This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the... See more...

Aliases for RPA1 Gene

Aliases for RPA1 Gene

  • Replication Protein A1 2 3 5
  • Replication Protein A 70 KDa DNA-Binding Subunit 3 4
  • Single-Stranded DNA-Binding Protein 3 4
  • Replication Factor A Protein 1 3 4
  • Replication Protein A1, 70kDa 2 3
  • RF-A Protein 1 3 4
  • RP-A P70 3 4
  • REPA1 3 4
  • RPA70 3 4
  • Replication Protein A1 (70kD) 2
  • MSTP075 3
  • MST075 3
  • HSSB 3
  • RF-A 3
  • RP-A 3

External Ids for RPA1 Gene

Previous GeneCards Identifiers for RPA1 Gene

  • GC17P002039
  • GC17P001684
  • GC17P001939
  • GC17P001680

Summaries for RPA1 Gene

Entrez Gene Summary for RPA1 Gene

  • This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]

GeneCards Summary for RPA1 Gene

RPA1 (Replication Protein A1) is a Protein Coding gene. Diseases associated with RPA1 include Ataxia-Telangiectasia and Xeroderma Pigmentosum, Complementation Group A. Among its related pathways are Metabolism of proteins and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and single-stranded DNA binding.

UniProtKB/Swiss-Prot Summary for RPA1 Gene

  • As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance (PubMed:17959650). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).

Gene Wiki entry for RPA1 Gene

Additional gene information for RPA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RPA1 Gene

Genomics for RPA1 Gene

GeneHancer (GH) Regulatory Elements for RPA1 Gene

Promoters and enhancers for RPA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J001828 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 506.7 +0.5 499 2.8 HNRNPK EP300 NRF1 POLR2G USF1 SP1 PHF8 FOS ZFX POLR2A SMYD4 RPA1 RF00017-2215 lnc-TLCD2-5 MIR22HG RF00017-2214
GH17J001712 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 36.4 -113.9 -113928 7 EP300 FOXK2 HNRNPK ZNF217 CTCF SIN3A NRF1 TCF12 POLR2G USF1 WDR81 MIR22 MIR22HG SMYD4 PRPF8 RPA1 SERPINF2 METTL16 GEMIN4 TSR1
GH17J001294 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 72.9 -535.4 -535353 1.2 RBAK ZNF354C ZNF623 ZNF274 ATF2 ZEB1 GATAD2B CTBP1 ZNF148 KDM1A PRPF8 RPA1 SMYD4 ENSG00000263050 DPH1 WDR81 CRK GEMIN4 MYO1C DBIL5P
GH17J001293 Enhancer 1.1 ENCODE dbSUPER 72.9 -536.0 -536008 0.1 RBAK ZNF639 ZNF354C ZBTB10 ZNF623 TARDBP ZNF274 ATF2 ZEB1 GATAD2B piR-32214-257 PRPF8 RPA1 SMYD4 ENSG00000263050 DPH1 WDR81 GEMIN4 CRK MYO1C
GH17J002029 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 34.9 +201.1 201099 3.2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 MYC TCF12 POLR2G USF1 DPH1 RPA1 SMYD4 TSR1 PRPF8 SRR METTL16 SMG6 RTN4RL1 piR-36609
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RPA1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RPA1

Top Transcription factor binding sites by QIAGEN in the RPA1 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • CREB
  • deltaCREB
  • MAZR
  • NF-Y

Genomic Locations for RPA1 Gene

Genomic Locations for RPA1 Gene
chr17:1,829,702-1,900,082
(GRCh38/hg38)
Size:
70,381 bases
Orientation:
Plus strand
chr17:1,732,996-1,803,376
(GRCh37/hg19)
Size:
70,381 bases
Orientation:
Plus strand

Genomic View for RPA1 Gene

Genes around RPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPA1 Gene

Proteins for RPA1 Gene

  • Protein details for RPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27694-RFA1_HUMAN
    Recommended name:
    Replication protein A 70 kDa DNA-binding subunit
    Protein Accession:
    P27694
    Secondary Accessions:
    • A8K0Y9
    • Q59ES9

    Protein attributes for RPA1 Gene

    Size:
    616 amino acids
    Molecular mass:
    68138 Da
    Quaternary structure:
    • Component of the canonical replication protein A complex (RPA), a heterotrimer composed of RPA1, RPA2 and RPA3 (PubMed:27723720, PubMed:27723717). Also component of the aRPA, the alternative replication protein A complex, a trimeric complex similar to the replication protein A complex/RPA but where RPA1 and RPA3 are associated with RPA4 instead of RPA2 (PubMed:7760808, PubMed:19116208). The DNA-binding activity may reside exclusively on the RPA1 subunit. Interacts with PRPF19; the PRP19-CDC5L complex is recruited to the sites of DNA repair where it ubiquitinates the replication protein A complex (RPA) (PubMed:24332808). Interacts with RIPK1 (PubMed:16135809). Interacts with the polymerase alpha subunit POLA1/p180; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp (PubMed:9214288). Interacts with RAD51 and SENP6 to regulate DNA repair (PubMed:20705237). Interacts with HELB; this interaction promotes HELB recruitment to chromatin following DNA damage (PubMed:22194613, PubMed:26774285). Interacts with PRIMPOL (PubMed:24126761). Interacts with XPA; the interaction is direct and associates XPA with the RPA complex (PubMed:7700386, PubMed:9699634, PubMed:10563794). Interacts with ETAA1; the interaction is direct and promotes ETAA1 recruitment at stalled replication forks (PubMed:27601467, PubMed:27723720, PubMed:27723717).
    SequenceCaution:
    • Sequence=BAD92969.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPA1 Gene

