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Aliases for RPL10A Gene

Aliases for RPL10A Gene

  • Ribosomal Protein L10a 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 6 3 4
  • Large Ribosomal Subunit Protein UL1 3 4
  • NEDD-6 3 4
  • NEDD6 3 4
  • 60S Ribosomal Protein L10a 3
  • Csa-19 3
  • CSA-19 4
  • CSA19 3
  • L10A 3

External Ids for RPL10A Gene

Previous HGNC Symbols for RPL10A Gene

  • NEDD6

Previous GeneCards Identifiers for RPL10A Gene

  • GC06P035438
  • GC06P035483
  • GC06P035544
  • GC06P035156
  • GC06P035582
  • GC06P035784
  • GC06P036309
  • GC06P037295
  • GC06P035652
  • GC06P035663
  • GC06P037766
  • GC06P038390
  • GC06P038980
  • GC06P039568
  • GC06P040129
  • GC06P041197

Summaries for RPL10A Gene

Entrez Gene Summary for RPL10A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL10A Gene

RPL10A (Ribosomal Protein L10a) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL10A Gene

  • Component of the large ribosomal subunit.

Gene Wiki entry for RPL10A Gene

Additional gene information for RPL10A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL10A Gene

Genomics for RPL10A Gene

GeneHancer (GH) Regulatory Elements for RPL10A Gene

Promoters and enhancers for RPL10A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J035467 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 679.1 +1.7 1739 5.4 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 RPL10A MIR7111 TAF11 ZNF76 BRPF3 ENSG00000272374 FANCE PPARD RPS10P13 RN7SL502P
GH06J035258 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 23.2 -208.2 -208202 4.1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF76 TCP11 GC06M038955 LOC101929285 TAF11 ENSG00000272374 RPL10A ENSG00000219023 RPS10 DEF6
GH06J035723 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.2 +260.7 260696 10.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 MCM3 SP3 NFYC ARMC12 FKBP5 TAF11 SRSF3 ZNF76 ENSG00000272374 RPL10A STK38 ENSG00000219023 FANCE
GH06J034886 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.7 -578.7 -578707 5.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TAF11 ANKS1A RPS10 RPL10A UHRF1BP1 FKBP5 ENSG00000219023 ZNF76 TEAD3 TCP11
GH06J035451 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 21.1 -15.1 -15141 3.8 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 E2F8 ZNF207 ZNF143 KLF13 FANCE RPL10A TAF11 BRPF3 ENSG00000272374 UHRF1BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL10A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL10A gene promoter:
  • ER-alpha
  • En-1
  • Tal-1
  • E47
  • ARP-1
  • GR
  • GR-alpha
  • HSF1short
  • HSF1 (long)

Genomic Locations for RPL10A Gene

Genomic Locations for RPL10A Gene
chr6:35,468,401-35,470,785
(GRCh38/hg38)
Size:
2,385 bases
Orientation:
Plus strand
chr6:35,436,178-35,438,562
(GRCh37/hg19)
Size:
2,385 bases
Orientation:
Plus strand

Genomic View for RPL10A Gene

Genes around RPL10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL10A Gene

Proteins for RPL10A Gene

  • Protein details for RPL10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62906-RL10A_HUMAN
    Recommended name:
    60S ribosomal protein L10a
    Protein Accession:
    P62906
    Secondary Accessions:
    • B2R801
    • P52859
    • P53025
    • Q5TZT6
    • Q8J013

    Protein attributes for RPL10A Gene

    Size:
    217 amino acids
    Molecular mass:
    24831 Da
    Quaternary structure:
    • Component of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPL10A Gene

neXtProt entry for RPL10A Gene

Post-translational modifications for RPL10A Gene

  • Ubiquitination at Lys133, Lys130, and posLast=106106
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL10A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL10A Gene

Domains & Families for RPL10A Gene

Gene Families for RPL10A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL10A Gene

Graphical View of Domain Structure for InterPro Entry

P62906

UniProtKB/Swiss-Prot:

RL10A_HUMAN :
  • Belongs to the universal ribosomal protein uL1 family.
Family:
  • Belongs to the universal ribosomal protein uL1 family.
genes like me logo Genes that share domains with RPL10A: view

Function for RPL10A Gene

Molecular function for RPL10A Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.
GENATLAS Biochemistry:
60S ribosomal protein L10A

Phenotypes From GWAS Catalog for RPL10A Gene

Gene Ontology (GO) - Molecular Function for RPL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 24725412
genes like me logo Genes that share ontologies with RPL10A: view
genes like me logo Genes that share phenotypes with RPL10A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL10A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL10A Gene

Localization for RPL10A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL10A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with RPL10A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL10A Gene

Pathways & Interactions for RPL10A Gene

genes like me logo Genes that share pathways with RPL10A: view

Pathways by source for RPL10A Gene

1 KEGG pathway for RPL10A Gene
1 GeneGo (Thomson Reuters) pathway for RPL10A Gene

Gene Ontology (GO) - Biological Process for RPL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0002181 cytoplasmic translation IDA 25957688
GO:0006364 rRNA processing TAS --
GO:0006412 translation IBA,NAS 12962325
genes like me logo Genes that share ontologies with RPL10A: view

