Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPA2 Gene

Aliases for RPA2 Gene

  • Replication Protein A2 2 3 5
  • Replication Protein A 34 KDa Subunit 3 4
  • Replication Factor A Protein 2 3 4
  • RF-A Protein 2 3 4
  • RP-A P32 3 4
  • RP-A P34 3 4
  • REPA2 3 4
  • RPA32 3 4
  • Replication Protein A 32 KDa Subunit 3
  • Replication Protein A2 (32kD) 2
  • Replication Protein A2, 32kDa 2
  • RPA34 4

External Ids for RPA2 Gene

Previous GeneCards Identifiers for RPA2 Gene

  • GC01P027225
  • GC01M027451
  • GC01M027822
  • GC01M028090
  • GC01M028218
  • GC01M026473

Summaries for RPA2 Gene

Entrez Gene Summary for RPA2 Gene

  • This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]

GeneCards Summary for RPA2 Gene

RPA2 (Replication Protein A2) is a Protein Coding gene. Diseases associated with RPA2 include Ataxia-Telangiectasia and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ubiquitin protein ligase binding. An important paralog of this gene is RPA4.

UniProtKB/Swiss-Prot for RPA2 Gene

  • As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

Gene Wiki entry for RPA2 Gene

Additional gene information for RPA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPA2 Gene

Genomics for RPA2 Gene

GeneHancer (GH) Regulatory Elements for RPA2 Gene

Promoters and enhancers for RPA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J027913 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 681.2 +0.3 286 1.8 FOXA2 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 RPA2 GMEB1 ACTG1P20 SNHG12 YTHDF2 TRNAU1AP RCC1 FAM76A ENSG00000231344 PPP1R8
GH01J027871 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.1 +40.2 40173 5.3 HDGF PKNOX1 ATF1 SMAD1 FEZF1 IRF4 GTF3C2 POLR2B ZNF207 ZNF143 THEMIS2 GMEB1 TRNAU1AP ACTG1P20 SNHG12 FGR YTHDF2 EYA3 GPN2 RPA2
GH01J027881 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 33.9 +27.0 26986 11.7 HDGF PKNOX1 BATF KLF5 IRF4 RARA SCRT2 ZNF143 ATF7 ETV6 RPA2 XKR8 THEMIS2 SMPDL3B ENSG00000227050 EYA3 SCARNA1 PPP1R8 RNU6-1245P FGR
GH01J027003 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +905.9 905912 10.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A YY1 POLR2B E2F8 TENT5B ARID1A LOC101928324 HMGN2 LOC101928728 GPN2 ACTG1P20 RPL17P9 FAM76A RPA2
GH01J026990 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +918.0 918004 13.3 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS TRNP1 ARID1A LOC101928324 PIGV RPL17P9 HMGN2 NR0B2 NUDC RPA2 NPM1P39
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPA2 gene promoter:
  • deltaCREB
  • CREB
  • C/EBPalpha
  • AP-4
  • PPAR-alpha
  • HEN1
  • MRF-2

Genomic Locations for RPA2 Gene

Genomic Locations for RPA2 Gene
chr1:27,891,524-27,914,797
(GRCh38/hg38)
Size:
23,274 bases
Orientation:
Minus strand
chr1:28,218,035-28,241,257
(GRCh37/hg19)
Size:
23,223 bases
Orientation:
Minus strand

Genomic View for RPA2 Gene

Genes around RPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPA2 Gene

Proteins for RPA2 Gene

  • Protein details for RPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15927-RFA2_HUMAN
    Recommended name:
    Replication protein A 32 kDa subunit
    Protein Accession:
    P15927
    Secondary Accessions:
    • Q52II0
    • Q5TEI9
    • Q5TEJ5