neXtProt entry for RPA1 Gene

Post-translational modifications for RPA1 Gene

  • DNA damage-induced 'Lys-63'-linked polyubiquitination by PRPF19 mediates ATRIP recruitment to the RPA complex at sites of DNA damage and activation of ATR (PubMed:24332808). Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination (PubMed:26474068).
  • Sumoylated on lysine residues Lys-449 and Lys-577, with Lys-449 being the major site. Sumoylation promotes recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Desumoylated by SENP6.
  • Ubiquitination at Lys22, Lys88, Lys157, Lys183, Lys196, Lys220, Lys244, Lys267, Lys331, Lys367, Lys410, Lys431, Lys443, Lys458, Lys489, Lys502, Lys553, Lys588, and Lys595
  • Modification sites at PhosphoSitePlus

Other Protein References for RPA1 Gene

No data available for DME Specific Peptides for RPA1 Gene

Domains & Families for RPA1 Gene

Gene Families for RPA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RPA1 Gene

Blocks:
  • OB-fold nucleic acid binding domain
  • Replication factor-A protein 1, N-terminal
  • Replication factor-A, C-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPA1 Gene

GenScript: Design optimal peptide antigens:
  • MSTP075 (Q7Z4G2_HUMAN)
  • Single-stranded DNA-binding protein (RFA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P27694

UniProtKB/Swiss-Prot:

RFA1_HUMAN :
  • Belongs to the replication factor A protein 1 family.
Family:
  • Belongs to the replication factor A protein 1 family.
genes like me logo Genes that share domains with RPA1: view

Function for RPA1 Gene

Molecular function for RPA1 Gene

UniProtKB/Swiss-Prot Function:
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance (PubMed:17959650). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).
GENATLAS Biochemistry:
replication protein A,subunit 1,component 70kDa of a trimeric single strand binding protein,involved in replication,homologous recombination and nucleotide excision repair,colocalizing with RAD51 on synapsed axes in meiosis and facilitating RAD51 function,also colocalizing with BLM in meiotic prophase of prophase nuclei of spermatocytes

Phenotypes From GWAS Catalog for RPA1 Gene

Gene Ontology (GO) - Molecular Function for RPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003684 damaged DNA binding IBA,IDA 7700386
GO:0003697 single-stranded DNA binding IDA,IEA 8990123
GO:0005515 protein binding IPI 1311258
genes like me logo Genes that share ontologies with RPA1: view
genes like me logo Genes that share phenotypes with RPA1: view

Animal Models for RPA1 Gene

MGI Knock Outs for RPA1:
  • Rpa1 Rpa1<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPA1

Clone Products

  • Addgene plasmids for RPA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPA1 Gene

Localization for RPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPA1 Gene

Nucleus. Nucleus, PML body. Note=Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. {ECO:0000269 PubMed:17959650}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPA1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
mitochondrion 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IBA 21873635
GO:0005634 nucleus IDA 17959650
GO:0005654 nucleoplasm TAS --
GO:0005662 DNA replication factor A complex IPI,IEA 16135809
GO:0016605 colocalizes_with PML body IDA,IEA 17959650
genes like me logo Genes that share ontologies with RPA1: view

Pathways & Interactions for RPA1 Gene

PathCards logo

SuperPathways for RPA1 Gene

SuperPathway Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
3 DNA Double-Strand Break Repair
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Mismatch repair
genes like me logo Genes that share pathways with RPA1: view

Pathways by source for RPA1 Gene

1 GeneGo (Thomson Reuters) pathway for RPA1 Gene
  • Cell cycle Start of DNA replication in early S phase
1 Cell Signaling Technology pathway for RPA1 Gene
1 GeneTex pathway for RPA1 Gene

SIGNOR curated interactions for RPA1 Gene

Activates:

Gene Ontology (GO) - Biological Process for RPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000723 telomere maintenance IC,IMP 17959650
GO:0000724 double-strand break repair via homologous recombination IBA,IMP 17765923
GO:0006260 DNA replication TAS --
GO:0006261 DNA-dependent DNA replication IBA,TAS 21873635
genes like me logo Genes that share ontologies with RPA1: view