No data available for SIGNOR curated interactions for RPL10A Gene

Drugs & Compounds for RPL10A Gene

No Compound Related Data Available

Transcripts for RPL10A Gene

mRNA/cDNA for RPL10A Gene

Unigene Clusters for RPL10A Gene

Ribosomal protein L10a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL10A

Alternative Splicing Database (ASD) splice patterns (SP) for RPL10A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7: - - - - -
SP8: - - -
SP9: -
SP10: - -

Relevant External Links for RPL10A Gene

GeneLoc Exon Structure for
RPL10A
ECgene alternative splicing isoforms for
RPL10A

Expression for RPL10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL10A Gene



Protein tissue co-expression partners for RPL10A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL10A Gene:

RPL10A

SOURCE GeneReport for Unigene cluster for RPL10A Gene:

Hs.148340

Evidence on tissue expression from TISSUES for RPL10A Gene

  • Liver(4.9)
  • Nervous system(4.9)
  • Eye(4.8)
  • Lung(4.8)
  • Pancreas(4.8)
  • Skin(4.8)
  • Intestine(4.6)
  • Blood(4.5)
  • Stomach(4.4)
  • Muscle(4.3)
  • Kidney(3.9)
  • Heart(3.7)
  • Bone(3.5)
  • Spleen(2.6)
  • Lymph node(2.5)
  • Bone marrow(2.4)
  • Thyroid gland(2.4)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with RPL10A: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL10A Gene

Orthologs for RPL10A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL10A 34 33
  • 99.69 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL10A 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 97 (a)
OneToMany
RPL10A 33
  • 90.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL10A 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl10a-ps2 34
  • 90 (a)
OneToOne
Rpl10a 16 33
  • 89.09 (n)
dog
(Canis familiaris)
Mammalia RPL10A 34 33
  • 89.86 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl10a 33
  • 89.71 (n)
chicken
(Gallus gallus)
Aves RPL10A 34 33
  • 82.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL10A 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl10a 33
  • 78.4 (n)
Str.17067 33
African clawed frog
(Xenopus laevis)
Amphibia rpl10a-prov 33
zebrafish
(Danio rerio)
Actinopterygii rpl10a 34 33
  • 79.84 (n)
OneToOne
wufb94f08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8350 33
fruit fly
(Drosophila melanogaster)
Insecta CG7283 35
  • 77 (a)
RpL10Ab 34 33
  • 71.74 (n)
OneToMany
RpL10Aa 34
  • 57 (a)
OneToMany
CG3843 35
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011298 33
  • 73.12 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71F9AL.13b 35
  • 75 (a)
rpl-1 34 35 33
  • 66.98 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL116W 33
  • 63.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02002g 33
  • 60.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL1A 36 34 33
  • 59.84 (n)
RPL1B 34
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PGY1 33
  • 62.17 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7697 33
soybean
(Glycine max)
eudicotyledons Gma.6491 33
rice
(Oryza sativa)
Liliopsida Os02g0321900 33
  • 62.17 (n)
corn
(Zea mays)
Liliopsida Zm.5240 33
wheat
(Triticum aestivum)
Liliopsida Ta.28647 33
barley
(Hordeum vulgare)
Liliopsida Hv.5459 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11350 34
  • 72 (a)
OneToOne
Cin.5227 33
bread mold
(Neurospora crassa)
Ascomycetes NCU00294 33
  • 64.19 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl101 33
  • 61.55 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5227 33
Species where no ortholog for RPL10A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL10A Gene

ENSEMBL:
Gene Tree for RPL10A (if available)
TreeFam:
Gene Tree for RPL10A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPL10A: view image

Paralogs for RPL10A Gene

No data available for Paralogs for RPL10A Gene

Variants for RPL10A Gene

Sequence variations from dbSNP and Humsavar for RPL10A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs16876572 likely-benign, Fanconi anemia 35,466,496(+) A/G/T upstream_transcript_variant
rs45584740 benign, Fanconi anemia 35,466,561(+) C/ upstream_transcript_variant
rs559999264 uncertain-significance, Fanconi anemia 35,466,667(+) C/T upstream_transcript_variant
rs886061333 uncertain-significance, Fanconi anemia 35,466,746(+) G/C upstream_transcript_variant
rs886061334 uncertain-significance, Fanconi anemia 35,467,074(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPL10A Gene

Variant ID Type Subtype PubMed ID
nsv519370 CNV loss 19592680
nsv528351 CNV loss 19592680
nsv602910 CNV loss 21841781
nsv830641 CNV loss 17160897
nsv965717 CNV duplication 23825009

Variation tolerance for RPL10A Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL10A Gene

Disorders for RPL10A Gene

Additional Disease Information for RPL10A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RPL10A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL10A Gene

Publications for RPL10A Gene

  1. Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19. (PMID: 7609734) Fisicaro N … Pearse M (Molecular immunology 1995) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova TI … Karpova GG (Journal of protein chemistry 2003) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for RPL10A Gene

Sources for RPL10A Gene

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