Aliases for RPE Gene

Aliases for RPE Gene

  • Ribulose-5-Phosphate-3-Epimerase 2 3 4 5
  • Ribulose-Phosphate 3-Epimerase 3 4
  • EC 5.1.3.1 4 52
  • RPE2-1 3

External Ids for RPE Gene

Previous GeneCards Identifiers for RPE Gene

  • GC02P209142
  • GC02P209591
  • GC02P210831
  • GC02P211069
  • GC02P210692
  • GC02P210575
  • GC02P202712
  • GC02P210867

Summaries for RPE Gene

GeneCards Summary for RPE Gene

RPE (Ribulose-5-Phosphate-3-Epimerase) is a Protein Coding gene. Among its related pathways are Pentose phosphate pathway and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and racemase and epimerase activity, acting on carbohydrates and derivatives. An important paralog of this gene is RPEL1.

UniProtKB/Swiss-Prot Summary for RPE Gene

  • Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

Gene Wiki entry for RPE Gene

Additional gene information for RPE Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPE Gene

Genomics for RPE Gene

GeneHancer (GH) Regulatory Elements for RPE Gene

Promoters and enhancers for RPE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J210001 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 506 +0.9 915 3.8 ZBTB40 SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 ZFX POLR2A ZBTB10 RPE ENSG00000229127 KANSL1L MAP2 NONHSAG030396.2
GH02J210189 Enhancer 0.6 ENCODE 11.1 +187.4 187407 0.1 NCOR1 BCL6 NFATC3 EHMT2 HNF4A REST CEBPB ZNF384 GATAD2A HNF4G RPE piR-38580-175 ENSG00000279317 lnc-KANSL1L-1 ACADL
GH02J210301 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE dbSUPER 4.9 +300.1 300136 2.2 SMARCA4 MYL1 KANSL1L RPE ENSG00000199203
GH02J210188 Enhancer 0.4 Ensembl 11.1 +186.1 186136 1 GATA3 GATA2 ZNF24 piR-38580-175 RPE ACADL ENSG00000279317 lnc-KANSL1L-1
GH02J210181 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 4.4 +178.6 178582 2.7 TEAD1 FOXA2 FOXA1 ZGPAT THAP11 DMAP1 ZNF48 EGR2 PKNOX1 SP5 lnc-RPE-8 RPE MAP2 ENSG00000279317 piR-38580-175
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPE on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPE

Top Transcription factor binding sites by QIAGEN in the RPE gene promoter:
  • AP-1
  • ATF-2
  • Sp1

Genomic Locations for RPE Gene

Genomic Locations for RPE Gene
chr2:210,002,565-210,024,599
(GRCh38/hg38)
Size:
22,035 bases
Orientation:
Plus strand
chr2:210,867,289-210,886,300
(GRCh37/hg19)
Size:
19,012 bases
Orientation:
Plus strand

Genomic View for RPE Gene

Genes around RPE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPE Gene

Proteins for RPE Gene

  • Protein details for RPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AT9-RPE_HUMAN
    Recommended name:
    Ribulose-phosphate 3-epimerase
    Protein Accession:
    Q96AT9
    Secondary Accessions:
    • A8K4S0
    • B4E016
    • C9JPQ7
    • O43767
    • Q53TV9
    • Q8N215
    • Q96N34
    • Q9BSB5

    Protein attributes for RPE Gene

    Size:
    228 amino acids
    Molecular mass:
    24928 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAB71076.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAC04212.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPE Gene

    Alternative splice isoforms for RPE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPE Gene

Selected DME Specific Peptides for RPE Gene

Q96AT9:
  • LVMTVEPG
  • MDGHFVPN
  • IEVDGGVGP

Post-translational modifications for RPE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for RPE Gene

Gene Families for RPE Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RPE Gene

Blocks:
  • Ribulose-phosphate 3-epimerase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPE Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52962, highly similar to Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (B4E016_HUMAN)
  • Ribulose-phosphate 3-epimerase (C9IZU8_HUMAN)
  • Ribulose-phosphate 3-epimerase (E7EW52_HUMAN)
  • Ribulose-5-phosphate-3-epimerase (RPE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96AT9

UniProtKB/Swiss-Prot:

RPE_HUMAN :
  • Belongs to the ribulose-phosphate 3-epimerase family.
Family:
  • Belongs to the ribulose-phosphate 3-epimerase family.
genes like me logo Genes that share domains with RPE: view

Function for RPE Gene

Molecular function for RPE Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-ribulose 5-phosphate = D-xylulose 5-phosphate; Xref=Rhea:RHEA:13677, ChEBI:CHEBI:57737, ChEBI:CHEBI:58121; EC=5.1.3.1; Evidence=. ;.
GENATLAS Biochemistry:
ribulose-5-phosphate-3-epimerase

Enzyme Numbers (IUBMB) for RPE Gene

Phenotypes From GWAS Catalog for RPE Gene

Gene Ontology (GO) - Molecular Function for RPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004750 ribulose-phosphate 3-epimerase activity IDA,IBA 20923965
GO:0016853 isomerase activity IEA --
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives IEA --
GO:0042802 identical protein binding IPI 16189514
GO:0042803 protein homodimerization activity IPI 20923965
genes like me logo Genes that share ontologies with RPE: view
genes like me logo Genes that share phenotypes with RPE: view

Animal Model Products

CRISPR Products

miRNA for RPE Gene

miRTarBase miRNAs that target RPE

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPE Gene

Localization for RPE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPE gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with RPE: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPE Gene

Pathways & Interactions for RPE Gene

genes like me logo Genes that share pathways with RPE: view

UniProtKB/Swiss-Prot Q96AT9-RPE_HUMAN

  • Pathway: Carbohydrate degradation.

