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This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
RPAP3 (RNA Polymerase II Associated Protein 3) is a Protein Coding gene. Diseases associated with RPAP3 include Primary Ciliary Dyskinesia. An important paralog of this gene is SPAG1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 18538670 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | IDA | -- |
GO:0036157 | outer dynein arm | IEA | -- |
GO:0097255 | R2TP complex | IDA | 26711270 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0070286 | axonemal dynein complex assembly | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RPAP3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RPAP3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RPAP3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rpap3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rpap3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RPAP3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RPAP3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RPAP3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rpap3 30 |
|
||
Str.10319 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.4828 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rpap3 30 31 |
|
OneToMany | |
RPAP3 (2 of 2) 31 |
|
OneToMany | |||
zgc56178 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9134 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | spag 30 31 |
|
ManyToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005014 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SGT2 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G56440 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os05g0129900 30 |
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11168196 | - | p.Asp564Tyr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2751101 | CNV | gain | 17911159 |
nsv1050043 | CNV | gain | 25217958 |
nsv517899 | CNV | gain | 19592680 |
nsv518487 | CNV | loss | 19592680 |
nsv695 | CNV | deletion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
primary ciliary dyskinesia |
|
|