Drugs & Compounds for RPA1 Gene

(23) Drugs for RPA1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1594
Nelarabine Approved, Investigational Pharma Prodrug of ara-G for T-LBL/T-ALL 0
Oxaliplatin Approved, Investigational Pharma Antitumor agent, Platinum 1864
Uridine Experimental, Investigational Pharma 0
Carmofur Withdrawn Pharma Cytostatic derivative of fluorouracilm,antineoplatic agent 0

(13) Additional Compounds for RPA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(10) ApexBio Compounds for RPA1 Gene

Compound Action Cas Number
Adenine sulfate Sulfate salt form of adenine 321-30-2
Blasticidin S HCl 3513-03-9
Capecitabine 154361-50-9
Carmofur Cytostatic derivative of fluorouracilm,antineoplatic agent 61422-45-5
Gemcitabine HCl Inhibits DNA synthesis,deoxycytidine analog 122111-03-9
Mercaptopurine (6-MP) Purine synthesis inhibitor 50-44-2
Nelarabine Prodrug of ara-G for T-LBL/T-ALL 121032-29-9
Oxaliplatin Antitumor agent 61825-94-3
Rifaximin (Xifaxan) RNA synthesis inhibitor, PXR activator 80621-81-4
Uridine 58-96-8
genes like me logo Genes that share compounds with RPA1: view

Drug Products

Transcripts for RPA1 Gene

mRNA/cDNA for RPA1 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RPA1

Clone Products

  • Addgene plasmids for RPA1

Alternative Splicing Database (ASD) splice patterns (SP) for RPA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: -
SP2: - -
SP3:

Relevant External Links for RPA1 Gene

GeneLoc Exon Structure for
RPA1

Expression for RPA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPA1 Gene

Protein differential expression in normal tissues from HIPED for RPA1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPA1 Gene



Protein tissue co-expression partners for RPA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RPA1

SOURCE GeneReport for Unigene cluster for RPA1 Gene:

Hs.461925

Evidence on tissue expression from TISSUES for RPA1 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with RPA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPA1 Gene

Orthologs for RPA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPA1 31 30
  • 99.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPA1 31 30
  • 88.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPA1 31 30
  • 87.45 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpa1 30
  • 84.89 (n)
mouse
(Mus musculus)
Mammalia Rpa1 17 31 30
  • 84.39 (n)
oppossum
(Monodelphis domestica)
Mammalia RPA1 31
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPA1 31
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPA1 31 30
  • 74.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPA1 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpa1 30
  • 71 (n)
Str.10339 30
African clawed frog
(Xenopus laevis)
Amphibia LOC397937 30
zebrafish
(Danio rerio)
Actinopterygii rpa1 31 30
  • 64.55 (n)
OneToOne
wufi14b08 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4321 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001421 30
  • 51.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpA-70 31 32 30
  • 51.2 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F18A1.5 32
  • 31 (a)
rpa-1 31
  • 26 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL008W 30
  • 48.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08844g 30
  • 48.2 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RFA1 33 31 30
  • 43.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G19130 30
  • 49.22 (n)
rice
(Oryza sativa)
Liliopsida Os05g0111000 30
  • 50.15 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03606 30
  • 49.26 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssb1 30
  • 48.89 (n)
Species where no ortholog for RPA1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPA1 Gene

ENSEMBL:
Gene Tree for RPA1 (if available)
TreeFam:
Gene Tree for RPA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RPA1: view image

Paralogs for RPA1 Gene

No data available for Paralogs for RPA1 Gene

Variants for RPA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RPA1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
718295 Benign: not provided 1,842,798(+) C/A INTRON_VARIANT
718296 Benign: not provided 1,843,952(+) G/A SYNONYMOUS_VARIANT
rs5030755 - p.Thr351Ala

Additional dbSNP identifiers (rs#s) for RPA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPA1 Gene

Variant ID Type Subtype PubMed ID
esv33335 CNV loss 17666407
esv3639700 CNV loss 21293372
nsv1056771 CNV gain 25217958
nsv1065585 CNV gain 25217958
nsv930496 CNV deletion 23359205
nsv960040 CNV duplication 23825009

Variation tolerance for RPA1 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPA1 Gene

Human Gene Mutation Database (HGMD)
RPA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPA1 Gene

Disorders for RPA1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for RPA1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search RPA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RPA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPA1 Gene

Publications for RPA1 Gene

  1. RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells. (PMID: 17765923) Sleeth KM … Helleday T (Journal of molecular biology 2007) 3 4 23 54
  2. Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-->C mutation associated with coronary spastic angina. (PMID: 11063722) Miyamoto Y … Nakao K (Human molecular genetics 2000) 3 23 41 54
  3. The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair. (PMID: 9430682) Lin YL … Dutta A (The Journal of biological chemistry 1998) 3 4 23 54
  4. RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. (PMID: 7700386) He Z … Ingles CJ (Nature 1995) 3 4 23 54
  5. Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A. (PMID: 8454588) Umbricht CB … Kelly TJ (The Journal of biological chemistry 1993) 2 3 23 54

Products for RPA1 Gene

  • Signalway ELISA kits for RPA1
  • Signalway Proteins for RPA1

Sources for RPA1 Gene