Gene Ontology (GO) - Biological Process for RPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IDA 20923965
GO:0006098 pentose-phosphate shunt TAS --
GO:0009052 pentose-phosphate shunt, non-oxidative branch IBA 21873635
GO:0019323 pentose catabolic process IBA 21873635
GO:0044262 cellular carbohydrate metabolic process IBA 21873635
genes like me logo Genes that share ontologies with RPE: view

No data available for SIGNOR curated interactions for RPE Gene

Drugs & Compounds for RPE Gene

(9) Drugs for RPE Gene - From: DrugBank, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ergocalciferol Approved Nutra Enzyme, substrate 1534
Huperzine A Approved, Experimental Pharma 14
Angiotensin II Approved, Investigational Pharma Full agonist, Agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1383
Cholinergic Agents Pharma 4830
Cholinesterase Inhibitors Pharma 704

(6) Additional Compounds for RPE Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Ribulose 5-phosphate
  • D-erythro-Pent-2-ulose 5-(dihydrogen phosphate)
  • D-erythro-Pent-2-ulose 5-(dihydrogen phosphoric acid)
  • D-Ribulose 5-phosphoric acid
4151-19-3
Xylulose 5-phosphate
  • 5-O-phosphono-D-threo-Pentos-2-ulose
  • 5-O-phosphono-D-Xylulose
  • D-Xylulose-5-phosphate
  • Xylulose 5-phosphoric acid
  • D-Xylulose-5-phosphoric acid
4212-65-1
genes like me logo Genes that share compounds with RPE: view

Transcripts for RPE Gene

mRNA/cDNA for RPE Gene

14 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for RPE Gene

GeneLoc Exon Structure for
RPE

Expression for RPE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPE Gene



Protein tissue co-expression partners for RPE Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPE

SOURCE GeneReport for Unigene cluster for RPE Gene:

Hs.282260

Evidence on tissue expression from TISSUES for RPE Gene

  • Skin(4.2)
  • Spleen(4.2)
  • Bone marrow(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with RPE: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPE Gene

Orthologs for RPE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPE 30
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia -- 31
  • 98 (a)
OneToMany
RPE 30
  • 93.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPE 31 30
  • 95.32 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Rpe 17 31 30
  • 91.96 (n)
rat
(Rattus norvegicus)
Mammalia Rpe 30
  • 91.46 (n)
chicken
(Gallus gallus)
Aves -- 31
  • 91 (a)
OneToMany
RPE 30
  • 79.79 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpe 30
  • 76.02 (n)
zebrafish
(Danio rerio)
Actinopterygii rpe 31 30
  • 72.81 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta boca 32
  • 62 (a)
CG30499 31 32 30
  • 60.49 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005080 30
  • 60.44 (n)
worm
(Caenorhabditis elegans)
Secernentea F08F8.7 31 32 30
  • 61.6 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15071g 30
  • 58.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPE1 33 31 30
  • 58.03 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL208C 30
  • 53.79 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63290 30
  • 57.59 (n)
rice
(Oryza sativa)
Liliopsida Os09g0505700 30
  • 57.16 (n)
Os.8665 30
corn
(Zea mays)
Liliopsida Zm.14811 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 65 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00519 30
  • 55.25 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC31G5.05c 30
  • 55.1 (n)
Species where no ortholog for RPE was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPE Gene

ENSEMBL:
Gene Tree for RPE (if available)
TreeFam:
Gene Tree for RPE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPE: view image

Paralogs for RPE Gene

Paralogs for RPE Gene

(9) SIMAP similar genes for RPE Gene using alignment to 13 proteins:

  • RPE_HUMAN
  • B4E016_HUMAN
  • C9IYE8_HUMAN
  • C9IZU8_HUMAN
  • C9J6A7_HUMAN
  • C9J8S0_HUMAN
  • C9J9T0_HUMAN
  • C9JCL8_HUMAN
  • C9JPQ7_HUMAN
  • E7ESZ6_HUMAN
  • E7EW52_HUMAN
  • E9PBG9_HUMAN
  • F8WBT4_HUMAN

Pseudogenes.org Pseudogenes for RPE Gene

genes like me logo Genes that share paralogs with RPE: view

Variants for RPE Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPE Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
717268 Benign: not provided 210,023,010(+) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for RPE Gene

Variation tolerance for RPE Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPE Gene

Disorders for RPE Gene

No disorders were found for RPE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPE Gene

Publications for RPE Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F … Valle G (Yeast (Chichester, England) 2001) 3 4 23 54
  2. Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE. (PMID: 20923965) Liang W … Liu ZJ (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for RPE Gene

Sources for RPE Gene