    Protein attributes for RPA2 Gene

    Size:
    270 amino acids
    Molecular mass:
    29247 Da
    Quaternary structure:
    • Component of the replication protein A complex (RPA/RP-A), a heterotrimeric complex composed of RPA1, RPA2 and RPA3 (PubMed:2406247, PubMed:19116208, PubMed:10449415). Interacts with PRPF19; the PRP19-CDC5L complex is recruited to the sites of DNA repair where it ubiquitinates the replication protein A complex (RPA) (PubMed:24332808). Interacts with SERTAD3 (PubMed:10982866). Interacts with TIPIN (PubMed:17141802, PubMed:17296725). Interacts with TIMELESS (PubMed:17141802). Interacts with PPP4R2; the interaction is direct, DNA damage-dependent and mediates the recruitment of the PP4 catalytic subunit PPP4C (PubMed:20154705). Interacts (hyperphosphorylated) with RAD51 (PubMed:20154705). Interacts with SMARCAL1; the interaction is direct and mediates the recruitment to the RPA complex of SMARCAL1 (PubMed:19793861, PubMed:19793862, PubMed:19793863). Interacts with RAD52 and XPA; those interactions are direct and associate RAD52 and XPA to the RPA complex (PubMed:7700386, PubMed:8702565, PubMed:17765923, PubMed:11081631). Interacts with FBXO18 (PubMed:23319600). Interacts with ETAA1; the interaction is direct and promotes ETAA1 recruitment at stalled replication forks (PubMed:27601467, PubMed:27723720, PubMed:27723717). Interacts with RFWD3 (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657).

    Three dimensional structures from OCA and Proteopedia for RPA2 Gene

    Alternative splice isoforms for RPA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPA2 Gene

Post-translational modifications for RPA2 Gene

  • Differentially phosphorylated throughout the cell cycle, becoming phosphorylated at the G1-S transition and dephosphorylated in late mitosis. Mainly phosphorylated at Ser-23 and Ser-29, by cyclin A-CDK2 and cyclin B-CDK1, respectively during DNA replication and mitosis. Dephosphorylation may require the serine/threonine-protein phosphatase 4. Phosphorylation at Ser-23 and Ser-29 is a prerequisite for further phosphorylation. Becomes hyperphosphorylated on additional residues including Ser-4, Ser-8, Thr-21 and Ser-33 in response to DNA damage. Hyperphosphorylation is mediated by ATM, ATR and PRKDC. Primarily recruited to DNA repair nuclear foci as a hypophosphorylated form it undergoes subsequent hyperphosphorylation, catalyzed by ATR. Hyperphosphorylation is required for RAD51 recruitment to chromatin and efficient DNA repair. Phosphorylation at Thr-21 depends upon RFWD3 presence.
  • DNA damage-induced Lys-63-linked polyubiquitination by PRPF19 mediates ATRIP recruitment to the RPA complex at sites of DNA damage and activation of ATR (PubMed:24332808). Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination (PubMed:26474068).
  • Ubiquitination at Lys127
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPA2 Gene

Domains & Families for RPA2 Gene

Gene Families for RPA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RPA2 Gene

Suggested Antigen Peptide Sequences for RPA2 Gene

Graphical View of Domain Structure for InterPro Entry

P15927

UniProtKB/Swiss-Prot:

RFA2_HUMAN :
  • Belongs to the replication factor A protein 2 family.
Family:
  • Belongs to the replication factor A protein 2 family.
genes like me logo Genes that share domains with RPA2: view

Function for RPA2 Gene

Molecular function for RPA2 Gene

UniProtKB/Swiss-Prot Function:
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
UniProtKB/Swiss-Prot Induction:
Translationally up-regulated in response to DNA damage (at protein level).
GENATLAS Biochemistry:
replication protein A,subunit 2,component of a trimeric single strand binding protein,involved in replication,homologous recombination and nucleotide excision repair,colocolizing with RAD51 on synapsed axes in meiosis and facilitating RAD51 function,also colocalizing with BLM in meiotic prophase of prophase nuclei of spermatocytes

Gene Ontology (GO) - Molecular Function for RPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003684 damaged DNA binding IDA 7700386
GO:0003697 single-stranded DNA binding ISS --
GO:0005515 protein binding IPI 2159011
GO:0019899 enzyme binding IPI 19793862
genes like me logo Genes that share ontologies with RPA2: view
genes like me logo Genes that share phenotypes with RPA2: view

Animal Model Products

Clone Products

  • Addgene plasmids for RPA2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPA2 Gene

Localization for RPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPA2 Gene

Nucleus. Nucleus, PML body. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. {ECO:0000269 PubMed:12814551}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 colocalizes_with chromosome, telomeric region IDA 17959650
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000785 chromatin IDA 10336450
GO:0005634 nucleus IDA 10982866
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with RPA2: view

Pathways & Interactions for RPA2 Gene

SuperPathway Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
3 DNA Double-Strand Break Repair
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Mismatch repair
genes like me logo Genes that share pathways with RPA2: view

