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Aliases for RPL10 Gene

Aliases for RPL10 Gene

  • Ribosomal Protein L10 2 3 4 5
  • Large Ribosomal Subunit Protein UL16 3 4
  • Laminin Receptor Homolog 3 4
  • Tumor Suppressor QM 3 4
  • DXS648E 3 4
  • QM 3 4
  • Wilms Tumor-Related Protein 3
  • 60S Ribosomal Protein L10 3
  • Protein QM 4
  • AUTSX5 3
  • DXS648 3
  • MRXS35 3
  • L10 3
  • NOV 3

External Ids for RPL10 Gene

Previous GeneCards Identifiers for RPL10 Gene

  • GC0XP147690
  • GC0XP150007
  • GC0XP151212
  • GC0XP152096
  • GC0XP152097
  • GC0XP153147
  • GC0XP153279
  • GC0XP153618

Summaries for RPL10 Gene

Entrez Gene Summary for RPL10 Gene

  • This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for RPL10 Gene

RPL10 (Ribosomal Protein L10) is a Protein Coding gene. Diseases associated with RPL10 include Mental Retardation, X-Linked, Syndromic, 35 and Autism X-Linked 5. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL10L.

UniProtKB/Swiss-Prot for RPL10 Gene

  • Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788).

Gene Wiki entry for RPL10 Gene

Additional gene information for RPL10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL10 Gene

Genomics for RPL10 Gene

GeneHancer (GH) Regulatory Elements for RPL10 Gene

Promoters and enhancers for RPL10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ154396 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.4 +9.5 9525 6.2 HNRNPUL1 PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 SNORA70 GC0XP154402 GC0XP154401 ENSG00000280195 RPL10 HCFC1 PLXNA3 DKC1 SNORA56 EMD
GH0XJ154388 Promoter/Enhancer 0.7 Ensembl dbSUPER 650.7 +0.0 46 2.4 RPL10 ENSG00000280195
GH0XJ154376 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.5 -10.8 -10810 5.7 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 POLR2B ZNF213 E2F8 ZNF207 EMD PLXNA3 DKC1 HCFC1 SNORA70 SLC10A3 SNORA56 TMEM187 RPL10 CH17-340M24.3
GH0XJ154443 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 12.8 +54.3 54271 2.3 HDGF RB1 ARNT SIN3A ZNF335 GLIS2 ATF7 CREM ZNF398 GATAD2B FAM50A GC0XM154443 GC0XM154444 GC0XP154446 GC0XP154443 GC0XM154442 LAGE3 UBL4A RPL10 MIR6858
GH0XJ154408 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 0.4 +19.3 19342 2 HDAC1 HDGF PKNOX1 CLOCK RB1 ARID4B KLF17 SIN3A ZBTB7B RFX5 DNASE1L1 TAZ FAM3A SNORA70 RPL10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPL10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPL10 gene promoter:
  • AP-2alpha isoform 4
  • AP-2alpha isoform 3
  • AP-2alpha isoform 2
  • AP-2alpha
  • AP-2alphaA
  • AML1a
  • AP-1
  • p53

Genomic Locations for RPL10 Gene

Genomic Locations for RPL10 Gene
19,214 bases
Plus strand
19,190 bases
Plus strand

Genomic View for RPL10 Gene

Genes around RPL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL10 Gene

Proteins for RPL10 Gene

  • Protein details for RPL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L10
    Protein Accession:
    Secondary Accessions:
    • A3KQT0
    • D3DWW6
    • Q16470
    • Q2HXT7
    • Q53FH7
    • Q6FGN8
    • Q8TDA5

    Protein attributes for RPL10 Gene

    214 amino acids
    Molecular mass:
    24604 Da
    Quaternary structure:
    • Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
    • Sequence=AAB22173.1; Type=Frameshift; Positions=124; Evidence={ECO:0000305}; Sequence=CAM45852.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM45853.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL10 Gene

neXtProt entry for RPL10 Gene

Post-translational modifications for RPL10 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at posLast=188188, Lys175, Lys145, posLast=7878, and Lys42
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL10 Gene

