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Aliases for RPL10L Gene

Aliases for RPL10L Gene

  • Ribosomal Protein L10 Like 2 3 5
  • Large Ribosomal Subunit Protein UL16-Like 3 4
  • 60S Ribosomal Protein L10-Like 3
  • Ribosomal Protein L10-Like 2
  • RPL10_5_1358 3

External Ids for RPL10L Gene

Previous GeneCards Identifiers for RPL10L Gene

  • GC14M044442
  • GC14M040916
  • GC14M045110
  • GC14M046189
  • GC14M047120
  • GC14M027238

Summaries for RPL10L Gene

Entrez Gene Summary for RPL10L Gene

  • This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL10L Gene

RPL10L (Ribosomal Protein L10 Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL10.

UniProtKB/Swiss-Prot for RPL10L Gene

  • May play a role in compensating for the inactivated X-linked gene during spermatogenesis.

Gene Wiki entry for RPL10L Gene

Additional gene information for RPL10L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL10L Gene

Genomics for RPL10L Gene

GeneHancer (GH) Regulatory Elements for RPL10L Gene

Top Transcription factor binding sites by QIAGEN in the RPL10L gene promoter:
  • LCR-F1
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • STAT1
  • STAT1alpha
  • STAT1beta
  • GR-beta
  • GR-alpha
  • GR

Genomic Locations for RPL10L Gene

Genomic Locations for RPL10L Gene
816 bases
Minus strand
813 bases
Minus strand

Genomic View for RPL10L Gene

Genes around RPL10L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL10L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL10L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL10L Gene

Proteins for RPL10L Gene

  • Protein details for RPL10L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L10-like
    Protein Accession:
    Secondary Accessions:
    • Q8IUD1

    Protein attributes for RPL10L Gene

    214 amino acids
    Molecular mass:
    24519 Da
    Quaternary structure:
    No Data Available
    • This gene has no introns in its coding regions, and therefore was most likely produced by retrotransposition of the original X-linked gene during evolution.

    Three dimensional structures from OCA and Proteopedia for RPL10L Gene

neXtProt entry for RPL10L Gene

Post-translational modifications for RPL10L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL10L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL10L Gene

Domains & Families for RPL10L Gene

Gene Families for RPL10L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL10L Gene

Suggested Antigen Peptide Sequences for RPL10L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL16 family.
  • Belongs to the universal ribosomal protein uL16 family.
genes like me logo Genes that share domains with RPL10L: view

Function for RPL10L Gene

Molecular function for RPL10L Gene

UniProtKB/Swiss-Prot Function:
May play a role in compensating for the inactivated X-linked gene during spermatogenesis.

Gene Ontology (GO) - Molecular Function for RPL10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with RPL10L: view
genes like me logo Genes that share phenotypes with RPL10L: view

Animal Model Products

CRISPR Products

miRNA for RPL10L Gene

miRTarBase miRNAs that target RPL10L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL10L

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL10L Gene

Localization for RPL10L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL10L gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IDA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL10L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL10L Gene

Pathways & Interactions for RPL10L Gene

genes like me logo Genes that share pathways with RPL10L: view

Pathways by source for RPL10L Gene

Gene Ontology (GO) - Biological Process for RPL10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0006412 translation IBA --
GO:0007283 spermatogenesis IEP 12490704
genes like me logo Genes that share ontologies with RPL10L: view

No data available for SIGNOR curated interactions for RPL10L Gene

Drugs & Compounds for RPL10L Gene

(3) Drugs for RPL10L Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL10L: view

Transcripts for RPL10L Gene

mRNA/cDNA for RPL10L Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL10L Gene

Ribosomal protein L10-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL10L

Alternative Splicing Database (ASD) splice patterns (SP) for RPL10L Gene

No ASD Table

Relevant External Links for RPL10L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL10L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL10L Gene

mRNA differential expression in normal tissues according to GTEx for RPL10L Gene

This gene is overexpressed in Testis (x50.6).

Protein differential expression in normal tissues from HIPED for RPL10L Gene

This gene is overexpressed in Liver (43.8) and Cervix (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RPL10L Gene

NURSA nuclear receptor signaling pathways regulating expression of RPL10L Gene:


SOURCE GeneReport for Unigene cluster for RPL10L Gene:


mRNA Expression by UniProt/SwissProt for RPL10L Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with RPL10L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL10L Gene

Orthologs for RPL10L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL10L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL10L 34 33
  • 99.22 (n)
(Bos Taurus)
Mammalia RPL10L 34
  • 96 (a)
(Canis familiaris)
Mammalia RPL10L 34
  • 94 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
-- 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Rpl10l 33
  • 85.2 (n)
(Mus musculus)
Mammalia Rpl10l 16 34 33
  • 83.96 (n)
(Gallus gallus)
Aves -- 34
  • 93 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6215 33
(Danio rerio)
Actinopterygii rpl10 34
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL10 34
  • 74 (a)
(Caenorhabditis elegans)
Secernentea rpl-10 34 33
  • 67.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL10 34
  • 62 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SAG24 33
  • 64.56 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5792 33
(Glycine max)
eudicotyledons Gma.11225 33
(Oryza sativa)
Liliopsida Os11g0220800 33
  • 65.38 (n)
(Hordeum vulgare)
Liliopsida Hv.11026 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3630 34
  • 75 (a)
Cin.11833 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11833 33
Species where no ortholog for RPL10L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL10L Gene

Gene Tree for RPL10L (if available)
Gene Tree for RPL10L (if available)
Evolutionary constrained regions (ECRs) for RPL10L: view image

Paralogs for RPL10L Gene

Paralogs for RPL10L Gene

(1) SIMAP similar genes for RPL10L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL10L: view

Variants for RPL10L Gene

Sequence variations from dbSNP and Humsavar for RPL10L Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs193920822 uncertain-significance, Malignant tumor of prostate 46,651,643(-) G/A coding_sequence_variant, missense_variant
rs1000565258 -- 46,652,400(-) AAAAA/AAAAAA upstream_transcript_variant
rs1000679806 -- 46,652,746(-) T/G upstream_transcript_variant
rs1001844898 -- 46,653,179(-) C/G/T upstream_transcript_variant
rs1001962411 -- 46,653,632(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL10L Gene

Variant ID Type Subtype PubMed ID
esv2751278 CNV gain 17911159
nsv517764 CNV loss 19592680
nsv983821 CNV duplication 23825009

Variation tolerance for RPL10L Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL10L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL10L Gene

Disorders for RPL10L Gene

Additional Disease Information for RPL10L

No disorders were found for RPL10L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL10L Gene

Publications for RPL10L Gene

  1. Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes. (PMID: 12490704) Uechi T … Kenmochi N (Nucleic acids research 2002) 3 4 22 58
  2. Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes. (PMID: 19123937) Balasubramanian S … Gerstein M (Genome biology 2009) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Repression of rRNA transcription by PARIS contributes to Parkinson's disease. (PMID: 25315684) Kang H … Shin JH (Neurobiology of disease 2015) 3 58
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58

Products for RPL10L Gene

Sources for RPL10L Gene

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