SIGNOR curated interactions for RPA2 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for RPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000723 telomere maintenance IC,IMP 17959650
GO:0000724 double-strand break repair via homologous recombination IMP 17765923
GO:0006260 DNA replication TAS --
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with RPA2: view

Drugs & Compounds for RPA2 Gene

(11) Drugs for RPA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for RPA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPA2: view

Transcripts for RPA2 Gene

Unigene Clusters for RPA2 Gene

Replication protein A2, 32kDa:
Representative Sequences:

Clone Products

  • Addgene plasmids for RPA2

Alternative Splicing Database (ASD) splice patterns (SP) for RPA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2:
SP3: -

Relevant External Links for RPA2 Gene

GeneLoc Exon Structure for
RPA2
ECgene alternative splicing isoforms for
RPA2

Expression for RPA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPA2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPA2 Gene



Protein tissue co-expression partners for RPA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPA2 Gene:

RPA2

SOURCE GeneReport for Unigene cluster for RPA2 Gene:

Hs.79411

Evidence on tissue expression from TISSUES for RPA2 Gene

  • Muscle(4.3)
  • Kidney(4.2)
  • Lung(4.2)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with RPA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPA2 Gene

Orthologs for RPA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPA2 34 33
  • 98.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPA2 34 33
  • 90.99 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPA2 34 33
  • 90.86 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpa2 33
  • 87.16 (n)
mouse
(Mus musculus)
Mammalia Rpa2 16 34 33
  • 85.56 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
ManyToMany
-- 34
  • 83 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPA2 34 33
  • 67.6 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpa2 33
  • 64.32 (n)
Str.6420 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5629 33
zebrafish
(Danio rerio)
Actinopterygii rpa2 34 33 33
  • 61.26 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8565 33
fruit fly
(Drosophila melanogaster)
Insecta RPA2 34 33
  • 43.93 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008332 33
  • 41.36 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07371g 33
  • 44.33 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL176W 33
  • 42.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFA2 36 34 33
  • 42.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPA2 33
  • 45.47 (n)
rice
(Oryza sativa)
Liliopsida Os02g0829100 33
  • 43.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssb2 33
  • 47.51 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07717 33
  • 46.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6662 34
  • 32 (a)
OneToMany
Species where no ortholog for RPA2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPA2 Gene

ENSEMBL:
Gene Tree for RPA2 (if available)
TreeFam:
Gene Tree for RPA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPA2: view image

Paralogs for RPA2 Gene

Paralogs for RPA2 Gene

(1) SIMAP similar genes for RPA2 Gene using alignment to 3 proteins:

  • RFA2_HUMAN
  • Q5TEJ0_HUMAN
  • Q5TEJ7_HUMAN

Pseudogenes.org Pseudogenes for RPA2 Gene

genes like me logo Genes that share paralogs with RPA2: view

Variants for RPA2 Gene

Sequence variations from dbSNP and Humsavar for RPA2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000118563 -- 27,902,353(-) C/T intron_variant
rs1000205853 -- 27,903,962(-) C/G/T intron_variant
rs1000212369 -- 27,915,877(-) C/T upstream_transcript_variant
rs1000431 -- 27,898,603(-) C/T intron_variant
rs1000432 -- 27,898,608(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPA2 Gene

Variant ID Type Subtype PubMed ID
esv3585564 CNV loss 21293372
esv3585565 CNV gain 21293372
esv3585566 CNV loss 21293372
nsv1133128 CNV tandem duplication 24896259
nsv509069 CNV insertion 20534489

Variation tolerance for RPA2 Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPA2 Gene

Human Gene Mutation Database (HGMD)
RPA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPA2 Gene

Disorders for RPA2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPA2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search RPA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPA2 Gene

Publications for RPA2 Gene

  1. A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. (PMID: 20154705) Lee DH … Chowdhury D (Nature structural & molecular biology 2010) 3 4 22 58
  2. ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. (PMID: 12814551) Barr SM … Cimprich KA (Current biology : CB 2003) 3 4 22 58
  3. Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. (PMID: 11927569) Bochkareva E … Bochkarev A (The EMBO journal 2002) 3 4 22 58
  4. RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A. (PMID: 10982866) Cho JM … Alaoui-Jamali MA (Nucleic acids research 2000) 3 4 22 58
  5. Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. (PMID: 9295339) Zernik-Kobak M … Dixon K (The Journal of biological chemistry 1997) 3 4 22 58

Products for RPA2 Gene

  • Addgene plasmids for RPA2

Sources for RPA2 Gene