Domains & Families for RPL10 Gene

Gene Families for RPL10 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL16 family.
  • Belongs to the universal ribosomal protein uL16 family.
genes like me logo Genes that share domains with RPL10: view

Function for RPL10 Gene

Molecular function for RPL10 Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788).
GENATLAS Biochemistry:
60S ribosomal protein L10

Gene Ontology (GO) - Molecular Function for RPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 10508860
GO:0045182 translation regulator activity IMP 26290468
genes like me logo Genes that share ontologies with RPL10: view
genes like me logo Genes that share phenotypes with RPL10: view

Human Phenotype Ontology for RPL10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL10 Gene

Localization for RPL10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL10 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 10508860
GO:0005783 endoplasmic reticulum IDA --
GO:0005790 colocalizes_with smooth endoplasmic reticulum IDA 10508860
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with RPL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL10 Gene

Pathways & Interactions for RPL10 Gene

genes like me logo Genes that share pathways with RPL10: view

Pathways by source for RPL10 Gene

1 KEGG pathway for RPL10 Gene
1 GeneGo (Thomson Reuters) pathway for RPL10 Gene

SIGNOR curated interactions for RPL10 Gene


Gene Ontology (GO) - Biological Process for RPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 10508860
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 12962325
genes like me logo Genes that share ontologies with RPL10: view

Drugs & Compounds for RPL10 Gene

(1) Drugs for RPL10 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
genes like me logo Genes that share compounds with RPL10: view

Transcripts for RPL10 Gene

Unigene Clusters for RPL10 Gene

Ribosomal protein L10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPL10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL10 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: -
SP6: -
SP7: - - - - -
SP9: -
SP10: - - - - -
SP11: -

Relevant External Links for RPL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL10 Gene

Protein differential expression in normal tissues from HIPED for RPL10 Gene

This gene is overexpressed in Nasal epithelium (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL10 Gene

Protein tissue co-expression partners for RPL10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL10 Gene:


SOURCE GeneReport for Unigene cluster for RPL10 Gene:


Evidence on tissue expression from TISSUES for RPL10 Gene

  • Liver(5)
  • Nervous system(5)
  • Pancreas(4.9)
  • Intestine(4.8)
  • Lung(4.8)
  • Skin(4.8)
  • Eye(4.7)
  • Stomach(4.7)
  • Blood(4.6)
  • Muscle(4.6)
  • Heart(4.2)
  • Kidney(4.1)
  • Bone(3.8)
  • Thyroid gland(3.4)
  • Spleen(3.2)
  • Adrenal gland(2.6)
  • Bone marrow(2.6)
  • Gall bladder(2.6)
  • Lymph node(2.6)
genes like me logo Genes that share expression patterns with RPL10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL10 Gene

Orthologs for RPL10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rpl10-ps3 34
  • 100 (a)
Rpl10 16 34 33
  • 90.5 (n)
(Pan troglodytes)
Mammalia RPL10 33
  • 98.91 (n)
-- 34
  • 96 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 98 (a)
-- 34
  • 90 (a)
-- 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
(Canis familiaris)
Mammalia RPL10 33
  • 91.43 (n)
-- 34
  • 70 (a)
(Bos Taurus)
Mammalia RPL10 34 34 33
  • 90.65 (n)
(Rattus norvegicus)
Mammalia Rpl10 33
  • 89.88 (n)
(Gallus gallus)
Aves -- 34
  • 96 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 97 (a)
African clawed frog
(Xenopus laevis)
Amphibia rpl10-prov 33
(Danio rerio)
Actinopterygii rpl10 34
  • 90 (a)
wufa93d03 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4144 33
fruit fly
(Drosophila melanogaster)
Insecta Qm 35
  • 78 (a)
RpL10 34
  • 75 (a)
(Caenorhabditis elegans)
Secernentea rpl-10 34 35
  • 71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL10 36 34
  • 63 (a)
(Oryza sativa)
Liliopsida Os.10134 33
(Zea mays)
Liliopsida Zm.14596 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3630 34
  • 76 (a)
Species where no ortholog for RPL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL10 Gene

