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Aliases for RPL11 Gene

Aliases for RPL11 Gene

  • Ribosomal Protein L11 2 3 5
  • Large Ribosomal Subunit Protein UL5 3 4
  • CLL-Associated Antigen KW-12 3 4
  • Cell Growth-Inhibiting Protein 34 3
  • 60S Ribosomal Protein L11 3
  • GIG34 3
  • DBA7 3
  • L11 3

External Ids for RPL11 Gene

Previous GeneCards Identifiers for RPL11 Gene

  • GC01P023575
  • GC01P023089
  • GC01P023487
  • GC01P023763
  • GC01P023890
  • GC01P024018
  • GC01P022268

Summaries for RPL11 Gene

Entrez Gene Summary for RPL11 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]

GeneCards Summary for RPL11 Gene

RPL11 (Ribosomal Protein L11) is a Protein Coding gene. Diseases associated with RPL11 include Diamond-Blackfan Anemia 7 and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL11 Gene

  • Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity).

Gene Wiki entry for RPL11 Gene

Additional gene information for RPL11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL11 Gene

Genomics for RPL11 Gene

GeneHancer (GH) Regulatory Elements for RPL11 Gene

Promoters and enhancers for RPL11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I023691 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 585.8 +0.8 844 3.1 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 RPL11 SRSF10 SRRM1 LINC01355 PNRC2 HNRNPR KDM1A ELOA ASAP3 GC01M023708
GH01I023166 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.6 -523.4 -523441 4.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 YY1 POLR2B ZNF213 ZNF548 LUZP1 GC01P023167 SRSF10 ZBTB40 PNRC2 RPL11 LINC01355 HNRNPR ELOA LACTBL1
GH01I023626 Enhancer 1.2 Ensembl ENCODE dbSUPER 37.6 -64.5 -64545 1.7 HDAC1 YBX3 PKNOX1 ATF1 ZNF133 MZF1 NFXL1 ZNF366 RUNX3 SMARCA5 SRSF10 RPL11 PNRC2 ELOA LINC01355 FUCA1 HNRNPR ID3 MDS2 E2F2
GH01I023975 Promoter/Enhancer 2.9 UCNEbase EPDnew Ensembl ENCODE dbSUPER 13.7 +287.1 287058 6.4 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SRSF10 ELOA SRRM1 LINC01355 KDM1A RPL11 ZNF436-AS1 PNRC2 CNR2 RUNX3
GH01I023553 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.7 -132.6 -132558 12.2 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ID3 GC01M023559 LOC105376859 PIR53087 GC01M023560 SRSF10 LINC01355 RPL11 MDS2 E2F2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPL11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL11 gene promoter:

Genomic Locations for RPL11 Gene

Genomic Locations for RPL11 Gene
chr1:23,691,779-23,696,425
(GRCh38/hg38)
Size:
4,647 bases
Orientation:
Plus strand
chr1:24,018,269-24,022,915
(GRCh37/hg19)

Genomic View for RPL11 Gene

Genes around RPL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL11 Gene

Proteins for RPL11 Gene

  • Protein details for RPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62913-RL11_HUMAN
    Recommended name:
    60S ribosomal protein L11
    Protein Accession:
    P62913
    Secondary Accessions:
    • P25121
    • P39026
    • Q8TDH2
    • Q9Y674

    Protein attributes for RPL11 Gene

    Size:
    178 amino acids
    Molecular mass:
    20252 Da
    Quaternary structure:
    • Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868). Interacts with PML (By similarity). Interacts with MDM2; negatively regulates MDM2-mediated TP53 ubiquitination and degradation (PubMed:24120868). Interacts with NOP53; retains RPL11 into the nucleolus (PubMed:24556985, PubMed:27829214).

    Three dimensional structures from OCA and Proteopedia for RPL11 Gene

    Alternative splice isoforms for RPL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL11 Gene

Post-translational modifications for RPL11 Gene

  • Ubiquitination at isoforms=8, Lys19, Lys38, isoforms=278, Lys85, and Lys169

Other Protein References for RPL11 Gene

No data available for DME Specific Peptides for RPL11 Gene

Domains & Families for RPL11 Gene

Gene Families for RPL11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Graphical View of Domain Structure for InterPro Entry

P62913

UniProtKB/Swiss-Prot:

RL11_HUMAN :
  • Belongs to the universal ribosomal protein uL5 family.
Family:
  • Belongs to the universal ribosomal protein uL5 family.
genes like me logo Genes that share domains with RPL11: view

Function for RPL11 Gene

Molecular function for RPL11 Gene

GENATLAS Biochemistry:
60S ribosomal protein L11
UniProtKB/Swiss-Prot Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity).

Phenotypes From GWAS Catalog for RPL11 Gene

Gene Ontology (GO) - Molecular Function for RPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,TAS 22681889
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 15195100
GO:0008097 5S rRNA binding IMP 18560357
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPL11: view
genes like me logo Genes that share phenotypes with RPL11: view

Human Phenotype Ontology for RPL11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for RPL11 Gene

miRTarBase miRNAs that target RPL11

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPL11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL11 Gene

Localization for RPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL11 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL11 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 23776465
GO:0005730 nucleolus IDA,IEA 15195100
GO:0005737 cytoplasm IDA,IEA 15314173
genes like me logo Genes that share ontologies with RPL11: view

Pathways & Interactions for RPL11 Gene

genes like me logo Genes that share pathways with RPL11: view

Pathways by source for RPL11 Gene

1 KEGG pathway for RPL11 Gene
1 GeneGo (Thomson Reuters) pathway for RPL11 Gene

SIGNOR curated interactions for RPL11 Gene

Activates:

Gene Ontology (GO) - Biological Process for RPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IMP 24120868
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL11: view

