)
Evolutionary constrained regions (ECRs) for RPL12: view image

Paralogs for RPL12 Gene

(1) SIMAP similar genes for RPL12 Gene using alignment to 1 proteins:

  • RL12_HUMAN
genes like me logo Genes that share paralogs with RPL12: view

No data available for Paralogs for RPL12 Gene

Variants for RPL12 Gene

Sequence variations from dbSNP and Humsavar for RPL12 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs116498902 likely-benign, Charcot-Marie-Tooth, Type 2 127,451,542(-) C/T upstream_transcript_variant
rs749626964 uncertain-significance, Charcot-Marie-Tooth, Type 2 127,451,785(-) TTGTTGT/TTGT upstream_transcript_variant
rs760403428 uncertain-significance, likely-benign, Charcot-Marie-Tooth, Type 2, not specified 127,451,659(-) A/G upstream_transcript_variant
rs886063451 uncertain-significance, Charcot-Marie-Tooth, Type 2 127,451,779(-) G/A/T upstream_transcript_variant
rs886063453 uncertain-significance, Charcot-Marie-Tooth, Type 2 127,451,808(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL12 Gene

Variant ID Type Subtype PubMed ID
nsv972452 CNV duplication 23825009

Variation tolerance for RPL12 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL12 Gene

Disorders for RPL12 Gene

Additional Disease Information for RPL12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RPL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL12 Gene

Publications for RPL12 Gene

  1. The primary structure of human ribosomal protein L12. (PMID: 8441690) Chu W … Burns DK (Nucleic acids research 1993) 2 3 4 22 58
  2. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A … Vieira AR (American journal of medical genetics. Part A 2010) 3 44 58
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58

Products for RPL12 Gene

Sources for RPL12 Gene

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