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This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
RPA4 (Replication Protein A4) is a Protein Coding gene. Diseases associated with RPA4 include Siberian Tick Typhus and Indian Tick Typhus. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Mismatch repair. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is RPA2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ097021 | Enhancer | 0.3 | Ensembl | 15.4 | +137.9 | 137892 | 1.2 | JUN NFE2L2 | RPA4 piR-52294-155 piR-35674-563 DIAPH2 ERVFC1 | |
GH0XJ096905 | Enhancer | 0.3 | Ensembl | 16.8 | +23.3 | 23293 | 2.8 | JUN | RPA4 NDUFB5P2 DIAPH2 ERVFC1 | |
GH0XJ096978 | Enhancer | 0.2 | ENCODE | 17.1 | +95.5 | 95460 | 1.2 | RPA4 DIAPH2 piR-52294-155 NDUFB5P2 ERVFC1 | ||
GH0XJ096908 | Enhancer | 0.2 | Ensembl | 16.2 | +25.6 | 25593 | 1.4 | RPA4 NDUFB5P2 DIAPH2 ERVFC1 | ||
GH0XJ096835 | Enhancer | 0.7 | Ensembl ENCODE | 0.3 | -48.0 | -48029 | 1.4 | PRDM10 TCF12 ARID3A RUNX3 NBN TBL1XR1 ATF2 IKZF1 | MN298114-326 RPA4 RF00017-8573 DIAPH2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003697 | single-stranded DNA binding | TAS,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000781 | chromosome, telomeric region | IBA | 21873635 |
GO:0005634 | nucleus | IBA,IDA | 19942684 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005662 | DNA replication factor A complex | TAS,IDA | 19116208 |
GO:0035861 | site of double-strand break | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
|
.80
|
2 | E2F mediated regulation of DNA replication |
.64
|
|
3 | Cell Cycle, Mitotic |
.83
|
|
4 | Mitotic G1-G1/S phases |
.83
|
|
5 | Telomere C-strand (Lagging Strand) Synthesis |
.67
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000077 | DNA damage checkpoint | IDA | 19942684 |
GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
GO:0000724 | double-strand break repair via homologous recombination | IBA | 21873635 |
GO:0006260 | DNA replication | IBA | 21873635 |
GO:0006270 | DNA replication initiation | TAS | 7760808 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RPA4 30 |
|
||
Dog (Canis familiaris) |
Mammalia | RPA4 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | RPA2 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | rpa2 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | RPA2 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RFA2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6662 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2642219 | - | p.Ala33Thr |
Disorder | Aliases | PubMed IDs |
---|---|---|
siberian tick typhus |
|
|
indian tick typhus |
|
|
israeli tick typhus |
|
|
boutonneuse fever |
|
|
ecthyma |
|
|