Drugs & Compounds for RPL11 Gene

(4) Drugs for RPL11 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
puromycin Experimental Pharma Target 0

(1) Additional Compounds for RPL11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL11: view

Transcripts for RPL11 Gene

Unigene Clusters for RPL11 Gene

Ribosomal protein L11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPL11

Alternative Splicing Database (ASD) splice patterns (SP) for RPL11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -
SP8: - - -
SP9:

Relevant External Links for RPL11 Gene

GeneLoc Exon Structure for
RPL11
ECgene alternative splicing isoforms for
RPL11

Expression for RPL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL11 Gene

This gene is overexpressed in Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL11 Gene



Protein tissue co-expression partners for RPL11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL11 Gene:

RPL11

SOURCE GeneReport for Unigene cluster for RPL11 Gene:

Hs.719951

Evidence on tissue expression from TISSUES for RPL11 Gene

  • Liver(4.9)
  • Nervous system(4.6)
  • Pancreas(4.3)
  • Lung(4.2)
  • Eye(4.1)
  • Intestine(4)
  • Skin(3.9)
  • Blood(3.7)
  • Kidney(3.5)
  • Bone(3.4)
  • Bone marrow(3.3)
  • Muscle(3.1)
  • Lymph node(3)
  • Stomach(3)
  • Heart(2.9)
  • Spleen(2.9)
  • Adrenal gland(2.8)
  • Gall bladder(2.8)
  • Thyroid gland(2.8)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL11 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • inner ear
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • skull
Thorax:
  • aorta
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • kidney
  • large intestine
Pelvis:
  • pelvis
  • penis
  • ureter
  • urethra
  • urinary bladder
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with RPL11: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL11 Gene

Orthologs for RPL11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
RPL11 33
  • 94.94 (n)
-- 34
  • 90 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL11 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm10036 34
  • 99 (a)
OneToMany
Gm10288 34
  • 99 (a)
OneToMany
Gm5093 34
  • 97 (a)
OneToMany
Gm7589 34
  • 96 (a)
OneToMany
Rpl11 33 16 34
  • 91.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL11 34
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL11 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL11 33 34
  • 93.26 (n)
rat
(Rattus norvegicus)
Mammalia Rpl11 33
  • 91.02 (n)
chicken
(Gallus gallus)
Aves RPL11 33
  • 79.21 (n)
lizard
(Anolis carolinensis)
Reptilia RPL11 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl11 33
  • 80.19 (n)
zebrafish
(Danio rerio)
Actinopterygii rpl11 33 34
  • 82.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL11 35 33 34
  • 72.35 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011173 33
  • 69.68 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-11.1 35 34
  • 81 (a)
rpl-11.2 35 33 34
  • 70.41 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL11B 34 36
  • 70 (a)
OneToMany
RPL11A 33 34
  • 65.87 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL325W 33
  • 68.86 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08261g 33
  • 67.66 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58700 33
  • 66.27 (n)
rice
(Oryza sativa)
Liliopsida Os02g0235600 33
  • 65.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.110 34
  • 74 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1101 33
  • 68.66 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02509 33
  • 65.51 (n)
Species where no ortholog for RPL11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL11 Gene

ENSEMBL:
Gene Tree for RPL11 (if available)
TreeFam:
Gene Tree for RPL11 (if available)

Paralogs for RPL11 Gene

genes like me logo Genes that share paralogs with RPL11: view

No data available for Paralogs for RPL11 Gene

Variants for RPL11 Gene

Sequence variations from dbSNP and Humsavar for RPL11 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs10917413 benign, Diamond-Blackfan anemia 23,691,787(+) C/A/G 5_prime_UTR_variant
rs121434389 pathogenic, Diamond-Blackfan anemia 7 23,693,872(+) C/T coding_sequence_variant, stop_gained
rs139286202 conflicting-interpretations-of-pathogenicity, Diamond-Blackfan anemia 23,692,632(+) C/T coding_sequence_variant, synonymous_variant
rs199772693 uncertain-significance, Diamond-Blackfan anemia 23,692,704(+) G/A/C coding_sequence_variant, synonymous_variant
rs371228733 likely-benign, not specified, Diamond-Blackfan anemia 23,695,794(+) A/G/T intron_variant

Variation tolerance for RPL11 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL11 Gene

Human Gene Mutation Database (HGMD)
RPL11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL11 Gene

Disorders for RPL11 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPL11 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 7
  • dba7
diamond-blackfan anemia
  • blackfan - diamond syndrome
macrocytic anemia
  • anemia macrocytic
pierre robin syndrome
  • prbns
congenital hypoplastic anemia
  • fanconi anemia
- elite association - COSMIC cancer census association via MalaCards
Search RPL11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RL11_HUMAN
  • Diamond-Blackfan anemia 7 (DBA7) [MIM:612562]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:19061985, ECO:0000269 PubMed:19191325}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for RPL11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPL11: view

No data available for Genatlas for RPL11 Gene

Publications for RPL11 Gene

  1. Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia. (PMID: 19191325) Cmejla R … Pospisilova D (Human mutation 2009) 3 4 22 58
  2. [Structural and functional analysis of the human ribosomal protein L11 gene]. (PMID: 12815950) Voronina EN … Filipenko ML (Molekuliarnaia biologiia 2003) 3 4 22 58
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  4. [Cloning and determination of the primary structure of DNA complementary to the mRNA of human ribosomal protein L11]. (PMID: 7748210) Mishin VP … Mertvetsov NP (Bioorganicheskaia khimiia 1995) 3 4 22 58
  5. PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. (PMID: 27829214) Chen H … Huang L (Oncotarget 2016) 3 4 58

Products for RPL11 Gene

Sources for RPL11 Gene

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