Aliases for RPA4 Gene
External Ids for RPA4 Gene
Previous GeneCards Identifiers for RPA4 Gene
This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
GeneCards Summary for RPA4 Gene
RPA4 (Replication Protein A4) is a Protein Coding gene. Diseases associated with RPA4 include Spinal Muscular Atrophy, X-Linked 2 and Cholestasis, Intrahepatic, Of Pregnancy, 1. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is RPA2.
UniProtKB/Swiss-Prot Summary for RPA4 Gene
As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.