Gene Tree for RPL10 (if available)
Gene Tree for RPL10 (if available)
Evolutionary constrained regions (ECRs) for RPL10: view image

Paralogs for RPL10 Gene

Paralogs for RPL10 Gene

(1) SIMAP similar genes for RPL10 Gene using alignment to 8 proteins:

  • RL10_HUMAN
  • B8A6G2_HUMAN
  • F8W7C6_HUMAN
  • H7C123_HUMAN
  • H7C2C5_HUMAN
  • H7C2U2_HUMAN
genes like me logo Genes that share paralogs with RPL10: view

Variants for RPL10 Gene

Sequence variations from dbSNP and Humsavar for RPL10 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs387906727 risk-factor, Autism, susceptibility to, X-linked 5 154,400,825(+) C/A 3_prime_UTR_variant, coding_sequence_variant, missense_variant, synonymous_variant
rs782521991 risk-factor, uncertain-significance, Autism, susceptibility to, X-linked 5, not specified 154,400,848(+) C/G 3_prime_UTR_variant, coding_sequence_variant, missense_variant
VAR_027795 Autism, X-linked 5 (AUTSX5) [MIM:300847] p.Leu206Met
VAR_027796 Autism, X-linked 5 (AUTSX5) [MIM:300847] p.His213Gln
VAR_079288 Mental retardation, X-linked, syndromic, 35 (MRXS35) [MIM:300998] p.Ala64Val

Structural Variations from Database of Genomic Variants (DGV) for RPL10 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv220 OTHER inversion 15895083
nsv481467 CNV novel sequence insertion 20440878
nsv519042 CNV gain 19592680
nsv7468 OTHER inversion 18451855

Variation tolerance for RPL10 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPL10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL10 Gene

Disorders for RPL10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPL10 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, x-linked, syndromic, 35
  • mrxs35
autism x-linked 5
  • autism, susceptibility to, x-linked 5
autism spectrum disorder
  • asd
  • autistic disorder
pervasive developmental disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards
Search RPL10 in MalaCards View complete list of genes associated with diseases


  • Autism, X-linked 5 (AUTSX5) [MIM:300847]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269 PubMed:16940977, ECO:0000269 PubMed:21567917, ECO:0000269 PubMed:25316788}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms.
  • Mental retardation, X-linked, syndromic, 35 (MRXS35) [MIM:300998]: A mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:25316788, ECO:0000269 PubMed:25846674, ECO:0000269 PubMed:26290468}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for RPL10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPL10: view

No data available for Genatlas for RPL10 Gene

Publications for RPL10 Gene

  1. An investigation of ribosomal protein L10 gene in autism spectrum disorders. (PMID: 19166581) Gong X … Bourgeron T (BMC medical genetics 2009) 3 22 44 58
  2. Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold. (PMID: 18258260) Nishimura M … Kobayashi Y (Journal of molecular biology 2008) 3 4 22 58
  3. QM, a putative tumor suppressor, regulates proto-oncogene c-yes. (PMID: 12138090) Oh HS … Yang CH (The Journal of biological chemistry 2002) 3 4 22 58
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  5. A Novel Mutation in RPL10 (Ribosomal Protein L10) Causes X-Linked Intellectual Disability, Cerebellar Hypoplasia, and Spondylo-Epiphyseal Dysplasia. (PMID: 26290468) Zanni G … Breitenbach-Koller L (Human mutation 2015) 3 4 58

Products for RPL10 Gene

Sources for RPL10 Gene

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